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Article ; Online: Anti-inflammatory activity of peiminine in acetic acid-induced ulcerative colitis model.

Ranjbar Bushehri, Maryam / Babaei, Nahid / Esmaeili Gouvarchin Ghaleh, Hadi / Khamisipour, Gholamreza / Farnoosh, Gholamreza

Inflammopharmacology

2023 Volume 32, Issue 1, Page(s) 657–665

Abstract: Ulcerative colitis is a chronic inflammatory disorder of the intestinal mucosa and a prevalent gastrointestinal condition in developed countries. Peiminine, derived from the Fritillaria imperialis plant, exhibits remarkable anti-inflammatory and anti- ... ...

Abstract	Ulcerative colitis is a chronic inflammatory disorder of the intestinal mucosa and a prevalent gastrointestinal condition in developed countries. Peiminine, derived from the Fritillaria imperialis plant, exhibits remarkable anti-inflammatory and anti-cancer properties. This study aims to investigate the anti-inflammatory effects of peiminine in an experimental model of ulcerative colitis. Ulcerative colitis was induced intra-rectally in all groups, except the negative control, using 100 μl of 4% acetic acid. Peiminine treatment was initiated after ulcerative colitis induction and symptom manifestation. After the final injection, mice were sacrificed on day 15 for assessment. Various parameters were evaluated, including disease activity index, myeloperoxidase activity, nitric oxide levels, production and expression of IL-1, IL-6, TNF-α cytokines, and expression of IL-1β, IL-6, TNF-α, iNOS, and COX2 genes. Microscopic pathological evaluation was performed on colon tissue. Peiminine treatment resulted in reduced levels of NO, MPO, IL-1β, IL-6, and TNF-α. Furthermore, the expression of IL-1β, IL-6, TNF-α genes, iNOS, and COX2 genes was decreased in response to peiminine treatment in these mice. This study demonstrates the effectiveness of peiminine in alleviating inflammatory manifestations and mitigating intestinal tissue damage in an experimental model of ulcerative colitis, probably by anti-inflammatory procedure. Peiminine holds potential as a therapeutic adjunct for the management of ulcerative colitis.
MeSH term(s)	Animals ; Mice ; Acetic Acid ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Cyclooxygenase 2 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents/pharmacology ; Interleukin-1beta ; Nitric Oxide ; Cevanes
Chemical Substances	Acetic Acid (Q40Q9N063P) ; peiminine (JKN43410XZ) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents ; Interleukin-1beta ; Nitric Oxide (31C4KY9ESH) ; Cevanes
Language	English
Publishing date	2023-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-023-01360-4
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Article ; Online: Effects of Platelet-Rich Plasma on Clinical and Inflammatory Manifestations in an Experimental Model of Ulcerative Colitis

Maryam Ranjbar Bushehri / Nahid Babaei / Hadi Esmaeili Gouvarchin Ghaleh / Gholamreza Khamisipour / Gholamreza Farnoosh

Journal of Mazandaran University of Medical Sciences, Vol 33, Iss 228, Pp 1-

2023 Volume 12

Abstract: Background and purpose: Ulcerative colitis is a kind of inflammatory bowel disease that involves factors such as genetic predisposition, environmental factors, and disproportionate function of the mucosal immune system in response to intestinal microbial ...

Abstract	Background and purpose: Ulcerative colitis is a kind of inflammatory bowel disease that involves factors such as genetic predisposition, environmental factors, and disproportionate function of the mucosal immune system in response to intestinal microbial flora. Platelet-rich plasma (PRP) is a blood derivative that has anti-inflammatory and cell-regenerating properties. This study aimed to investigate the effects of PRP on the clinical and inflammatory manifestations in an experimental model of ulcerative colitis. Materials and methods: In this experiment, male BALB/c mice were segregated into four groups, each consisting of 10 mice: the healthy group (negative control), the colitis group without treatment (positive control), the colitis group receiving PRP, and colitis group receiving sulfasalazine. All animals, except for those in the negative control group, were subjected to colitis induction via intrarectal injection of 100 µl of 4% acetic acid. The treatment regimen commenced after the onset of UC symptoms. The mice were euthanasia after 15 days of the last injection, and the disease activity index, as well as the inflammatory factors, were assessed. Results: According to the results, the treatment groups showed a significant decrease in disease activity index, the severity of inflammation, the level of MPO, NO, and IL-1β, IL-6, and TNF-α cytokines expression and production, as well as inflammatory genes COX2 and iNOS expression, compared to the positive control group. Conclusion: The results showed that PRP has favorable anti-inflammatory effects in ulcerative colitis and after additional evaluations, it can be used as an adjunctive treatment along with the drugs used in the treatment of ulcerative colitis patients.
Keywords	ulcerative colitis ; inflammation ; platelet-rich plasma ; sulfasalazine ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	630 ; 610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Mazandaran University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Is Alcohol More Dangerous Than Severe Acute Respiratory Syndrome Coronavirus 2 in Iran?

Farnoosh, Gholamreza / Hosseini Zijoud, Seyed Reza

Disaster medicine and public health preparedness

2020 Volume 15, Issue 5, Page(s) e5–e6

MeSH term(s)	COVID-19 ; Humans ; Iran/epidemiology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2020.110
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Article ; Online: Improving the specificity of organophosphorus hydrolase to acephate by mutagenesis at its binding site: a computational study.

Badakhshan, Reza / Mohammadi, Mozafar / Farnoosh, Gholamreza

Journal of molecular modeling

2021 Volume 27, Issue 6, Page(s) 164

Abstract: Organophosphorus hydrolase (OPH) is one of the most important enzymes in order to bioremediation of organophosphorus (OP) pesticides. OPH is capable of degrading a wide variety of OPs, but it has poor specificity to OPs with P-S bond, including acephate. ...

Abstract	Organophosphorus hydrolase (OPH) is one of the most important enzymes in order to bioremediation of organophosphorus (OP) pesticides. OPH is capable of degrading a wide variety of OPs, but it has poor specificity to OPs with P-S bond, including acephate. Given that the binding site residues of OPH determine its substrate specificity, this study was carried out to find the best OPH mutants containing a single point mutation in the binding site that possess improved specificity to acephate. Hence, we generated all possible mutant models and performed molecular docking of acephate with wild-type OPH (OPH-WT) and its mutants. After that, molecular dynamic (MD) simulations of OPH-WT and the best mutants, according to the docking results, were performed in both apo- and complex with acephate forms. Docking results signified that 51 out of 228 mutants possessed increased binding affinities to acephate, as compared to OPH-WT. Of them, W131N, W131G, and H254Y were the best mutants considering the high binding affinities and proper orientation of the ligand at their active sites. MD simulations confirmed the stability of the three mutants in both apo- and complex with acephate forms and also showed that these formed more stable complexes with acephate, as compared to OPH-WT. MD results also suggested that W131N and W131G, in addition to enhanced specificity, could keep the necessary configuration for acephate hydrolysis during the simulations.
Language	English
Publishing date	2021-05-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1284729-X
ISSN	0948-5023 ; 1610-2940
ISSN (online)	0948-5023
ISSN	1610-2940
DOI	10.1007/s00894-021-04749-6
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Article: Fabrication of Fe(III)-doped mesoporous silica nanoparticles as biocompatible and biodegradable theranostic system for Remdesivir delivery and MRI contrast agent.

Arkaban, Hasan / Jaberi, Javad / Bahramifar, Ali / Zolfaghari Emameh, Reza / Farnoosh, Gholamreza / Arkaban, Mehdi / Taheri, Ramezan Ali

Inorganic chemistry communications

2023 Volume 150, Page(s) 110398

Abstract: Coronavirus causes the majority of common colds and is spread in the same way that all viruses attack the respiratory system. Despite the trials and efforts to produce a suitable vaccine, there are solutions for the quick, effective and efficient use of ... ...

Abstract	Coronavirus causes the majority of common colds and is spread in the same way that all viruses attack the respiratory system. Despite the trials and efforts to produce a suitable vaccine, there are solutions for the quick, effective and efficient use of existing drugs to prevent infections and improve the condition of patients. In this study, we synthesized mSiO
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2026959-6
ISSN	1387-7003
ISSN	1387-7003
DOI	10.1016/j.inoche.2023.110398
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Article: Molecular characterization of canine and feline kobuvirus infections in Iran.

Aftab, Ghazal / Arfaee, Farnoosh / Akhtardanesh, Baharak / Nikbakht Brojeni, Gholamreza

Veterinary research forum : an international quarterly journal

2022 Volume 13, Issue 3, Page(s) 447–450

Abstract: Kobuviruses are viral pathogens with broad host range presented in human gastroenteritis cases; but, the pathogenesis of these viruses in companion animals is not well described. In the present study, the presence of canine (CaKVs) and feline kobuviruses ...

Abstract	Kobuviruses are viral pathogens with broad host range presented in human gastroenteritis cases; but, the pathogenesis of these viruses in companion animals is not well described. In the present study, the presence of canine (CaKVs) and feline kobuviruses (FeKVs) was detected in the 100 fecal samples of diarrhoeic and healthy companion dogs and cats by polymerase chain reaction in Tehran, Iran. The prevalence of infection was estimated as 8.00% and 4.00% in dogs and cats, respectively. All positive samples were belonged to non-diarrhoeic animals except for a feline sample being co-infected with panleukopenia. Sequence analysis showed multiple point mutations in canine and feline Iranian strains and new feline strain was detected in the present study. This is the first detection of CaKVs and FeKVs in Iran; but, the exact role of these enteric viral pathogens and their zoonotic risks are better to be clarified in all endemic regions.
Language	English
Publishing date	2022-09-15
Publishing country	Iran
Document type	Journal Article
ISSN	2008-8140
ISSN	2008-8140
DOI	10.30466/vrf.2020.128667.2975
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Article: Effects of Growth Factors and the MicroRNA-183 Family on Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells Towards Auditory Neuron-Like Cells.

Farnoosh, Gholamreza / Mahmoudian-Sani, Mohammad-Reza

Stem cells and cloning : advances and applications

2020 Volume 13, Page(s) 79–89

Abstract: Introduction: Hearing Loss (HL) is known as the most common sensory processing disorder across the world. An effective treatment which has been currently used for patients suffering from this condition is cochlear implant (CI). The major limitation of ... ...

Abstract	Introduction: Hearing Loss (HL) is known as the most common sensory processing disorder across the world. An effective treatment which has been currently used for patients suffering from this condition is cochlear implant (CI). The major limitation of this treatment is the need for a healthy auditory neuron (AN). Accordingly, mesenchymal cells (MCs) are regarded as good candidates for cell-based therapeutic approaches. The present study aimed to investigate the potentials of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) for differentiation towards ANs along with using treatments with growth factors and microRNA (miRNA) transfection Methods: To this end, neurospheres derived from hBM-MSCs were treated via basic fibroblast growth factor (bFGF), neurotrophin-3 (NT-3), and brain-derived neurotrophic factor (BDNF) as growth factors N2 and B27 supplements, as well as miRNA-96, -182, -183 transfected into hBM-MSCs in order to evaluate the differentiation of such cells into ANs. Results: Treatments with growth factors demonstrated a significant increase in Discussion: It can be concluded that miRNA is probably a good substitute for growth factors used in differentiating into ANs. Transdifferentiation of hBM-MSCs into ANs, which does not occur under normal conditions, may be thus facilitated by miRNAs, especially miRNA-182, or via a combination of miRNA and growth factors.
Language	English
Publishing date	2020-09-10
Publishing country	New Zealand
Document type	Journal Article
ISSN	1178-6957
ISSN	1178-6957
DOI	10.2147/SCCAA.S248526
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Article ; Online: Utilization of SUMO Tag and Freeze-thawing Method for a High-level Expression and Solubilization of Recombinant Human Angiotensinconverting Enzyme 2 (rhACE2) Protein in

Mohammadi, Mozafar / Taheri, Ramezan Ali / Bemani, Peyman / Hashemzadeh, Mohammad Sadegh / Farnoosh, Gholamreza / Amini, Razieh

Protein and peptide letters

2022 Volume 29, Issue 7, Page(s) 605–610

Abstract: Background: SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as a receptor for entering the host cells. Production of the ACE2 molecule is important because of its potency to use as a blocker and therapeutic agent against SARS-CoV-2 for the ... ...

Abstract	Background: SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as a receptor for entering the host cells. Production of the ACE2 molecule is important because of its potency to use as a blocker and therapeutic agent against SARS-CoV-2 for the prophylaxis and treatment of COVID-19. Objective: The recombinant human ACE2 (rhACE2) is prone to form an inclusion body when expressed in the bacterial cells. Methods: We used the SUMO tag fused to the rhACE2 molecule to increase the expression level and solubility of the fusion protein. Afterward, the freeze-thawing method plus 2 M urea solubilized aggregated proteins. Subsequently, the affinity of solubilized rhACE2 to the receptor binding domain (RBD) of the SARS-CoV-2 spike was assayed by ELISA and SPR methods. Results: SUMO protein succeeded in increasing the expression level but not solubilization of the fusion protein. The freeze-thawing method could solubilize and recover the aggregated fusion proteins significantly. Also, ELISA and SPR assays confirmed the interaction between solubilized rhACE2 and RBD with high affinity. Conclusion: The SUMO tag and freeze- Conclusion: The SUMO tag and freeze-thawing method would be utilized for high-level expression and solubilization of recombinant rhACE2 protein.
MeSH term(s)	Angiotensin-Converting Enzyme 2/genetics ; COVID-19 ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Humans ; Protein Binding ; SARS-CoV-2 ; Small Ubiquitin-Related Modifier Proteins/genetics ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Urea/metabolism
Chemical Substances	Small Ubiquitin-Related Modifier Proteins ; Urea (8W8T17847W) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2022-07-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1280776-x
ISSN	1875-5305 ; 0929-8665
ISSN (online)	1875-5305
ISSN	0929-8665
DOI	10.2174/0929866529666220715101357
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Zs.A 4452: Show issues

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Article ; Online: Polymorphisms in genes involved in breast cancer among Iranian patients.

Farnoosh, Gholamreza / Saeedi-Boroujeni, Ali / Jalali, Akram / Keikhaei, Bijan / Mahmoudian-Sani, Mohammad-Reza

Personalized medicine

2021 Volume 18, Issue 2, Page(s) 153–169

Abstract: This review gives a summary of the important genetic polymorphisms in breast cancer with a focus on people in Iran. Several single nucleotide polymorphisms were considered as breast cancer susceptibility polymorphisms within genes ( ...

Abstract	This review gives a summary of the important genetic polymorphisms in breast cancer with a focus on people in Iran. Several single nucleotide polymorphisms were considered as breast cancer susceptibility polymorphisms within genes (
MeSH term(s)	Antioxidants/metabolism ; Biomarkers, Tumor ; Breast Neoplasms/genetics ; Cell Cycle/genetics ; DNA Repair/genetics ; Female ; Genes, Tumor Suppressor ; Genetic Predisposition to Disease ; Humans ; Iran ; Polymorphism, Single Nucleotide ; Prognosis ; Risk Factors ; Signal Transduction/genetics
Chemical Substances	Antioxidants ; Biomarkers, Tumor
Language	English
Publishing date	2021-02-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2299146-3
ISSN	1744-828X ; 1741-0541
ISSN (online)	1744-828X
ISSN	1741-0541
DOI	10.2217/pme-2020-0003
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Zs.A 6549: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Desmoplastic fibroma of the lower jaw in a 2-year-old patient; report of a rare case.

Mohammadi, Farnoosh / Shirani, Gholamreza / Derakhshan, Samira / Faghihi, Taraneh

Dental research journal

2020 Volume 17, Issue 3, Page(s) 231–234

Abstract: Desmoplastic fibroma (DF) is a rare benign but aggressive fibrous lesion with an unknown etiology. It has an affinity for the mandible. DF has a high rate of recurrence after surgical resection. In this study, we report the therapeutic management of a ... ...

Abstract	Desmoplastic fibroma (DF) is a rare benign but aggressive fibrous lesion with an unknown etiology. It has an affinity for the mandible. DF has a high rate of recurrence after surgical resection. In this study, we report the therapeutic management of a recurrence of DF in the lower jaw in a 2-year-old boy. He responded well to second surgical intervention with wide resection and immediate reconstruction with plate. The purpose of this case report is to emphasize the particularity of the case, treatment modalities, and differential diagnosis in DF.
Language	English
Publishing date	2020-05-23
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2418290-4
ISSN	2008-0255 ; 1735-3327
ISSN (online)	2008-0255
ISSN	1735-3327
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