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Article ; Online: Is COVID-19 a New Hematologic Disease?

Debuc, Benjamin / Smadja, David M

2020 Volume 17, Issue 1, Page(s) 4–8

Abstract: SARS-CoV-2 viruses are positive single-stranded RNA viruses, whose infection can be asymptomatic or lead to the coronavirus disease 2019 (Covid-19). Covid-19 is a respiratory infection with a significant impact on the hematopoietic system and hemostasis ... ...

Abstract	SARS-CoV-2 viruses are positive single-stranded RNA viruses, whose infection can be asymptomatic or lead to the coronavirus disease 2019 (Covid-19). Covid-19 is a respiratory infection with a significant impact on the hematopoietic system and hemostasis leading to several cardiovascular complications. Hematologic consequences of this new infection allowed medical community to start new treatment approaches concerning infection going from targeted anti-inflammatory drugs to anticoagulation or stem cell therapies. A better understanding of Covid-19 pathophysiology, in particular hematological disorders, will help to choose appropriate treatment strategies.
MeSH term(s)	Blood Coagulation/genetics ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/pathology ; COVID-19/virology ; Cytokines/genetics ; Hematologic Diseases/blood ; Hematologic Diseases/epidemiology ; Hematologic Diseases/pathology ; Hematologic Diseases/virology ; Humans ; Inflammation/blood ; Inflammation/epidemiology ; Inflammation/pathology ; Inflammation/virology ; Lymphopenia/blood ; Lymphopenia/epidemiology ; Lymphopenia/virology ; Mesenchymal Stem Cells/virology ; SARS-CoV-2/pathogenicity ; Thrombosis/blood ; Thrombosis/epidemiology ; Thrombosis/pathology ; Thrombosis/virology
Chemical Substances	Cytokines
Keywords	covid19
Language	English
Publishing date	2020-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-020-09987-4
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Article ; Online: Is COVID-19 a New Hematologic Disease?

Debuc, Benjamin / Smadja, David M.

Stem Cell Reviews and Reports ; ISSN 2629-3269 2629-3277

2020

Keywords	covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1007/s12015-020-09987-4
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Is COVID-19 a New Hematologic Disease?

Debuc, Benjamin / Smadja, David M

Abstract	SARS-CoV-2 viruses are positive single-stranded RNA viruses, whose infection can be asymptomatic or lead to the coronavirus disease 2019 (Covid-19). Covid-19 is a respiratory infection with a significant impact on the hematopoietic system and hemostasis leading to several cardiovascular complications. Hematologic consequences of this new infection allowed medical community to start new treatment approaches concerning infection going from targeted anti-inflammatory drugs to anticoagulation or stem cell therapies. A better understanding of Covid-19 pathophysiology, in particular hematological disorders, will help to choose appropriate treatment strategies.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #244923
Database	COVID19

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Article ; Online: Is COVID-19 a New Hematologic Disease?

Debuc, Benjamin / Smadja, David M

ISSN: 1550-8943 ; Stem Cell Reviews and Reports ; https://www.hal.inserm.fr/inserm-02611228 ; Stem Cell Reviews and Reports, Humana Press, 2020, Epub ahead of print. ⟨10.1007/s12015-020-09987-4⟩

2020

Abstract: International audience ... SARS-CoV-2 viruses are positive single-stranded RNA viruses, whose infection can be asymptomatic or lead to the coronavirus disease 2019 (Covid-19). Covid-19 is a respiratory infection with a significant impact on the ... ...

Abstract	International audience SARS-CoV-2 viruses are positive single-stranded RNA viruses, whose infection can be asymptomatic or lead to the coronavirus disease 2019 (Covid-19). Covid-19 is a respiratory infection with a significant impact on the hematopoietic system and hemostasis leading to several cardiovascular complications. Hematologic consequences of this new infection allowed medical community to start new treatment approaches concerning infection going from targeted anti-inflammatory drugs to anticoagulation or stem cell therapies. A better understanding of Covid-19 pathophysiology, in particular hematological disorders, will help to choose appropriate treatment strategies.
Keywords	Thrombosis ; Stem cells ; Coagulopathy ; Covid-19 ; Cytokine ; D-dimers ; Inflammation ; Lymphopenia ; Mesenchymal stem cells ; SARS-CoV-2 ; [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ; [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ; covid19
Language	English
Publishing date	2020-05-12
Publisher	HAL CCSD
Publishing country	fr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Is COVID-19 a New Hematologic Disease?

Debuc, Benjamin / Smadja, David M

ISSN: 1550-8943 ; Stem Cell Reviews and Reports ; https://www.hal.inserm.fr/inserm-02611228 ; Stem Cell Reviews and Reports, Humana Press, 2020, Epub ahead of print. ⟨10.1007/s12015-020-09987-4⟩

2020

Abstract	International audience SARS-CoV-2 viruses are positive single-stranded RNA viruses, whose infection can be asymptomatic or lead to the coronavirus disease 2019 (Covid-19). Covid-19 is a respiratory infection with a significant impact on the hematopoietic system and hemostasis leading to several cardiovascular complications. Hematologic consequences of this new infection allowed medical community to start new treatment approaches concerning infection going from targeted anti-inflammatory drugs to anticoagulation or stem cell therapies. A better understanding of Covid-19 pathophysiology, in particular hematological disorders, will help to choose appropriate treatment strategies.
Keywords	Thrombosis ; Stem cells ; Coagulopathy ; Covid-19 ; Cytokine ; D-dimers ; Inflammation ; Lymphopenia ; Mesenchymal stem cells ; SARS-CoV-2 ; [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ; [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ; covid19
Language	English
Publishing date	2020-05-12
Publisher	HAL CCSD
Publishing country	fr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Improving Autologous Fat Grafting in Regenerative Surgery through Stem Cell-Assisted Lipotransfer.

Debuc, Benjamin / Gendron, Nicolas / Cras, Audrey / Rancic, Jeanne / Philippe, Aurélien / Cetrulo, Curtis L / Lellouch, Alexandre G / Smadja, David M

Stem cell reviews and reports

2023 Volume 19, Issue 6, Page(s) 1726–1754

Abstract: Autologous fat transplantation -i.e., lipofilling- has become a promising and popular technique in aesthetic and reconstructive surgery with several application such as breast reconstruction, facial and hand rejuvenation. However, the use of this ... ...

Abstract	Autologous fat transplantation -i.e., lipofilling- has become a promising and popular technique in aesthetic and reconstructive surgery with several application such as breast reconstruction, facial and hand rejuvenation. However, the use of this technology is still limited due to an unpredictable and low graft survival rate (which ranges from 25%-80%). A systematic literature review was performed by thoroughly searching 12 terms using the PubMed database. The objective of this study is to present the current evidence for the efficacy of adjuvant regenerative strategies and cellular factors, which have been tested to improve fat graft retention. We present the main results (fat retention rate, histological analysis for pre-clinical studies and satisfaction/ complication for clinical studies) obtained from the studies of the three main fat grafting enrichment techniques: platelet-rich plasma (PRP), the stromal vascular fraction (SVF) and adipose-derived stem cells (ADSCs) and discuss the promising role of recent angiogenic cell enrichment that could induce early vascularization of fat graft. All in all, adding stem or progenitor cells to autologous fat transplantation might become a new concept in lipofilling. New preclinical models should be used to find mechanisms able to increase fat retention, assure safety and transfer these technologies to a good manufacturing practice (GMP) compliant facility, to manufacture an advanced therapy medicinal product (ATMP).
MeSH term(s)	Adipose Tissue/transplantation ; Adipocytes/transplantation ; Plastic Surgery Procedures ; Transplantation, Autologous ; Stem Cells
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-023-10568-4
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Article: Predictive Factor for COVID-19 Worsening: Insights for High-Sensitivity Troponin and D-Dimer and Correlation With Right Ventricular Afterload.

Goudot, Guillaume / Chocron, Richard / Augy, Jean-Loup / Gendron, Nicolas / Khider, Lina / Debuc, Benjamin / Aissaoui, Nadia / Peron, Nicolas / Hauw-Berlemont, Caroline / Vedie, Benoit / Cheng, Charles / Mohamedi, Nassim / Krzisch, Daphné / Philippe, Aurélien / Puscas, Tania / Hermann, Bertrand / Brichet, Julie / Juvin, Philippe / Planquette, Benjamin /

Messas, Emmanuel / Pere, Hélène / Veyer, David / Gaussem, Pascale / Sanchez, Olivier / Diehl, Jean-Luc / Mirault, Tristan / Smadja, David M

Frontiers in medicine

2020 Volume 7, Page(s) 586307

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-11-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2020.586307
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Article ; Online: Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients.

Angiogenesis

2020 Volume 23, Issue 4, Page(s) 611–620

Abstract: Background: Coronavirus disease-2019 (COVID-19), a respiratory disease has been associated with ischemic complications, coagulation disorders, and an endotheliitis.: Objectives: To explore endothelial damage and activation-related biomarkers in COVID- ...

Abstract	Background: Coronavirus disease-2019 (COVID-19), a respiratory disease has been associated with ischemic complications, coagulation disorders, and an endotheliitis. Objectives: To explore endothelial damage and activation-related biomarkers in COVID-19 patients with criteria of hospitalization for referral to intensive care unit (ICU) and/or respiratory worsening. Methods: Analysis of endothelial and angiogenic soluble markers in plasma from patients at admission. Results: Study enrolled 40 consecutive COVID-19 patients admitted to emergency department that fulfilled criteria for hospitalization. Half of them were admitted in conventional wards without any ICU transfer during hospitalization; whereas the 20 others were directly transferred to ICU. Patients transferred in ICU were more likely to have lymphopenia, decreased SpO2 and increased D-dimer, CRP and creatinine levels. In those patients, soluble E-selectin and angiopoietin-2 were significantly increased (p value at 0.009 and 0.003, respectively). Increase in SELE gene expression (gene coding for E-selectin protein) was confirmed in an independent cohort of 32 patients using a whole blood gene expression profile analysis. In plasma, we found a strong association between angiopoetin-2 and CRP, creatinine and D-dimers (with p value at 0.001, 0.001 and 0.003, respectively). ROC curve analysis identified an Angiopoietin-2 cut-off of 5000 pg/mL as the best predictor for ICU outcome (Se = 80.1%, Sp = 70%, PPV = 72.7%, NPV = 77%), further confirmed in multivariate analysis after adjustment for creatinine, CRP or D-dimers. Conclusion: Angiopoietin-2 is a relevant predictive factor for ICU direct admission in COVID-19 patients. This result showing an endothelial activation reinforces the hypothesis of a COVID-19-associated microvascular dysfunction.
MeSH term(s)	Aged ; Angiopoietin-2/blood ; Betacoronavirus ; Biomarkers/blood ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/therapy ; Critical Care/methods ; E-Selectin/blood ; Endothelium, Vascular/metabolism ; Female ; Gene Expression Profiling ; Hospitalization ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pandemics ; Patient Admission ; Pneumonia, Viral/blood ; Pneumonia, Viral/therapy ; Prospective Studies ; Respiration, Artificial ; SARS-CoV-2
Chemical Substances	ANGPT2 protein, human ; Angiopoietin-2 ; Biomarkers ; E-Selectin
Keywords	covid19
Language	English
Publishing date	2020-05-27
Publishing country	Germany
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1484717-6
ISSN	1573-7209 ; 0969-6970
ISSN (online)	1573-7209
ISSN	0969-6970
DOI	10.1007/s10456-020-09730-0
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Article ; Online: Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells.

Guerin, Coralie L / Guyonnet, Léa / Goudot, Guillaume / Revets, Dominique / Konstantinou, Maria / Chipont, Anna / Chocron, Richard / Blandinieres, Adeline / Khider, Lina / Rancic, Jeanne / Peronino, Christophe / Debuc, Benjamin / Cras, Audrey / Knosp, Camille / Latremouille, Christian / Capel, Antoine / Ollert, Markus / Diehl, Jean-Luc / Jansen, Piet /

Planquette, Benjamin / Sanchez, Olivier / Gaussem, Pascale / Mirault, Tristan / Carpentier, Alain / Gendron, Nicolas / Smadja, David M

Stem cell reviews and reports

2020 Volume 17, Issue 2, Page(s) 639–651

Abstract: Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but they are more often described as ... ...

Abstract	Endothelial progenitor cells (EPCs) are involved in vasculogenesis and cardiovascular diseases. However, the phenotype of circulating EPCs remains elusive but they are more often described as CD34
MeSH term(s)	Antigens, CD19/metabolism ; COVID-19/metabolism ; Endothelial Progenitor Cells/metabolism ; Endothelial Progenitor Cells/pathology ; Female ; Gene Expression Regulation ; Heart, Artificial ; Humans ; Male ; Middle Aged ; Proteomics ; SARS-CoV-2/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Chemical Substances	Antigens, CD19 ; CD19 molecule, human ; KDR protein, human (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
Keywords	covid19
Language	English
Publishing date	2020-11-17
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-020-10062-1
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Article ; Online: Lupus Anticoagulant Single Positivity During the Acute Phase of COVID-19 Is Not Associated With Venous Thromboembolism or In-Hospital Mortality.

Gendron, Nicolas / Dragon-Durey, Marie-Agnès / Chocron, Richard / Darnige, Luc / Jourdi, Georges / Philippe, Aurélien / Chenevier-Gobeaux, Camille / Hadjadj, Jérôme / Duchemin, Jérôme / Khider, Lina / Yatim, Nader / Goudot, Guillaume / Krzisch, Daphné / Debuc, Benjamin / Mauge, Laetitia / Levavasseur, Françoise / Pene, Frédéric / Boussier, Jeremy / Sourdeau, Elise /

Brichet, Julie / Ochat, Nadège / Goulvestre, Claire / Peronino, Christophe / Szwebel, Tali-Anne / Pages, Franck / Gaussem, Pascale / Samama, Charles-Marc / Cheurfa, Cherifa / Planquette, Benjamin / Sanchez, Olivier / Diehl, Jean-Luc / Mirault, Tristan / Fontenay, Michaela / Terrier, Benjamin / Smadja, David M

Arthritis & rheumatology (Hoboken, N.J.)

2021 Volume 73, Issue 11, Page(s) 1976–1985

Abstract: Objective: The clinical relevance of antiphospholipid antibodies (aPLs) in COVID-19 is controversial. This study was undertaken to investigate the prevalence and prognostic value of conventional and nonconventional aPLs in patients with COVID-19.: ... ...

Abstract	Objective: The clinical relevance of antiphospholipid antibodies (aPLs) in COVID-19 is controversial. This study was undertaken to investigate the prevalence and prognostic value of conventional and nonconventional aPLs in patients with COVID-19. Methods: This was a multicenter, prospective observational study in a French cohort of patients hospitalized with suspected COVID-19. Results: Two hundred forty-nine patients were hospitalized with suspected COVID-19, in whom COVID-19 was confirmed in 154 and not confirmed in 95. We found a significant increase in lupus anticoagulant (LAC) positivity among patients with COVID-19 compared to patients without COVID-19 (60.9% versus 23.7%; P < 0.001), while prevalence of conventional aPLs (IgG and IgM anti-β Conclusion: Patients with COVID-19 have an increased prevalence of LAC positivity associated with biologic markers of inflammation. However, LAC positivity at the time of hospital admission is not associated with VTE risk and/or in-hospital mortality.
MeSH term(s)	Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/complications ; COVID-19/mortality ; Female ; Hospital Mortality ; Humans ; Lupus Coagulation Inhibitor/blood ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Risk Factors ; Survival Rate ; Venous Thromboembolism/blood ; Venous Thromboembolism/etiology
Chemical Substances	Lupus Coagulation Inhibitor
Language	English
Publishing date	2021-09-22
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.41777
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