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  1. Article ; Online: Letter to the Editor, regarding Li L, Zhu X, Chen X, Gao J, Ding C, et al. Advances in targeted therapy for pulmonary arterial hypertension in children. Eur J Pediatr. 2022 Dec 17.

    Beghetti, Maurice / Ivy, Dunbar / Scott, Nicola / Machlitt-Northen, Sandra / Lukas, Mary Ann

    European journal of pediatrics

    2023  Volume 182, Issue 5, Page(s) 2453–2454

    MeSH term(s) Humans ; Child ; Pulmonary Arterial Hypertension
    Language English
    Publishing date 2023-02-27
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-023-04877-6
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  2. Article: Surface Soil Moisture Retrieval Using the L-Band Synthetic Aperture Radar Onboard the Soil Moisture Active-Passive Satellite and Evaluation at Core Validation Sites.

    Kim, Seung-Bum / van Zyl, Jakob J / Johnson, Joel T / Moghaddam, Matha / Tsang, Leung / Colliander, Andreas / Dunbar, Roy Scott / Jackson, Thomas J / Jaruwatanadilok, Sermsak / West, Richard / Berg, Aaron / Caldwell, Todd / Cosh, Michael H / Goodrich, David C / Livingston, Stanley / López-Baeza, Ernesto / Rowlandson, Tracy / Thibeault, Marc / Walker, Jeffrey P /
    Entekhabi, Dara / Njoku, Eni G / O'Neill, Peggy E / Yueh, Simon H

    IEEE transactions on geoscience and remote sensing : a publication of the IEEE Geoscience and Remote Sensing Society

    2019  Volume Volume 55, Issue Iss 4, Page(s) 1897–1914

    Abstract: ... resolution using L-band dual-copolarized Soil Moisture Active-Passive (SMAP) synthetic aperture radar (SAR ...

    Abstract This paper evaluates the retrieval of soil moisture in the top 5-cm layer at 3-km spatial resolution using L-band dual-copolarized Soil Moisture Active-Passive (SMAP) synthetic aperture radar (SAR) data that mapped the globe every three days from mid-April to early July, 2015. Surface soil moisture retrievals using radar observations have been challenging in the past due to complicating factors of surface roughness and vegetation scattering. Here, physically based forward models of radar scattering for individual vegetation types are inverted using a time-series approach to retrieve soil moisture while correcting for the effects of static roughness and dynamic vegetation. Compared with the past studies in homogeneous field scales, this paper performs a stringent test with the satellite data in the presence of terrain slope, subpixel heterogeneity, and vegetation growth. The retrieval process also addresses any deficiencies in the forward model by removing any time-averaged bias between model and observations and by adjusting the strength of vegetation contributions. The retrievals are assessed at 14 core validation sites representing a wide range of global soil and vegetation conditions over grass, pasture, shrub, woody savanna, corn, wheat, and soybean fields. The predictions of the forward models used agree with SMAP measurements to within 0.5 dB unbiased-root-mean-square error (ubRMSE) and -0.05 dB (bias) for both copolarizations. Soil moisture retrievals have an accuracy of 0.052 m
    Language English
    Publishing date 2019-07-22
    Publishing country United States
    Document type Journal Article
    ISSN 0196-2892
    ISSN 0196-2892
    DOI 10.1109/TGRS.2016.2631126
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  3. Article: T-DNA-tagged chromosome 12 in donor Lycopersicon esculentum × L. pennellii is retained in asymmetric somatic hybrids with recipient Solanum lycopersicoides.

    McCabe, P F / Dunbar, L J / Guri, A / Sink, K C

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

    2013  Volume 86, Issue 2-3, Page(s) 377–382

    Abstract: ... of donor Lycopersicon esculentum × L. pennellii (EP) interspecific hybrid with callus-derived protoplasts ... and the T-DNA insert mapped to the L. esculentum chromosome 12. The T-DNA insert conferred ...

    Abstract Asymmetric somatic hybrid plants were recovered after fusing irradiated mesophyll protoplasts of donor Lycopersicon esculentum × L. pennellii (EP) interspecific hybrid with callus-derived protoplasts of recipient Solanum lycopersicoides. EP plant A54 had been previously transformed by an agrobacterium vector, and the T-DNA insert mapped to the L. esculentum chromosome 12. The T-DNA insert conferred kanamycin resistance to EP that was subsequently used to select cell fusion products and recover asymmetric hybrid plants that retained tagged chromosome 12. Doses of 50- and 100-Gy irradiation promoted the elimination of only a few donor chromosomes. At 200 Gy, the regenerated plants had ploidy levels higher than tetraploid. However, the T-DNA tagged chromosome 12 was always retained in the asymmetric hybrid plants tested. Likewise, all plants from the 100-Gy series, with the exception of number 160, were mixoploid in the root-tip cells. Such mixoploid asymmetric somatic hybrids could be stabilized by inducing adventitious shoots on leaf strips cultured on shoot regeneration medium containing kanamycin. The asymmetric hybrid plants did not produce viable seed when self-pollinated or backcrossed to tomato or S. lycopersicoides.
    Language English
    Publishing date 2013-10-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2170-2
    ISSN 1432-2242 ; 0040-5752
    ISSN (online) 1432-2242
    ISSN 0040-5752
    DOI 10.1007/BF00222105
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  4. Article ; Online: Erratum to: "Orbital prefrontal cortex volume correlates with social cognitive competence" by Powell, J.L. et al. [Neuropsychologia 48 (12) (2010) 3554-3562].

    Powell, Joanne L / Lewis, Penelope A / Dunbar, Robin I M / Roberts, Neil / García-Fiñana, Marta

    Neuropsychologia

    2011  Volume 49, Issue 5, Page(s) 1390

    Language English
    Publishing date 2011-04
    Publishing country England
    Document type Published Erratum
    ZDB-ID 207151-4
    ISSN 1873-3514 ; 0028-3932
    ISSN (online) 1873-3514
    ISSN 0028-3932
    DOI 10.1016/j.neuropsychologia.2011.01.031
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    Zs.A 524: Show issues Location:
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  5. Article ; Online: Treatment of Creatine Transporter (SLC6A8) Deficiency With Oral S-Adenosyl Methionine as Adjunct to L-arginine, Glycine, and Creatine Supplements.

    Jaggumantri, Sravan / Dunbar, Mary / Edgar, Vanessa / Mignone, Cristina / Newlove, Theresa / Elango, Rajavel / Collet, Jean Paul / Sargent, Michael / Stockler-Ipsiroglu, Sylvia / van Karnebeek, Clara D M

    Pediatric neurology

    2015  Volume 53, Issue 4, Page(s) 360–363.e2

    Abstract: ... developmental disability. A third of patients are amenable to treatment with high-dose oral creatine, glycine, and L ...

    Abstract Background: Creatine transporter (SLC6A8) deficiency is an X-linked inborn error of metabolism characterized by cerebral creatine deficiency, behavioral problems, seizures, hypotonia, and intellectual developmental disability. A third of patients are amenable to treatment with high-dose oral creatine, glycine, and L-arginine supplementation.
    Methods: Given the limited treatment response, we initiated an open-label observational study to evaluate the effect of adjunct S-adenosyl methionine to further enhance intracerebral creatine synthesis.
    Results: Significant and reproducible issues with sleep and behavior were noted in both male patients on a dose of 50/mg/kg. One of the two patients stopped S-adenosyl methionine and did not come for any follow-up. A safe and tolerable dose (17 mg/kg/day) was identified in the other patient. On magnetic resonance spectroscopy, this 8-year-old male did not show an increase in intracerebral creatine. However, significant improvement in speech/language skills, muscle mass were observed as well as in personal outcomes as defined by the family in activities related to communication and decision making.
    Discussion: Further research is needed to assess the potential of S-adenosyl methionine as an adjunctive therapy for creatine transporter deficiency patients and to define the optimal dose. Our study also illustrates the importance of pathophysiology-based treatment, individualized outcome assessment, and patient/family participation in rare diseases research.
    MeSH term(s) Administration, Oral ; Arginine/administration & dosage ; Basal Ganglia/drug effects ; Basal Ganglia/metabolism ; Brain Diseases, Metabolic, Inborn/drug therapy ; Brain Diseases, Metabolic, Inborn/physiopathology ; Brain Diseases, Metabolic, Inborn/psychology ; Central Nervous System Agents/administration & dosage ; Child ; Creatine/administration & dosage ; Creatine/deficiency ; Drug Therapy, Combination ; Follow-Up Studies ; Glycine/administration & dosage ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Medication Adherence ; Mental Retardation, X-Linked/drug therapy ; Mental Retardation, X-Linked/physiopathology ; Mental Retardation, X-Linked/psychology ; Plasma Membrane Neurotransmitter Transport Proteins/deficiency ; S-Adenosylmethionine/administration & dosage ; Treatment Outcome
    Chemical Substances Central Nervous System Agents ; Plasma Membrane Neurotransmitter Transport Proteins ; S-Adenosylmethionine (7LP2MPO46S) ; Arginine (94ZLA3W45F) ; Creatine (MU72812GK0) ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Case Reports ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2015.05.006
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    Zs.A 2260: Show issues Location:
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  6. Article ; Online: Revisiting Proton Pump Inhibitors as Chemoprophylaxis Against the Progression of Barrett's Esophagus.

    Shah, Shawn L / Dunbar, Kerry

    Current gastroenterology reports

    2023  Volume 25, Issue 12, Page(s) 374–379

    Abstract: Purpose of review: Barrett's esophagus (BE) is associated with chronic gastroesophageal reflux disease and is a known precursor to esophageal adenocarcinoma. While endoscopic surveillance strategies and the role for endoscopic eradication therapy have ... ...

    Abstract Purpose of review: Barrett's esophagus (BE) is associated with chronic gastroesophageal reflux disease and is a known precursor to esophageal adenocarcinoma. While endoscopic surveillance strategies and the role for endoscopic eradication therapy have been well established, there has been much interest in identifying chemopreventive agents to disrupt or halt the metaplasia-dysplasia-carcinoma sequence in patients with BE.
    Recent findings: No pharmacological agent has held more hope in reducing the risk of neoplastic progression in BE than proton pump inhibitors (PPIs). However, data supporting PPIs for chemoprevention have largely been from observational cohort and case-control studies with mixed results. In this review, we revisit the literature and highlight the role of PPIs in patients with BE as it pertains to chemoprophylaxis against the progression of BE to dysplasia and esophageal adenocarcinoma.
    MeSH term(s) Humans ; Barrett Esophagus/complications ; Barrett Esophagus/drug therapy ; Barrett Esophagus/pathology ; Proton Pump Inhibitors/therapeutic use ; Proton Pump Inhibitors/pharmacology ; Esophageal Neoplasms/etiology ; Esophageal Neoplasms/prevention & control ; Adenocarcinoma/etiology ; Adenocarcinoma/prevention & control ; Chemoprevention/methods
    Chemical Substances Proton Pump Inhibitors
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2041376-2
    ISSN 1534-312X ; 1522-8037
    ISSN (online) 1534-312X
    ISSN 1522-8037
    DOI 10.1007/s11894-023-00905-5
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  7. Article ; Online: The COVID-19 vaccination campaign in Switzerland and its impact on disease spread.

    Bekker-Nielsen Dunbar, M / Held, L

    Epidemics

    2024  Volume 47, Page(s) 100745

    Abstract: We analyse infectious disease case surveillance data to estimate COVID-19 spread and gain an understanding of the impact of introducing vaccines to counter the disease in Switzerland. The data used in this work is extensive and detailed and includes ... ...

    Abstract We analyse infectious disease case surveillance data to estimate COVID-19 spread and gain an understanding of the impact of introducing vaccines to counter the disease in Switzerland. The data used in this work is extensive and detailed and includes information on weekly number of cases and vaccination rates by age and region. Our approach takes into account waning immunity. The statistical analysis allows us to determine the effects of choosing alternative vaccination strategies. Our results indicate greater uptake of vaccine would have led to fewer cases with a particularly large effect on undervaccinated regions. An alternative distribution scheme not targeting specific age groups also leads to fewer cases overall but could lead to more cases among the elderly (a potentially vulnerable population) during the early stage of prophylaxis rollout.
    Language English
    Publishing date 2024-02-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2467993-8
    ISSN 1878-0067 ; 1755-4365
    ISSN (online) 1878-0067
    ISSN 1755-4365
    DOI 10.1016/j.epidem.2024.100745
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  8. Article ; Online: "Interferon" with MPN hematopoietic stem cells.

    Dunbar, Andrew / Levine, Ross L

    Blood

    2021  Volume 137, Issue 16, Page(s) 2129–2130

    MeSH term(s) Antiviral Agents ; Hematopoietic Stem Cells ; Humans ; Interferons ; Myeloproliferative Disorders
    Chemical Substances Antiviral Agents ; Interferons (9008-11-1)
    Language English
    Publishing date 2021-04-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021011273
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  9. Article ; Online: Aerial maneuvers of leaping lemurs: The physics of whole-body rotations while airborne.

    Dunbar, Donald C

    American journal of primatology

    2020  Volume 16, Issue 4, Page(s) 291–303

    Abstract: ... of critical body positions that were extracted from the filmed sequences. One L. catta specimen was segmented ...

    Abstract Several prosimian species begin a leap from a vertical support with their back toward the landing target. To reorient themselves from this dorsally facing, head-first lift-off to a ventrally facing, feet-first landing, the animals combine an initial twist with a partial backward somersault. Cinefilms of a captive colony of ringtailed lemurs (Lemur catta) revealed that during leaps from vertical poles to horizontal supports, the backward somersaulting rotations were often initiated while the animals were airborne. How could these prosimians initiate rotations in the absence of externally applied forces without violating angular momentum conservation? The problem was approached through vector analysis to demonstrate angular momentum (H) changes about the three principal (symmetrical) axes of rotation for a series of critical body positions that were extracted from the filmed sequences. One L. catta specimen was segmented to provide the dimensions and weights necessary for modeling the various body positions. These data were also used to calculate moments of inertia about the three principal axes in order to predict if rotations about these axes were stable or metastable. Lemurs, like any projectile, must conserve the total angular momentum (H
    Language English
    Publishing date 2020-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1495834-X
    ISSN 1098-2345 ; 0275-2565
    ISSN (online) 1098-2345
    ISSN 0275-2565
    DOI 10.1002/ajp.1350160402
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  10. Article: Controlling Genome Topology with Sequences that Trigger Post-replication Gap Formation During Replisome Passage: The

    Pham, Phuong / Wood, Elizabeth A / Dunbar, Emma L / Cox, Michael M / Goodman, Myron F

    bioRxiv : the preprint server for biology

    2024  

    Abstract: We report that ... ...

    Abstract We report that the
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.01.560376
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