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  1. Article ; Online: Standardizing Endoscopic Reporting in Patients with IBD: JEDII™ to the Rescue?

    Massironi, Sara / Laffusa, Alice / Parigi, Tommaso Lorenzo / Danese, Silvio

    Digestive diseases and sciences

    2023  Volume 68, Issue 12, Page(s) 4287–4289

    MeSH term(s) Humans ; Inflammatory Bowel Diseases ; Endoscopy
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-023-08121-x
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  2. Article ; Online: HCV screening: Moving from theory to practice.

    Parigi, Tommaso Lorenzo / Aghemo, Alessio

    Liver international : official journal of the International Association for the Study of the Liver

    2020  Volume 40, Issue 7, Page(s) 1538–1540

    MeSH term(s) Hepacivirus ; Hepatitis C ; Humans ; Italy ; Mass Screening
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.14515
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  3. Article ; Online: Endoscopic Surveillance in Inflammatory Bowel Disease: The VIRTUE Is in High Definition.

    Parigi, Tommaso Lorenzo / Peyrin-Biroulet, Laurent / Danese, Silvio

    Gastroenterology

    2021  Volume 162, Issue 3, Page(s) 988–990

    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.10.025
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  4. Article ; Online: Blockade of IL-23: What is in the Pipeline?

    Parigi, Tommaso Lorenzo / Iacucci, Marietta / Ghosh, Subrata

    Journal of Crohn's & colitis

    2022  Volume 16, Issue Supplement_2, Page(s) ii64–ii72

    Abstract: Interleukin 23 [IL-23] plays a key role in the pathogenesis of both Crohn's disease [CD] and ulcerative colitis [UC], promoting a Th17 cell-related immune response. The combined blockade of IL-23 and IL-12 with ustekinumab has been demonstrated to be ... ...

    Abstract Interleukin 23 [IL-23] plays a key role in the pathogenesis of both Crohn's disease [CD] and ulcerative colitis [UC], promoting a Th17 cell-related immune response. The combined blockade of IL-23 and IL-12 with ustekinumab has been demonstrated to be safe and effective in the treatment of inflammatory bowel disease [IBD]. Studies on preclinical models and observations of other immune-mediated diseases, such as psoriasis, suggest that the selective inhibition of IL-23 could be beneficial in IBD. Four monoclonal antibodies [risankizumab, mirikizumab, brazikumab and guselkumab] are currently in advance clinical trials for either CD or UC. In this review, we provide an overview of the main results from published studies of selective anti IL-23 agents.
    MeSH term(s) Colitis, Ulcerative/drug therapy ; Crohn Disease/drug therapy ; Crohn Disease/pathology ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Interleukin-23 ; Ustekinumab/therapeutic use
    Chemical Substances Interleukin-23 ; Ustekinumab (FU77B4U5Z0)
    Language English
    Publishing date 2022-05-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjab185
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  5. Article ; Online: Image-Enhanced Endoscopy Surveillance of Colon and Pouch Dysplasia in IBD.

    Parigi, Tommaso Lorenzo / Nardone, Olga Maria / Iacucci, Marietta

    Diseases of the colon and rectum

    2022  Volume 65, Issue S1, Page(s) S119–S128

    Abstract: Background: Patients with longstanding ulcerative colitis and Crohn's colitis are at risk for developing colorectal cancer and need regular endoscopic surveillance to detect and remove precursor lesions. To do so, different technologies are available.!## ...

    Abstract Background: Patients with longstanding ulcerative colitis and Crohn's colitis are at risk for developing colorectal cancer and need regular endoscopic surveillance to detect and remove precursor lesions. To do so, different technologies are available.
    Data sources: The sources are observational and controlled studies, meta-analysis, and expert consensus articles available on PubMed.
    Study selection: The selected materials include articles reporting outcomes of and recommendations on endoscopic surveillance and resection of dysplasia in the gastrointestinal tract, including the ileoanal pouch and the anal transition zone, in patients with inflammatory bowel disease.
    Main outcome measures: Incidence and detection rate of dysplasia and cancer with different endoscopic techniques in patients with inflammatory bowel disease.
    Results: Risk of cancer is proportional to the duration and extent of the disease, and surveillance interval should be tailored on the individual risk in a range of 1 to 5 years. High-definition imaging and virtual chromoendoscopy have improved the detection of dysplasia and are now comparable with conventional dye spray chromoendoscopy. After restorative proctocolectomy with ileoanal pouch, the risk of cancer is modest, but its high mortality warrants endoscopic surveillance. The evidence to guide pouch surveillance is limited, and recently, the first expert consensus provided a framework of recommendations, which include an initial assessment 1 year after surgery and follow-up depending on individual risk factors.
    Limitations: The limitation includes scarcity of data on ileoanal pouch surveillance.
    Conclusions: Virtual chromoendoscopy and high-definition imaging have improved endoscopic surveillance, and more progress is expected with the implementation of artificial intelligence systems.
    MeSH term(s) Humans ; Artificial Intelligence ; Colitis, Ulcerative/surgery ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/pathology ; Endoscopy, Gastrointestinal
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000002548
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  6. Article: Inflammatory Bowel Diseases: Does One Histological Score Fit All?

    Villanacci, Vincenzo / Del Sordo, Rachele / Parigi, Tommaso Lorenzo / Leoncini, Giuseppe / Bassotti, Gabrio

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 12

    Abstract: Mucosal healing (MH) is the main treatment target in ulcerative colitis (UC) and Crohn's disease, and it is defined by the combination of complete endoscopic and histologic remission. The complete resolution of mucosal inflammation should be confirmed by ...

    Abstract Mucosal healing (MH) is the main treatment target in ulcerative colitis (UC) and Crohn's disease, and it is defined by the combination of complete endoscopic and histologic remission. The complete resolution of mucosal inflammation should be confirmed by histology but its assessment is not always univocal. Neutrophil infiltration represents the unique histological marker in discriminating the active vs. quiescent phases of the disease, together with crypt injuries (cryptitis and crypt abscesses), erosions, and ulcerations. On the contrary, basal plasmacytosis is not indicative of activity or the remission of inflammatory bowel diseases (IBDs) but instead represents a diagnostic clue, mostly at the onset. Several histological scoring systems have been developed to assess grade severity, particularly for UC. However, most are complex and/or subjective. The aim of this review was to summarize available scores, their characteristics and limitations, and to present the advantages of a simplified mucosa healing scheme (SHMHS) based on neutrophils and their distribution in the gut mucosa. Finally, we overview future developments including artificial intelligence models for standardization of disease assessments and novel molecular markers of inflammation with potential application in diagnostic practice.
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13122112
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  7. Article ; Online: Gut virome in inflammatory bowel disease and beyond.

    Tun, Hein Min / Peng, Ye / Massimino, Luca / Sin, Zhen Ye / Parigi, Tommaso Lorenzo / Facoetti, Amanda / Rahman, Shaila / Danese, Silvio / Ungaro, Federica

    Gut

    2024  Volume 73, Issue 2, Page(s) 350–360

    Abstract: Objective: The gut virome is a dense community of viruses inhabiting the gastrointestinal tract and an integral part of the microbiota. The virome coexists with the other components of the microbiota and with the host in a dynamic equilibrium, serving ... ...

    Abstract Objective: The gut virome is a dense community of viruses inhabiting the gastrointestinal tract and an integral part of the microbiota. The virome coexists with the other components of the microbiota and with the host in a dynamic equilibrium, serving as a key contributor to the maintenance of intestinal homeostasis and functions. However, this equilibrium can be interrupted in certain pathological states, including inflammatory bowel disease, causing dysbiosis that may participate in disease pathogenesis. Nevertheless, whether virome dysbiosis is a causal or bystander event requires further clarification.
    Design: This review seeks to summarise the latest advancements in the study of the gut virome, highlighting its cross-talk with the mucosal microenvironment. It explores how cutting-edge technologies may build upon current knowledge to advance research in this field. An overview of virome transplantation in diseased gastrointestinal tracts is provided along with insights into the development of innovative virome-based therapeutics to improve clinical management.
    Results: Gut virome dysbiosis, primarily driven by the expansion of
    Conclusions: The field of gut virome is progressively expanding, thanks to the advancements of sequencing technologies and bioinformatic pipelines. These have contributed to a better understanding of how virome dysbiosis is linked to intestinal disease pathogenesis and how the modulation of virome composition may help the clinical intervention to ameliorate gut disease management.
    MeSH term(s) Humans ; Virome ; Dysbiosis ; Inflammatory Bowel Diseases/therapy ; Viruses ; Microbiota
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-330001
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  8. Article ; Online: Difficult-to-treat inflammatory bowel disease: Effectiveness and safety of 4th and 5th lines of treatment.

    Caron, Bénédicte / Habert, Alexandre / Bonsack, Olivier / Camara, Houda / Jeanbert, Elodie / Parigi, Tommaso Lorenzo / Netter, Patrick / Danese, Silvio / Peyrin-Biroulet, Laurent

    United European gastroenterology journal

    2024  

    Abstract: Background: Many patients with inflammatory bowel disease (IBD) have signs or symptoms of active disease despite multiple treatment attempts. This emerging concept is defined as difficult-to-treat IBD.: Aim: The objective of this study was to ... ...

    Abstract Background: Many patients with inflammatory bowel disease (IBD) have signs or symptoms of active disease despite multiple treatment attempts. This emerging concept is defined as difficult-to-treat IBD.
    Aim: The objective of this study was to investigate for the first time the treatment persistence, efficacy and safety of biologics or small molecules used in 4th or 5th line therapy.
    Methods: We reviewed all consecutive patients with IBD treated at the Nancy University Hospital between July 2022 and April 2023 with the 4th or 5th line treatment for at least three months. The primary outcome was to assess the persistence rate of 4th and 5th line therapy.
    Results: We enrolled 82 patients with IBD (4th line: 44; 5th line: 38). On Kaplan-Meier analysis, the duration of risankizumab, ustekinumab or vedolizumab therapy did not differ significantly (p > 0.05) as 4th and 5th line treatment. The restricted mean survival time analysis showed that the persistence rate of risankizumab was the highest as 4th line therapy (risankizumab vs. vedolizumab: 36.0 and 29.4 weeks, respectively, p = 0.008; risankizumab vs. ustekinumab: 36.0 and 32.8 weeks, respectively, p = 0.035). In multivariate regression, Crohn's disease diagnosis (Odd ratio 4.6; 95% confidence interval 1.7-12.4) was significantly associated with treatment persistence.
    Conclusion: In this first real-world setting, risankizumab could have a longer persistence rate as 4th line treatment for IBD than other agents. Persistence of biological agents was greater in Crohn's disease than in ulcerative colitis. More studies are needed to compare treatment efficacy in patients with difficult-to-treat IBD.
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12547
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  9. Article ; Online: Defining difficult-to-treat inflammatory bowel disease: why and how.

    Danese, Silvio / Parigi, Tommaso Lorenzo / Peyrin-Biroulet, Laurent / Ghosh, Subrata

    The lancet. Gastroenterology & hepatology

    2021  Volume 6, Issue 7, Page(s) 520–522

    MeSH term(s) Decision Making ; Disease Management ; Humans ; Inflammatory Bowel Diseases/therapy
    Language English
    Publishing date 2021-05-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(21)00141-2
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  10. Article ; Online: Do JAK inhibitors have a realistic future in treating Crohn's disease?

    Parigi, Tommaso Lorenzo / Solitano, Virginia / Peyrin-Biroulet, Laurent / Danese, Silvio

    Expert review of clinical immunology

    2021  Volume 18, Issue 3, Page(s) 181–183

    MeSH term(s) Crohn Disease/drug therapy ; Humans ; Janus Kinase Inhibitors/therapeutic use
    Chemical Substances Janus Kinase Inhibitors
    Language English
    Publishing date 2021-12-31
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2022.2020101
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