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  1. Article ; Online: Atrial Cardiomyopathy Manifestations in the General Population: The Tip or the Iceberg?

    Nattel, Stanley

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 11, Page(s) 2250–2252

    MeSH term(s) Humans ; Atrial Fibrillation/epidemiology ; Cardiomyopathies/complications ; Cardiomyopathies/epidemiology
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.09.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Atrial Fibrosis, Endocardial Damage, and Thrombosis in Atrial Fibrillation: Association With Underlying Conditions or Causal?

    Nattel, Stanley

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 7 Pt 2, Page(s) 1169–1171

    MeSH term(s) Humans ; Atrial Fibrillation/complications ; Heart Atria ; Thrombosis/etiology ; Fibrosis
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Digital Technologies: Revolutionizing Cardiovascular Medicine and Reshaping the World.

    Nattel, Stanley

    The Canadian journal of cardiology

    2021  Volume 38, Issue 2, Page(s) 142–144

    MeSH term(s) Cardiology/organization & administration ; Digital Technology/organization & administration ; Humans ; Machine Learning ; Periodicals as Topic
    Language English
    Publishing date 2021-12-23
    Publishing country England
    Document type Editorial
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2021.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2150: Show issues Location:
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  4. Article ; Online: Physical activity and atrial fibrillation risk: it's complicated; and sex is critical.

    Nattel, Stanley

    European heart journal

    2020  Volume 41, Issue 15, Page(s) 1487–1489

    MeSH term(s) Atrial Fibrillation/epidemiology ; Biological Specimen Banks ; Cohort Studies ; Exercise ; Humans ; United Kingdom
    Language English
    Publishing date 2020-01-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehz906
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    Zs.A 1563: Show issues Location:
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  5. Article ; Online: Factor XIa inhibition in atrial fibrillation: insights and knowledge gaps emerging from the PACIFIC-AF trial.

    Ninni, Sandro / Nattel, Stanley

    Cardiovascular research

    2023  Volume 119, Issue 1, Page(s) e111–e114

    MeSH term(s) Humans ; Administration, Oral ; Anticoagulants/therapeutic use ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Factor XIa ; Risk Factors ; Rivaroxaban/therapeutic use ; Stroke/drug therapy ; Treatment Outcome
    Chemical Substances Anticoagulants ; Factor XIa (EC 3.4.21.27) ; Rivaroxaban (9NDF7JZ4M3)
    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  6. Article ; Online: Atrial fibrillation: pathophysiology, genetic and epigenetic mechanisms.

    Vinciguerra, Manlio / Dobrev, Dobromir / Nattel, Stanley

    The Lancet regional health. Europe

    2024  Volume 37, Page(s) 100785

    Abstract: Atrial fibrillation (AF) is the most common supraventricular arrhythmia affecting up to 1% of the general population. Its prevalence dramatically increases with age and could reach up to ∼10% in the elderly. The management of AF is a complex issue that ... ...

    Abstract Atrial fibrillation (AF) is the most common supraventricular arrhythmia affecting up to 1% of the general population. Its prevalence dramatically increases with age and could reach up to ∼10% in the elderly. The management of AF is a complex issue that is object of extensive ongoing basic and clinical research, it depends on its genetic and epigenetic causes, and it varies considerably geographically and also according to the ethnicity. Mechanistically, over the last decade, Genome Wide Association Studies have uncovered over 100 genetic loci associated with AF, and have shown that European ancestry is associated with elevated risk of AF. These AF-associated loci revolve around different types of disturbances, including inflammation, electrical abnormalities, and structural remodeling. Moreover, the discovery of epigenetic regulatory mechanisms, involving non-coding RNAs, DNA methylation and histone modification, has allowed unravelling what modifications reshape the processes leading to arrhythmias. Our review provides a current state of the field regarding the identification and functional characterization of AF-related genetic and epigenetic regulatory networks, including ethnic differences. We discuss clear and emerging connections between genetic regulation and pathophysiological mechanisms of AF.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-7762
    ISSN (online) 2666-7762
    DOI 10.1016/j.lanepe.2023.100785
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  7. Article ; Online: Computational models of the atrial fibrillation substrate: can they explain post-ablation recurrences and help to prevent them.

    Nattel, Stanley

    Cardiovascular research

    2019  Volume 115, Issue 12, Page(s) 1681–1683

    MeSH term(s) Atrial Fibrillation/surgery ; Catheter Ablation ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Recurrence
    Language English
    Publishing date 2019-04-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvz121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  8. Article ; Online: Notes From Cardiology Clinic: Medicine Is More Than Just Pills, Procedures, and Devices.

    Nattel, Stanley

    The Canadian journal of cardiology

    2019  Volume 35, Issue 10, Page(s) 1263–1264

    MeSH term(s) Ambulatory Care Facilities ; Cardiology ; Humans
    Language English
    Publishing date 2019-08-21
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2019.08.018
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  9. Article ; Online: The Canadian Journal of Cardiology: Open and Growing.

    Nattel, Stanley

    The Canadian journal of cardiology

    2019  Volume 35, Issue 2, Page(s) 133–137

    Language English
    Publishing date 2019-01-03
    Publishing country England
    Document type Editorial
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2018.12.037
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  10. Article ; Online: Aging and Protein Kinase Activation: Is It the Missing Link Between Age and Atrial Fibrillation?

    Nattel, Stanley

    Circulation research

    2018  Volume 122, Issue 6, Page(s) 799–801

    MeSH term(s) Atrial Fibrillation ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Heart Atria ; Heart Conduction System ; Humans ; Signal Transduction
    Chemical Substances Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17)
    Language English
    Publishing date 2018-04-23
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.118.312786
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