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Article ; Online: In vitro

Jurić, Ivana / Bošnjak, Zrinka / Ćorić, Mario / Lešin, Joško / Mareković, Ivana

Journal of chemotherapy (Florence, Italy)

2021 Volume 34, Issue 1, Page(s) 67–70

Abstract: The main obstacle in treatment of infections caused by carbapenem-resistant Enterobacterales (CRE) are limited treatment options. The novel antimicrobial agents other than β-lactams with activity not being dependent on β-lactamase class are especially ... ...

Abstract	The main obstacle in treatment of infections caused by carbapenem-resistant Enterobacterales (CRE) are limited treatment options. The novel antimicrobial agents other than β-lactams with activity not being dependent on β-lactamase class are especially important. Eravacycline (ERV) is the first fully synthetic fluorocycline indicated for the treatment of complicated intra-abdominal infections in adults. Eighty CRE isolates at the University Hospital Centre Zagreb, Croatia were examined for susceptibility to ERV by disc diffusion method and minimal inhibitory concentration (MIC). Total of 54 (54/80; 67.5%) isolates were susceptible to ERV with MIC
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Carbapenem-Resistant Enterobacteriaceae/drug effects ; Carbapenem-Resistant Enterobacteriaceae/genetics ; Croatia ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Tetracyclines/pharmacology ; beta-Lactamase Inhibitors/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Tetracyclines ; beta-Lactamase Inhibitors ; eravacycline (07896928ZC)
Language	English
Publishing date	2021-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1036294-0
ISSN	1973-9478 ; 1120-009X
ISSN (online)	1973-9478
ISSN	1120-009X
DOI	10.1080/1120009X.2021.1965335
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Zs.A 2701: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 387: Show issues

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Article: Successful Treatment of a Rare Cholesterol Homeostasis Disorder Due to

Brlek, Petar / Bulić, Luka / Glavaš Weinberger, David / Bošnjak, Jelena / Pavlović, Tomislav / Tomić, Svetlana / Krivdić Dupan, Zdravka / Borić, Igor / Primorac, Dragan

Biomedicines

2023 Volume 11, Issue 5

Abstract: Cerebrotendinous xanthomatosis (CTX) is a genetic disorder of the cholesterol metabolic pathway, most often associated with variants in the CYP27A1 gene. The dysregulation of cholesterol metabolism results in the accumulation of metabolites such as ... ...

Abstract	Cerebrotendinous xanthomatosis (CTX) is a genetic disorder of the cholesterol metabolic pathway, most often associated with variants in the CYP27A1 gene. The dysregulation of cholesterol metabolism results in the accumulation of metabolites such as cholestanol, which has a predilection for neuronal tissue and tendons. The condition is treatable with chenodeoxycholic acid (CDCA), which halts the production of these metabolites. We present two adult brothers, without diagnosis, suffering from ataxia, general muscle weakness and cognitive deficits. Both brothers suffered from early onset cataracts, watery stools and thoracic kyphoscoliosis. Magnetic resonance imaging revealed hyperintense alterations in the central nervous system and intratendinous xanthomas in the Achilles tendons. A biochemical analysis showed elevated levels of cholestanol, lathosterol and 7-dehydrocholesterol. Their family history was negative for neurological and metabolic disorders. Genetic testing revealed a pathogenic
Language	English
Publishing date	2023-05-12
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11051430
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Article ; Online: Conservative Treatment for Spontaneous Resolution of Postoperative Symptomatic Thoracic Spinal Epidural Hematoma-A Case Report.

Dokuzović, Stjepan / Španić, Mario / Muthu, Sathish / Pavešić, Jure / Ivandić, Stjepan / Eder, Gregor / Bošnjak, Bogdan / Prodan, Ksenija / Lončar, Zoran / Ćorluka, Stipe

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 9

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	Humans ; Hematoma, Epidural, Spinal/surgery ; Hematoma, Epidural, Spinal/etiology ; Conservative Treatment ; Hematoma, Epidural, Cranial ; Thoracic Vertebrae/surgery ; Disease Progression ; Magnetic Resonance Imaging/adverse effects
Language	English
Publishing date	2023-09-02
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59091590
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Zs.A 6270: Show issues

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Article: Cardiac Melanoma Metastasis with ERBB2 Gene Amplification: A Potential for Future Targeted Therapy.

Gams, Polona / Dolenc Stražar, Zvezdana / Šoštarič, Maja / Bošnjak, Matic / Kšela, Juš

Case reports in oncology

2021 Volume 14, Issue 1, Page(s) 622–627

Abstract: Cardiac tumors are rare, and their treatment differs interindividually regarding the histopathological proprieties and the stage of disease. Authors present a case of symptomatic cardiac melanoma metastasis that expressed ... ...

Abstract	Cardiac tumors are rare, and their treatment differs interindividually regarding the histopathological proprieties and the stage of disease. Authors present a case of symptomatic cardiac melanoma metastasis that expressed an
Language	English
Publishing date	2021-03-29
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2458961-5
ISSN	1662-6575
ISSN	1662-6575
DOI	10.1159/000514981
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Article ; Online: Effects of changing supply water quality on drinking water distribution networks: Changes in NOM optical properties, disinfection byproduct formation, and Mn deposition and release.

Kurajica, L / Ujević Bošnjak, M / Kinsela, A S / Štiglić, J / Waite, T D / Capak, K / Pavlić, Z

The Science of the total environment

2020 Volume 762, Page(s) 144159

Abstract: Field studies were conducted in a Croatian city supplied by two distinct groundwater sources (referred to as A and B) to investigate both the effects of changing water source on the water quality in the drinking water supply system, as well as to further ...

Abstract	Field studies were conducted in a Croatian city supplied by two distinct groundwater sources (referred to as A and B) to investigate both the effects of changing water source on the water quality in the drinking water supply system, as well as to further understand discoloration events that occurred in city locations that switched water from source A to B. The water treatment processes at site A were found to alter organic matter (OM) characteristics, removing humic substances while enhancing protein-derived (tryptophan) content. Although the humic-like component predominated in raw waters, microbially/protein-derived components were found to increase throughout the distribution networks of both systems. Disinfection byproducts (DBPs) such as total trihalomethane (TTHM) and total haloacetic acid (THAA) were prevalent in water distribution system (WDS)-A, which correlated with elevated OM content as well as re-chlorination with hypochlorite (NaOCl). Our field study revealed that THMs were more readily formed than HAAs during ClO
MeSH term(s)	Disinfectants/analysis ; Disinfection ; Drinking Water/analysis ; Halogenation ; Trihalomethanes/analysis ; Water Pollutants, Chemical/analysis ; Water Purification ; Water Quality ; Water Supply
Chemical Substances	Disinfectants ; Drinking Water ; Trihalomethanes ; Water Pollutants, Chemical
Language	English
Publishing date	2020-12-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.144159
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Zs.A 949: Show issues

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Article ; Online: Mixing of arsenic-rich groundwater and surface water in drinking water distribution systems: Implications for contaminants, disinfection byproducts and organic components.

Kurajica, L / Ujević Bošnjak, M / Kinsela, A S / Bieroza, M / Štiglić, J / Waite, T D / Capak, K / Romić, Ž

Chemosphere

2021 Volume 292, Page(s) 133406

Abstract: The utilization of groundwaters containing high levels of arsenic (As) for drinking water purposes presents major health and economic challenges for water utilities. One low-cost approach is to mix arsenic-rich groundwater (GW) with arsenic-free surface ... ...

Abstract	The utilization of groundwaters containing high levels of arsenic (As) for drinking water purposes presents major health and economic challenges for water utilities. One low-cost approach is to mix arsenic-rich groundwater (GW) with arsenic-free surface waters (SW) to achieve acceptable As levels. In this study we investigated the effect of different mixing ratios on water quality in an eastern Croatian water distribution system (WDS). To investigate the effects of mixing on drinking water quality, we measured the organic matter (OM) composition, disinfection byproduct (DBP) and metal concentrations in differently mixed ratios of GW and SW within the WDS. Fluorescence analysis revealed that the GW and SW had similar OM composition, with an almost equal ratio of humic- and protein-like OM throughout the WDS despite fluorescence indices revealing slightly different OM sources between the two water types. The tyrosine-like OM component was more variable, increasing during warmer months and towards the end of the WDS, most likely due to enhanced biofilm formation. Arsenic concentrations decreased to below 10 μg/L in the second half of the sampling campaign. Acceptable water quality was achieved after a period of destabilization and solubilization of loose deposits within the WDS resulting in their mobilization caused by water quality changes. Principal component and classification analysis, regression models and Spearman correlation coefficients revealed an association between As, OM and DBP concentrations with these correlations suggestive of their role in As mobilization in the WDS. Changing source waters, with different OM content and characteristics, corresponded to variable As release within the WDS.
Language	English
Publishing date	2021-12-24
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.133406
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Zs.A 2540: Show issues

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Article: Difference of Symptoms Networks in Early and Late Phase Schizophrenia; A Cross-Sectional Network Analysis.

Đuran, Nataša / Sušac, Jelena / Vidović, Domagoj / Bošnjak, Dina / Vukojević, Jakša / Bajić, Žarko / Henigsberg, Neven / Jukić, Vlado

Psychiatria Danubina

2021 Volume 33, Issue Suppl 4, Page(s) 710–718

Abstract: Objective: The functional remission or recovery of schizophrenia patients is a challenging task which relies on pharmacotherapy but also on the timing of psychotherapy and other therapeutic interventions. The study aimed to assess the difference in ... ...

Abstract	Objective: The functional remission or recovery of schizophrenia patients is a challenging task which relies on pharmacotherapy but also on the timing of psychotherapy and other therapeutic interventions. The study aimed to assess the difference in strength and structure of symptoms networks between early and late phase schizophrenia. Our secondary objective was to check whether the overall, positive, negative, and general symptoms severity change over the course of treatment and disorder. Methods: This nested cross-sectional analysis combined the samples from two studies performed during 2014-2016 at University Psychiatric Hospital Vrapče, Zagreb, Croatia on the consecutive sample of men 30-60 years old diagnosed with schizophrenia, 85 of them in the early (≤5 years from diagnosis), and 143 in the late phase of the illness. The study was funded by the project: "Biomarkers in schizophrenia - integration of complementary methods in longitudinal follow up of FEP patients". Results: Median (IQR) age of the participant in the early phase was 36 (32-45) years and in the late phase 44 (38-49) years. Patients in the early phase had significantly higher odds for being in the symptomatic remission compared to the patients in the late-phase schizophrenia (OR=2.11; 95% CI 1.09-4.09) and had 10% less pronounced negative symptoms. The global strength, density, and structure of the symptoms network were not significantly different between the two study groups. Conclusions: Negative symptoms severity change with the course of illness and differ from the early to the late phase of schizophrenia. However, the overall network of psychotic symptoms is relatively stable, and overall strengths or density and the partial relationship between particular symptoms do not change significantly. The observed worsening of negative symptoms is probably at least partially caused by the lack of clear guidelines and effective treatment options aimed specifically toward negative symptoms.
MeSH term(s)	Adult ; Cross-Sectional Studies ; Hospitals, Psychiatric ; Humans ; Male ; Middle Aged ; Psychotherapy ; Psychotic Disorders ; Schizophrenia/therapy
Language	English
Publishing date	2021-10-31
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1067580-2
ISSN	0353-5053
ISSN	0353-5053
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Zs.A 3158: Show issues

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Article ; Online: Unprecedented Epimerization of an Azithromycin Analogue: Synthesis, Structure and Biological Activity of 2'-Dehydroxy-5″-Epi-Azithromycin.

Kragol, Goran / Steadman, Victoria A / Marušić Ištuk, Zorica / Čikoš, Ana / Bosnar, Martina / Jelić, Dubravko / Ergović, Gabrijela / Trzun, Marija / Bošnjak, Berislav / Bokulić, Ana / Padovan, Jasna / Glojnarić, Ines / Eraković Haber, Vesna

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 3

Abstract: Certain macrolide antibiotics, azithromycin included, possess anti-inflammatory properties that are considered fundamental for their efficacy in the treatment of chronic inflammatory diseases, such as diffuse pan-bronchiolitis and cystic fibrosis. In ... ...

Abstract	Certain macrolide antibiotics, azithromycin included, possess anti-inflammatory properties that are considered fundamental for their efficacy in the treatment of chronic inflammatory diseases, such as diffuse pan-bronchiolitis and cystic fibrosis. In this study, we disclose a novel azithromycin analog obtained via Barton-McCombie oxidation during which an unprecedented epimerization on the cladinose sugar occurs. Its structure was thoroughly investigated using NMR spectroscopy and compared to the natural epimer, revealing how the change in configuration of one single stereocenter (out of 16) profoundly diminished the antimicrobial activity through spatial manipulation of ribosome binding epitopes. At the same time, the anti-inflammatory properties of parent macrolide were retained, as demonstrated by inhibition of LPS- and cigarette-smoke-induced pulmonary inflammation. Not surprisingly, the compound has promising developable properties including good oral bioavailability and a half-life that supports once-daily dosing. This novel anti-inflammatory candidate has significant potential to fill the gap in existing anti-inflammatory agents and broaden treatment possibilities.
MeSH term(s)	Animals ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Azithromycin/analogs & derivatives ; Azithromycin/chemical synthesis ; Azithromycin/pharmacology ; Bacteria/drug effects ; Bacterial Infections/drug therapy ; Cells, Cultured ; Humans ; Macrolides/chemical synthesis ; Macrolides/chemistry ; Macrolides/pharmacology ; Mice, Inbred BALB C ; Models, Molecular ; Oxidation-Reduction ; Pneumonia/drug therapy ; Mice
Chemical Substances	Anti-Bacterial Agents ; Anti-Inflammatory Agents ; Macrolides ; Azithromycin (83905-01-5)
Language	English
Publishing date	2022-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27031034
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Article: Mixing of arsenic-rich groundwater and surface water in drinking water distribution systems: Implications for contaminants, disinfection byproducts and organic components

Kurajica, L. / Ujević Bošnjak, M. / Kinsela, A.S. / Bieroza, M. / Štiglić, J. / Waite, T.D. / Capak, K. / Romić, Ž

Chemosphere. 2022 Apr., v. 292

2022

Abstract	The utilization of groundwaters containing high levels of arsenic (As) for drinking water purposes presents major health and economic challenges for water utilities. One low-cost approach is to mix arsenic-rich groundwater (GW) with arsenic-free surface waters (SW) to achieve acceptable As levels. In this study we investigated the effect of different mixing ratios on water quality in an eastern Croatian water distribution system (WDS). To investigate the effects of mixing on drinking water quality, we measured the organic matter (OM) composition, disinfection byproduct (DBP) and metal concentrations in differently mixed ratios of GW and SW within the WDS. Fluorescence analysis revealed that the GW and SW had similar OM composition, with an almost equal ratio of humic- and protein-like OM throughout the WDS despite fluorescence indices revealing slightly different OM sources between the two water types. The tyrosine-like OM component was more variable, increasing during warmer months and towards the end of the WDS, most likely due to enhanced biofilm formation. Arsenic concentrations decreased to below 10 μg/L in the second half of the sampling campaign. Acceptable water quality was achieved after a period of destabilization and solubilization of loose deposits within the WDS resulting in their mobilization caused by water quality changes. Principal component and classification analysis, regression models and Spearman correlation coefficients revealed an association between As, OM and DBP concentrations with these correlations suggestive of their role in As mobilization in the WDS. Changing source waters, with different OM content and characteristics, corresponded to variable As release within the WDS.
Keywords	arsenic ; biofilm ; byproducts ; disinfection ; fluorescence ; groundwater ; organic matter ; solubilization ; surface water ; water distribution ; water quality
Language	English
Dates of publication	2022-04
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.133406
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2540: Show issues

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Article ; Online: Overcoming barriers to timely recognition and treatment of cancer cachexia: Sharing Progress in Cancer Care Task Force Position Paper and Call to Action.

Arends, Jann / Muscaritoli, Maurizio / Anker, Stefan / Audisio, Riccardo / Barazzoni, Rocco / Bosnjak, Snezana / Bossi, Paolo / Bowman, Jacqueline / Gijssels, Stefan / Krznarić, Željko / Strasser, Florian / Aapro, Matti

Critical reviews in oncology/hematology

2023 Volume 185, Page(s) 103965

Abstract: Cachexia is a life-threatening disorder affecting an estimated 50-80% of cancer patients. The loss of skeletal muscle mass in patients with cachexia is associated with an increased risk of anticancer treatment toxicity, surgical complications and reduced ...

Abstract	Cachexia is a life-threatening disorder affecting an estimated 50-80% of cancer patients. The loss of skeletal muscle mass in patients with cachexia is associated with an increased risk of anticancer treatment toxicity, surgical complications and reduced response. Despite international guidelines, the identification and management of cancer cachexia remains a significant unmet need owing in part to the lack of routine screening for malnutrition and suboptimal integration of nutrition and metabolic care into clinical oncology practice. In June 2020, Sharing Progress in Cancer Care (SPCC) convened a multidisciplinary task force of medical experts and patient advocates to examine the barriers preventing the timely recognition of cancer cachexia, and provide practical recommendations to improve clinical care. This position paper summarises the key points and highlights available resources to support the integration of structured nutrition care pathways.
MeSH term(s)	Humans ; Cachexia/diagnosis ; Cachexia/etiology ; Cachexia/therapy ; Sarcopenia/diagnosis ; Sarcopenia/etiology ; Sarcopenia/therapy ; Malnutrition/diagnosis ; Malnutrition/etiology ; Malnutrition/therapy ; Neoplasms/complications ; Neoplasms/therapy ; Nutritional Status
Language	English
Publishing date	2023-03-15
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2023.103965
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