Result 1 - 10 of total 51
(Springer protocols)
2021
| Author's details | ed. by Volkmar Weissig, Marvin Edeas |
|---|---|
| Series title | Springer protocols |
| Language | English |
| Dates of publication | 2021-2021 |
| Edition | Second edition |
| Publisher | Humana Press |
| Publishing place | New York u.a. |
| Publishing country | United States |
| Document type | Book ; Collection (display volumes) |
| HBZ-ID | HT020892568 |
| Database | Catalogue ZB MED Medicine, Health |
(Methods in molecular biology ; 2276 ; Springer protocols)
2021
| Author's details | ed. by Volkmar Weissig, Marvin Edeas |
|---|---|
| Series title | Methods in molecular biology ; 2276 Springer protocols Mitochondrial medicine |
| Collection | Mitochondrial medicine |
| Language | English |
| Size | xvi, 459 Seiten, Illustrationen |
| Publishing country | United States |
| Document type | Book |
| HBZ-ID | HT020892611 |
| ISBN | 978-1-0716-1265-1 ; 1-0716-1265-4 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| Zs A 7042 -2276- | verfügbar in Königswinter | Königswinter |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
(Methods in molecular biology ; 2275 ; Springer protocols)
2021
| Author's details | ed. by Volkmar Weissig, Marvin Edeas |
|---|---|
| Series title | Methods in molecular biology ; 2275 Springer protocols Mitochondrial medicine |
| Collection | Mitochondrial medicine |
| Language | English |
| Size | x, 502 Seiten, Illustrationen |
| Publishing country | United States |
| Document type | Book |
| HBZ-ID | HT020892582 |
| ISBN | 978-1-0716-1261-3 ; 1-0716-1261-1 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| Zs A 7042 -2275- | verfügbar in Königswinter | Königswinter |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
(Methods in molecular biology ; 2277 ; Springer protocols)
2021
| Author's details | ed. by Volkmar Weissig, Marvin Edeas |
|---|---|
| Series title | Methods in molecular biology ; 2277 Springer protocols Mitochondrial medicine |
| Collection | Mitochondrial medicine |
| Language | English |
| Size | viii, 524 Seiten, Illustrationen |
| Publishing country | United States |
| Document type | Book |
| HBZ-ID | HT020892587 |
| ISBN | 978-1-0716-1269-9 ; 9781071612705 ; 1-0716-1269-7 ; 1071612700 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| Zs A 7042 -2277- | verfügbar in Königswinter | Königswinter |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
4 open, Vol 5, p
2022 Volume 5
Abstract: Called “bioblasts” in 1890, named “mitochondria” in 1898, baptized in 1957 as the “powerhouse of the cell” and christened in 1999 as the “motor of cell death”, mitochondria have been anointed in 2017 as “powerhouses of immunity”. In 1962, for the first ... ...
| Abstract | Called “bioblasts” in 1890, named “mitochondria” in 1898, baptized in 1957 as the “powerhouse of the cell” and christened in 1999 as the “motor of cell death”, mitochondria have been anointed in 2017 as “powerhouses of immunity”. In 1962, for the first time a causal link between mitochondria and human diseases was described, the genetic basis for which was revealed in 1988. The term “mitochondrial medicine” was coined in 1994. Research into mitochondria has been conducted ever since light microscopic studies during the end of the 19th century revealed their existence. To this day, new discoveries around this organelle and above all new insights into their fundamental role for human health and disease continue to surprise. Nowadays hardly any disease is known for which either the etiology or pathogenesis is not associated with malfunctioning mitochondria. In this second part of our review about recent developments in mitochondrial medicine we continue tracking and highlighting selected lines of mitochondrial research from their beginnings up to the present time. Mainly written for readers not familiar with this cell organelle, we hope both parts of our review will substantiate what we articulated over a decade ago, namely that the future of medicine will come through better understanding of the mitochondrion. |
|---|---|
| Keywords | mitochondrial medicine ; aging ; microbiota ; covid-19 ; humanin ; reactive oxygen species ; Medicine ; R ; Science ; Q |
| Subject code | 610 |
| Language | English |
| Publishing date | 2022-01-01T00:00:00Z |
| Publisher | EDP Sciences |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
4 open, Vol 4, p
2021 Volume 2
Abstract: Research into elucidating structure and function of mitochondria has been quite steady between the time of discovery during the end of the 19th century until towards the late 1980’s. During the 1990s there was talk about a “comeback” of this organelle ... ...
| Abstract | Research into elucidating structure and function of mitochondria has been quite steady between the time of discovery during the end of the 19th century until towards the late 1980’s. During the 1990s there was talk about a “comeback” of this organelle reflecting a widely revitalized interest into mitochondrial research which was based on two major discoveries made during that time. The first was the etiological association between human diseases and mitochondrial DNA mutations, while the second revealed the crucial function of mitochondria during apoptosis. The March 5th, 1999 issue of Science even featured a textbook image of a mitochondrion on its front cover and was entirely dedicated to this organelle. Whilst the term “comeback” might have been appropriate to describe the general excitement surrounding the new mitochondrial discoveries made during the 1990s, a term for describing the progress made in mitochondrial research during the last two decades is difficult to find. Between 2000 and 2020 the number of publications on mitochondria has skyrocketed. It is now widely accepted that there hardly exists any human disease for which either the etiology or pathogenesis does not seem to be associated with mitochondrial malfunction. In this review we will discuss and follow several lines of mitochondrial research from their early beginnings up to the present. We hope to be able to convince the reader of what we expressed about a decade ago, that the future of medicine will come through mitochondria. |
|---|---|
| Keywords | biochemistry ; cells ; dqasome ; lipoplexe ; heteroplasmy ; mirna ; mitochondrial medicine ; mitochondrial diseases ; mitochondrial dna ; mitochondrial dysfunction ; mitochondrial research ; mitochondrion ; mitochondrium ; mitomirs ; mtdna ; organelle ; physiology ; pna ; research ; science ; Medicine ; R ; Q |
| Subject code | 610 |
| Language | English |
| Publishing date | 2021-01-01T00:00:00Z |
| Publisher | EDP Sciences |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2022 Volume 9, Page(s) 985141
Abstract: Iron is a double-edged sword. It is vital for all that's living, yet its deficiency or overload can be fatal. In humans, iron homeostasis is tightly regulated at both cellular and systemic levels. Extracellular vesicles (EVs), now known as major players ... ...
| Abstract | Iron is a double-edged sword. It is vital for all that's living, yet its deficiency or overload can be fatal. In humans, iron homeostasis is tightly regulated at both cellular and systemic levels. Extracellular vesicles (EVs), now known as major players in cellular communication, potentially play an important role in regulating iron metabolism. The gut microbiota was also recently reported to impact the iron metabolism process and indirectly participate in regulating iron homeostasis, yet there is no proof of whether or not microbiota-derived EVs interfere in this relationship. In this review, we discuss the implication of EVs on iron metabolism and homeostasis. We elaborate on the blooming role of gut microbiota in iron homeostasis while focusing on the possible EVs contribution. We conclude that EVs are extensively involved in the complex iron metabolism process; they carry ferritin and express transferrin receptors. Bone marrow-derived EVs even induce hepcidin expression in β-thalassemia. The gut microbiota, in turn, affects iron homeostasis on the level of iron absorption and possibly macrophage iron recycling, with still no proof of the interference of EVs. This review is the first step toward understanding the multiplex iron metabolism process. Targeting extracellular vesicles and gut microbiota-derived extracellular vesicles will be a huge challenge to treat many diseases related to iron metabolism alteration. |
|---|---|
| Language | English |
| Publishing date | 2022-10-13 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2775999-4 |
| ISSN | 2296-858X |
| ISSN | 2296-858X |
| DOI | 10.3389/fmed.2022.985141 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2020 Volume 8, Issue 2
Abstract: Fecal Microbiota Transplantation (FMT) is suggested as an efficacious therapeutic strategy for restoring intestinal microbial balance, and thus for treating disease associated with alteration of gut microbiota. FMT consists of the administration of fresh ...
| Abstract | Fecal Microbiota Transplantation (FMT) is suggested as an efficacious therapeutic strategy for restoring intestinal microbial balance, and thus for treating disease associated with alteration of gut microbiota. FMT consists of the administration of fresh or frozen fecal microorganisms from a healthy donor into the intestinal tract of diseased patients. At this time, in according to healthcare authorities, FMT is mainly used to treat recurrent |
|---|---|
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-04-15 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2720869-2 |
| ISSN | 2079-9721 |
| ISSN | 2079-9721 |
| DOI | 10.3390/diseases8020009 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Methods in molecular biology (Clifton, N.J.)
2021 Volume 2276, Page(s) 1–29
Abstract: Until recently restricted to hereditary mitochondrial diseases, mitochondrial dysfunction is now recognized as a key player and strategic factor in the pathophysiological of many human diseases, ranging from the metabolism, vascular, cardiac, and ... ...
| Abstract | Until recently restricted to hereditary mitochondrial diseases, mitochondrial dysfunction is now recognized as a key player and strategic factor in the pathophysiological of many human diseases, ranging from the metabolism, vascular, cardiac, and neurodegenerative diseases to cancer. Because of their participation in a myriad of cellular functions and signaling pathways, precisely identifying the cause of mitochondrial "dysfunctions" can be challenging and requires robust and controlled techniques. Initially limited to the analysis of the respiratory chain functioning, these analytical techniques now enlarge to the analyses of mitochondrial and cellular metabolism, based on metabolomic approaches.Here, we address the methods used to assay mitochondrial dysfunction, with a highlight on the techniques used in diagnosis on tissues and cells derived from patients, the information they provide, and their strength and weakness.Targeting mitochondrial dysfunction by various strategies is a huge challenge, requires robust methods of evaluation, and should be able to take into consideration the mitochondria dynamics and localization. The future of mitochondrial medicine is strongly related to a perfect comprehension of its dysfunction. |
|---|---|
| MeSH term(s) | Animals ; Biosensing Techniques/methods ; Energy Metabolism ; Humans ; Metabolomics/methods ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Diseases/metabolism ; Mitochondrial Diseases/pathology |
| Language | English |
| Publishing date | 2021-05-30 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ISSN | 1940-6029 |
| ISSN (online) | 1940-6029 |
| DOI | 10.1007/978-1-0716-1266-8_1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2020 Volume 97, Page(s) 303–305
Abstract: The coronavirus 2 (SARS-CoV-2) pandemic is viciously spreading through the continents with rapidly increasing mortality rates. Current management of COVID-19 is based on the premise that respiratory failure is the leading cause of mortality. However, ... ...
| Abstract | The coronavirus 2 (SARS-CoV-2) pandemic is viciously spreading through the continents with rapidly increasing mortality rates. Current management of COVID-19 is based on the premise that respiratory failure is the leading cause of mortality. However, mounting evidence links accelerated pathogenesis in gravely ill COVID-19 patients to a hyper-inflammatory state involving a cytokine storm. Several components of the heightened inflammatory state were addressed as therapeutic targets. Another key component of the heightened inflammatory state is hyper-ferritinemia which reportedly identifies patients with increased mortality risk. In spite of its strong association with mortality, it is not yet clear if hyper-ferritinemia in COVID-19 patients is merely a systemic marker of disease progression, or a key modulator in disease pathogenesis. Here we address implications of a possible role for hyper-ferritinemia, and altered iron homeostasis in COVID-19 pathogenesis, and potential therapeutic targets in this regard. |
|---|---|
| MeSH term(s) | Betacoronavirus ; COVID-19 ; Coronavirus Infections/mortality ; Coronavirus Infections/pathology ; Cytokine Release Syndrome/virology ; Ferroptosis ; Hepcidins/physiology ; Humans ; Inflammation ; Iron/blood ; Iron Overload/virology ; Mitochondria/pathology ; Mitochondria/physiology ; Oxidative Stress ; Pandemics ; Pneumonia, Viral/mortality ; Pneumonia, Viral/pathology ; SARS-CoV-2 |
| Chemical Substances | Hepcidins ; Iron (E1UOL152H7) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-06-02 |
| Publishing country | Canada |
| Document type | Journal Article ; Review |
| ZDB-ID | 1331197-9 |
| ISSN | 1878-3511 ; 1201-9712 |
| ISSN (online) | 1878-3511 |
| ISSN | 1201-9712 |
| DOI | 10.1016/j.ijid.2020.05.110 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4516: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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