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  1. Article: Potential Benefits of Antioxidant Phytochemicals on Endogenous Antioxidants Defences in Chronic Diseases.

    Fratta Pasini, Anna Maria / Cominacini, Luciano

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Chronic diseases and cancer are worldwide health problems which result in death and disability for millions of people [ ... ]. ...

    Abstract Chronic diseases and cancer are worldwide health problems which result in death and disability for millions of people [...].
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12040890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Potential Benefits of Antioxidant Phytochemicals on Endogenous Antioxidants Defences in Chronic Diseases

    Fratta Pasini, Anna Maria / Cominacini, Luciano

    Antioxidants. 2023 Apr. 06, v. 12, no. 4

    2023  

    Abstract: Chronic diseases and cancer are worldwide health problems which result in death and disability for millions of people [ ... ] ...

    Abstract Chronic diseases and cancer are worldwide health problems which result in death and disability for millions of people [...]
    Keywords antioxidants ; death ; phytochemicals
    Language English
    Dates of publication 2023-0406
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12040890
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Effect of Antioxidant Therapy on Oxidative Stress In Vivo 2021.

    Fratta Pasini, Anna Maria / Cominacini, Luciano

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 3

    Abstract: Oxidative stress (OS) is an imbalance between the formation of reactive oxygen and nitrogen species and antioxidant defenses [ ... ]. ...

    Abstract Oxidative stress (OS) is an imbalance between the formation of reactive oxygen and nitrogen species and antioxidant defenses [...].
    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11030448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Effect of Antioxidant Therapy on Oxidative Stress In Vivo 2021

    Fratta Pasini, Anna Maria / Cominacini, Luciano

    Antioxidants. 2022 Feb. 24, v. 11, no. 3

    2022  

    Abstract: Oxidative stress (OS) is an imbalance between the formation of reactive oxygen and nitrogen species and antioxidant defenses [ ... ] ...

    Abstract Oxidative stress (OS) is an imbalance between the formation of reactive oxygen and nitrogen species and antioxidant defenses [...]
    Keywords antioxidants ; nitrogen ; oxidative stress ; oxygen ; therapeutics
    Language English
    Dates of publication 2022-0224
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11030448
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Effect of Antioxidant Therapy on Oxidative Stress In Vivo.

    Fratta Pasini, Anna Maria / Cominacini, Luciano

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: Over the last few decades, many efforts have been put into fields that explore the potential benefits of antioxidants, especially with regards to aging, cancer, cardiovascular diseases, and neurodegenerative diseases. [ ... ]. ...

    Abstract Over the last few decades, many efforts have been put into fields that explore the potential benefits of antioxidants, especially with regards to aging, cancer, cardiovascular diseases, and neurodegenerative diseases. [...].
    Language English
    Publishing date 2021-02-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10030344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effect of Antioxidant Therapy on Oxidative Stress in Vivo

    Pasini, Anna Maria Fratta / Cominacini, Luciano

    Antioxidants. 2021 Feb. 25, v. 10, no. 3

    2021  

    Abstract: Over the last few decades, many efforts have been put into fields that explore the potential benefits of antioxidants, especially with regards to aging, cancer, cardiovascular diseases, and neurodegenerative diseases [ ... ] ...

    Abstract Over the last few decades, many efforts have been put into fields that explore the potential benefits of antioxidants, especially with regards to aging, cancer, cardiovascular diseases, and neurodegenerative diseases [...]
    Keywords antioxidants ; oxidative stress ; therapeutics
    Language English
    Dates of publication 2021-0225
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10030344
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: New Insights into the Role of Ferroptosis in Cardiovascular Diseases.

    Fratta Pasini, Anna Maria / Stranieri, Chiara / Busti, Fabiana / Di Leo, Edoardo Giuseppe / Girelli, Domenico / Cominacini, Luciano

    Cells

    2023  Volume 12, Issue 6

    Abstract: Cardiovascular diseases (CVDs) are the principal cause of disease burden and death worldwide. Ferroptosis is a new form of regulated cell death mainly characterized by altered iron metabolism, increased polyunsaturated fatty acid peroxidation by reactive ...

    Abstract Cardiovascular diseases (CVDs) are the principal cause of disease burden and death worldwide. Ferroptosis is a new form of regulated cell death mainly characterized by altered iron metabolism, increased polyunsaturated fatty acid peroxidation by reactive oxygen species, depletion of glutathione and inactivation of glutathione peroxidase 4. Recently, a series of studies have indicated that ferroptosis is involved in the death of cardiac and vascular cells and has a key impact on the mechanisms leading to CVDs such as ischemic heart disease, ischemia/reperfusion injury, cardiomyopathies, and heart failure. In this article, we reviewed the molecular mechanism of ferroptosis and the current understanding of the pathophysiological role of ferroptosis in ischemic heart disease and in some cardiomyopathies. Moreover, the comprehension of the machinery governing ferroptosis in vascular cells and cardiomyocytes may provide new insights into preventive and therapeutic strategies in CVDs.
    MeSH term(s) Humans ; Ferroptosis ; Cell Death ; Iron/metabolism ; Lipid Peroxidation ; Cardiovascular Diseases ; Cardiomyopathies ; Myocardial Ischemia
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12060867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Intracellular Polyphenol Wine Metabolites Oppose Oxidative Stress and Upregulate Nrf2/ARE Pathway.

    Stranieri, Chiara / Guzzo, Flavia / Gambini, Sofia / Cominacini, Luciano / Fratta Pasini, Anna Maria

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 10

    Abstract: Moderate wine consumption has been associated with several benefits to human health due to its high polyphenol content. In this study, we investigated whether polyphenols contained in a particular red wine, rich in polyphenols, can pass the cell membrane ...

    Abstract Moderate wine consumption has been associated with several benefits to human health due to its high polyphenol content. In this study, we investigated whether polyphenols contained in a particular red wine, rich in polyphenols, can pass the cell membrane and switch the oxidant/antioxidant balance toward an antioxidant pattern of THP-1 cells and human cardiomyocytes through a gene regulatory system. First, we identified which metabolite polyphenols present in red wine extract cross cell membranes and may be responsible for antioxidant effects. The results showed that the wine metabolites in treated cells belonged mainly to stilbenes, flavan-3-ols derivatives, and flavonoids. Other metabolites present in cells were not typical wine metabolites. Then, we found that red wine extract dose-dependently lowered reactive oxygen species (ROS) induced by tert-butyl hydroperoxide (TBHP) up to 50 ± 7% in both cell lines (p < 0.01). Furthermore, wine extract increased nuclear Nrf2 of about 35 ± 5% in both cell lines (p < 0.01) and counteracted its reduction induced by TBHP (p < 0.01). The rise in Nrf2 was paralleled by the increase in hemeoxygenase-1 and glutamate-cysteine ligase catalytic subunit gene expression (both mRNA and protein) (p < 0.01). These results could help explain the healthful activity of wine polyphenols within cells.
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11102055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Is Ferroptosis a Key Component of the Process Leading to Multiorgan Damage in COVID-19?

    Fratta Pasini, Anna Maria / Stranieri, Chiara / Girelli, Domenico / Busti, Fabiana / Cominacini, Luciano

    Antioxidants. 2021 Oct. 25, v. 10, no. 11

    2021  

    Abstract: Even though COVID-19 is mostly well-known for affecting respiratory pathology, it can also result in several extrapulmonary manifestations, leading to multiorgan damage. A recent reported case of SARS-CoV-2 myocarditis with cardiogenic shock showed a ... ...

    Abstract Even though COVID-19 is mostly well-known for affecting respiratory pathology, it can also result in several extrapulmonary manifestations, leading to multiorgan damage. A recent reported case of SARS-CoV-2 myocarditis with cardiogenic shock showed a signature of myocardial and kidney ferroptosis, a novel, iron-dependent programmed cell death. The term ferroptosis was coined in the last decade to describe the form of cell death induced by the small molecule erastin. As a specific inducer of ferroptosis, erastin inhibits cystine-glutamate antiporter system Xc-, blocking transportation into the cytoplasm of cystine, a precursor of glutathione (GSH) in exchange with glutamate and the consequent malfunction of GPX4. Ferroptosis is also promoted by intracellular iron overload and by the iron-dependent accumulation of polyunsaturated fatty acids (PUFA)-derived lipid peroxides. Since depletion of GSH, inactivation of GPX4, altered iron metabolism, and upregulation of PUFA peroxidation by reactive oxygen species are peculiar signs of COVID-19, there is the possibility that SARS-CoV-2 may trigger ferroptosis in the cells of multiple organs, thus contributing to multiorgan damage. Here, we review the molecular mechanisms of ferroptosis and its possible relationship with SARS-CoV-2 infection and multiorgan damage. Finally, we analyze the potential interventions that may combat ferroptosis and, therefore, reduce multiorgan damage.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antiporters ; cystine ; cytoplasm ; ferroptosis ; glutamic acid ; glutathione ; iron absorption ; iron overload ; kidneys ; myocarditis ; peroxidation ; transportation
    Language English
    Dates of publication 2021-1025
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10111677
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Is Ferroptosis a Key Component of the Process Leading to Multiorgan Damage in COVID-19?

    Fratta Pasini, Anna Maria / Stranieri, Chiara / Girelli, Domenico / Busti, Fabiana / Cominacini, Luciano

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: Even though COVID-19 is mostly well-known for affecting respiratory pathology, it can also result in several extrapulmonary manifestations, leading to multiorgan damage. A recent reported case of SARS-CoV-2 myocarditis with cardiogenic shock showed a ... ...

    Abstract Even though COVID-19 is mostly well-known for affecting respiratory pathology, it can also result in several extrapulmonary manifestations, leading to multiorgan damage. A recent reported case of SARS-CoV-2 myocarditis with cardiogenic shock showed a signature of myocardial and kidney ferroptosis, a novel, iron-dependent programmed cell death. The term ferroptosis was coined in the last decade to describe the form of cell death induced by the small molecule erastin. As a specific inducer of ferroptosis, erastin inhibits cystine-glutamate antiporter system Xc-, blocking transportation into the cytoplasm of cystine, a precursor of glutathione (GSH) in exchange with glutamate and the consequent malfunction of GPX4. Ferroptosis is also promoted by intracellular iron overload and by the iron-dependent accumulation of polyunsaturated fatty acids (PUFA)-derived lipid peroxides. Since depletion of GSH, inactivation of GPX4, altered iron metabolism, and upregulation of PUFA peroxidation by reactive oxygen species are peculiar signs of COVID-19, there is the possibility that SARS-CoV-2 may trigger ferroptosis in the cells of multiple organs, thus contributing to multiorgan damage. Here, we review the molecular mechanisms of ferroptosis and its possible relationship with SARS-CoV-2 infection and multiorgan damage. Finally, we analyze the potential interventions that may combat ferroptosis and, therefore, reduce multiorgan damage.
    Language English
    Publishing date 2021-10-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10111677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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