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Article: Correction: Kim, Young-Gun; Jeon, Ja Young; Kim, Hae Jin; Kim, Dae Jung; Lee, Kwan-Woo; Moon, So Young; Han, Seung Jin. Risk of Dementia in Older Patients with Type 2 Diabetes on Dipeptidyl-Peptidase IV Inhibitors versus Sulfonylureas: A Real-World Population-Based Cohort Study.

Kim, Young-Gun / Jeon, Ja Young / Kim, Hae Jin / Kim, Dae Jung / Lee, Kwan-Woo / Moon, So Young / Han, Seung Jin

2019 Volume 8, Issue 3

Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

Abstract	The authors wish to make the following corrections to this paper [...].
Language	English
Publishing date	2019-03-20
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm8030389
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparative Effectiveness of Cognitive Behavioral Therapy and Behavioral Therapy in Obesity: A Systematic Review and Network Meta-Analysis.

Cha, Jin-Young / Kim, Seo-Young / Lim, Young-Woo / Choi, Ka-Hye / Shin, In-Soo

Journal of clinical psychology in medical settings

2024

Abstract: We aimed to evaluate the effects of obesity treatment with behavioral therapy (BT) and cognitive behavioral therapy (CBT) interventions compared with multiple comparators and find effective techniques or combinations of techniques in BT and CBT ... ...

Abstract	We aimed to evaluate the effects of obesity treatment with behavioral therapy (BT) and cognitive behavioral therapy (CBT) interventions compared with multiple comparators and find effective techniques or combinations of techniques in BT and CBT interventions for weight loss. We systematically searched electronic databases and selected randomized controlled trials using CBT or BT intervention for obesity treatment in overweight adults or adults with obesity without psychological symptoms. Both pairwise meta-analysis and network meta-analysis were performed to comprehensively evaluate the comparative effects between interventions. We classified the techniques used in BT and CBT interventions and compared the treatment effects between techniques. Compared with no treatment as a common comparator, CBT was most effective for weight loss, followed by BT, usual care (UC), and minimal care (MC). CBT was a more effective intervention than BT, but the effect of CBT compared to BT was not remarkable in network estimates. The most used BT techniques were feedback and monitoring, and the most used CBT technique was cognitive restructuring. Our results indicated that CBT and BT are effective interventions for weight loss, and that successful weight loss requires more aggressive interventions such as BT or CBT than MC and UC.
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1235893-9
ISSN	1573-3572 ; 1068-9583
ISSN (online)	1573-3572
ISSN	1068-9583
DOI	10.1007/s10880-023-10000-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4286: Show issues

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Article ; Online: Magnetic Ordering, Anomalous Lifshitz Transition, and Topological Grain Boundaries in Two-Dimensional Biphenylene Network.

Son, Young-Woo / Jin, Hosub / Kim, Sejoong

Nano letters

2022 Volume 22, Issue 7, Page(s) 3112–3117

Abstract: We study the electronic properties of a new planar carbon crystal formed through networking biphenylene molecules. Novel electronic features among carbon materials such as zone-center saddle point and peculiar type-II Dirac fermionic states are shown to ... ...

Abstract	We study the electronic properties of a new planar carbon crystal formed through networking biphenylene molecules. Novel electronic features among carbon materials such as zone-center saddle point and peculiar type-II Dirac fermionic states are shown to exist in the low-energy electronic spectrum. The type-II state here has a nearly flat branch and is close to a transition to type I. Possible magnetic instabilities related to low-energy bands are discussed. Furthermore, with a moderate uniaxial strain, a pair of Dirac points merge with the zone-center saddle point, realizing concurrent Lifshitz transitions of van Hove singularity as well as pair annihilation of the Dirac fermions. A new effective Hamiltonian encompassing all distinctive low-energy states is constructed, revealing a finite winding number of the pseudospin texture around the Dirac point, quantized Zak phases, and topological grain boundary states.
Language	English
Publishing date	2022-03-28
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.2c00528
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessing Age-Friendliness: Individualistic vs. Collectivistic Cultures.

Brossoie, Nancy / Hwang, Eunju / Song, Kimin / Jeong, Jin Wook / Young-Woo, Kim

Journal of aging & social policy

2022 Volume 34, Issue 2, Page(s) 311–334

Abstract: A major task ahead for South Korea is to create age-friendly communities and environments that can support older residents' health, well-being, and quality of life. To that end, international partnerships have emerged to share information, assess need, ... ...

Abstract	A major task ahead for South Korea is to create age-friendly communities and environments that can support older residents' health, well-being, and quality of life. To that end, international partnerships have emerged to share information, assess need, and develop response strategies. In this study, the transferability of a US-developed age-friendly community resident survey, based on the WHO framework, was tested in two South Korean cities by comparing results to the same survey conducted in a US city. Descriptive, relational, and predictive analyses revealed the survey items were a better fit for the US city than the South Korean cities. Limited response variances collected in the Korean cities challenged the comparison of data between the Korean sites. Thus, a cultural lens was used to explain response patterns that reflect their understanding of social norms including avoiding disagreement and conflict in order to maintain social equilibrium and five cultural dimensions found in Western and Eastern societies (Individualism vs. collectivism, universalism vs. particularism, low vs. high power distance, low vs. high context, and inner vs, outer control). Recommendations for future assessments in South Korea include shifting focus away from the individual to the individual's social network and community to improve understanding of need.
MeSH term(s)	Cities ; Humans ; Quality of Life ; Republic of Korea ; Surveys and Questionnaires
Language	English
Publishing date	2022-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1046396-3
ISSN	1545-0821 ; 0895-9420
ISSN (online)	1545-0821
ISSN	0895-9420
DOI	10.1080/08959420.2022.2049569
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Zs.A 3032: Show issues

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Article: Effect and mechanisms of Gambi-jung against high-fat diet-induced cardiac apoptosis in mice.

Park, Yea-Jin / Kim, Hyo-Jung / Koh, Duck-Jae / Kim, Eunjoo / Lim, Young-Woo / An, Hyo-Jin

Heliyon

2024 Volume 10, Issue 8, Page(s) e29161

Abstract: Obesity is associated with an increased risk of cardiovascular disease. Gambi-jung (GBJ), a modified herbal formula of Taeumjowi-tang, induces weight loss in high-fat diet (HFD)-fed obese mice. Meanwhile, concerns have been raised ... ...

Abstract	Obesity is associated with an increased risk of cardiovascular disease. Gambi-jung (GBJ), a modified herbal formula of Taeumjowi-tang, induces weight loss in high-fat diet (HFD)-fed obese mice. Meanwhile, concerns have been raised regarding
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e29161
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Article ; Online: Modification of microenvironmental pH of nanoparticles for enhanced solubility and oral bioavailability of poorly water-soluble celecoxib.

Ran Woo, Mi / Bak, Young-Woo / Cheon, Seunghyun / Suk Kim, Jung / Hun Ji, Sang / Park, Seonghyeon / Woo, Sanghyun / Oh Kim, Jong / Giu Jin, Sung / Choi, Han-Gon

International journal of pharmaceutics

2024 , Page(s) 124179

Abstract: This study aimed to develop a novel pH-modified nanoparticle with improved solubility and oral bioavailability of poorly water-soluble celecoxib by modifying the microenvironmental pH. After assessing the impact of hydrophilic polymers, surfactants and ... ...

Abstract	This study aimed to develop a novel pH-modified nanoparticle with improved solubility and oral bioavailability of poorly water-soluble celecoxib by modifying the microenvironmental pH. After assessing the impact of hydrophilic polymers, surfactants and alkaline pH modifiers on the drug solubility, copovidone, sodium lauryl sulfate (SLS) and meglumine were chosen. The optimal formulation of solvent-evaporated, surface-attached and pH-modified nanoparticles composed of celecoxib/copovidone/SLS/meglumine at weight ratios of 1:1:0.2:0, 1:0.375:1.125:0 and 1:1:1:0.2:0.02, respectively, were manufactured using spray drying technique. Their physicochemical characteristics, solubility, dissolution and pharmacokinetics in rats were evaluated compared to the celecoxib powder. The solvent-evaporated and pH-modified nanoparticles converted a crystalline to an amorphous drug, resulting in a spherical shape with a reduced particle size compared to celecoxib powder. However, the surface-attached nanoparticles with insignificant particle size exhibited the unchangeable crystalline drug. All of them gave significantly higher solubility, dissolution, and oral bioavailability than celecoxib powder. Among them, the pH-modified nanoparticles demonstrated the most significant improvement in solubility (approximately 1600-fold) and oral bioavailability (approximately 4-fold) compared to the drug powder owing to the alkaline microenvironment formation effect of meglumine and the conversion to the amorphous drug. Thus, the pH-modified nanoparticle system would be a promising strategy for improving the solubility and oral bioavailability of poorly water-soluble and weakly acidic celecoxib.
Language	English
Publishing date	2024-04-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2024.124179
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Zs.A 1409: Show issues

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Article: Assessment of Pharmacokinetic Effects of Herbal Medicines on Escitalopram.

Jung, Yun Seob / Jin, Byung Hak / Choi, Ju Eun / Park, Min Soo / Kim, Young-Woo / Kang, Hyung Won / Cho, Sunyoung / Kim, Choon Ok

Therapeutics and clinical risk management

2024 Volume 20, Page(s) 151–160

Abstract: Purpose: Herbal medicines are occasionally used in combination with conventional antidepressants to mitigate various depression-associated symptoms. However, there is limited information on herb-antidepressant interactions. In this study, we ... ...

Abstract	Purpose: Herbal medicines are occasionally used in combination with conventional antidepressants to mitigate various depression-associated symptoms. However, there is limited information on herb-antidepressant interactions. In this study, we investigated the pharmacokinetic (PK) effects of four herbal medicines (Gami-soyosan, Banhasasim-tang, Ojeok-san, and Bojungikgi-tang) on escitalopram, a commonly used antidepressant. Patients and methods: In this open-label, fixed-sequence, three-period, crossover study, 18 participants were enrolled and divided into two groups. Each group received a 10 mg oral dose of escitalopram in period 1. Participants took escitalopram once daily and their assigned herbal medicines thrice a day for 7 d in periods 2 (group 1: Gami-soyosan, group 2: Ojeok-san) and 3 (group 1: Banhasasim-tang; group 2: Bojungikgi-tang). The primary endpoints were C Results: Of 18 participants, 16 completed the study. Systemic exposure to escitalopram resulted in a minor increase in the presence of each herbal medicine. The geometric mean ratios (GMRs, combination with herbal medicines/escitalopram monotherapy) and their 90% confidence intervals (CIs) for C Conclusion: The co-administration of escitalopram with Gami-soyosan, Banhasasim-tang, Ojeok-san, or Bojungikgi-tang did not exert significant PK effects on escitalopram. These findings provide valuable insights into the safe use of herbal medicines along with escitalopram.
Language	English
Publishing date	2024-02-26
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186560-7
ISSN	1178-203X ; 1176-6336
ISSN (online)	1178-203X
ISSN	1176-6336
DOI	10.2147/TCRM.S448090
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Zs.A 6067: Show issues

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Article: Unraveling the Antioxidant Capacity of

Bae, Su-Jin / Lee, Won-Yung / Bak, Seon-Been / Kim, Young-Eun / Kim, Min-Jin / Kim, Young-Woo

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 5

Abstract: Nonalcoholic fatty liver disease (NAFLD) is a global health problem that is closely associated with obesity and metabolic syndrome. ...

Abstract	Nonalcoholic fatty liver disease (NAFLD) is a global health problem that is closely associated with obesity and metabolic syndrome.
Language	English
Publishing date	2023-05-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12051097
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fibular Fixation in Same-Level Distal Third Tibiofibular Fractures: Is Fibular Fracture Regarded as a Secondary Importance?

Lee, Jin-Woo / Byun, Seong-Eun / Kim, Young-Woo / Byun, Young-Soo / Yoon, Yong-Cheol / Sohn, Hoon-Sang

Clinics in orthopedic surgery

2023 Volume 15, Issue 5, Page(s) 704–710

Abstract: Background: Although most studies focused on the alignment or union of the tibia in same-level distal third tibiofibular fractures, the outcome of a concomitant fibular fracture is generally regarded as being of secondary importance in the literature. ... ...

Abstract	Background: Although most studies focused on the alignment or union of the tibia in same-level distal third tibiofibular fractures, the outcome of a concomitant fibular fracture is generally regarded as being of secondary importance in the literature. This study aimed to assess the outcomes of fibular fractures in same-level distal third tibiofibular fractures. Methods: In this retrospective study, we enrolled 111 patients with same-level distal third tibiofibular fractures treated at our institute between January 2016 and August 2020. Tibial fractures were stabilized with intramedullary nailing, and the cases were divided into two groups based on whether they additionally underwent fibular fixation (group 1, 57 cases) or not (group 2, 54 cases). Clinical and radiographic outcomes were used for the evaluation of tibial and fibular alignments, union of the tibia and fibula, number of interlocking screws in the distal tibial fragment, range of motion of the ankle joint, and complications. Results: No statistically significant differences in the tibial union rate or mean tibial alignment were observed between the two groups on either the immediate postoperative or final radiographs. The fibular union rate in group 1 was significantly higher than that in group 2 (fibular nonunion, 0 vs. 15; Conclusions: Regardless of whether fibular fixation was performed, the overall tibial alignment with intramedullary nailing was well restored and the union rate of the tibia was comparable in the two groups. Fibular nonunion is not uncommon in unfixed fibula fractures. Displacement of the fibula as seen on immediate postoperative radiographs was related to fibular nonunion.
MeSH term(s)	Humans ; Fibula/diagnostic imaging ; Fibula/surgery ; Retrospective Studies ; Fracture Fixation, Internal ; Tibial Fractures/diagnostic imaging ; Tibial Fractures/surgery ; Tibia/surgery ; Fracture Fixation, Intramedullary ; Treatment Outcome
Language	English
Publishing date	2023-09-15
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2502788-8
ISSN	2005-4408 ; 2005-291X
ISSN (online)	2005-4408
ISSN	2005-291X
DOI	10.4055/cios23036
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6807: Show issues

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Article ; Online: Unraveling the Antioxidant Capacity of Spatholobi caulis in Nonalcoholic Fatty Liver Disease: A Multiscale Network Approach Integrated with Experimental Validation

Bae, Su-Jin / Lee, Won-Yung / Bak, Seon-Been / Kim, Young-Eun / Kim, Min-jin / Kim, Young-Woo

Antioxidants. 2023 May 13, v. 12, no. 5

2023

Abstract: Nonalcoholic fatty liver disease (NAFLD) is a global health problem that is closely associated with obesity and metabolic syndrome. Spatholobi caulis (SC) is a herbal medicine with potential hepatoprotective effects; however, its active compounds and ... ...

Abstract	Nonalcoholic fatty liver disease (NAFLD) is a global health problem that is closely associated with obesity and metabolic syndrome. Spatholobi caulis (SC) is a herbal medicine with potential hepatoprotective effects; however, its active compounds and underlying mechanisms have not been fully explored. In this study, we combined a multiscale network-level approach with experimental validation to investigate SC’s antioxidant properties and their impact on NAFLD. Data collection and network construction were performed, and active compounds and key mechanisms were identified through multi-scale network analysis. Validation was conducted using in vitro steatotic hepatocyte models and in vivo high-fat diet-induced NAFLD models. Our findings revealed that SC treatment improved NAFLD by modulating multiple proteins and signaling pathways, including AMPK signaling pathways. Subsequent experiments showed that SC treatment reduced lipid accumulation and oxidative stress. We also validated SC’s effects on AMPK and its crosstalk pathways, emphasizing their role in hepatoprotection. We predicted procyanidin B2 to be an active compound of SC and validated it using a lipogenesis in vitro model. Histological and biochemical analyses confirmed that SC ameliorated liver steatosis and inflammation in mice. This study presents SC’s potential use in NAFLD treatment and introduces a novel approach for identifying and validating active compounds in herbal medicine.
Keywords	active ingredients ; antioxidant activity ; antioxidants ; data collection ; fatty liver ; hepatoprotective effect ; herbal medicines ; high fat diet ; histology ; inflammation ; lipids ; lipogenesis ; metabolic syndrome ; models ; obesity ; oxidative stress ; procyanidins
Language	English
Dates of publication	2023-0513
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12051097
Database	NAL-Catalogue (AGRICOLA)

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