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  1. Article ; Online: Health inequity assessment in Brazil: is EQ-5D-3L sensible enough to detect differences among distinct socioeconomic groups?

    Tura, Bernardo Rangel / da Costa, Milene Rangel / Lordello, Sylvia / Barros, Danillo / Souza, Yuri / da Silva Santos, Marisa

    Health and quality of life outcomes

    2024  Volume 22, Issue 1, Page(s) 22

    Abstract: Background: Multidimensional health-related quality of life (HRQOL) instruments, such as the EQ-5D, are increasingly used to assess inequalities in health. However, it is necessary to explore the ability of these instruments to capture differences ... ...

    Abstract Background: Multidimensional health-related quality of life (HRQOL) instruments, such as the EQ-5D, are increasingly used to assess inequalities in health. However, it is necessary to explore the ability of these instruments to capture differences between population groups, especially in low/middle-income countries. This study aimed to investigate whether the EQ-5D-3L instrument can detect differences in HRQOL between groups of different socioeconomic status (SES) in Brazil.
    Methods: Data collection occurred during the Brazilian EQ-5D-3L valuation study and included respondents aged 18 to 64 years enrolled in urban areas. SES was aggregated into three categories: "higher" (A and B), "intermediate" (C) and "lower" (D and E). EQ-5D-3L index was calculated considering the Brazilian value set. A mixed-effects regression model was estimated with random effects on individuals and marginal effects on SES, sex, and educational attainment. Odds ratios for the chance of reporting problems for each EQ-5D dimension were estimated by logistic regression.
    Results: A total of 9,148 respondents were included in the study. Mean age was 37.80 ± 13.13 years, 47.4% were men and the majority was ranked as classes B or C (38.4% and 50.7%, respectively). Participants in lower SES classes reported increasingly poorer health compared to individuals in higher classes. The mean EQ-5D-3L index decreased as SES deteriorates being significantly higher for classes A and B (0.874 ± 0.14) compared to class C (0.842 ± 0.15) and classes D and E (0.804 ± 0.17) (p < 0.001). The same was observed for the mean EQ-VAS scores (84.0 ± 13.8 in classes A and B, 81.0 ± 17 in class C and 78.3 ± 18.7 in class C [p < 0.001]). The multivariate analysis confirmed that SES is an independent factor that effects EQ-5D-3L index measures. Participants in intermediate and lower SES classes have a statistically significant lower EQ-5D-3L index compared to participants in classes A and B, regardless of age, sex, and educational attainment.
    Conclusion: In a Brazilian population sample, the EQ-5D-3L instrument was able to detect important differences between groups with distinct socioeconomic statuses (SES). The EQ-5D-3L is useful for exploring inequities in health.
    MeSH term(s) Male ; Humans ; Female ; Young Adult ; Adult ; Middle Aged ; Quality of Life ; Health Status ; Brazil ; Surveys and Questionnaires ; Social Class ; Health Inequities
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2098765-1
    ISSN 1477-7525 ; 1477-7525
    ISSN (online) 1477-7525
    ISSN 1477-7525
    DOI 10.1186/s12955-024-02235-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Synthesis and Phytocytogenotoxic Activity of

    Pinheiro, Patrícia Fontes / da Costa, Thais Lazarino Maciel / Corrêa, Kellen Barelo / Bastos Soares, Taís Cristina / Parreira, Luciana Alves / Werner, Elias Terra / de Paula, Matheus da Silva Alcantara Trindade / Pereira, Ulisses Alves / Praça-Fontes, Milene Miranda

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 9, Page(s) 4610–4621

    Abstract: The excessive use of herbicides has caused a series of problems related to human health, environmental pollution, and an increase in the resistance of plants to commercial herbicides. As an alternative, natural compounds and their semisynthetic ... ...

    Abstract The excessive use of herbicides has caused a series of problems related to human health, environmental pollution, and an increase in the resistance of plants to commercial herbicides. As an alternative, natural compounds and their semisynthetic derivatives have been widely studied to obtain environmentally friendly and more effective herbicides than the usual ones. In view of these factors, the aim of this work was to synthesize new molecules with herbicidal potential using thymol as a starting material, a natural phenol that has a pronounced phytotoxic effect. Novel
    MeSH term(s) Humans ; Thymol/toxicity ; Herbicides/toxicity ; Glyphosate ; Plants
    Chemical Substances Thymol (3J50XA376E) ; Herbicides ; Glyphosate (4632WW1X5A)
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c06889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A cost-effectiveness analysis of a novel algorithm to sequentially diagnose leprosy based on manufactured tests under the SUS perspective.

    Costa, Milene Rangel da / Magliano, Carlos Alberto da Silva / Barros, Bruno Monteiro / Morais, Quenia Cristina Dias / Braga, Andressa Araujo / Senna, Kátia Marie Simões E / Gomes, Ciro Martins / Macedo, Alexandre Casimiro de / Santos, Marisa da Silva

    Cadernos de saude publica

    2024  Volume 40, Issue 1, Page(s) e00038723

    Abstract: Brazil has the second largest number of leprosy cases (a disease with a significant burden) in the world. Despite global and local efforts to eliminate this public health problem, inadequate or late diagnosis contribute to perpetuate its transmission, ... ...

    Abstract Brazil has the second largest number of leprosy cases (a disease with a significant burden) in the world. Despite global and local efforts to eliminate this public health problem, inadequate or late diagnosis contribute to perpetuate its transmission, especially among household contacts. Tests such as the rapid IgM antibody detection (RT) and real-time polymerase chain reaction (RT-PCR) were developed to overcome the challenges of early diagnosis of leprosy. This study aimed to analyze the cost-effectiveness of a new diagnostic algorithm recommended by the Brazilian government to diagnose leprosy in household contacts of confirmed leprosy cases, which includes the RT and RT-PCR tests. A decision tree model was constructed and the perspective of the Brazilian Unified National Health System (SUS) and a 1-year time horizon were adopted. Only direct medical costs related to diagnostic tests were included. Effectiveness was measured as the number of avoided undiagnosed leprosy cases. Different scenarios were analyzed. The sequential use of RT, slit-skin smear (SSS) microscopy, and RT-PCR as recommended by the Brazilian Ministry of Health was compared to a base case (isolated SSS microscopy), yielding an incremental cost-effectiveness ratio of USD 616.46 per avoided undiagnosed leprosy case. Univariate sensitivity analysis showed that the prevalence of leprosy among household contacts was the variable that influenced the model the most. This is the first economic model to analyze a diagnostic algorithm of leprosy. Results may aid managers to define policies and strategies to eradicate leprosy in Brazil.
    MeSH term(s) Humans ; Cost-Effectiveness Analysis ; Brazil/epidemiology ; Algorithms ; Commerce ; Leprosy/diagnosis ; Leprosy/epidemiology
    Language English
    Publishing date 2024-01-08
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1115730-6
    ISSN 1678-4464 ; 0102-311X
    ISSN (online) 1678-4464
    ISSN 0102-311X
    DOI 10.1590/0102-311XEN038723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: PLGA-Based Composites for Various Biomedical Applications.

    Rocha, Cátia Vieira / Gonçalves, Victor / da Silva, Milene Costa / Bañobre-López, Manuel / Gallo, Juan

    International journal of molecular sciences

    2022  Volume 23, Issue 4

    Abstract: Polymeric materials have been extensively explored in the field of nanomedicine; within them, poly lactic-co-glycolic acid (PLGA) holds a prominent position in micro- and nanotechnology due to its biocompatibility and controllable biodegradability. In ... ...

    Abstract Polymeric materials have been extensively explored in the field of nanomedicine; within them, poly lactic-co-glycolic acid (PLGA) holds a prominent position in micro- and nanotechnology due to its biocompatibility and controllable biodegradability. In this review we focus on the combination of PLGA with different inorganic nanomaterials in the form of nanocomposites to overcome the polymer's limitations and extend its field of applications. We discuss their physicochemical properties and a variety of well-established synthesis methods for the preparation of different PLGA-based materials. Recent progress in the design and biomedical applications of PLGA-based materials are thoroughly discussed to provide a framework for future research.
    MeSH term(s) Biocompatible Materials/chemistry ; Nanocomposites/chemistry ; Nanomedicine/methods ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
    Chemical Substances Biocompatible Materials ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS)
    Language English
    Publishing date 2022-02-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23042034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Myrtucommulones and Related Acylphloroglucinols from Myrtaceae as a Promising Source of Multitarget SARS-CoV-2 Cycle Inhibitors.

    Mendonça, Simony Carvalho / Gomes, Brendo Araujo / Campos, Mariana Freire / da Fonseca, Thamirys Silva / Esteves, Maria Eduarda Alves / Andriolo, Bruce Veiga / Cheohen, Caio Felipe de Araujo Ribas / Constant, Larissa Esteves Carvalho / da Silva Costa, Stephany / Calil, Pedro Telles / Tucci, Amanda Resende / Oliveira, Thamara Kelcya Fonseca de / Rosa, Alice Dos Santos / Ferreira, Vivian Neuza Dos Santos / Lima, Julia Nilo Henrique / Miranda, Milene Dias / da Costa, Luciana Jesus / da Silva, Manuela Leal / Scotti, Marcus Tullius /
    Allonso, Diego / Leitão, Gilda Guimarães / Leitão, Suzana Guimarães

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 4

    Abstract: The LABEXTRACT plant extract bank, featuring diverse members of the Myrtaceae family from Brazilian hot spot regions, provides a promising avenue for bioprospection. Given the pivotal roles of the Spike protein and ... ...

    Abstract The LABEXTRACT plant extract bank, featuring diverse members of the Myrtaceae family from Brazilian hot spot regions, provides a promising avenue for bioprospection. Given the pivotal roles of the Spike protein and 3CL
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17040436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Influence of the ethical climate on workers' health among healthcare professionals: a systematic review.

    Lanes, Taís Carpes / Dalmolin, Graziele de Lima / Silva, Augusto Maciel da / Bernardi, Camila Milene Soares / Schutz, Thaís Costa / Tiguman, Gustavo Magno Baldin

    Revista gaucha de enfermagem

    2023  Volume 44, Page(s) e20220247

    Abstract: Objective: To evaluate the influence of the ethical climate on workers' health among healthcare professionals.: Method: Systematic review and meta-analysis conducted in MEDLINE/PubMed, EMBASE, SciVerse Scopus (Elsevier), Cumulative Index to Nursing ... ...

    Abstract Objective: To evaluate the influence of the ethical climate on workers' health among healthcare professionals.
    Method: Systematic review and meta-analysis conducted in MEDLINE/PubMed, EMBASE, SciVerse Scopus (Elsevier), Cumulative Index to Nursing and Allied Health Literature and Web of Science. Trained reviewers performed the selection, data extraction, and assessment of methodological quality. Meta-analysis was applied for data synthesis.
    Results: Among the 2644 studies, 20 were included for analysis, in which three (15.0%) articles were classified as high quality (score ≥ 80%), while 17 (85.0%) were classified as regular (score 50-79%). There was a moderate negative correlation between the ethical climate and overall moral distress (r=-0.43; 95%CI -0.50; -0.36) and the frequency of moral distress (r=-0.36; 95%CI -0.45; -0.25), as well as the positive and strong correlation between ethical climate and job satisfaction (r=0.71; 95%CI 0.39-0.88).
    Conclusion: The negative and positive perception of the ethical climate among healthcare professionals, respectively, influenced the increase in moral distress and job satisfaction.
    MeSH term(s) Humans ; Health Personnel ; Attitude of Health Personnel ; Occupational Health ; Job Satisfaction ; Morals
    Language Portuguese
    Publishing date 2023-10-27
    Publishing country Brazil
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2639673-7
    ISSN 1983-1447 ; 1983-1447
    ISSN (online) 1983-1447
    ISSN 1983-1447
    DOI 10.1590/1983-1447.2023.20220247.en
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A cost-effectiveness analysis of a novel algorithm to sequentially diagnose leprosy based on manufactured tests under the SUS perspective

    Milene Rangel da Costa / Carlos Alberto da Silva Magliano / Bruno Monteiro Barros / Quenia Cristina Dias Morais / Andressa Araujo Braga / Kátia Marie Simões e Senna / Ciro Martins Gomes / Alexandre Casimiro de Macedo / Marisa da Silva Santos

    Cadernos de Saúde Pública, Vol 40, Iss

    2024  Volume 1

    Abstract: Abstract: Brazil has the second largest number of leprosy cases (a disease with a significant burden) in the world. Despite global and local efforts to eliminate this public health problem, inadequate or late diagnosis contribute to perpetuate its ... ...

    Abstract Abstract: Brazil has the second largest number of leprosy cases (a disease with a significant burden) in the world. Despite global and local efforts to eliminate this public health problem, inadequate or late diagnosis contribute to perpetuate its transmission, especially among household contacts. Tests such as the rapid IgM antibody detection (RT) and real-time polymerase chain reaction (RT-PCR) were developed to overcome the challenges of early diagnosis of leprosy. This study aimed to analyze the cost-effectiveness of a new diagnostic algorithm recommended by the Brazilian government to diagnose leprosy in household contacts of confirmed leprosy cases, which includes the RT and RT-PCR tests. A decision tree model was constructed and the perspective of the Brazilian Unified National Health System (SUS) and a 1-year time horizon were adopted. Only direct medical costs related to diagnostic tests were included. Effectiveness was measured as the number of avoided undiagnosed leprosy cases. Different scenarios were analyzed. The sequential use of RT, slit-skin smear (SSS) microscopy, and RT-PCR as recommended by the Brazilian Ministry of Health was compared to a base case (isolated SSS microscopy), yielding an incremental cost-effectiveness ratio of USD 616.46 per avoided undiagnosed leprosy case. Univariate sensitivity analysis showed that the prevalence of leprosy among household contacts was the variable that influenced the model the most. This is the first economic model to analyze a diagnostic algorithm of leprosy. Results may aid managers to define policies and strategies to eradicate leprosy in Brazil.
    Keywords Leprosy ; Routine Diagnostic Test ; Cost Effectiveness ; Medicine ; R ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Redox double-switch cancer theranostics through Pt(IV) functionalised manganese dioxide nanostructures.

    Brito, Beatriz / Ruggiero, Maria Rosaria / Price, Thomas W / da Costa Silva, Milene / Genicio, Núria / Wilson, Annah J / Tyurina, Olga / Rosecker, Veronika / Eykyn, Thomas R / Bañobre-López, Manuel / Stasiuk, Graeme J / Gallo, Juan

    Nanoscale

    2023  Volume 15, Issue 25, Page(s) 10763–10775

    Abstract: Manganese dioxide ( ... ...

    Abstract Manganese dioxide (MnO
    MeSH term(s) Mice ; Animals ; Cisplatin ; Oxides/pharmacology ; Oxides/chemistry ; Manganese Compounds/pharmacology ; Manganese Compounds/chemistry ; Precision Medicine ; Prodrugs/chemistry ; Nanostructures/chemistry ; Nanoparticles/chemistry ; Oxidation-Reduction ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy
    Chemical Substances Cisplatin (Q20Q21Q62J) ; manganese dioxide (TF219GU161) ; Oxides ; Manganese Compounds ; Prodrugs
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr00076a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Aurones: A Promising Scaffold to Inhibit SARS-CoV-2 Replication.

    Caleffi, Guilherme S / Rosa, Alice S / de Souza, Luana G / Avelar, João L S / Nascimento, Sarah M R / de Almeida, Vitor M / Tucci, Amanda R / Ferreira, Vivian N / da Silva, Alcides J M / Santos-Filho, Osvaldo A / Miranda, Milene D / Costa, Paulo R R

    Journal of natural products

    2023  Volume 86, Issue 6, Page(s) 1536–1549

    Abstract: Aurones are a small subgroup of flavonoids in which the basic ... ...

    Abstract Aurones are a small subgroup of flavonoids in which the basic C
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Benzofurans/pharmacology ; Flavonoids/pharmacology ; Flavonoids/chemistry ; Antiviral Agents/pharmacology ; Protease Inhibitors/pharmacology ; Molecular Docking Simulation
    Chemical Substances aurone ; Benzofurans ; Flavonoids ; Antiviral Agents ; Protease Inhibitors
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c00249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Targeted treatment of triple-negative-breast cancer through pH-triggered tumour associated macrophages using smart theranostic nanoformulations.

    Scialla, Stefania / Hanafy, Mahmoud S / Wang, Jie-Liang / Genicio, Nuria / Costa Da Silva, Milene / Costa, Marta / Oliveira-Pinto, Sofia / Baltazar, Fátima / Gallo, Juan / Cui, Zhengrong / Bañobre-López, Manuel

    International journal of pharmaceutics

    2023  Volume 632, Page(s) 122575

    Abstract: Triple-negative breast cancer (TNBC) represents 15-25 % of the new breast cancer cases diagnosed worldwide every year. TNBC is among the most aggressive and worst prognosis breast cancer, mainly because targeted therapies are not available. Herein, we ... ...

    Abstract Triple-negative breast cancer (TNBC) represents 15-25 % of the new breast cancer cases diagnosed worldwide every year. TNBC is among the most aggressive and worst prognosis breast cancer, mainly because targeted therapies are not available. Herein, we developed a magnetic theranostic hybrid nanovehicle for targeted treatment of TNBC through pH-triggered tumour associated macrophages (TAMs) targeting. The lipid core of the nanovehicle was composed of a Carnaúba wax matrix that simultaneously incorporated iron oxide nanoparticles and doxorubicin (DOX) - a chemotherapeutic drug. These drug-loaded wax nanovehicles were modified with a combination of two functional and complementary molecules: (i) a mannose ligand (macrophage targeting) and (ii) an acid-sensitive sheddable polyethylene glycol (PEG) moiety (specificity). The TAMs targeting strategy relied on the mannose - mannose receptor recognition exclusively after acid-sensitive "shedding" of the PEG in the relatively low tumour microenvironment pH. The pH-induced targeting capability towards TAMs was confirmed in vitro in a J774A.1 macrophage cell line at different pH (7.4 and 6.5). Biocompatibility and efficacy of the final targeted formulations were demonstrated in vitro in the TNBC MDA-MB-231 cell line and in vivo in an M-Wnt tumour-bearing (TNBC) mouse model. A preferential accumulation of the DOX-loaded lipid nanovehicles in the tumours of M-Wnt-tumour bearing mice was observed, which resulted both on an efficient tumour growth inhibition and a significantly reduced off-target toxicity compared to free DOX. Additionally, the developed magnetic hybrid nanovehicles showed outstanding performances as T
    MeSH term(s) Humans ; Animals ; Mice ; Triple Negative Breast Neoplasms/pathology ; Precision Medicine ; Tumor-Associated Macrophages/pathology ; Cell Line, Tumor ; Mannose ; Hyperthermia, Induced ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Polyethylene Glycols ; Hydrogen-Ion Concentration ; Lipids ; Theranostic Nanomedicine/methods ; Nanoparticles ; Tumor Microenvironment
    Chemical Substances Mannose (PHA4727WTP) ; Doxorubicin (80168379AG) ; Polyethylene Glycols (3WJQ0SDW1A) ; Lipids
    Language English
    Publishing date 2023-01-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2022.122575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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