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  1. Book ; Online ; E-Book: Plattformökonomie im Gesundheitswesen

    Stummeyer, Christian / Raab, Andrea E. / Behm, Moritz Erasmus

    Health-as-a-Service – Digitale Geschäftsmodelle für bessere Behandlungsqualität und Patient Experience

    2023  

    Author's details Christian Stummeyer, Andrea Raab, Moritz Erasmus Behm Hrsg
    Keywords Business ; Management science ; Health services administration ; Medical economics
    Language German
    Size 1 Online-Ressource (XXXIII, 328 Seiten), Illustrationen
    Publisher Springer Gabler
    Publishing place Wiesbaden
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021779580
    ISBN 978-3-658-35991-1 ; 9783658359904 ; 3-658-35991-9 ; 3658359900
    DOI 10.1007/978-3-658-35991-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Welche Kriterien sind entscheidend für die Einweisungsentscheidung von niedergelassenen Ärzten?

    Raab, Andrea E. / Konrad, Susanne

    eine empirische Untersuchung von arzt- und patientenbezogenen Variablen und deren Einfluss auf das Einweisungsverhalten

    (Arbeitsberichte - Working papers / Technische Hochschule Ingolstadt ; Heft Nr. 29)

    2014  

    Abstract: In diesem Working-Paper werden Faktoren untersucht, die die Einweisungsentscheidung niedergelassener Ärzte in der Praxis beeinflussen. Im Rahmen dessen wurden Hypothesen formuliert, welche auf der Datenbasis von neun teilnehmenden Krankenhäusern am ... ...

    Author's details Prof. Dr. Andrea E. Raab, Susanne Konrad M.A
    Series title Arbeitsberichte - Working papers / Technische Hochschule Ingolstadt ; Heft Nr. 29
    Arbeitsberichte / Technische Hochschule Ingolstadt
    Collection Arbeitsberichte / Technische Hochschule Ingolstadt
    Abstract In diesem Working-Paper werden Faktoren untersucht, die die Einweisungsentscheidung niedergelassener Ärzte in der Praxis beeinflussen. Im Rahmen dessen wurden Hypothesen formuliert, welche auf der Datenbasis von neun teilnehmenden Krankenhäusern am durchgeführten Projekt zum Einweiser- Benchmarking 2013 validiert wurden. Gegenstand der Hypothesenprüfung war es, mögliche Zusammenhänge zwischen arztbezogenen bzw. patientenbezogenen Merkmalen und dem Einweisungsverhalten von niedergelassenen Ärzten zu untersuchen. Die Erkenntnisse daraus wurden in Zusammenhang mit der einschlägigen Literatur interpretiert. Abschließend werden Grenzen der Arbeit und ein Ausblick aufgezeigt.
    Keywords Ärzte ; Entscheidung ; Medizinische Behandlung ; Krankenhaus ; Deutschland
    Subject code 610
    Language German
    Size 1 Online-Resource (23 Seiten), Illustrationen, Diagramme
    Publisher Technische Hochschule Ingolstadt
    Publishing place Ingolstadt
    Publishing country Germany
    Document type Book ; Online
    Note Parallel als Druckausgabe erschienen ; Open Access
    HBZ-ID HT021260856
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Einweiserbeziehungsmanagement

    Raab, Andrea E. / Drissner, Alexandra

    wie Krankenhäuser erfolgreich Win-Win-Beziehungen zu niedergelassenen Ärzten aufbauen

    2011  

    Author's details Andrea Raab ; Alexandra Drissner
    Keywords Krankenhaus ; Beziehungsmarketing ; Niedergelassener Arzt ; Einweisung ; Stationäre Behandlung
    Subject Klinik ; Klinikum ; Krankenanstalt ; Krankenhauswesen ; Spital ; Stationäre Versorgung ; Stationäre ärztliche Versorgung ; Stationäre Therapie ; Stationäre Krankenversorgung ; Überweisung ; Freiberuflich tätiger Arzt ; Relationship-Marketing
    Language German
    Size 240 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT016819476
    ISBN 978-3-17-021714-0 ; 3-17-021714-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 1760 order for loan Magazin

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  4. Book ; Online ; Thesis: Einfluss der Arbeitsbelastung des Personals auf die Patientenzufriedenheit im Krankenhaus - eine empirische Untersuchung

    Beck, Udo [Verfasser] / Ringlstetter, Max [Akademischer Betreuer] / Raab-Kuchenbuch, Andrea [Akademischer Betreuer]

    2021  

    Author's details Udo Beck ; Max Ringlstetter, Andrea Raab-Kuchenbuch
    Keywords Soziale Probleme, Sozialarbeit ; Social problems, Social work
    Subject code sg360
    Language German
    Publisher Katholische Universität Eichstätt-Ingolstadt
    Publishing place Eichstätt-Ingolstadt
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Book ; Online ; Thesis: Die Bedeutung der Einweiserbindung für den wirtschaftlichen Erfolg eines Krankenhauses – eine empirische Untersuchung am Beispiel der Region 10

    Fischer, Susanne Verfasser] / [Genosko, Joachim [Akademischer Betreuer] / Raab-Kuchenbuch, Andrea [Akademischer Betreuer]

    2021  

    Author's details Susanne Fischer ; Joachim Genosko, Andrea Raab-Kuchenbuch
    Keywords Soziale Probleme, Sozialarbeit ; Social problems, Social work
    Subject code sg360
    Language German
    Publisher Katholische Universität Eichstätt-Ingolstadt
    Publishing place Eichstätt-Ingolstadt
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article: Ionic Liquids Beyond Simple Solvents: Glimpses at the State of the Art in Organic Chemistry.

    Kuchenbuch, Andrea / Giernoth, Ralf

    ChemistryOpen

    2015  Volume 4, Issue 6, Page(s) 677–681

    Abstract: Within the last 25 years ionic liquids have written a tremendous success story, which is documented in a nearly uncountable amount of original research papers, reviews, and numerous applications in research and industry. These days, ionic liquids can be ... ...

    Abstract Within the last 25 years ionic liquids have written a tremendous success story, which is documented in a nearly uncountable amount of original research papers, reviews, and numerous applications in research and industry. These days, ionic liquids can be considered as a mature class of compounds for many different applications. Frequently, they are used as neoteric solvents for chemical tansformations, and the number of reviews on this field of research is huge. In this focused review, though, we are trying to evaluate the state of the art of ionic liquid chemistry beyond using them simply as solvents for chemical transformations. It is not meant to be a comprehensive overview on the topic; the choice of emphasis and examples rather refects the authors' personal view on the field. We are especially highlighting fields in which we believe the most fundamental developments within the next five years will take place: biomass processing, (chiral) ionic liquids from natural sources, biotransformations, and organic synthesis.
    Language English
    Publishing date 2015-08-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2655605-4
    ISSN 2191-1363
    ISSN 2191-1363
    DOI 10.1002/open.201500113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Application of room-temperature aprotic and protic ionic liquids for oxidative folding of cysteine-rich peptides.

    Heimer, Pascal / Tietze, Alesia A / Böhm, Miriam / Giernoth, Ralf / Kuchenbuch, Andrea / Stark, Annegret / Leipold, Enrico / Heinemann, Stefan H / Kandt, Christian / Imhof, Diana

    Chembiochem : a European journal of chemical biology

    2014  Volume 15, Issue 18, Page(s) 2754–2765

    Abstract: The oxidation of the conotoxin μ-SIIIA in different ionic liquids was investigated, and the results were compared with those obtained in [C2 mim][OAc]. Conversion of the reduced precursor into the oxidized product was observed in the protic ILs methyl- ... ...

    Abstract The oxidation of the conotoxin μ-SIIIA in different ionic liquids was investigated, and the results were compared with those obtained in [C2 mim][OAc]. Conversion of the reduced precursor into the oxidized product was observed in the protic ILs methyl- and ethylammonium formate (MAF and EAf, respectively), whereas choline dihydrogenphosphate and Ammoeng 110 failed to yield folded peptide. However, the quality and yield of the peptide obtained in MAF and EAF were lower than in the case of the product from [C2 mim][OAc]. Reaction conditions (temperature, water content) also had an impact on peptide conversion. A closer look at the activities of μ-SIIIA versions derived from an up-scaled synthesis in [C2 mim][OAc] revealed a significant loss of the effect on ion channel NaV 1.4 relative to the buffer-oxidized peptide, whereas digestion of either μ-SIIIA product by trypsin was unaffected. This was attributed to adherence of ions from the IL to the peptide, because the disulfide connectivity is basically the same for the differentially oxidized μ-SIIIA versions.
    MeSH term(s) Animals ; Calcium Channel Blockers/chemistry ; Calcium Channel Blockers/pharmacology ; Conotoxins/chemistry ; Conotoxins/pharmacology ; Conus Snail/chemistry ; Cysteine/chemistry ; HEK293 Cells ; Humans ; Ionic Liquids/chemistry ; Molecular Dynamics Simulation ; Oxidation-Reduction ; Peptides/chemistry ; Peptides/pharmacology ; Protein Folding ; Temperature
    Chemical Substances Calcium Channel Blockers ; Conotoxins ; Ionic Liquids ; Peptides ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2014-12-15
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.201402356
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  8. Article ; Online: Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration.

    Schmidt, Reinhold / Markart, Philipp / Ruppert, Clemens / Wygrecka, Malgorzata / Kuchenbuch, Tim / Walmrath, Dieter / Seeger, Werner / Guenther, Andreas

    Respiratory research

    2007  Volume 8, Page(s) 55

    Abstract: Background: Alterations to pulmonary surfactant composition have been encountered in the Acute Respiratory Distress Syndrome (ARDS). However, only few data are available regarding the time-course and duration of surfactant changes in ARDS patients, ... ...

    Abstract Background: Alterations to pulmonary surfactant composition have been encountered in the Acute Respiratory Distress Syndrome (ARDS). However, only few data are available regarding the time-course and duration of surfactant changes in ARDS patients, although this information may largely influence the optimum design of clinical trials addressing surfactant replacement therapy. We therefore examined the time-course of surfactant changes in 15 patients with direct ARDS (pneumonia, aspiration) over the first 8 days after onset of mechanical ventilation.
    Methods: Three consecutive bronchoalveolar lavages (BAL) were performed shortly after intubation (T0), and four days (T1) and eight days (T2) after intubation. Fifteen healthy volunteers served as controls. Phospholipid-to-protein ratio in BAL fluids, phospholipid class profiles, phosphatidylcholine (PC) molecular species, surfactant proteins (SP)-A, -B, -C, -D, and relative content and surface tension properties of large surfactant aggregates (LA) were assessed.
    Results: At T0, a severe and highly significant reduction in SP-A, SP-B and SP-C, the LA fraction, PC and phosphatidylglycerol (PG) percentages, and dipalmitoylation of PC (DPPC) was encountered. Surface activity of the LA fraction was greatly impaired. Over time, significant improvements were encountered especially in view of LA content, DPPC, PG and SP-A, but minimum surface tension of LA was not fully restored (15 mN/m at T2). A highly significant correlation was observed between PaO2/FiO2 and minimum surface tension (r = -0.83; p < 0.001), SP-C (r = 0.64; p < 0.001), and DPPC (r = 0.59; p = 0.003). Outcome analysis revealed that non-survivors had even more unfavourable surfactant properties as compared to survivors.
    Conclusion: We concluded that a profound impairment of pulmonary surfactant composition and function occurs in the very early stage of the disease and only gradually resolves over time. These observations may explain why former surfactant replacement studies with a short treatment duration failed to improve outcome and may help to establish optimal composition and duration of surfactant administration in future surfactant replacement studies in acute lung injury.
    MeSH term(s) Adult ; Bronchoalveolar Lavage Fluid/chemistry ; Female ; Humans ; Male ; Middle Aged ; Pneumonia/complications ; Pneumonia/physiopathology ; Pneumonia, Aspiration/complications ; Pneumonia, Aspiration/physiopathology ; Pulmonary Alveoli/chemistry ; Pulmonary Alveoli/physiology ; Respiratory Aspiration/complications ; Respiratory Aspiration/physiopathology ; Respiratory Distress Syndrome, Adult/etiology ; Respiratory Distress Syndrome, Adult/physiopathology ; Surface Tension ; Time Factors
    Language English
    Publishing date 2007-07-27
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-9921
    ISSN (online) 1465-993X
    ISSN 1465-9921
    DOI 10.1186/1465-9921-8-55
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  9. Article ; Online: Dry powder aerosolization of a recombinant surfactant protein-C-based surfactant for inhalative treatment of the acutely inflamed lung.

    Ruppert, Clemens / Kuchenbuch, Tim / Boensch, Marc / Schmidt, Sebastian / Mathes, Uwe / Hillebrand, Vera / Henneke, Ingrid / Markart, Philipp / Reiss, Irwin / Schermuly, Ralph T / Seeger, Werner / Günther, Andreas

    Critical care medicine

    2010  Volume 38, Issue 7, Page(s) 1584–1591

    Abstract: Objective: Inhalative application of substantial amounts of pulmonary surfactant to the acutely inflamed lung represents a desirable therapeutic approach but was impossible under clinical conditions because of the technical limitations of currently ... ...

    Abstract Objective: Inhalative application of substantial amounts of pulmonary surfactant to the acutely inflamed lung represents a desirable therapeutic approach but was impossible under clinical conditions because of the technical limitations of currently available devices. We developed a new dry powder aerosolizer for administration of a recombinant surfactant protein-C-based surfactant, determined aerosol characteristics, and evaluated its use in animal models of acute lung injury.
    Design: Laboratory experiment.
    Setting: University laboratory.
    Subjects: Rabbits and mice.
    Interventions: The efficacy of an aerosol application of recombinant surfactant protein-C surfactant was assessed in three animal models of acute lung injury: in rabbits with acute lung injury caused by repetitive lavage with prolonged and injurious ventilation; in rabbits at day 4 after inhalative application of bleomycin; and in bleomycin-challenged, spontaneously breathing mice.
    Measurements and main results: Analysis of aerosolizer characteristics revealed favorable properties making inhalative surfactant treatment in acute lung injury/acute respiratory distress syndrome possible. The generated aerosol had a mass median aerodynamic diameter of 1.6 microm, with 85% of all particles being smaller than 5 microm. The average mass of surfactant being aerosolized was approximately 800 mg/min, thus allowing delivery of large amounts of surfactant. Biochemical and biophysical surfactant properties remained unaltered after aerosolization. In both rabbit models aerosolization of approximately 500 mg recombinant surfactant protein-C surfactant resulted in a far-reaching restoration of gas exchange and compliance, with Pao2/Fio2 values approaching control values. In bleomycin-challenged, spontaneously breathing mice, surfactant aerosolization resulted in a restoration of compliance.
    Conclusions: The described dry powder aerosolizer may be applicable to surfactant therapy of acute lung injury/acute respiratory distress syndrome. This conclusion is based on four main factors. High doses comparable to those used for intratracheal instillation in humans can be generated within a relatively short time period, the device can be connected to the inspiratory limb of the ventilator circuit, the aerosolized surfactant material is biophysically fully active, and therapeutic efficacy was proven in three different animal models of acute lung injury/acute respiratory distress syndrome.
    MeSH term(s) Acute Lung Injury/drug therapy ; Acute Lung Injury/physiopathology ; Administration, Inhalation ; Aerosols ; Animals ; Bronchoalveolar Lavage Fluid/chemistry ; Dose-Response Relationship, Drug ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Particle Size ; Powders ; Pulmonary Surfactant-Associated Protein C/administration & dosage ; Pulmonary Surfactant-Associated Protein C/chemistry ; Pulmonary Surfactant-Associated Protein C/therapeutic use ; Rabbits ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/chemistry ; Recombinant Proteins/therapeutic use ; Species Specificity
    Chemical Substances Aerosols ; Powders ; Pulmonary Surfactant-Associated Protein C ; Recombinant Proteins
    Language English
    Publishing date 2010-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0b013e3181dfcb3b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
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  10. Article: Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application.

    Wygrecka, Malgorzata / Markart, Philipp / Ruppert, Clemens / Kuchenbuch, Tim / Fink, Ludger / Bohle, Rainer Maria / Grimminger, Friedrich / Seeger, Werner / Günther, Andreas

    Thrombosis and haemostasis

    2004  Volume 92, Issue 3, Page(s) 529–540

    Abstract: Intraalveolar and intravascular fibrin formation are typical hallmarks of acute inflammatory lung diseases, and may foster subsequent fibroproliferative events. We investigated the regulation and cellular sources of key coagulation and fibrinolysis ... ...

    Abstract Intraalveolar and intravascular fibrin formation are typical hallmarks of acute inflammatory lung diseases, and may foster subsequent fibroproliferative events. We investigated the regulation and cellular sources of key coagulation and fibrinolysis factors in lungs undergoing compartmentalized challenge with endotoxin (LPS). BALB/c mice received 15 ng LPS either by intravenous injection or by inhalation. Quantitative gene expression analysis (real-time RT-PCR) was performed for tissue factor (TF), TF pathway inhibitor (TFPI), tissue-type plasminogen activator (t-PA), urokinase-type-PA (u-PA), PA inhibitor-1 (PAI-1), and PAI-2 in peripheral white blood cells (PBC) as well as in alveolar macrophages (AM), type-II pneumocytes (ATII), endothelial cells (EC) and smooth muscle cells (SMC), all obtained by laser microdissection. Neither route of LPS administration caused substantial protein leakage or leukocyte recruitment into the alveolar space. Compartmentalized upregulation of procoagulant and downregulation of fibrinolytic activities was, however, observed in response to both modes of LPS challenge. Intraalveolar endotoxin, in particular, caused strong upregulation of TF ( approximately 20-fold increase in gene expression) and PAI-2 (225-fold increase) in microdissected AM, upregulation of PAI-1 in microdissected ATII (300-fold increase) and EC (180-fold increase), upregulation of t-PA in EC (40-fold), and downregulation of u-PA in vascular smooth muscle cells. TFPI was largely unchanged in all cell types, and PBC showed no major gene regulatory response to inhaled endotoxin. We conclude that the lung possesses a cell-specific alveolar coagulation and fibrinolysis system, being independent of the vascular coagulation cascade and responding readily with enhanced procoagulant and anti-fibrinolytic activities to LPS challenge.
    MeSH term(s) Administration, Inhalation ; Animals ; Blood Coagulation ; Blood Coagulation Factors/genetics ; Cell Compartmentation ; Fibrinolysis ; Gene Expression Regulation ; In Vitro Techniques ; Injections, Intraventricular ; Lipopolysaccharides/administration & dosage ; Lipopolysaccharides/pharmacology ; Lung/blood supply ; Lung/cytology ; Lung/metabolism ; Mice ; Mice, Inbred BALB C ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/metabolism ; Tissue Distribution
    Chemical Substances Blood Coagulation Factors ; Lipopolysaccharides
    Language English
    Publishing date 2004-09
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
    DOI 10.1160/TH04-02-0126
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