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Article ; Online: d-

Williams, Dean / Jamshidi, Mohammad P / St Michael, Frank / Chisholm, Kenneth / Cox, Andrew / Sauvageau, Janelle

2021 Volume 86, Issue 3, Page(s) 2184–2199

Abstract: ... Recently, newly discovered pathogen-associated molecular patterns, d- ...

Abstract	Pathogen-associated molecular patterns activate the immune system via pattern recognition receptors. Recently, newly discovered pathogen-associated molecular patterns, d-
MeSH term(s)	Heptoses ; Humans ; Immunologic Factors ; Phosphates ; Phosphorylation
Chemical Substances	Heptoses ; Immunologic Factors ; Phosphates ; mannoheptose
Language	English
Publishing date	2021-01-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.0c02333
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Article ; Online: Quantification of murine myocardial infarct size using 2-D and 4-D high-frequency ultrasound.

Dann, Melissa M / Clark, Sydney Q / Trzaskalski, Natasha A / Earl, Conner C / Schepers, Luke E / Pulente, Serena M / Lennord, Ebonee N / Annamalai, Karthik / Gruber, Joseph M / Cox, Abigail D / Lorenzen-Schmidt, Ilka / Seymour, Richard / Kim, Kyoung-Han / Goergen, Craig J / Mulvihill, Erin E

American journal of physiology. Heart and circulatory physiology

2022 Volume 322, Issue 3, Page(s) H359–H372

Abstract: ... study aims to demonstrate the efficacy of quantitating infarct size via two-dimensional (2-D ... echocardiographic akinetic length and four-dimensional (4-D) echocardiographic infarct volume and surface area ... left coronary artery ligation. Ejection fraction and infarct size were measured through 2-D and 4-D ...

Abstract	Ischemic heart disease is the leading cause of death in the United States, Canada, and worldwide. Severe disease is characterized by coronary artery occlusion, loss of blood flow to the myocardium, and necrosis of tissue, with subsequent remodeling of the heart wall, including fibrotic scarring. The current study aims to demonstrate the efficacy of quantitating infarct size via two-dimensional (2-D) echocardiographic akinetic length and four-dimensional (4-D) echocardiographic infarct volume and surface area as in vivo analysis techniques. We further describe and evaluate a new surface area strain analysis technique for estimating myocardial infarction (MI) size after ischemic injury. Experimental MI was induced in mice via left coronary artery ligation. Ejection fraction and infarct size were measured through 2-D and 4-D echocardiography. Infarct size established via histology was compared with ultrasound-based metrics via linear regression analysis. Two-dimensional echocardiographic akinetic length (
MeSH term(s)	Algorithms ; Animals ; Cardiac Output ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Imaging, Three-Dimensional/methods ; Imaging, Three-Dimensional/standards ; Male ; Mice ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Sensitivity and Specificity ; Ultrasonography/methods ; Ultrasonography/standards
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00476.2021
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Article: D-dimer as a Rule-Out for Aortic Dissection.

Carter, Jeremy M / Tom, Roshan B / Sunesra, Raheed / Bilby, Nathaniel J / Mireles, Blake / Paul, Krishna K / Koscumb, Paul A / Cox, Mitchell W / Jehle, Dietrich V

Cureus

2023 Volume 15, Issue 12, Page(s) e50170

Abstract: ... case. Furthermore, limited research on D-dimer's utility in ruling out AAD has been conducted due ... patients. The objective is to evaluate the sensitivity of an elevated D-dimer level in diagnosing AAD ... this dataset, there were 1,319 patients identified with a confirmed AAD who had undergone D-dimer testing ...

Abstract	Introduction Acute aortic dissection (AAD) represents a significant diagnostic challenge with a high mortality rate if not treated promptly. This challenge arises from the diverse clinical presentations of AAD, and its symptom overlap with other medical conditions. Although both helical CT and transesophageal echocardiography are reliable diagnostic tools for AAD, they are not feasible for every suspected case. Furthermore, limited research on D-dimer's utility in ruling out AAD has been conducted due to the condition's rarity. Methods This study utilizes the TriNetX database (https://trinetx.com/), encompassing data from 54 healthcare organizations across the United States over the past two decades from 85 million patients. The objective is to evaluate the sensitivity of an elevated D-dimer level in diagnosing AAD across a much larger patient cohort than previously studied. Results Retrospectively analyzing this dataset, there were 1,319 patients identified with a confirmed AAD who had undergone D-dimer testing within a day of diagnosis. Of these, 1,252 patients exhibited D-dimer levels exceeding 400 ng/ml while 1,227 had levels surpassing 500 ng/ml. Notably, a D-dimer cutoff of 400 ng/ml demonstrated a sensitivity of 0.949 while a 500 ng/ml cutoff yielded a sensitivity of 0.930. Conclusion This large retrospective cohort study demonstrates that a blood D-dimer level is highly sensitive in assaying for AAD. The D-dimer levels analyzed showed a remarkable sensitivity in ruling out AAD, avoiding the need for more invasive testing in low-risk patients.
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.50170
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Article ; Online: Assessment of serum total 25-hydroxyvitamin D assay commutability of Standard Reference Materials and College of American Pathologists Accuracy-Based Vitamin D (ABVD) Scheme and Vitamin D External Quality Assessment Scheme (DEQAS) materials: Vitamin D Standardization Program (VDSP) Commutability Study 2.

Camara, Johanna E / Wise, Stephen A / Hoofnagle, Andrew N / Williams, Emma L / Carter, Graham D / Jones, Julia / Burdette, Carolyn Q / Hahm, Grace / Nalin, Federica / Kuszak, Adam J / Merkel, Joyce / Durazo-Arvizu, Ramón A / Lukas, Pierre / Cavalier, Étienne / Popp, Christian / Beckert, Christian / Schultess, Jan / Van Slooten, Glen / Tourneur, Carole /

Pease, Camille / Kaul, Ravi / Villarreal, Alfredo / Ivison, Fiona / Fischer, Ralf / van den Ouweland, Jody M W / Ho, Chung S / Law, Emmett W K / Simard, Jean-Nicolas / Gonthier, Renaud / Holmquist, Brett / Batista, Marcelo Cidade / Pham, Heather / Bennett, Alex / Meadows, Sarah / Cox, Lorna / Jansen, Eugene / Khan, Dilshad Ahmed / Robyak, Kimberly / Creer, Michael H / Kilbane, Mark / Twomey, Patrick J / Freeman, James / Parker, Neil / Yuan, Jinyun / Fitzgerald, Robert / Mushtaq, Sohail / Clarke, Michael W / Breen, Norma / Simpson, Christine / Sempos, Christopher T

Analytical and bioanalytical chemistry

2021 Volume 413, Issue 20, Page(s) 5067–5084

Abstract: An interlaboratory study was conducted through the Vitamin D Standardization Program (VDSP ... assessment (PT/EQA) samples for determination of serum total 25-hydroxyvitamin D [25(OH)D] using ligand ... serum samples were assigned target values for 25-hydroxyvitamin D ...

Abstract	An interlaboratory study was conducted through the Vitamin D Standardization Program (VDSP) to assess commutability of Standard Reference Materials® (SRMs) and proficiency testing/external quality assessment (PT/EQA) samples for determination of serum total 25-hydroxyvitamin D [25(OH)D] using ligand binding assays and liquid chromatography-tandem mass spectrometry (LC-MS/MS). A set of 50 single-donor serum samples were assigned target values for 25-hydroxyvitamin D
MeSH term(s)	Humans ; Reference Standards ; Societies, Medical/standards ; Specimen Handling ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/chemistry
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2021-06-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-021-03470-w
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Article ; Online: Assessment of serum total 25-hydroxyvitamin D assays for Vitamin D External Quality Assessment Scheme (DEQAS) materials distributed at ambient and frozen conditions.

Sempos, Christopher T / Williams, Emma L / Carter, Graham D / Jones, Julia / Camara, Johanna E / Burdette, Carolyn Q / Hahm, Grace / Nalin, Federica / Duewer, David L / Kuszak, Adam J / Merkel, Joyce / Hoofnagle, Andrew N / Lukas, Pierre / Cavalier, Étienne / Durazo-Arvizu, Ramón A / Crump, Peter M / Popp, Christian / Beckert, Christian / Schultess, Jan /

Van Slooten, Glen / Tourneur, Carole / Pease, Camille / Kaul, Ravi / Villarreal, Alfredo / Ivison, Fiona / Fischer, Ralf / van den Ouweland, Jody M W / Ho, Chung S / Law, Emmett W K / Simard, Jean-Nicolas / Gonthier, Renaud / Holmquist, Brett / Batista, Marcelo Cidade / Meadows, Sarah / Cox, Lorna / Jansen, Eugene / Khan, Dilshad Ahmed / Robyak, Kimberly / Creer, Michael H / Kilbane, Mark / Twomey, Patrick J / Freeman, James / Parker, Neil / Yuan, Jinyun / Fitzgerald, Robert / Mushtaq, Sohail / Clarke, Michael W / Breen, Norma / Simpson, Christine / Wise, Stephen A

Analytical and bioanalytical chemistry

2021 Volume 414, Issue 2, Page(s) 1015–1028

Abstract: The Vitamin D External Quality Assessment Scheme (DEQAS) distributes human serum samples four times ... per year to over 1000 participants worldwide for the determination of total serum 25-hydroxyvitamin D [25 ... OH)D)]. These samples are stored at -40 °C prior to distribution and the participants are instructed ...

Abstract	The Vitamin D External Quality Assessment Scheme (DEQAS) distributes human serum samples four times per year to over 1000 participants worldwide for the determination of total serum 25-hydroxyvitamin D [25(OH)D)]. These samples are stored at -40 °C prior to distribution and the participants are instructed to store the samples frozen at -20 °C or lower after receipt; however, the samples are shipped to participants at ambient conditions (i.e., no temperature control). To address the question of whether shipment at ambient conditions is sufficient for reliable performance of various 25(OH)D assays, the equivalence of DEQAS human serum samples shipped under frozen and ambient conditions was assessed. As part of a Vitamin D Standardization Program (VDSP) commutability study, two sets of the same nine DEQAS samples were shipped to participants at ambient temperature and frozen on dry ice. Twenty-eight laboratories participated in this study and provided 34 sets of results for the measurement of 25(OH)D using 20 ligand binding assays and 14 liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods. Equivalence of the assay response for the frozen versus ambient DEQAS samples for each assay was evaluated using multi-level modeling, paired t-tests including a false discovery rate (FDR) approach, and ordinary least squares linear regression analysis of frozen versus ambient results. Using the paired t-test and confirmed by FDR testing, differences in the results for the ambient and frozen samples were found to be statistically significant at p < 0.05 for four assays (DiaSorin, DIAsource, Siemens, and SNIBE prototype). For all 14 LC-MS/MS assays, the differences in the results for the ambient- and frozen-shipped samples were not found to be significant at p < 0.05 indicating that these analytes were stable during shipment at ambient conditions. Even though assay results have been shown to vary considerably among different 25(OH)D assays in other studies, the results of this study also indicate that sample handling/transport conditions may influence 25(OH)D assay response for several assays.
MeSH term(s)	Chromatography, Liquid/methods ; Freezing ; Humans ; Tandem Mass Spectrometry/methods ; Vitamin D/analogs & derivatives ; Vitamin D/blood
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2021-11-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-021-03742-5
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Article ; Online: Extra-striatal D

Jaworska, Natalia / Cox, Sylvia M L / Tippler, Maria / Castellanos-Ryan, Natalie / Benkelfat, Chawki / Parent, Sophie / Dagher, Alain / Vitaro, Frank / Boivin, Michel / Pihl, Robert O / Côté, Sylvana M / Tremblay, Richard E / Séguin, Jean R / Leyton, Marco

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2020 Volume 45, Issue 9, Page(s) 1498–1505

Abstract: The neurobiological traits that confer risk for addictions remain poorly understood. However, dopaminergic function throughout the prefrontal cortex, limbic system, and upper brainstem has been implicated in behavioral features that influence addiction ... ...

Abstract	The neurobiological traits that confer risk for addictions remain poorly understood. However, dopaminergic function throughout the prefrontal cortex, limbic system, and upper brainstem has been implicated in behavioral features that influence addiction vulnerability, including poor impulse control, and altered sensitivity to rewards and punishments (i.e., externalizing features). To test these associations in humans, we measured type-2/3 dopamine receptor (DA
MeSH term(s)	Adolescent ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism ; Humans ; Impulsive Behavior ; Positron-Emission Tomography ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/metabolism
Chemical Substances	Receptors, Dopamine D2 ; Receptors, Dopamine D3
Language	English
Publishing date	2020-04-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-020-0662-7
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Article ; Online: d-Glycero-β-d-Manno-Heptose 1-Phosphate and d-Glycero-β-d-Manno-Heptose 1,7-Biphosphate Are Both Innate Immune Agonists.

Adekoya, Itunuoluwa A / Guo, Cynthia X / Gray-Owen, Scott D / Cox, Andrew D / Sauvageau, Janelle

Journal of immunology (Baltimore, Md. : 1950)

2018 Volume 201, Issue 8, Page(s) 2385–2391

Abstract: d-Glycero-β-d-manno-heptose 1,7-biphosphate (β-HBP) is a novel microbial-associated molecular ... embryonic kidney cells (HEK 293T) and colonic epithelial cells (HCT 116). Of the analogs tested, only d ... glycero-β-d-manno-heptose 1-phosphate (β-HMP) induced TIFA-dependent NF-κB activation and cytokine ...

Abstract	d-Glycero-β-d-manno-heptose 1,7-biphosphate (β-HBP) is a novel microbial-associated molecular pattern that triggers inflammation and thus has the potential to act as an immune modulator in many therapeutic contexts. To better understand the structure-activity relationship of this molecule, we chemically synthesized analogs of β-HBP and tested their ability to induce canonical TIFA-dependent inflammation in human embryonic kidney cells (HEK 293T) and colonic epithelial cells (HCT 116). Of the analogs tested, only d-glycero-β-d-manno-heptose 1-phosphate (β-HMP) induced TIFA-dependent NF-κB activation and cytokine production in a manner similar to β-HBP. This finding expands the spectrum of metabolites from the Gram-negative ADP-heptose biosynthesis pathway that can function as innate immune agonists and provides a more readily available agonist of the TIFA-dependent inflammatory pathway that can be easily produced by synthetic methods.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Gram-Negative Bacteria/physiology ; HEK293 Cells ; Heptoses/chemical synthesis ; Heptoses/immunology ; Humans ; Immunity, Innate ; Immunization ; Immunologic Factors/chemical synthesis ; Immunologic Factors/immunology ; Inflammation/chemically induced ; Inflammation/immunology ; Mannose/chemical synthesis ; Mannose/immunology ; Pathogen-Associated Molecular Pattern Molecules/immunology ; Phosphates/chemical synthesis ; Phosphates/immunology ; Pyrans/chemical synthesis ; Pyrans/immunology ; Signal Transduction ; Structure-Activity Relationship ; Substrate Specificity
Chemical Substances	Adaptor Proteins, Signal Transducing ; Heptoses ; Immunologic Factors ; Pathogen-Associated Molecular Pattern Molecules ; Phosphates ; Pyrans ; TIFA protein, human ; d-glycero-beta-d-manno-heptose 1,7-biphosphate ; d-glycero-beta-d-manno-heptose 1-phosphate ; glycero-manno-heptose (4305-74-2) ; Mannose (PHA4727WTP)
Language	English
Publishing date	2018-09-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1801012
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Article: Assessment of serum total 25-hydroxyvitamin D assays for Vitamin D External Quality Assessment Scheme (DEQAS) materials distributed at ambient and frozen conditions

Sempos, Christopher T. / Williams, Emma L. / Carter, Graham D. / Jones, Julia / Camara, Johanna E. / Burdette, Carolyn Q. / Hahm, Grace / Nalin, Federica / Duewer, David L. / Kuszak, Adam J. / Merkel, Joyce / Hoofnagle, Andrew N. / Lukas, Pierre / Cavalier, Étienne / Durazo-Arvizu, Ramón A. / Crump, Peter M. / Popp, Christian / Beckert, Christian / Schultess, Jan /

Van Slooten, Glen / Tourneur, Carole / Pease, Camille / Kaul, Ravi / Villarreal, Alfredo / Ivison, Fiona / Fischer, Ralf / van den Ouweland, Jody M. W. / Ho, Chung S. / Law, Emmett W. K. / Simard, Jean-Nicolas / Gonthier, Renaud / Holmquist, Brett / Batista, Marcelo Cidade / Meadows, Sarah / Cox, Lorna / Jansen, Eugene / Khan, Dilshad Ahmed / Robyak, Kimberly / Creer, Michael H. / Kilbane, Mark / Twomey, Patrick J. / Freeman, James / Parker, Neil / Yuan, Jinyun / Fitzgerald, Robert / Mushtaq, Sohail / Clarke, Michael W. / Breen, Norma / Simpson, Christine / Wise, Stephen A.

Analytical and bioanalytical chemistry. 2022 Jan., v. 414, no. 2

2022

Abstract: The Vitamin D External Quality Assessment Scheme (DEQAS) distributes human serum samples four times ... per year to over 1000 participants worldwide for the determination of total serum 25-hydroxyvitamin D [25 ... OH)D)]. These samples are stored at −40 °C prior to distribution and the participants are instructed ...

Abstract	The Vitamin D External Quality Assessment Scheme (DEQAS) distributes human serum samples four times per year to over 1000 participants worldwide for the determination of total serum 25-hydroxyvitamin D [25(OH)D)]. These samples are stored at −40 °C prior to distribution and the participants are instructed to store the samples frozen at −20 °C or lower after receipt; however, the samples are shipped to participants at ambient conditions (i.e., no temperature control). To address the question of whether shipment at ambient conditions is sufficient for reliable performance of various 25(OH)D assays, the equivalence of DEQAS human serum samples shipped under frozen and ambient conditions was assessed. As part of a Vitamin D Standardization Program (VDSP) commutability study, two sets of the same nine DEQAS samples were shipped to participants at ambient temperature and frozen on dry ice. Twenty-eight laboratories participated in this study and provided 34 sets of results for the measurement of 25(OH)D using 20 ligand binding assays and 14 liquid chromatography–tandem mass spectrometry (LC–MS/MS) methods. Equivalence of the assay response for the frozen versus ambient DEQAS samples for each assay was evaluated using multi-level modeling, paired t-tests including a false discovery rate (FDR) approach, and ordinary least squares linear regression analysis of frozen versus ambient results. Using the paired t-test and confirmed by FDR testing, differences in the results for the ambient and frozen samples were found to be statistically significant at p < 0.05 for four assays (DiaSorin, DIAsource, Siemens, and SNIBE prototype). For all 14 LC–MS/MS assays, the differences in the results for the ambient- and frozen-shipped samples were not found to be significant at p < 0.05 indicating that these analytes were stable during shipment at ambient conditions. Even though assay results have been shown to vary considerably among different 25(OH)D assays in other studies, the results of this study also indicate that sample handling/transport conditions may influence 25(OH)D assay response for several assays.
Keywords	ambient temperature ; analytical chemistry ; blood serum ; chemical species ; dry ice ; humans ; ligands ; liquid chromatography ; prototypes ; t-test ; tandem mass spectrometry
Language	English
Dates of publication	2022-01
Size	p. 1015-1028.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ISSN	1618-2642
DOI	10.1007/s00216-021-03742-5
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Article ; Online: Vitamin D deficiency in Europe: pandemic?

Cashman, Kevin D / Dowling, Kirsten G / Škrabáková, Zuzana / Gonzalez-Gross, Marcela / Valtueña, Jara / De Henauw, Stefaan / Moreno, Luis / Damsgaard, Camilla T / Michaelsen, Kim F / Mølgaard, Christian / Jorde, Rolf / Grimnes, Guri / Moschonis, George / Mavrogianni, Christina / Manios, Yannis / Thamm, Michael / Mensink, Gert Bm / Rabenberg, Martina / Busch, Markus A /

Cox, Lorna / Meadows, Sarah / Goldberg, Gail / Prentice, Ann / Dekker, Jacqueline M / Nijpels, Giel / Pilz, Stefan / Swart, Karin M / van Schoor, Natasja M / Lips, Paul / Eiriksdottir, Gudny / Gudnason, Vilmundur / Cotch, Mary Frances / Koskinen, Seppo / Lamberg-Allardt, Christel / Durazo-Arvizu, Ramon A / Sempos, Christopher T / Kiely, Mairead

The American journal of clinical nutrition

2016 Volume 103, Issue 4, Page(s) 1033–1044

Abstract: Background: Vitamin D deficiency has been described as being pandemic, but serum 25-hydroxyvitamin ... D [25(OH)D] distribution data for the European Union are of very variable quality. The NIH-led ... international Vitamin D Standardization Program (VDSP) has developed protocols for standardizing existing 25(OH ...

Abstract	Background: Vitamin D deficiency has been described as being pandemic, but serum 25-hydroxyvitamin D [25(OH)D] distribution data for the European Union are of very variable quality. The NIH-led international Vitamin D Standardization Program (VDSP) has developed protocols for standardizing existing 25(OH)D values from national health/nutrition surveys. Objective: This study applied VDSP protocols to serum 25(OH)D data from representative childhood/teenage and adult/older adult European populations, representing a sizable geographical footprint, to better quantify the prevalence of vitamin D deficiency in Europe. Design: The VDSP protocols were applied in 14 population studies [reanalysis of subsets of serum 25(OH)D in 11 studies and complete analysis of all samples from 3 studies that had not previously measured it] by using certified liquid chromatography-tandem mass spectrometry on biobanked sera. These data were combined with standardized serum 25(OH)D data from 4 previously standardized studies (for a total n= 55,844). Prevalence estimates of vitamin D deficiency [using various serum 25(OH)D thresholds] were generated on the basis of standardized 25(OH)D data. Results: An overall pooled estimate, irrespective of age group, ethnic mix, and latitude of study populations, showed that 13.0% of the 55,844 European individuals had serum 25(OH)D concentrations <30 nmol/L on average in the year, with 17.7% and 8.3% in those sampled during the extended winter (October-March) and summer (April-November) periods, respectively. According to an alternate suggested definition of vitamin D deficiency (<50 nmol/L), the prevalence was 40.4%. Dark-skinned ethnic subgroups had much higher (3- to 71-fold) prevalence of serum 25(OH)D <30 nmol/L than did white populations. Conclusions: Vitamin D deficiency is evident throughout the European population at prevalence rates that are concerning and that require action from a public health perspective. What direction these strategies take will depend on European policy but should aim to ensure vitamin D intakes that are protective against vitamin D deficiency in the majority of the European population.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Chromatography, Liquid ; Databases, Factual ; Europe/epidemiology ; Female ; Humans ; Infant ; Male ; Middle Aged ; Nutrition Surveys ; Nutritional Status ; Pandemics ; Prevalence ; Seasons ; Tandem Mass Spectrometry ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/ethnology ; Young Adult
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2016-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.3945/ajcn.115.120873
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Article ; Online: Measurement of the Dependence of the Hadron Production Fraction Ratios f_{s}/f_{u} and f_{d}/f_{u} on B Meson Kinematic Variables in Proton-Proton Collisions at sqrt[s]=13 TeV.

Tumasyan, A / Adam, W / Andrejkovic, J W / Bergauer, T / Chatterjee, S / Damanakis, K / Dragicevic, M / Escalante Del Valle, A / Hussain, P S / Jeitler, M / Krammer, N / Lechner, L / Liko, D / Mikulec, I / Paulitsch, P / Schieck, J / Schöfbeck, R / Schwarz, D / Sonawane, M /

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Physical review letters

2023 Volume 131, Issue 12, Page(s) 121901

Abstract: ... to B^{+} meson production fractions, f_{d}/f_{u}, is also measured, for the first time in proton-proton ...

Abstract	The dependence of the ratio between the B_{s}^{0} and B^{+} hadron production fractions, f_{s}/f_{u}, on the transverse momentum (p_{T}) and rapidity of the B mesons is studied using the decay channels B_{s}^{0}→J/ψϕ and B^{+}→J/ψK^{+}. The analysis uses a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the CMS experiment in 2018 and corresponding to an integrated luminosity of 61.6 fb^{-1}. The f_{s}/f_{u} ratio is observed to depend on the B p_{T} and to be consistent with becoming asymptotically constant at large p_{T}. No rapidity dependence is observed. The ratio of the B^{0} to B^{+} meson production fractions, f_{d}/f_{u}, is also measured, for the first time in proton-proton collisions, using the B^{0}→J/ψK^{*0} decay channel. The result is found to be within 1 standard deviation of unity and independent of p_{T} and rapidity, as expected from isospin invariance.
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.121901
Database	MEDical Literature Analysis and Retrieval System OnLINE

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