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  1. Book ; Online: Integrative Approaches to the Molecular Physiology of Inflammation

    Hernández-Lemus, Enrique / Elena Soto, María / Rosales, Carlos / Elena Soto, María

    2019  

    Keywords Science: general issues ; Physiology ; Inflammation ; Molecular Physiology ; Integrative Approaches ; Complex Diseases
    Size 1 electronic resource (334 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229859
    ISBN 9782889458004 ; 2889458008
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Editorial: Integrative Approaches to the Molecular Physiology of Inflammation, Volume II.

    Hernández-Lemus, Enrique / Rosales, Carlos / Soto, María Elena

    Frontiers in physiology

    2022  Volume 13, Page(s) 873295

    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.873295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Editorial

    Enrique Hernández-Lemus / Carlos Rosales / María Elena Soto

    Frontiers in Physiology, Vol

    Integrative Approaches to the Molecular Physiology of Inflammation, Volume II

    2022  Volume 13

    Keywords inflammation ; molecular physiology ; integrative biology ; immune responses ; systemic inflammation ; Physiology ; QP1-981
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: Multifunctionalized Carbon Dots as an Active Nanocarrier for Drug Delivery to the Glioblastoma Cell Line.

    Algarra, Manuel / Soto, Juan / Pino-González, Maria Soledad / Gonzalez-Munoz, Elena / Dučić, Tanja

    ACS omega

    2024  Volume 9, Issue 12, Page(s) 13818–13830

    Abstract: Nanoparticle-based nanocarriers represent a viable alternative to conventional direct administration in cancer cells. This advanced approach employs the use of nanotechnology to transport therapeutic agents directly to cancer cells, thereby reducing the ... ...

    Abstract Nanoparticle-based nanocarriers represent a viable alternative to conventional direct administration in cancer cells. This advanced approach employs the use of nanotechnology to transport therapeutic agents directly to cancer cells, thereby reducing the risk of damage to healthy cells and enhancing the efficacy of treatment. By approving nanoparticle-based nanocarriers, the potential for targeted, effective treatment is greatly increased. The so-called carbon-based nanoparticles, or carbon dots, have been hydrothermally prepared and initiated by a polymerization process. We synthesized and characterized nanoparticles of 2-acrylamido-2-methylpropanesulfonic acid, which showed biocompatibility with glioblastoma cells, and further, we tested them as a carrier for the drug riluzole. The obtained nanoparticles have been extensively characterized by techniques to obtain the exact composition of their surface by using Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), and nuclear magnetic resonance (NMR) spectroscopy, as well as cryo-transmission electron microscopy. We found that the surface of the synthesized nanoparticles (NPs) is covered mainly by sulfonated, carboxylic, and substituted amide groups. These functional groups make them suitable as carriers for drug delivery in cancer cells. Specifically, we have successfully utilized the NPs as a delivery system for the drug riluzole, which has shown efficacy in treating glioblastoma cancer cells. The effect of nanoparticles as carriers for the riluzole system on glioblastoma cells was studied using live-cell synchrotron-based FTIR microspectroscopy to monitor
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Alteration of the aortic vascular reactivity associated to excessive consumption of

    Manzano-Pech, Linaloe / Guarner-Lans, Verónica / Elena Soto, María / Díaz-Díaz, Eulises / Pérez-Torres, Israel

    Heliyon

    2023  Volume 9, Issue 9, Page(s) e20020

    Abstract: The moderate production of reactive oxidative species (ROS) is important because ROS act as second messengers. However, their depletion through the over-activity of the antioxidant system may lead to reductive stress (RS) which is characterized by an ... ...

    Abstract The moderate production of reactive oxidative species (ROS) is important because ROS act as second messengers. However, their depletion through the over-activity of the antioxidant system may lead to reductive stress (RS) which is characterized by an increase in reducing equivalents and an elevation of some components of the antioxidant system disturbing redox homeostasis.
    Language English
    Publishing date 2023-09-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e20020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Frailty and the Interactions between Skeletal Muscle, Bone, and Adipose Tissue-Impact on Cardiovascular Disease and Possible Therapeutic Measures.

    Soto, María Elena / Pérez-Torres, Israel / Rubio-Ruiz, María Esther / Cano-Martínez, Agustina / Manzano-Pech, Linaloe / Guarner-Lans, Verónica

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Frailty is a global health problem that impacts clinical practice. It is complex, having a physical and a cognitive component, and it is the result of many contributing factors. Frail patients have oxidative stress and elevated proinflammatory cytokines. ...

    Abstract Frailty is a global health problem that impacts clinical practice. It is complex, having a physical and a cognitive component, and it is the result of many contributing factors. Frail patients have oxidative stress and elevated proinflammatory cytokines. Frailty impairs many systems and results in a reduced physiological reserve and increased vulnerability to stress. It is related to aging and to cardiovascular diseases (CVD). There are few studies on the genetic factors of frailty, but epigenetic clocks determine age and frailty. In contrast, there is genetic overlap of frailty with cardiovascular disease and its risk factors. Frailty is not yet considered a risk factor for CVD. It is accompanied by a loss and/or poor functioning of muscle mass, which depends on fiber protein content, resulting from the balance between protein breakdown and synthesis. Bone fragility is also implied, and there is a crosstalk between adipocytes, myocytes, and bone. The identification and assessment of frailty is difficult, without there being a standard instrument to identify or treat it. Measures to prevent its progression include exercises, as well as supplementing the diet with vitamin D and K, calcium, and testosterone. In conclusion, more research is needed to better understand frailty and to avoid complications in CVD.
    MeSH term(s) Humans ; Aged ; Frailty/complications ; Cardiovascular Diseases/complications ; Frail Elderly ; Muscle, Skeletal ; Adipose Tissue
    Language English
    Publishing date 2023-02-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Frailty and the Interactions between Skeletal Muscle, Bone, and Adipose Tissue-Impact on Cardiovascular Disease and Possible Therapeutic Measures

    María Elena Soto / Israel Pérez-Torres / María Esther Rubio-Ruiz / Agustina Cano-Martínez / Linaloe Manzano-Pech / Verónica Guarner-Lans

    International Journal of Molecular Sciences, Vol 24, Iss 4534, p

    2023  Volume 4534

    Abstract: Frailty is a global health problem that impacts clinical practice. It is complex, having a physical and a cognitive component, and it is the result of many contributing factors. Frail patients have oxidative stress and elevated proinflammatory cytokines. ...

    Abstract Frailty is a global health problem that impacts clinical practice. It is complex, having a physical and a cognitive component, and it is the result of many contributing factors. Frail patients have oxidative stress and elevated proinflammatory cytokines. Frailty impairs many systems and results in a reduced physiological reserve and increased vulnerability to stress. It is related to aging and to cardiovascular diseases (CVD). There are few studies on the genetic factors of frailty, but epigenetic clocks determine age and frailty. In contrast, there is genetic overlap of frailty with cardiovascular disease and its risk factors. Frailty is not yet considered a risk factor for CVD. It is accompanied by a loss and/or poor functioning of muscle mass, which depends on fiber protein content, resulting from the balance between protein breakdown and synthesis. Bone fragility is also implied, and there is a crosstalk between adipocytes, myocytes, and bone. The identification and assessment of frailty is difficult, without there being a standard instrument to identify or treat it. Measures to prevent its progression include exercises, as well as supplementing the diet with vitamin D and K, calcium, and testosterone. In conclusion, more research is needed to better understand frailty and to avoid complications in CVD.
    Keywords frailty ; skeletal muscle ; bone ; adipose tissue ; cardiovascular diseases ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The usefulness of the genetic panel in the classification and refinement of diagnostic accuracy of Mexican patients with Marfan syndrome and other connective tissue disorders.

    Fuentevilla-Álvarez, Giovanny / Soto, María Elena / Torres-Paz, Yazmín Estela / Meza-Toledo, Sergio Enrique / Vargas-Alarcón, Gilberto / González-Moyotl, Nadia / Pérez-Torres, Israel / Manzano-Pech, Linaloe / Mejia, Ana Maria / Huesca-Gómez, Claudia / Gamboa, Ricardo

    Biomolecules & biomedicine

    2024  Volume 24, Issue 2, Page(s) 302–314

    Abstract: Marfan syndrome (MFS) is a multisystem genetic disorder with over 3000 mutations described in the fibrillin 1 (FBN1) gene. Like MFS, other connective tissue disorders also require a deeper understanding of the phenotype-genotype relationship due to the ... ...

    Abstract Marfan syndrome (MFS) is a multisystem genetic disorder with over 3000 mutations described in the fibrillin 1 (FBN1) gene. Like MFS, other connective tissue disorders also require a deeper understanding of the phenotype-genotype relationship due to the complexity of the clinical presentation, where diagnostic criteria often overlap. Our objective was to identify mutations in patients with connective tissue disorders using a genetic multipanel and to analyze the genotype-phenotype associations in a cohort of Mexican patients. We recruited 136 patients with MFS and related syndromes from the National Institute of Cardiology. Mutations were identified using next-generation sequencing (NGS). To examine the correlation between mutation severity and severe cardiovascular conditions, we focused on patients who had undergone Bentall-de Bono surgery or aortic valve repair. The genetic data obtained allowed us to reclassify the initial clinical diagnosis across various types of connective tissue disorders. The transforming growth factor beta receptor 2 (TGFBR2) rs79375991 mutation was found in 10 out of 16 (63%) Loeys-Dietz patients. We observed a high prevalence (65%) of more severe mutations, such as frameshift indels and stop codons, among patients requiring invasive treatments like aortic valve-sparing surgery, Bentall and de Bono procedures, or aortic valve replacement due to severe cardiovascular injury. Although our study did not achieve precise phenotype-genotype correlations, it underscores the importance of a multigenetic panel evaluation. This could pave the way for a more comprehensive diagnostic approach and inform medical and surgical treatment decision-making.
    MeSH term(s) Humans ; Marfan Syndrome/diagnosis ; Receptors, Transforming Growth Factor beta/genetics ; Protein Serine-Threonine Kinases/genetics ; Fibrillin-1/genetics ; Connective Tissue Diseases ; Cardiovascular Diseases ; Connective Tissue
    Chemical Substances Receptors, Transforming Growth Factor beta ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Fibrillin-1
    Language English
    Publishing date 2024-03-11
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ISSN 2831-090X
    ISSN (online) 2831-090X
    DOI 10.17305/bb.2023.9578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pesquisa activa en la Atención Primaria de Salud para enfrentar la COVID-19

    Carlos Alejandro López Lima / María Elena Soto Entenza / Oscar Ernesto Velázquez-Soto

    Revista Cubana de Medicina, Vol 60, Iss

    2021  Volume 1

    Keywords Medicine ; R
    Language Spanish
    Publishing date 2021-02-01T00:00:00Z
    Publisher Editorial Ciencias Médicas
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: N-Acetyl Cysteine Restores the Diminished Activity of the Antioxidant Enzymatic System Caused by SARS-CoV-2 Infection: Preliminary Findings.

    Soto, María Elena / Manzano-Pech, Linaloe / Palacios-Chavarría, Adrían / Valdez-Vázquez, Rafael Ricardo / Guarner-Lans, Verónica / Pérez-Torres, Israel

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 4

    Abstract: SARS-CoV-2 infects type II pneumocytes and disrupts redox homeostasis by overproducing reactive oxygen species (ROS). N-acetyl cysteine (NAC) is a precursor of the synthesis of glutathione (GSH) and it restores the loss of redox homeostasis associated to ...

    Abstract SARS-CoV-2 infects type II pneumocytes and disrupts redox homeostasis by overproducing reactive oxygen species (ROS). N-acetyl cysteine (NAC) is a precursor of the synthesis of glutathione (GSH) and it restores the loss of redox homeostasis associated to viral infections. The aim of the study is to evaluate the effect of the treatment with NAC on the enzymatic antioxidant system in serum from patients infected by SARS-CoV-2. We evaluated the enzymatic activities of thioredoxin reductase (TrxR), glutathione peroxidase (GPx), -S-transferase (GST), and reductase (GR) by spectrophotometry and the concentrations of the glutathione (GSH), total antioxidant capacity (TAC), thiols, nitrites (NO
    Language English
    Publishing date 2023-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16040591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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