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  1. Book ; Online ; E-Book: Chronic inflammation

    Miyasaka, Masayuki / Takatsu, Kiyoshi

    mechanisms and regulation

    2016  

    Author's details Masayuki Miyasaka, Kiyoshi Takatsu editors
    Language English
    Size 1 Online-Ressource (xi, 702 Seiten), Illustrationen
    Publisher Springer
    Publishing place Tokyo
    Publishing country Japan
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019157337
    ISBN 978-4-431-56068-5 ; 9784431560661 ; 4-431-56068-8 ; 4431560661
    DOI 10.1007/978-4-431-56068-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article: Editorial: Towards a better understanding of the physiology of the lymphatics.

    Miyasaka, Masayuki

    Inflammation and regeneration

    2022  Volume 42, Issue 1, Page(s) 19

    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Editorial
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-022-00200-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The lymphatic system and COVID-19 vaccines.

    Miyasaka, Masayuki

    Frontiers in immunology

    2022  Volume 13, Page(s) 1041025

    Abstract: Understanding the precise mechanism of vaccine-induced protection and the immune correlates of protection against coronavirus disease 2019 (COVID-19) is crucially important for developing next-generation vaccines that confer durable and protective ... ...

    Abstract Understanding the precise mechanism of vaccine-induced protection and the immune correlates of protection against coronavirus disease 2019 (COVID-19) is crucially important for developing next-generation vaccines that confer durable and protective immunity against COVID-19. Similar factors are also important for other infectious diseases. Here, I briefly summarize the mechanism of action of the currently used COVID-19 mRNA vaccines from the viewpoint of the function of the lymphatic system.
    MeSH term(s) Humans ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2 ; Viral Vaccines ; Lymphatic System
    Chemical Substances COVID-19 Vaccines ; Viral Vaccines
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1041025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 and immunity: quo vadis?

    Miyasaka, Masayuki

    International immunology

    2021  Volume 33, Issue 10, Page(s) 507–513

    Abstract: Understanding the precise nature and durability of protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential in order to gain insight into the pathophysiology of coronavirus disease 2019 (COVID-19) and to ... ...

    Abstract Understanding the precise nature and durability of protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential in order to gain insight into the pathophysiology of coronavirus disease 2019 (COVID-19) and to develop novel treatment strategies to this disease. Here, I succinctly summarize what is currently known and unknown about the immune response during COVID-19 and discuss whether natural infections can lead to herd immunity.
    MeSH term(s) Animals ; COVID-19/immunology ; Humans ; Immunity, Herd/immunology ; Immunity, Innate/immunology ; SARS-CoV-2/immunology
    Language English
    Publishing date 2021-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxab008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A short review on lymphatic endothelial cell heterogeneity.

    Miyasaka, Masayuki

    Inflammation and regeneration

    2021  Volume 41, Issue 1, Page(s) 32

    Abstract: Recent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in distinct locations in the body. These studies ...

    Abstract Recent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in distinct locations in the body. These studies have also revealed a conserved pattern of gene expression in LECs across animal species, as well as specialized sets of genes unique to each species. However, the extent to which this heterogeneity is adaptive to the external milieu surrounding LECs has remained unclear. The transcriptional and regulatory pathways that program the different subsets of LECs also remain unexplored.
    Language English
    Publishing date 2021-10-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-021-00183-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Is BCG vaccination causally related to reduced COVID-19 mortality?

    Miyasaka, Masayuki

    EMBO molecular medicine

    2020  Volume 12, Issue 6, Page(s) e12661

    Abstract: The ongoing severe acute respiratory sickness coronavirus 2 (SARS-CoV-2) pandemic has resulted in more than 3,600,000 detected cases of COVID-19 illness and nearly 260,000 deaths worldwide as of May 6, 2020. Recently, BCG vaccination was shown to ... ...

    Abstract The ongoing severe acute respiratory sickness coronavirus 2 (SARS-CoV-2) pandemic has resulted in more than 3,600,000 detected cases of COVID-19 illness and nearly 260,000 deaths worldwide as of May 6, 2020. Recently, BCG vaccination was shown to correlate with reduced COVID-19 case fatality rates (preprint: Miller et al, 2020; preprint: Sala & Miyakawa, 2020; https://www.jsatonotes.com/2020/03/if-i-were-north-americaneuropeanaustral.html). The most recent data from publicly available resources also indicate that both COVID-19 incidence and total deaths are strongly associated with the presence or absence of national mandatory BCG vaccination programs. As seen in Table 1, seven of eight countries with very low numbers of total deaths (< 40 per 1 million population) adopted a mandatory BCG vaccination program using one of a set of 6 separate BCG strains (Table 1). In contrast, COVID-19 mortality was markedly higher in countries where BCG vaccination is not widely administered or is given only to high-risk groups. COVID-19 mortality was also higher in countries where widespread BCG vaccination was discontinued more than 20 years ago and in countries that used the BCG Denmark strain regularly or temporarily. This raises the question of whether BCG vaccination and reduced COVID-19 mortality are causally related. An additional question is why different BCG strains may be variably associated with mortality.
    MeSH term(s) BCG Vaccine/immunology ; Betacoronavirus/isolation & purification ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; COVID-19 ; Coronavirus Infections/mortality ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Cytokines/metabolism ; Humans ; Mycobacterium bovis/genetics ; Mycobacterium bovis/immunology ; Mycobacterium bovis/metabolism ; Pandemics ; Pneumonia, Viral/mortality ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Risk ; SARS-CoV-2 ; Serogroup ; Survival Analysis ; Vaccination
    Chemical Substances BCG Vaccine ; Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.202012661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Is BCG vaccination causally related to reduced COVID‐19 mortality?

    Masayuki Miyasaka

    EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)

    2020  

    Abstract: The ongoing severe acute respiratory sickness coronavirus 2 (SARS‐CoV‐2) pandemic has resulted in more than 3,600,000 detected cases of COVID‐19 illness and nearly 260,000 deaths worldwide as of May 6, 2020. Recently, BCG vaccination was shown to ... ...

    Abstract The ongoing severe acute respiratory sickness coronavirus 2 (SARS‐CoV‐2) pandemic has resulted in more than 3,600,000 detected cases of COVID‐19 illness and nearly 260,000 deaths worldwide as of May 6, 2020. Recently, BCG vaccination was shown to correlate with reduced COVID‐19 case fatality rates (preprint: Miller et al, 2020; preprint: Sala & Miyakawa, 2020; https://www.jsatonotes.com/2020/03/if-i-were-north-americaneuropeanaustral.html). The most recent data from publicly available resources also indicate that both COVID‐19 incidence and total deaths are strongly associated with the presence or absence of national mandatory BCG vaccination programs. As seen in Table 1, seven of eight countries with very low numbers of total deaths (< 40 per 1 million population) adopted a mandatory BCG vaccination program using one of a set of 6 separate BCG strains (Table 1). In contrast, COVID‐19 mortality was markedly higher in countries where BCG vaccination is not widely administered or is given only to high‐risk groups. COVID‐19 mortality was also higher in countries where widespread BCG vaccination was discontinued more than 20 years ago and in countries that used the BCG Denmark strain regularly or temporarily. This raises the question of whether BCG vaccination and reduced COVID‐19 mortality are causally related. An additional question is why different BCG strains may be variably associated with mortality.
    Keywords Medicine (General) ; R5-920 ; Genetics ; QH426-470 ; covid19
    Subject code 310
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Is BCG vaccination causally related to reduced COVID-19 mortality?

    Miyasaka, Masayuki

    EMBO Mol Med

    Abstract: The ongoing severe acute respiratory sickness coronavirus 2 (SARS-CoV-2) pandemic has resulted in more than 3,600,000 detected cases of COVID-19 illness and nearly 260,000 deaths worldwide as of May 6, 2020. Recently, BCG vaccination was shown to ... ...

    Abstract The ongoing severe acute respiratory sickness coronavirus 2 (SARS-CoV-2) pandemic has resulted in more than 3,600,000 detected cases of COVID-19 illness and nearly 260,000 deaths worldwide as of May 6, 2020. Recently, BCG vaccination was shown to correlate with reduced COVID-19 case fatality rates (preprint: Miller et al, 2020; preprint: Sala & Miyakawa, 2020; https://www.jsatonotes.com/2020/03/if-i-were-north-americaneuropeanaustral.html). The most recent data from publicly available resources also indicate that both COVID-19 incidence and total deaths are strongly associated with the presence or absence of national mandatory BCG vaccination programs. As seen in Table 1, seven of eight countries with very low numbers of total deaths (< 40 per 1 million population) adopted a mandatory BCG vaccination program using one of a set of 6 separate BCG strains (Table 1). In contrast, COVID-19 mortality was markedly higher in countries where BCG vaccination is not widely administered or is given only to high-risk groups. COVID-19 mortality was also higher in countries where widespread BCG vaccination was discontinued more than 20 years ago and in countries that used the BCG Denmark strain regularly or temporarily. This raises the question of whether BCG vaccination and reduced COVID-19 mortality are causally related. An additional question is why different BCG strains may be variably associated with mortality.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32379923
    Database COVID19

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  9. Article ; Online: Physicians' Perspective Toward Hypertensive Disorders of Pregnancy and Future Cardiovascular Diseases in Japan.

    Egawa, Makiko / Ikeda, Masami / Miyasaka, Naoyuki / Harada-Shiba, Mariko / Yoshida, Masayuki

    Journal of atherosclerosis and thrombosis

    2024  

    Abstract: Aim: Hypertensive disorders of pregnancy (HDP) are among the obstetric complications reportedly associated with later-life cardiovascular disease (CVD). This study examined physicians' recognition of reproductive history by elucidating their attitude ... ...

    Abstract Aim: Hypertensive disorders of pregnancy (HDP) are among the obstetric complications reportedly associated with later-life cardiovascular disease (CVD). This study examined physicians' recognition of reproductive history by elucidating their attitude and knowledge.
    Methods: This study included council members of the Japan Atherosclerosis Society. An Internet-based survey was conducted between August 9 and September 9, 2022.
    Results: A total of 137 council members completed the questionnaire (response rate: 36%). In terms of the internal medicine subspeciality of the participants, endocrinology was the most common (46%), followed by cardiology (38%). About 70% of the participants considered reproductive history to be important and obtained more information than those who considered it otherwise. In the questionnaire for knowledge about HDP and future diseases, physicians correctly answered 6.8 of 9 questions. Endocrinologists were more likely to ask regarding reproductive history at the initial visit than cardiologists (82.5% vs. 61.5%; p=0.012) and obtained more information from women below 50 years old. Contrarily, cardiologists obtained information on reproductive history from older women (those approaching menopause and those in their 60s and 70s).
    Conclusion: We found that physicians had a high level of knowledge about HDP and the importance of reproductive information. However, the manner of obtaining information, including the target population, differed depending on the subspeciality. In the future, effective interventions for women with a history of HDP need to be developed in order to encourage physicians to obtain reproductive information to prevent CVD.
    Language English
    Publishing date 2024-02-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.64453
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  10. Article ; Online: The role of extracellular ATP in homeostatic immune cell migration.

    Kobayashi, Daichi / Umemoto, Eiji / Miyasaka, Masayuki

    Current opinion in pharmacology

    2022  Volume 68, Page(s) 102331

    Abstract: Antigen stimulation induces adenosine triphosphate (ATP) release from naïve lymphocytes in lymphoid tissues. However, previous studies indicated that the non-lytic release of ATP also occurs in most tissues and cell types under physiological conditions. ... ...

    Abstract Antigen stimulation induces adenosine triphosphate (ATP) release from naïve lymphocytes in lymphoid tissues. However, previous studies indicated that the non-lytic release of ATP also occurs in most tissues and cell types under physiological conditions. Here, we show that extracellular ATP (eATP) is indeed constitutively produced by naïve T cells in response to lymphoid chemokines in uninflamed lymph nodes and is involved in the regulation of immune cell migration. In this review, we briefly summarize the homeostatic role of extracellular ATP in immune cell migration in vivo.
    MeSH term(s) Humans ; Adenosine Triphosphate/metabolism ; T-Lymphocytes ; Lymph Nodes/metabolism ; Cell Movement
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2022-12-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2022.102331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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