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Article ; Online: Behavioral Pharmacology of Five Uncommon

Sakalem, Marna Eliana / Tabach, Ricardo / de Oliveira, Miriane / Carlini, Elisaldo Araújo

Central nervous system agents in medicinal chemistry

2022 Volume 22, Issue 2, Page(s) 125–138

Abstract: Background: There are over 500 species in the Passiflora genus, and while some of them are very well known in folk medicine for their anxiolytic effects, very little is known for the other genus representants, which could also present medicinal effects.! ...

Abstract	Background: There are over 500 species in the Passiflora genus, and while some of them are very well known in folk medicine for their anxiolytic effects, very little is known for the other genus representants, which could also present medicinal effects. Objective: In this study, we performed an interspecific pharmacological comparison of five investigated Passiflora species, all native to Brazil, namely P. bahiensis, P. coccinea, P. quadrangularis, P. sidaefolia, and P. vitifolia. Methods: Extracts were administered to mice before behavioral testing, including a general pharmacological screening and anxiolytic-like effect investigation. Results: Three of the species (P. coccinea, P. quadrangularis, and P. sidaefolia) induced a decrease in locomotor activity of mice; P. coccinea also reduced the latency to sleep. Importantly, none of the species interfered with motor coordination. Oral administration evoked no severe signs of toxicity, even at higher doses. Regarding the anxiolytic-like profile, P. sidaefolia reduced the anxious-like behavior in the Holeboard test in a similar way to the positive control, Passiflora incarnata, while not affecting total motricity. Conclusion: These results indicated that P. coccinea, P. quadrangularis, and P. sidaefolia reduced the general activity of mice and conferred a calmative/sedative potential to these three species, which must be further elucidated by future investigations.
MeSH term(s)	Anti-Anxiety Agents/pharmacology ; Anti-Anxiety Agents/therapeutic use ; Anxiety/drug therapy ; Hypnotics and Sedatives/pharmacology ; Hypnotics and Sedatives/therapeutic use ; Passiflora ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use
Chemical Substances	Anti-Anxiety Agents ; Hypnotics and Sedatives ; Plant Extracts
Language	English
Publishing date	2022-04-26
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2227560-5
ISSN	1875-6166 ; 1871-5249
ISSN (online)	1875-6166
ISSN	1871-5249
DOI	10.2174/1871524922666220426102650
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Article ; Online: RNA-seq reveals that anti-obesity irisin and triiodothyronine (T3) hormones differentially affect the purinergic signaling transcriptomics in differentiated human adipocytes.

Mathias, Lucas Solla / Herman-de-Sousa, Carina / Cury, Sarah Santiloni / Nogueira, Célia Regina / Correia-de-Sá, Paulo / de Oliveira, Miriane

Biochimica et biophysica acta. Molecular and cell biology of lipids

2023 Volume 1868, Issue 4, Page(s) 159276

Abstract: The anti-obesity thyroid hormone, triiodothyronine (T3), and irisin, an exercise- and/or cold-induced myokine, stimulate thermogenesis and energy consumption while decreasing lipid accumulation. The involvement of ATP signaling in adipocyte cell function ...

Abstract	The anti-obesity thyroid hormone, triiodothyronine (T3), and irisin, an exercise- and/or cold-induced myokine, stimulate thermogenesis and energy consumption while decreasing lipid accumulation. The involvement of ATP signaling in adipocyte cell function and obesity has attracted increasing attention, but the crosstalk between the purinergic signaling cascade and anti-obesity hormones lacks experimental evidence. In this study, we investigated the effects of T3 and irisin in the transcriptomics of membrane-bound purinoceptors, ectonucleotidase enzymes and nucleoside transporters participating in the purinergic signaling in cultured human adipocytes. The RNA-seq analysis revealed that differentiated adipocytes express high amounts of ADORA1, P2RY11, P2RY12, and P2RX6 gene transcripts, along with abundant levels of transcriptional products encoding to purine metabolizing enzymes (ENPP2, ENPP1, NT5E, ADA and ADK) and transporters (SLC29A1, SCL29A2). The transcriptomics of purinergic signaling markers changed in parallel to the upsurge of "browning" adipocyte markers, like UCP1 and P2RX5, after treatment with T3 and irisin. Upregulation of ADORA1, ADORA2A and P2RX4 gene transcription was obtained with irisin, whereas T3 preferentially upregulated NT5E, SLC29A2 and P2RY11 genes. Irisin was more powerful than T3 towards inhibition of the leptin gene transcription, the SCL29A1 gene encoding for the ENT1 transporter, the E-NPP2 (autotaxin) gene, and genes that encode for two ADP-sensitive P2Y receptors, P2RY1 and P2RY12. These findings indicate that anti-obesity irisin and T3 hormones differentially affect the purinergic signaling transcriptomics, which might point towards new directions for the treatment of obesity and related metabolic disorders that are worth to be pursued in future functional studies.
MeSH term(s)	Humans ; Adipocytes/drug effects ; Adipocytes/metabolism ; Fibronectins/genetics ; Fibronectins/metabolism ; Obesity/genetics ; Obesity/metabolism ; RNA-Seq ; Transcriptome ; Triiodothyronine/pharmacology ; Triiodothyronine/metabolism
Chemical Substances	Fibronectins ; Triiodothyronine (06LU7C9H1V) ; FNDC5 protein, human
Language	English
Publishing date	2023-01-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbalip.2022.159276
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Article: Effects of Triiodothyronine on Human Osteoblast-Like Cells: Novel Insights From a Global Transcriptome Analysis.

Rodrigues, Bruna Moretto / Mathias, Lucas Solla / Deprá, Igor de Carvalho / Cury, Sarah Santiloni / de Oliveira, Miriane / Olimpio, Regiane Marques Castro / De Sibio, Maria Teresa / Gonçalves, Bianca Mariani / Nogueira, Célia Regina

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 886136

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-06-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.886136
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Article ; Online: Airway and Alveoli Organoids as Valuable Research Tools in COVID-19.

de Oliveira, Miriane / De Sibio, Maria T / Costa, Felipe A S / Sakalem, Marna E

ACS biomaterials science & engineering

2021 Volume 7, Issue 8, Page(s) 3487–3502

Abstract: The coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, SARS-CoV-2, affects tissues from different body systems but mostly the respiratory system, and the damage evoked in the lungs may occasionally result in severe respiratory ... ...

Abstract	The coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, SARS-CoV-2, affects tissues from different body systems but mostly the respiratory system, and the damage evoked in the lungs may occasionally result in severe respiratory complications and eventually lead to death. Studies of human respiratory infections have been limited by the scarcity of functional models that mimic in vivo physiology and pathophysiology. In the last decades, organoid models have emerged as potential research tools due to the possibility of reproducing in vivo tissue in culture. Despite being studied for over one year, there is still no effective treatment against COVID-19, and investigations using pulmonary tissue and possible therapeutics are still very limited. Thus, human lung organoids can provide robust support to simulate SARS-CoV-2 infection and replication and aid in a better understanding of their effects in human tissue. The present review describes methodological aspects of different protocols to develop airway and alveoli organoids, which have a promising perspective to further investigate COVID-19.
MeSH term(s)	COVID-19 ; Humans ; Lung ; Organoids ; Pulmonary Alveoli ; SARS-CoV-2
Language	English
Publishing date	2021-07-21
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.1c00306
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Article ; Online: Historical evolution of spheroids and organoids, and possibilities of use in life sciences and medicine.

Sakalem, Marna Eliana / De Sibio, Maria Teresa / da Costa, Felipe Allan da Silva / de Oliveira, Miriane

Biotechnology journal

2021 Volume 16, Issue 5, Page(s) e2000463

Abstract: Background: An impressive percentage of biomedical advances were achieved through animal research and cell culture investigations. For drug testing and disease researches, both animal models and preclinical trials with cell cultures are extremely ... ...

Abstract	Background: An impressive percentage of biomedical advances were achieved through animal research and cell culture investigations. For drug testing and disease researches, both animal models and preclinical trials with cell cultures are extremely important, but present some limitations, such as ethical concern and inability of representing complex tissues and organs. 3D cell cultures arise providing a more realistic in vitro representation of tissues and organs. Environment and cell type in 3D cultures can represent in vivo conditions and thus provide accurate data on cell-to-cell interactions, and cultivation techniques are based on a scaffold, usually hydrogel or another polymeric material, or without scaffold, such as suspended microplates, magnetic levitation, and microplates for spheroids with ultra-low fixation coating. Purpose and scope: This review aims at presenting an updated summary of the most common 3D cell culture models available, as well as a historical background of their establishment and possible applications. Summary: Even though 3D culturing is incapable of replacing other current research types, they will continue to substitute some unnecessary animal experimentation, as well as complement monolayer cultures. Conclusion: In this aspect, 3D culture emerges as a valuable alternative to the investigation of functional, biochemical, and molecular aspects of human pathologies.
MeSH term(s)	Animals ; Biological Science Disciplines ; Cell Culture Techniques ; Humans ; Models, Animal ; Organoids ; Spheroids, Cellular
Language	English
Publishing date	2021-01-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2221885-3
ISSN	1860-7314 ; 1860-6768
ISSN (online)	1860-7314
ISSN	1860-6768
DOI	10.1002/biot.202000463
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Article ; Online: Comparison of generic and specific instruments to assess the quality of life in patients with melasma.

Meneguin, Silmara / Mourão, Ioana Bitencourt / Pollo, Camila Fernandes / Miot, Helio Amante / Garuzi, Miriane / de Oliveira, Cesar

BMC medical research methodology

2022 Volume 22, Issue 1, Page(s) 117

Abstract: Objective: To compare the psychometric performance of a generic and specific instruments in assessing melasma-related quality of life.: Methods: A cross-sectional study was conducted with 150 patients with melasma attending an outpatient dermatology ... ...

Abstract	Objective: To compare the psychometric performance of a generic and specific instruments in assessing melasma-related quality of life. Methods: A cross-sectional study was conducted with 150 patients with melasma attending an outpatient dermatology clinic of a public hospital in São Paulo state, Brazil. Data were collected using a questionnaire containing sociodemographic and clinical data as well as the generic WHOQOL-BREF, and the dermatological-specific Skindex-16 and HRQ-Melasma. Results: The overall internal consistency of the domains of the three instruments was ≥ 0.7. A strong positive correlation was identified between the Skindex-16 and HRQ-Melasma domains (0.68-0.78). Item-response theory showed that most Skindex-16 and HRQ-Melasma domains were more informative than WHOQOL-BREF. Conclusion: The three instruments for assessing QOL tested presented good psychometric performance, with satisfactory internal consistency values. Only the two dermatological instruments, however, demonstrated a strong correlation between the domains that assess social, emotional, and functional aspects of QOL, indicating that both were able to identify impairments in other QOL dimensions in addition to the physical domain.
MeSH term(s)	Brazil ; Cross-Sectional Studies ; Humans ; Melanosis/psychology ; Psychometrics ; Quality of Life/psychology ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2022-04-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041362-2
ISSN	1471-2288 ; 1471-2288
ISSN (online)	1471-2288
ISSN	1471-2288
DOI	10.1186/s12874-022-01599-5
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Article ; Online: Comparison of generic and specific instruments to assess the quality of life in patients with melasma

Silmara Meneguin / Ioana Bitencourt Mourão / Camila Fernandes Pollo / Helio Amante Miot / Miriane Garuzi / Cesar de Oliveira

BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-

2022 Volume 8

Abstract: Abstract Objective To compare the psychometric performance of a generic and specific instruments in assessing melasma-related quality of life. Methods A cross-sectional study was conducted with 150 patients with melasma attending an outpatient ... ...

Abstract	Abstract Objective To compare the psychometric performance of a generic and specific instruments in assessing melasma-related quality of life. Methods A cross-sectional study was conducted with 150 patients with melasma attending an outpatient dermatology clinic of a public hospital in São Paulo state, Brazil. Data were collected using a questionnaire containing sociodemographic and clinical data as well as the generic WHOQOL-BREF, and the dermatological-specific Skindex-16 and HRQ-Melasma. Results The overall internal consistency of the domains of the three instruments was ≥ 0.7. A strong positive correlation was identified between the Skindex-16 and HRQ-Melasma domains (0.68-0.78). Item-response theory showed that most Skindex-16 and HRQ-Melasma domains were more informative than WHOQOL-BREF. Conclusion The three instruments for assessing QOL tested presented good psychometric performance, with satisfactory internal consistency values. Only the two dermatological instruments, however, demonstrated a strong correlation between the domains that assess social, emotional, and functional aspects of QOL, indicating that both were able to identify impairments in other QOL dimensions in addition to the physical domain.
Keywords	Melasma ; Quality of life ; Psychometry ; Questionnaire ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Psychometric characteristics of DLQI-BRA and Skindex-16 to measure the impact of dermatological diseases on quality of life in Brazilian patients.

Meneguin, Silmara / de Souza Matos, Ticiane Dionozio / Pollo, Camila Fernandes / Garuzi, Miriane / Miot, Hélio Amante / de Oliveira, César

PloS one

2021 Volume 16, Issue 8, Page(s) e0254882

Abstract: Objective: To compare the psychometric performance of the Dermatology Life Quality Index (DLQI-BRA) and Skindex-16 to assess quality of life (QoL) in Brazilian patients with dermatological diseases.: Methods: This was a cross-sectional study carried ... ...

Abstract	Objective: To compare the psychometric performance of the Dermatology Life Quality Index (DLQI-BRA) and Skindex-16 to assess quality of life (QoL) in Brazilian patients with dermatological diseases. Methods: This was a cross-sectional study carried out in a dermatology outpatient clinic of the São Paulo State University, with 188 patients with dermatological diseases. QoL was evaluated using the Dermatology Life Quality Index (DLQI-BRA) and Skindex-16. Cronbach's alpha and Intraclass Correlation for Perfect Concordance (ICC) were used to analyse the reliability and temporal stability, respectively. Results: A positive correlation was found between the total Skindex-16 score and DLQI-BRA (0.75). Both instruments showed a significant (p< 0.01) reduction in their scores at the second assessment, demonstrating that they were sensitive in detecting changes in responsiveness in cases where there was a clinical change. Cronbach alpha coefficients for the instruments showed satisfactory performance (>0,7), but Skindex-16 displayed the highest Cronbach alpha (0.94; CI = 0.93-0.95). Conclusion: Both instruments tested showed a good psychometric performance assessing QoL in patients with skin dermatoses. The instruments displayed reliability and temporal stability as well as responsiveness.
MeSH term(s)	Brazil ; Female ; Humans ; Male ; Middle Aged ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Skin Diseases/psychology ; Statistics, Nonparametric ; Time Factors
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0254882
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Article ; Online: A sociedade do espetáculo e o ato de fotografar nas viagens

Gislaine Cristina de Oliveira / Miriane Sigiliano Frossard

PASOS Revista de Turismo y Patrimonio Cultural, Vol 15, Iss 1, Pp 261-

2017 Volume 272

Abstract: Themes such as tourism, photography, image, consumption, society of spectacle and tourism experience permeate discussions of this work in order to examine the relation between the act of photographing and the travel experience of tourists. For this, we ... ...

Abstract	Themes such as tourism, photography, image, consumption, society of spectacle and tourism experience permeate discussions of this work in order to examine the relation between the act of photographing and the travel experience of tourists. For this, we try to analyze tourism as a commodity in the society of spectacle, reflecting and analyzing the act of photographing incorporated into this type of society. Such discussions allow to identify the importance, the significance, and what represents the photographic record for photographer tourists, as object built from the travel experience. We conclude that individuals use travel photography as representation of the perfect trip, which only becomes perfect through clicks at the right places, to be shared, displayed, be liked and commented on social networks. Moreover, its importance lies in the fact that enables the transformation of immaterial into material. This research takes a qualitative approach with exploratory purpose and uses literature and field research as methodological tools.
Keywords	Recreation. Leisure ; GV1-1860
Subject code	910
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Instituto de Investigación Social y Turismo
Document type	Article ; Online
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Article ; Online: Psychometric characteristics of DLQI-BRA and Skindex-16 to measure the impact of dermatological diseases on quality of life in Brazilian patients.

Silmara Meneguin / Ticiane Dionozio de Souza Matos / Camila Fernandes Pollo / Miriane Garuzi / Hélio Amante Miot / César de Oliveira

PLoS ONE, Vol 16, Iss 8, p e

2021 Volume 0254882

Abstract: Objective To compare the psychometric performance of the Dermatology Life Quality Index (DLQI-BRA) and Skindex-16 to assess quality of life (QoL) in Brazilian patients with dermatological diseases. Methods This was a cross-sectional study carried out in ... ...

Abstract	Objective To compare the psychometric performance of the Dermatology Life Quality Index (DLQI-BRA) and Skindex-16 to assess quality of life (QoL) in Brazilian patients with dermatological diseases. Methods This was a cross-sectional study carried out in a dermatology outpatient clinic of the São Paulo State University, with 188 patients with dermatological diseases. QoL was evaluated using the Dermatology Life Quality Index (DLQI-BRA) and Skindex-16. Cronbach's alpha and Intraclass Correlation for Perfect Concordance (ICC) were used to analyse the reliability and temporal stability, respectively. Results A positive correlation was found between the total Skindex-16 score and DLQI-BRA (0.75). Both instruments showed a significant (p< 0.01) reduction in their scores at the second assessment, demonstrating that they were sensitive in detecting changes in responsiveness in cases where there was a clinical change. Cronbach alpha coefficients for the instruments showed satisfactory performance (>0,7), but Skindex-16 displayed the highest Cronbach alpha (0.94; CI = 0.93-0.95). Conclusion Both instruments tested showed a good psychometric performance assessing QoL in patients with skin dermatoses. The instruments displayed reliability and temporal stability as well as responsiveness.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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