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  1. Book ; Online: Chapter 7 Vitamin C in Pneumonia and Sepsis

    Carr, Anitra C.

    2020  

    Abstract: In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid ... ...

    Abstract In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by members of the SLC23 family, SLC23A1/SVCT1 and SLC23A2/SVCT2. We present in silico models of these transporters that provide new insights into the structure of the SLC23 family. While SVCT1 is mainly responsible for uptake of ascorbic acid from the intestine into the blood and for reabsorption in the kidney, the more broadly expressed transporter SVCT2 delivers ascorbic acid into tissues that are in high demand of the vitamin. The oxidized form of ascorbic acid, dehydroascorbic acid (DHA), is a substrate of the GLUT transporters belonging to the SLC2 family. They play important roles in ascorbic acid recycling, such as in the brain and in erythrocytes. Ascorbic acid serves as an essential co-factor of metal ion-dependent enzymes, keeping their metal ions in the reduced state. In addition, it serves as an effective antioxidant in cells with high metabolic activity such as neurons. Thus, it is not too surprising that changes in expression and function of the SVCTs have nutritional and pathological consequences such as during ageing, malnutrition and chronic alcohol abuse or in cancer, neurodegenerative diseases and chronic inflammation diseases. In the future, SVCT1 and SVCT2 may furthermore prove useful as drug delivery systems, to enhance transport of novel pharmaceutical agents more efficiently across the intestinal epithelium and the blood-cerebrospinal fluid barrier
    Keywords Medicine (General) ; Biology (General)
    Size 1 electronic resource (26 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020590143
    ISBN 9781138337992 ; 1138337994
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Vitamin C: Current Concepts in Human Physiology

    Carr, Anitra C. / Natarajan, Ramesh

    2018  

    Abstract: ... describe the book in straightforward and consumer-friendly terms.[Vitamin C is synthesized by almost ... details have emerged regarding differences in its uptake by oral and intravenous modes. While vitamin C ... pharmacological roles for high-dose, intravenous vitamin C in many disease states have now been postulated and ...

    Abstract ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[Vitamin C is synthesized by almost all animals. However, for humans, it is a vitamin that needs constant replenishment in the diet. While its role as an anti-oxidant and for preventing scurvy have been known for a long time, novel functions and unrecognized associations continue to be identified for this enigmatic molecule. In the past decade, new details have emerged regarding differences in its uptake by oral and intravenous modes. While vitamin C deficiency remains largely unknown and poorly addressed in many segments of the population, novel pharmacological roles for high-dose, intravenous vitamin C in many disease states have now been postulated and investigated. This has shifted its role in health and disease from the long-perceived notion as merely a vitamin and an anti-oxidant to a pleiotropic molecule with a broad anti-inflammatory, epigenetic, and anti-cancer profile.This Special Issue comprises original research papers and reviews on vitamin C metabolism and function that relate to the following topics: understanding its role in the modulation of inflammation and immunity, therapeutic applications and safety of pharmacological ascorbate in disease, and the emerging role of vitamin C as a pleiotropic modulator of critical care illness and cancer.]
    Keywords Therapeutics. Pharmacology ; Biology (General)
    Size 1 electronic resource (148 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020099327
    ISBN 9783038972945 ; 9783038972952 ; 3038972940 ; 3038972959
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Vitamin C in Health and Disease

    Lykkesfeldt, Jens / Carr, Anitra C.

    2018  

    Abstract: Vitamin C is a pivotal water soluble electron donor in nature and an essential nutrient in man ... Despite its many years as a research focus, new and increasingly regulatory functions of vitamin C ... strong associations between poor vitamin C status and increased morbidity and mortality.In this Special ...

    Abstract Vitamin C is a pivotal water soluble electron donor in nature and an essential nutrient in man. Despite its many years as a research focus, new and increasingly regulatory functions of vitamin C in human health are continually being unravelled. This improved mechanistic insight is starting to provide rationales explaining the extensive epidemiological literature that, for decades, has consistently shown strong associations between poor vitamin C status and increased morbidity and mortality.In this Special Issue, we include original research and literature reviews by experts in the field outlining the roles of vitamin C in early, daily and late life, as well as the roles of deficiency in cardiovascular disease, inflammation and cancer
    Keywords Diseases of the circulatory (Cardiovascular) system
    Size 1 electronic resource (X, 288 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note english ; Open Access
    HBZ-ID HT020099010
    ISBN 9783038970293 ; 9783038970309 ; 3038970298 ; 3038970301
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Vitamin C.

    Lykkesfeldt, Jens / Carr, Anitra C

    Advances in nutrition (Bethesda, Md.)

    2023  Volume 15, Issue 1, Page(s) 100155

    MeSH term(s) Humans ; Ascorbic Acid/therapeutic use ; Vitamins
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Vitamins
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2156-5376
    ISSN (online) 2156-5376
    ISSN 2156-5376
    DOI 10.1016/j.advnut.2023.100155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Vitamin C and COVID-19: should clinical trials be prioritised for low income settings and vitamin C-deficient populations?

    Carr, Anitra C / Rowe, Sam

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2023  Volume 23, Issue 1, Page(s) 119–120

    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    DOI 10.51893/2021.1.L1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6672: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Is "Mega-Dose" IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?

    Carr, Anitra C

    Critical care medicine

    2021  Volume 49, Issue 4, Page(s) e477–e478

    MeSH term(s) Ascorbic Acid ; COVID-19 ; Humans ; SARS-CoV-2 ; Shock, Septic ; Vitamins
    Chemical Substances Vitamins ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Does Aging Affect Vitamin C Status Relative to Intake? Findings from NHANES 2017-2018.

    Carr, Anitra C / Lykkesfeldt, Jens

    Nutrients

    2023  Volume 15, Issue 4

    Abstract: ... expenditure. In this study, we examine vitamin C dose-concentration relationships based on data ...

    Abstract The aging population is growing and fueling a global increase in chronic diseases and healthcare expenditure. In this study, we examine vitamin C dose-concentration relationships based on data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 to identify a possible age-dependent change in intake vs. concentration relationship among non-supplemented individuals (
    MeSH term(s) Humans ; Aged ; Ascorbic Acid ; Nutrition Surveys ; Vitamins ; Aging ; Recommended Dietary Allowances
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Vitamins
    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15040892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Vitamin C - a scoping review for Nordic Nutrition Recommendations 2023.

    Lykkesfeldt, Jens / Carr, Anitra C

    Food & nutrition research

    2023  Volume 67

    Abstract: Vitamin C has multiple metabolic functions in the body, but the available information on the exact ... attempts to objectively measure adequacy of vitamin C status, including, for example, replacement ... correlation between body weight and vitamin C status exists, recommended intakes (RIs) for other age groups ...

    Abstract Vitamin C has multiple metabolic functions in the body, but the available information on the exact relationship between these functions and the intake necessary to maintain them is very limited. However, most attempts to objectively measure adequacy of vitamin C status, including, for example, replacement of metabolic turnover, chronic disease prevention, urinary excretion, and saturation of immune cells and body compartment, currently point toward 50 µmol/L as a reasonable target plasma concentration. As a strong correlation between body weight and vitamin C status exists, recommended intakes (RIs) for other age groups may be extrapolated from the adult RI based on weight. However, as body weights above 70 kg are becoming increasingly common - also in the Nordic region - an RI of 140 mg/day for individuals weighing 100 kg or more should be considered to compensate for the larger volume of distribution. Finally, smoking continues to be a common contributor to poor vitamin C status; therefore, it is proposed that people who smoke increase their daily vitamin C intake by 40 mg/day to compensate for the increased metabolic turnover induced by smoking.
    Language English
    Publishing date 2023-12-28
    Publishing country Sweden
    Document type Journal Article ; Review
    ZDB-ID 2418338-6
    ISSN 1654-661X
    ISSN 1654-661X
    DOI 10.29219/fnr.v67.10300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Does Aging Have an Impact on Vitamin C Status and Requirements? A Scoping Review of Comparative Studies of Aging and Institutionalisation.

    Carr, Anitra C / Zawari, Masuma

    Nutrients

    2023  Volume 15, Issue 4

    Abstract: ... of micronutrient deficiencies, including immune-supportive vitamin C, which is both a contributor to and ... with depleted vitamin C status and increased requirements for the vitamin is less certain. A systematic scoping ... review was carried out to assess comparative studies that reported the vitamin C status and prevalence ...

    Abstract The global healthcare burden of an aging population continues to increase, with nearly a quarter of the total global burden of disease attributable to people aged ≥60 years. Older people are at greater risk of micronutrient deficiencies, including immune-supportive vitamin C, which is both a contributor to and a consequence of acute and chronic illnesses. However, whether healthy aging, per se, is associated with depleted vitamin C status and increased requirements for the vitamin is less certain. A systematic scoping review was carried out to assess comparative studies that reported the vitamin C status and prevalence of deficiency in older versus younger people and in older people relative to residential status. Furthermore, vitamin C requirements were assessed through comparative studies reporting vitamin C status and pharmacokinetics in older people relative to younger people. Overall, there was limited evidence to suggest that healthy aging, per se, is related to lower vitamin C status or higher requirements for the vitamin. However, institutionalised elderly had lower vitamin C status and enhanced vitamin C requirements, primarily as a result of low intakes and/or chronic illnesses, which were not being met by hospital or residential diets. Because institutionalised elderly are vulnerable to malnutrition and micronutrient deficiencies, it is imperative that appropriate nutritional interventions are instigated to provide optimal micronutrient intake to support healthy aging.
    MeSH term(s) Aged ; Humans ; Ascorbic Acid ; Aging ; Vitamins ; Diet ; Malnutrition ; Institutionalization ; Nutritional Status ; Micronutrients ; Nutritional Requirements
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Vitamins ; Micronutrients
    Language English
    Publishing date 2023-02-11
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15040915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Factors Affecting the Vitamin C Dose-Concentration Relationship: Implications for Global Vitamin C Dietary Recommendations.

    Carr, Anitra C / Lykkesfeldt, Jens

    Nutrients

    2023  Volume 15, Issue 7

    Abstract: Vitamin C status is known to be associated with several demographic and lifestyle factors ... 2017-2018 datasets to assess the impact of these factors on vitamin C dose-concentration relationships ... to establish if there are higher requirements for vitamin C in certain subpopulations, and the possible extent ...

    Abstract Vitamin C status is known to be associated with several demographic and lifestyle factors. These include gender, age, ethnicity, pregnancy/lactation, body weight, smoking status and dietary habits. In the present study, our aim was to investigate the National Health and Nutrition Examination Survey (NHANES) 2017-2018 datasets to assess the impact of these factors on vitamin C dose-concentration relationships to establish if there are higher requirements for vitamin C in certain subpopulations, and the possible extent of these additional requirements. The final cohort comprised 2828 non-supplementing adult males and females (aged 18-80+ years) with both vitamin C serum concentrations and dietary intake data available. The data were subsequently stratified by gender, age tertiles (≤36, 37-58, ≥59 years), ethnicity (non-Hispanic white, non-Hispanic black, and total Hispanic), socioeconomic tertiles (poverty income ratios: ≤1.35, 1.36-3.0, >3.0), weight tertiles (<72, 72-91, >91 kg), BMI tertiles (<26, 26-32, >32 kg/m
    MeSH term(s) Male ; Female ; Pregnancy ; Humans ; Aged ; Ascorbic Acid ; Nutrition Surveys ; Diet ; Vitamins ; Body Weight
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Vitamins
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15071657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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