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  1. Article ; Online: Postvaccination immune-mediated hepatitis: what do we really know?

    Lasagna, Angioletta / Pedrazzoli, Paolo / Bruno, Raffaele / Sacchi, Paolo

    Immunotherapy

    2023  Volume 15, Issue 9, Page(s) 627–630

    Abstract: Tweetable abstract The percentage of patients with immune-mediated vaccine-associated hepatitis is minimal compared with the number of patients vaccinated worldwide. ...

    Abstract Tweetable abstract The percentage of patients with immune-mediated vaccine-associated hepatitis is minimal compared with the number of patients vaccinated worldwide.
    MeSH term(s) Humans ; Hepatitis, Autoimmune ; Vaccination ; Immunization
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2023-0038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The 'hit-and-run' strategy and viral carcinogenesis.

    Lasagna, Angioletta / Cassaniti, Irene / Sacchi, Paolo / Figini, Simone / Baldanti, Fausto / Bruno, Raffaele / Pedrazzoli, Paolo

    Future oncology (London, England)

    2023  Volume 19, Issue 5, Page(s) 341–344

    MeSH term(s) Humans ; Carcinogenesis/genetics ; Herpesvirus 4, Human
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2022-1171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6478: Show issues Location:
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  3. Article: Long-COVID in Patients with Cancer Previously Treated with Early Anti-SARS-CoV-2 Therapies in an Out-of-Hospital Setting: A Single-Center Experience.

    Lasagna, Angioletta / Albi, Giuseppe / Figini, Simone / Basile, Sara / Sacchi, Paolo / Bruno, Raffaele / Pedrazzoli, Paolo

    Cancers

    2023  Volume 15, Issue 4

    Abstract: The incidence of long COVID in a cohort of patients with cancer with or without previous treatment with early therapies anti-SARS-CoV-2 in an out-of-hospital setting have to be elucidated. We prospectively enrolled all patients treated for a solid tumor ... ...

    Abstract The incidence of long COVID in a cohort of patients with cancer with or without previous treatment with early therapies anti-SARS-CoV-2 in an out-of-hospital setting have to be elucidated. We prospectively enrolled all patients treated for a solid tumor at the department of Medical Oncology of the Fondazione IRCCS Policlinico San Matteo with a positive SARS-CoV-2 antigen or polymerase chain reaction test from January to September 2022 (Omicron surge). Ninety-seven patients answered the survey questions by telephone at least 12 weeks after COVID-19 diagnosis in order to evaluate the incidence of long COVID symptoms. Only twelve patients (12.4%) reported long COVID. No significant difference between early therapies anti-SARS-CoV-2 31 and long COVID (
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041269
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  4. Article ; Online: Infectious complications and immunotherapy: old pitfalls and new horizons.

    Lasagna, Angioletta / Cassaniti, Irene / Sacchi, Paolo / Baldanti, Fausto / Bruno, Raffaele / Pedrazzoli, Paolo

    Future oncology (London, England)

    2022  Volume 18, Issue 22, Page(s) 2377–2381

    MeSH term(s) Humans ; Immunologic Factors ; Immunotherapy/adverse effects
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Editorial
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2022-0277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pediatric Solid Cancers: Dissecting the Tumor Microenvironment to Improve the Results of Clinical Immunotherapy.

    Belgiovine, Cristina / Mebelli, Kristiana / Raffaele, Alessandro / De Cicco, Marica / Rotella, Jessica / Pedrazzoli, Paolo / Zecca, Marco / Riccipetitoni, Giovanna / Comoli, Patrizia

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Despite advances in their diagnosis and treatment, pediatric cancers remain among the leading causes of death in childhood. The development of immunotherapies and other forms of targeted therapies has significantly changed the prognosis of some ... ...

    Abstract Despite advances in their diagnosis and treatment, pediatric cancers remain among the leading causes of death in childhood. The development of immunotherapies and other forms of targeted therapies has significantly changed the prognosis of some previously incurable cancers in the adult population. However, so far, the results in pediatric cohorts are disappointing, which is mainly due to differences in tumor biology, including extreme heterogeneity and a generally low tumor mutational burden. A central role in the limited efficacy of immunotherapeutic approaches is played by the peculiar characteristics of the tumor microenvironment (TME) in pediatric cancer, with the scarcity of tumor infiltration by T cells and the abundance of stromal cells endowed with lymphocyte suppressor and tumor-growth-promoting activity. Thus, progress in the treatment of pediatric solid tumors will likely be influenced by the ability to modify the TME while delivering novel, more effective therapeutic agents. In this review, we will describe the TME composition in pediatric solid tumors and illustrate recent advances in treatment for the modulation of immune cells belonging to the TME.
    MeSH term(s) Humans ; Child ; Tumor Microenvironment ; Neoplasms/pathology ; Immunotherapy/methods ; T-Lymphocytes
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063225
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  6. Article ; Online: Lights and shadows on the role of rhG-CSF in cancer patients during the COVID-19 pandemic and future perspectives of research.

    Lasagna, Angioletta / Muzzana, Marta / Pedrazzoli, Paolo

    Immunotherapy

    2021  Volume 13, Issue 17, Page(s) 1369–1372

    MeSH term(s) COVID-19/epidemiology ; COVID-19/therapy ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Neoplasms/drug therapy ; Pandemics ; SARS-CoV-2
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ISSN 1750-7448
    ISSN (online) 1750-7448
    DOI 10.2217/imt-2021-0219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir.

    Lasagna, Angioletta / Piralla, Antonio / Secondino, Simona / Sacchi, Paolo / Baldanti, Fausto / Bruno, Raffaele / Pedrazzoli, Paolo

    Frontiers in medicine

    2022  Volume 9, Page(s) 944855

    Abstract: Coronavirus disease (COVID-19) in patients undergoing hematopoietic stem cell transplantation (HSCT) is a major issue. None of the published papers have reported data on the outcome of HSCT patients with COVID-19 according to the vaccination status and ... ...

    Abstract Coronavirus disease (COVID-19) in patients undergoing hematopoietic stem cell transplantation (HSCT) is a major issue. None of the published papers have reported data on the outcome of HSCT patients with COVID-19 according to the vaccination status and the short course of remdesivir (RDV). Therefore, we present the case of a 22-year-old man with relapsed testicular non-seminomatous germ-cell tumor who was diagnosed with COVID-19 during his first auto-HSCT. Our case report is the first one describing the efficacy of early RDV (and its anti-inflammatory effects that might counterbalance the negative effect of the recombinant human granulocyte-colony stimulating factors -rhG-CSF-) in the context of severe neutropenia following HSCT with the concomitant onset of COVID-19.
    Language English
    Publishing date 2022-07-22
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.944855
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  8. Article ; Online: G-CSF and G-CSF-related vasculitis: a systematic review of the literature and intriguing future research perspectives.

    Muzzana, Marta / Pedrazzoli, Paolo / Lasagna, Angioletta

    Future oncology (London, England)

    2021  Volume 17, Issue 33, Page(s) 4619–4634

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Chemotherapy-Induced Febrile Neutropenia/drug therapy ; Diagnosis, Differential ; Filgrastim/administration & dosage ; Filgrastim/adverse effects ; Glucocorticoids/administration & dosage ; Glucocorticoids/adverse effects ; Humans ; Neoplasms/blood ; Neoplasms/drug therapy ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/adverse effects ; Vasculitis/chemically induced ; Vasculitis/diagnosis ; Vasculitis/epidemiology ; Vasculitis/prevention & control
    Chemical Substances Glucocorticoids ; pegfilgrastim (3A58010674) ; Polyethylene Glycols (3WJQ0SDW1A) ; Filgrastim (PVI5M0M1GW)
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2021-0701
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6478: Show issues Location:
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  9. Article ; Online: Italian oncologists and vaccinations against infectious diseases: Results of a survey of the Italian Association of Medical Oncology.

    Lasagna, Angioletta / Brunello, Antonella / Silvestris, Nicola / Pedrazzoli, Paolo / Di Maio, Massimo / Cinieri, Saverio

    Tumori

    2023  Volume 110, Issue 1, Page(s) 60–68

    Abstract: Background: Patients with cancer present a higher risk of vaccine-preventable diseases. Recommended vaccinations are the most cost-effective measure to reduce the risk of transmission and related complications. Nevertheless, vaccination rates are ... ...

    Abstract Background: Patients with cancer present a higher risk of vaccine-preventable diseases. Recommended vaccinations are the most cost-effective measure to reduce the risk of transmission and related complications. Nevertheless, vaccination rates are inadequate. Oncologists have a central role in tailored vaccine communication to their patients. We present the results of a survey conducted by AIOM in 2022, focusing on the perception of the problem by oncologists.
    Materials and methods: An anonymous 31-item online questionnaire was shared on 15 September 2022 on the AIOM website. The objectives of this survey were to examine the perception of Italian oncologists on vaccine-preventable diseases and the main available vaccines, their attitude towards recommending vaccines and the COVID-19 pandemic impact on their habits regarding vaccine-preventable diseases.
    Results: Between September 2022 and January 2023, 114 medical oncologists (5% of the members) completed the anonymous questionnaire. At the first oncological visit, only 30% of respondents usually propose a vaccination schedule to all their patient, 41% do not usually discuss vaccinations at the first visit and 29% recommend vaccines exclusively to specific categories of patients. For 56% of respondents, patients are more aware of the benefits of vaccines, whereas 36% reported that patients are worried of receiving too many vaccines.
    Conclusion: This is the first survey conducted among Italian oncologists to better understand the perception and attitudes towards the vaccination. It highlights the urgent issues of educating and training oncologists in vaccine-preventable diseases and vaccine awareness and the need to build (or implement) a network of multidisciplinary collaborations.
    MeSH term(s) Humans ; Pandemics ; Vaccine-Preventable Diseases/chemically induced ; Vaccination ; Vaccines/adverse effects ; Surveys and Questionnaires ; Communicable Diseases/chemically induced ; Medical Oncology ; Oncologists ; Italy
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280962-x
    ISSN 2038-2529 ; 0300-8916
    ISSN (online) 2038-2529
    ISSN 0300-8916
    DOI 10.1177/03008916231191547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 287: Show issues

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  10. Article: Occult hepatitis B in patients with cancer during immunotherapy with or without chemotherapy: A real-life retrospective single-center cohort study.

    Lasagna, Angioletta / Albi, Giuseppe / Maserati, Renato / Zuccarini, Andrea / Quaccini, Mattia / Baldanti, Fausto / Sacchi, Paolo / Bruno, Raffaele / Pedrazzoli, Paolo

    Frontiers in oncology

    2023  Volume 13, Page(s) 1044098

    Abstract: Introduction: Few data about the safety of immune checkpoint inhibitors (ICIs) in the patients with solid tumor with Occult Hepatitis B Virus (OBI) are available. According to the Taormina Workshop on Occult HBV Infection Faculty Members we defined as ... ...

    Abstract Introduction: Few data about the safety of immune checkpoint inhibitors (ICIs) in the patients with solid tumor with Occult Hepatitis B Virus (OBI) are available. According to the Taormina Workshop on Occult HBV Infection Faculty Members we defined as potential-OBI (pOBI) the HBV DNA negativity with anti-hepatitis B core antibody (anti-HBc) positivity (pOBI seropositive), and the patients with HBsAg-negative and anti-HBc-negative and Hepatitis B surface antibody (anti-HBs)-negative are defined pOBI seronegative. The aim of this study is to investigate the prevalence of OBI in patients with solid tumors undergoing ICIs with or without chemotherapy and the incidence of reactivation (HBVr).
    Methods: We retrospectively enrolled all HBsAg negative subjects who had received ICIs for at least three months. HBsAg and HBV DNA levels were repeated every 3 months until the end of the study and/or in case of ALT alterations. A univariate analysis was conducted in order to study for each variable available its ability to distinguish a potential OBI seropositive patient from a seronegative one.
    Results: 150 patients in our Oncology Unit were eligible. One hundred and seventeen patients (78%) received ICI as monotherapy, whereas 33 patients (22%) were treated with chemo-immunotherapy. The mainly used drugs for the ICI monotherapy were Pembrolizumab (47%), Nivolumab (33%) and Atezolizumab (11%). The prevalence of pOBI seropositive patients was 25.3%. We did not observe alterations of liver biochemistry nor HBVr.
    Discussion: This study highlights that about a quarter of our population had a potential occult hepatitis B. Immunotherapy might be considered as low risk of reactivation, regardless of the potential presence of episomal covalently closed circular DNA (cccDNA) in the liver, but the correct management still represents a challenge for oncologists and hepatologists.
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1044098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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