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  1. Article: Hypercalcemia as the Initial Presentation of Acute T-cell Leukemia/Lymphoma.

    Ramachandran, Vignesh

    Cureus

    2022  Volume 14, Issue 3, Page(s) e23705

    Abstract: Adult T-cell leukemia/lymphoma (ATLL) is a T-cell malignancy that generally presents with widespread involvement of lymph nodes, peripheral blood, and/or skin. It is an uncommon malignancy linked to the human T-lymphotropic virus 1 (HTLV-1). Herein, we ... ...

    Abstract Adult T-cell leukemia/lymphoma (ATLL) is a T-cell malignancy that generally presents with widespread involvement of lymph nodes, peripheral blood, and/or skin. It is an uncommon malignancy linked to the human T-lymphotropic virus 1 (HTLV-1). Herein, we present a case of ATLL that was diagnosed after a patient presented to our hospital with nonspecific symptoms of fatigue and weakness and was subsequently found to have hypercalcemia secondary to his blood malignancy. We engage in a discussion of the etiology, epidemiology, and management of patients with this rare malignancy as well as the mechanisms that result in hypercalcemia.
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.23705
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  2. Article: Myonecrosis complicating uncontrolled diabetes mellitus.

    Ramachandran, Vignesh

    Proceedings (Baylor University. Medical Center)

    2022  Volume 35, Issue 5, Page(s) 693–694

    Abstract: A 37-year-old woman with uncontrolled type 1 diabetes mellitus and end-stage renal disease presented to our hospital with 10 days of severe left thigh pain. Physical examination revealed warmth, swelling, and tenderness of the left anterior and medial ... ...

    Abstract A 37-year-old woman with uncontrolled type 1 diabetes mellitus and end-stage renal disease presented to our hospital with 10 days of severe left thigh pain. Physical examination revealed warmth, swelling, and tenderness of the left anterior and medial thigh. Workup revealed a mildly elevated creatinine kinase. Magnetic resonance imaging without contrast revealed diffuse extensive soft tissue edema and a heterogeneous, tubular fluid collection within the adductor magnus. Needle aspiration revealed hematoma and myonecrosis. Cultures and cytology were negative. A diagnosis of diabetic myonecrosis was made. Myonecrosis is a rare complication of diabetes, and the gold standard for diagnosis is tissue biopsy. However, magnetic resonance imaging may be sensitive and specific for diagnosis and prevent morbidity.
    Language English
    Publishing date 2022-06-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2703932-8
    ISSN 1525-3252 ; 0899-8280
    ISSN (online) 1525-3252
    ISSN 0899-8280
    DOI 10.1080/08998280.2022.2086787
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  3. Article ; Online: Purification, structural characterization, and neuroprotective effect of 3,6-diisobutyl-2,5-piperazinedione from Halomonas pacifica CARE-V15 against okadaic acid-induced neurotoxicity in zebrafish model.

    Narasimman, Vignesh / Ramachandran, Saravanan

    Journal of biochemical and molecular toxicology

    2024  Volume 38, Issue 4, Page(s) e23708

    Abstract: Halomonas pacifica CARE-V15 was isolated from the southeastern coast of India to determine its genome sequence. Secondary metabolite gene clusters were identified using an anti-SMASH server. The concentrated crude ethyl acetate extract was evaluated by ... ...

    Abstract Halomonas pacifica CARE-V15 was isolated from the southeastern coast of India to determine its genome sequence. Secondary metabolite gene clusters were identified using an anti-SMASH server. The concentrated crude ethyl acetate extract was evaluated by GC-MS. The bioactive compound from the crude ethyl acetate extract was fractionated by gel column chromatography. HPLC was used to purify the 3,6-diisobutyl-2,5-piperazinedione (DIP), and the structure was determined using FTIR and NMR spectroscopy. Purified DIP was used in an in silico molecular docking analysis. Purified DIP exhibits a stronger affinity for antioxidant genes like glutathione peroxidase (GPx), glutathione-S-transferase (GST), and glutathione reductase (GSR). Using in silco molecular docking analysis, the protein-ligand binding affinities of GSR (-4.70 kcal/mol), GST (-5.27 kcal/mol), and GPx (-5.37 kcal/mol) were measured. The expression of antioxidant genes were investigated by qRT-PCR. The in vivo reactive oxygen species production, lipid peroxidation, and cell death levels were significantly (p ≤ 0.05) increased in OA-induced group, but all these levels were significantly (p ≤ 0.05) decreased in the purified DIP pretreated group. Purified DIP from halophilic bacteria could thus be a useful treatment for neurological disorders associated with oxidative stress.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Zebrafish/metabolism ; Neuroprotective Agents/pharmacology ; Okadaic Acid/metabolism ; Okadaic Acid/pharmacology ; Molecular Docking Simulation ; Oxidative Stress ; Glutathione Peroxidase/metabolism ; Glutathione Reductase/metabolism ; Diketopiperazines/metabolism ; Diketopiperazines/pharmacology ; Glutathione Transferase/metabolism ; Acetates ; Halomonas
    Chemical Substances Antioxidants ; ethyl acetate (76845O8NMZ) ; Neuroprotective Agents ; Okadaic Acid (1W21G5Q4N2) ; Glutathione Peroxidase (EC 1.11.1.9) ; Glutathione Reductase (EC 1.8.1.7) ; Diketopiperazines ; Glutathione Transferase (EC 2.5.1.18) ; Acetates
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1410020-4
    ISSN 1099-0461 ; 1095-6670
    ISSN (online) 1099-0461
    ISSN 1095-6670
    DOI 10.1002/jbt.23708
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    Zs.A 2201: Show issues Location:
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  4. Article ; Online: A Decade of Venture Investment in Artificial Intelligence in Dermatology Amidst Macroeconomic Shifts and Technological Advancements.

    Ramachandran, Vignesh / Jairath, Neil K / Orlow, Seth J

    The Journal of investigative dermatology

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2024.02.024
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  5. Article ; Online: Revolutionizing Dermatology Residency: AI for Knowledge and Clinical Milestones Assessment.

    Ramachandran, Vignesh / Jairath, Neil / Cheraghlou, Shayan / Palhayants, Vartan

    Clinical and experimental dermatology

    2023  

    Language English
    Publishing date 2023-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llad324
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  6. Article ; Online: Fostering innovation as a pillar of academic advancement in medicine: Strategies for incentivizing innovation in academic dermatology.

    Ramachandran, Vignesh / Pahalyants, Vartan / Cheraghlou, Shayan / Jairath, Neil

    The Australasian journal of dermatology

    2023  Volume 65, Issue 2, Page(s) 224–225

    MeSH term(s) Humans ; Dermatology ; Motivation ; Academic Medical Centers ; Faculty, Medical
    Language English
    Publishing date 2023-10-25
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.14176
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    Zs.A 236: Show issues Location:
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  7. Article: Recent advances in HIV diagnostics: Point-of-care CD4 + T-cell count & viral load assays.

    Balakrishnan, Pachamuthu / Saravanan, Shanmugam / Vignesh, Ramachandran / Shankar, Esaki M

    The Indian journal of medical research

    2024  Volume 158, Issue 5&6, Page(s) 447–450

    MeSH term(s) Humans ; Viral Load ; Point-of-Care Systems ; CD4-Positive T-Lymphocytes ; Lymphocyte Count ; HIV Infections ; CD4 Lymphocyte Count ; RNA, Viral
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2024-01-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.ijmr_1616_23
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  8. Article ; Online: Mohs micrographic surgery versus wide local excision for eyelid melanoma: An analysis of a national database.

    Ramachandran, Vignesh / Phan, Kevin

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2022  Volume 75, Issue 12, Page(s) 4410–4415

    Abstract: Background: Although eyelid melanomas represent less than 1% of eyelid neoplasms, they have the worst prognosis. Wide local excision (WLE) and Mohs micrographic surgery (MMS) are mainstay treatment options. We conducted a retrospective analysis to ... ...

    Abstract Background: Although eyelid melanomas represent less than 1% of eyelid neoplasms, they have the worst prognosis. Wide local excision (WLE) and Mohs micrographic surgery (MMS) are mainstay treatment options. We conducted a retrospective analysis to assess all-cause and cause-specific mortality rates in patients undergoing WLE or MMS for eyelid melanoma.
    Methods: A retrospective analysis of Surveillance, Epidemiology, and End Results (SEER) registry was performed for eyelid melanoma treated with WLE or MMS. Cases were limited to American Joint Committee on Cancer (AJCC) stage T1 primary malignancies.
    Results: A total of 45 cases of WLE were identified along with 48 cases of MMS for eyelid melanoma. There was no significant difference between subgroups in age group, sex, race, ethnicity, marital status at diagnosis, AJCC N stage, AJCC M stage, melanoma histology, chemotherapy use, and radiotherapy use. Among the cohort, all tumors were unilateral. Kaplan-Meier analysis with log-rank demonstrated no significant difference between MMS and WLE subgroups with regard to overall survival (P = 0.662) and cancer-specific survival (P = 0.494). Cox regression adjusting for variables with α<0.10 and found no significant difference in all-cause mortality (HR, 0.923; 95% CI 0.310-2.747; P = 0.885) or cancer-specific mortality (HR, 0.518; 95% CI 0.047-5.711; P = 0.591) when patients who underwent MMS were compared to those who underwent WLE.
    Conclusion: While our study is limited by a small number of patients, our analysis demonstrated no significant difference in all-cause or cause-specific survival for patients with eyelid melanoma treated with MMS compared with WLE. In areas requiring preservation of tissue due to cosmetic or functional purposes, MMS is a reasonable surgical approach.
    MeSH term(s) Humans ; Mohs Surgery/methods ; Eyelid Neoplasms/surgery ; Retrospective Studies ; Skin Neoplasms/pathology ; Melanoma/pathology ; Eyelids/surgery ; Neoplasm Recurrence, Local/pathology
    Language English
    Publishing date 2022-08-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2022.08.076
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  9. Article ; Online: Knotted lanugo in a newborn: Cultural practices revealed.

    Needle, Carli D / Ramachandran, Vignesh / Oza, Vikash S

    Pediatric dermatology

    2023  Volume 41, Issue 1, Page(s) 164–165

    Abstract: Across the world, there are varied cultural practices applied in the newborn period that pediatric dermatologists need to be familiar with. This report details a 9-day-old girl who presented with black, spike-like hairs across the back after her mother ... ...

    Abstract Across the world, there are varied cultural practices applied in the newborn period that pediatric dermatologists need to be familiar with. This report details a 9-day-old girl who presented with black, spike-like hairs across the back after her mother had been rubbing breast milk on her back in a circular motion for the first 7 days of life. On dermatoscopic exam, these lesions were found to be tight bundles of lanugo hairs, consistent with a diagnosis of knotted lanugo. Improved understanding of cultural practices and newborn skin care routines is critical for diagnosis, treatment, and counseling.
    MeSH term(s) Female ; Infant, Newborn ; Humans ; Child ; Hair/pathology ; Skin ; Mothers ; Dermoscopy ; Skin Care
    Language English
    Publishing date 2023-12-10
    Publishing country United States
    Document type Letter
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15490
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  10. Article ; Online: General dermatology and dermatology in primary health care.

    Buontempo, Michael G / Ramachandran, Vignesh / Freedman, Jeremy / Meehan, Shane A / Lo Sicco, Kristen / Saitta, Peter A

    Clinical and experimental dermatology

    2024  

    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llae086
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