Article ; Online: Irradiation à faible dose des affections non cancéreuses : avons-nous jeté le bébé avec l’eau du bain ?
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
2021 Volume 25, Issue 3, Page(s) 279–282
Abstract: The irradiation of non-malignant diseases, essentially for anti-inflammatory purpose, have been largely proposed and performed worldwide until the 1970-80s. At that time, the better assessment of the radio-induced malignancies, essentially in children ... ...
| Title translation | Low-dose irradiation of non-malignant diseases: Did we throw the baby out with the bathwater? |
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| Abstract | The irradiation of non-malignant diseases, essentially for anti-inflammatory purpose, have been largely proposed and performed worldwide until the 1970-80s. At that time, the better assessment of the radio-induced malignancies, essentially in children and young patients, as well as the efficacy of the new anti-inflammatory drugs (steroids and non-steroids), led to the almost disappearance of those techniques, at least in France. In contrast, our German colleagues are still going on treating about 50,000 patients per year for non-malignant (more or less severe) diseases. After a short historical overview, the present article suggests that we were possibly going too far in the rejection of those low-dose irradiations for benign lesions. The recent emergence of new preclinical data, the better understanding of the risk of radio-induced secondary tumours (almost nil in the elderly), and the severity of some situations, such as the cytokine storm of the COVID-19, should probably lead us to reconsider those low - and sometimes very low (less than 1Gy) - irradiations for well-selected indications in the elderly. |
| MeSH term(s) | Evidence-Based Medicine ; Humans ; Neoplasms, Radiation-Induced ; Radiotherapy/trends ; Radiotherapy Dosage |
| Language | French |
| Publishing date | 2021-01-12 |
| Publishing country | France |
| Document type | Journal Article |
| ZDB-ID | 1397169-4 |
| ISSN | 1769-6658 ; 1278-3218 |
| ISSN (online) | 1769-6658 |
| ISSN | 1278-3218 |
| DOI | 10.1016/j.canrad.2020.09.002 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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