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  1. Article ; Online: Immunization guidelines and applications

    Vipin M Vashishtha

    Indian Journal of Medical Research, Vol 158, Iss 3, Pp 324-

    2023  Volume 324

    Keywords Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The durability of vaccine-induced protection: an overview.

    Vashishtha, Vipin M / Kumar, Puneet

    Expert review of vaccines

    2024  Volume 23, Issue 1, Page(s) 389–408

    Abstract: Introduction: Current vaccines vary widely in both their efficacy against infection and disease, and the durability of the efficacy. Some vaccines provide practically lifelong protection with a single dose, while others provide only limited protection ... ...

    Abstract Introduction: Current vaccines vary widely in both their efficacy against infection and disease, and the durability of the efficacy. Some vaccines provide practically lifelong protection with a single dose, while others provide only limited protection following annual boosters. What variables make vaccine-induced immune responses last? Can breakthroughs in these factors and technologies help us produce vaccines with better protection and fewer doses? The durability of vaccine-induced protection is now a hot area in vaccinology research, especially after COVID-19 vaccines lost their luster. It has fueled discussion on the eventual utility of existing vaccines to society and bolstered the anti-vaxxer camp. To sustain public trust in vaccines, lasting vaccines must be developed.
    Areas covered: This review summarizes licensed vaccines' protection. It analyses immunological principles and vaccine and vaccinee parameters that determine longevity of antibodies. The review concludes with challenges and the way forward to improve vaccine durability.
    Expert opinion: Despite enormous advances, we still lack essential markers and reliable correlates of lasting protection. Most research has focused on humoral immune responses, but we must also focus on innate, mucosal, and cellular responses - their assessment, correlates, determinants, and novel adjuvants. Suitable vaccine designs and platforms for durable immunity must be found.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Immunity, Cellular ; Vaccines ; Adjuvants, Immunologic ; Immunization, Secondary ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Vaccines ; Adjuvants, Immunologic ; Antibodies, Viral
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2024.2331065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is 'original antigenic sin' complicating indian vaccination drive against Covid-19?

    Vashishtha, Vipin M

    Human vaccines & immunotherapeutics

    2021  Volume 17, Issue 10, Page(s) 3314–3315

    Abstract: India is in the grip of a devastating second wave of Covid-19. Many experts believe new variants of concern (VOC) are behind this unprecedented surge. Some media reports are hinting toward higher risk of Covid infection following Covid vaccinations. ' ... ...

    Abstract India is in the grip of a devastating second wave of Covid-19. Many experts believe new variants of concern (VOC) are behind this unprecedented surge. Some media reports are hinting toward higher risk of Covid infection following Covid vaccinations. 'Original antigenic sin,' in which a prior exposure to an antigen leads to an ineffective response to a related antigen, may offer one immunological explanation for this unusual association. There is an urgent need of undertaking a detailed study to prove/disprove this association.
    MeSH term(s) Antigens ; COVID-19 ; Humans ; India ; SARS-CoV-2 ; Vaccination
    Chemical Substances Antigens
    Language English
    Publishing date 2021-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2021.1945904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Conjunctival Involvement in Infants as an Unusual Symptom of Omicron XBB.1.16 Driven Surge.

    Vashishtha, Vipin M / Kumar, Puneet

    Indian pediatrics

    2023  Volume 60, Issue 10, Page(s) 861–862

    Abstract: We describe clinical characteristics of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infected children during the XBB.1.16 variant-driven surge in April, 2023 in India. A signi-ficantly higher positivity rate in young infants than in ... ...

    Abstract We describe clinical characteristics of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infected children during the XBB.1.16 variant-driven surge in April, 2023 in India. A signi-ficantly higher positivity rate in young infants than in older children (37.4% vs 13.3%; P<0.001), and a predominance of respiratory symptoms were noticed. Notably, non-purulent con-junctivitis was found in 36.8% of SARS-CoV-2 positive infants. All recovered with symptomatic treatment as outpatients.
    MeSH term(s) Child ; Humans ; Infant ; COVID-19/epidemiology ; India/epidemiology ; SARS-CoV-2 ; Conjunctival Neoplasms/epidemiology
    Language English
    Publishing date 2023-10-11
    Publishing country India
    Document type Letter
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
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    Zs.A 859: Show issues Location:
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  5. Article ; Online: Recurring Outbreaks of Circulating Vaccine-derived Polioviruses: Implications for Global Poliovirus Immunization Strategy.

    Vashishtha, Vipin M / Kumar, Puneet

    Indian pediatrics

    2023  Volume 60, Issue 6, Page(s) 437–441

    Abstract: The incidence of polio has decreased by more than 99.9% and currently, only two countries are endemic for wild poliovirus. However, increasing outbreaks of circulating vaccine-derived poliovirus globally in the last few years, with the latest ones in ... ...

    Abstract The incidence of polio has decreased by more than 99.9% and currently, only two countries are endemic for wild poliovirus. However, increasing outbreaks of circulating vaccine-derived poliovirus globally in the last few years, with the latest ones in high-income, exclusive inactivated polio virus vaccine (IPV)-using countries have brought out a new dimension to the end game of polio eradication. The inability of the current IPV to induce efficient mucosal immunity in the intestine is likely to be one of the key reasons behind the silent transmission of the polio virus in these countries. New challenges demand concerted global efforts with renewed vigor to cross the last mile. We need to aggressively cover up areas of under-vaccination and continue large-scale genomic surveillance. Further, the availability of a novel oral polio vaccine (nOPV2), and the likely availability of Sabin IPV and a more refined IPV with mucosal adjuvant in the near future is likely to go a long way in achieving this remarkable feat.
    MeSH term(s) Humans ; Disease Outbreaks/prevention & control ; Global Health ; Poliomyelitis/epidemiology ; Poliomyelitis/prevention & control ; Poliovirus ; Poliovirus Vaccine, Inactivated ; Poliovirus Vaccine, Oral/adverse effects ; Vaccination
    Chemical Substances Poliovirus Vaccine, Inactivated ; Poliovirus Vaccine, Oral
    Language English
    Publishing date 2023-03-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 859: Show issues Location:
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  6. Article ; Online: Responding to new challenges: is there a need to relook and revise our COVID-19 vaccination strategy?

    Vashishtha, Vipin M / Kumar, Puneet

    Expert review of vaccines

    2022  Volume 21, Issue 8, Page(s) 1015–1018

    MeSH term(s) Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Vaccination
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2022-05-17
    Publishing country England
    Document type Editorial
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2022.2077196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6077: Show issues Location:
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  7. Article ; Online: Are BCG-induced non-specific effects adequate to provide protection against COVID-19?

    Vashishtha, Vipin M

    Human vaccines & immunotherapeutics

    2020  Volume 17, Issue 1, Page(s) 88–91

    Abstract: The world is experiencing a pandemic of Coronavirus Disease (COVID-19) caused by type-2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Vaccination is the only option to prevent future surges of the disease. Efforts for developing an ... ...

    Abstract The world is experiencing a pandemic of Coronavirus Disease (COVID-19) caused by type-2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Vaccination is the only option to prevent future surges of the disease. Efforts for developing an effective vaccine are underway, but the timeline for the widespread availability of safe and effective vaccines is unknown. Some ecological reports have linked regional universal use of the Bacillus Calmette-Guerin (BCG) vaccine with reduced morbidity and mortality of COVID-19. BCG protects from non-tuberculous diseases through 'non-specific' effects mediated by the modulation of innate immunity. This commentary provides details of the immunological mechanism of BCG-induced 'trained innate immunity' responsible for its nonspecific protective effects. A probable role of the BCG vaccine in the current pandemic is also examined.
    MeSH term(s) BCG Vaccine/therapeutic use ; COVID-19/immunology ; COVID-19/prevention & control ; Coronavirus/immunology ; Coronavirus/pathogenicity ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Humans ; Immunity, Innate/immunology ; Pandemics/prevention & control ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity
    Chemical Substances BCG Vaccine
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2020.1794219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: IAP-ACVIP Immunization Recommendations: Focus on an 'Individual' Child in 'Office Practice' Setting.

    Vashishtha, Vipin M

    Indian pediatrics

    2019  Volume 56, Issue 6, Page(s) 510–511

    MeSH term(s) Adolescent ; Advisory Committees ; Child ; Humans ; Immunization ; Immunization Schedule ; Pediatrics ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2019-06-25
    Publishing country India
    Document type Letter ; Comment
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 859: Show issues Location:
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  9. Article ; Online: Investigating the Muzaffarpur Outbreaks in the Backdrop of Western Uttar Pradesh Experience: The Way Forward.

    Vashishtha, Vipin M

    Indian pediatrics

    2019  Volume 56, Issue 10, Page(s) 885–887

    MeSH term(s) Acute Febrile Encephalopathy/epidemiology ; Acute Febrile Encephalopathy/prevention & control ; Child ; Child, Preschool ; Communicable Disease Control/organization & administration ; Disease Outbreaks ; Female ; Forecasting ; Humans ; India/epidemiology ; Male ; Primary Prevention/trends ; Program Development ; Risk Assessment ; Socioeconomic Factors
    Language English
    Publishing date 2019-12-12
    Publishing country India
    Document type Letter
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 859: Show issues Location:
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