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  1. Article ; Online: Genetic Coupling of Mate Recognition Systems in the Genomic Era.

    Ritchie, Michael G / Butlin, Roger K

    Cold Spring Harbor perspectives in biology

    2024  Volume 16, Issue 4

    Abstract: The concept of "genetic coupling" in mate recognition systems arose in the 1960s as a potential mechanism to maintain coordination between signals and receivers during evolutionary divergence. At its most basic it proposed that the same genes might ... ...

    Abstract The concept of "genetic coupling" in mate recognition systems arose in the 1960s as a potential mechanism to maintain coordination between signals and receivers during evolutionary divergence. At its most basic it proposed that the same genes might influence trait and preference, and therefore mutations could result in coordinated changes in both traits. Since then, the concept has expanded in scope and is often used to include linkage or genetic correlation between recognition system components. Here we review evidence for genetic coupling, concentrating on proposed examples of a common genetic basis for signals and preferences. Mapping studies have identified several examples of tight genetic linkage between genomic regions influencing signals and preferences, or assortative mating. Whether this extends as far as demonstrating pleiotropy remains a more open question. Some studies, notably of
    MeSH term(s) Animals ; Phenotype ; Biological Evolution ; Genomics ; Mutation ; Reproduction/genetics ; Drosophila/genetics
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a041437
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  2. Article ; Online: Is It the Missing Piece for Coronavirus Disease 2019, Acute Respiratory Distress Syndrome, and Venovenous Extracorporeal Membrane Oxygenation?

    Ritchie, Michael K / Fox, Matthew P

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2020  Volume 66, Issue 10, Page(s) 1084–1086

    Keywords covid19
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001313
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  3. Article: Is It the Missing Piece for Coronavirus Disease 2019, Acute Respiratory Distress Syndrome, and Venovenous Extracorporeal Membrane Oxygenation?

    Ritchie, Michael K / Fox, Matthew P

    ASAIO J

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #900646
    Database COVID19

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  4. Article ; Online: Prevalence of Pathogenic Variants in Dilated Cardiomyopathy-Associated Genes in Patients Evaluated for Cardiac Sarcoidosis.

    Reza, Nosheen / Levin, Michael G / Vidula, Mahesh K / Bravo, Paco E / Damrauer, Scott M / Ritchie, Marylyn D / Chahal, C Anwar A / Owens, Anjali Tiku

    Circulation. Genomic and precision medicine

    2023  Volume 16, Issue 4, Page(s) 409–411

    MeSH term(s) Humans ; Cardiomyopathy, Dilated/epidemiology ; Cardiomyopathy, Dilated/genetics ; Prevalence ; Sarcoidosis/epidemiology ; Sarcoidosis/genetics ; Myocarditis
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2574-8300
    ISSN (online) 2574-8300
    DOI 10.1161/CIRCGEN.122.003850
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  5. Article ; Online: Epidemiology of Emergency Medical Search and Rescue in the North Shore Mountains of Vancouver, Canada, from 1995 to 2020.

    Collins, Dylan / Crickmer, Michael / Brolly, Kayla / Abrams, Daniel / Ritchie, Alec / Milsom, William

    Wilderness & environmental medicine

    2023  Volume 34, Issue 1, Page(s) 55–62

    Abstract: Introduction: Little is known about the epidemiology of emergency medical search and rescue incidents globally. The purpose of this study was to describe the epidemiology of emergency medical search and rescue incidents in the North Shore Mountains of ... ...

    Abstract Introduction: Little is known about the epidemiology of emergency medical search and rescue incidents globally. The purpose of this study was to describe the epidemiology of emergency medical search and rescue incidents in the North Shore Mountains of Vancouver, British Columbia, Canada.
    Methods: This was a retrospective review and descriptive analysis of search and rescue incident reports created by North Shore Rescue over a 25 y period from 1995 to 2019, inclusive. Incident reports were screened for inclusion against a priori criteria defining a medical callout. The National Advisory Committee of Aeronautics (NACA) severity score was used as a method to grade medical acuity of included subjects.
    Results: We included 906 subjects. Their median age was 35 y (interquartile range, 24-53), and 65% of subjects were men. Forty-one percent (n=371) of subjects were classified as non-trauma and 54% (n=489) as trauma. The top 3 activities were hiking (53%), biking (10%), and snow sports (10%). Forty-nine percent of incidents were classified as having a NACA score of ≥3. For subjects with trauma, the top 3 body regions were lower limb (52%), head (18%), and torso (12%). For subjects with non-traumatic conditions, the top 3 causes were mental health crises (25%), exposure (25%), and cardiovascular incidents (11%).
    Conclusions: Half of the incidents were serious enough to require medical assessment at a hospital (NACA score ≥3). Given this medical acuity, there is a need for evidence-based guidelines and core training competencies for mountain medical search and rescue. Standardized core data sets and outcomes are needed to monitor quality of care over time.
    MeSH term(s) Male ; Humans ; Adult ; Female ; Emergency Medical Services ; Rescue Work ; Mountaineering/injuries ; Sports ; British Columbia/epidemiology ; Retrospective Studies
    Language English
    Publishing date 2023-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1238909-2
    ISSN 1545-1534 ; 1080-6032
    ISSN (online) 1545-1534
    ISSN 1080-6032
    DOI 10.1016/j.wem.2022.11.004
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  6. Article ; Online: The Year in Thoracic Anesthesia: Selected Highlights from 2022.

    Alfaras-Melainis, Konstantinos / Fernando, Rohesh J / Boisen, Michael L / Hoffman, Paul J / Rosenkrans, Daniel J / Teeter, Emily / Cardi, Alessandra I / Laney, Jeremy / Reagan, Aaron / Rao, Vidya K / Anderson, Michael / Luke, Charles B / Subramani, Sudhakar / Schisler, Travis / Ritchie, Peter J / Gelzinis, Theresa A

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 38, Issue 1, Page(s) 29–56

    Abstract: This article reviews research highlights in the field of thoracic anesthesia. The highlights of this year included new developments in the preoperative assessment and prehabilitation of patients requiring thoracic surgery, updates on the use of devices ... ...

    Abstract This article reviews research highlights in the field of thoracic anesthesia. The highlights of this year included new developments in the preoperative assessment and prehabilitation of patients requiring thoracic surgery, updates on the use of devices for one-lung ventilation (OLV) in adults and children, updates on the anesthetic and postoperative management of these patients, including protective OLV ventilation, the use of opioid-sparing techniques and regional anesthesia, and outcomes using enhanced recovery after surgery, as well as the use of expanding indications for extracorporeal membrane oxygenation, specialized anesthetic techniques for airway surgery, and nonintubated video-assisted thoracic surgery.
    MeSH term(s) Adult ; Child ; Humans ; Anesthesiology ; Anesthesia, Conduction ; One-Lung Ventilation/methods ; Analgesics, Opioid ; Anesthetics ; Thoracic Surgery, Video-Assisted/methods
    Chemical Substances Analgesics, Opioid ; Anesthetics
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.09.006
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  7. Article ; Online: Two decades of diabetes prevention efforts: A call to innovate and revitalize our approach to lifestyle change.

    Golovaty, Ilya / Ritchie, Natalie D / Tuomilehto, Jaakko / Mohan, Viswanathan / Ali, Mohammed K / Gregg, Edward W / Bergman, Michael / Moin, Tannaz

    Diabetes research and clinical practice

    2022  Volume 198, Page(s) 110195

    Abstract: The impact of global diabetes prevention efforts has been modest despite the promise of landmark diabetes prevention trials nearly twenty years ago. While national and regional initiatives show potential, challenges remain to adapt large-scale strategies ...

    Abstract The impact of global diabetes prevention efforts has been modest despite the promise of landmark diabetes prevention trials nearly twenty years ago. While national and regional initiatives show potential, challenges remain to adapt large-scale strategies in the real-world that fits individuals and their communities. Additionally, the sedentary lifestyle changes during the COVID-19 pandemic and guidelines that now call for earlier screening (e.g., US Preventative Task Force) will increase the pool of eligible adults worldwide. Thus, a more adaptable, person-centered approach that expands the current toolkit is urgently needed to innovate and revitalize our approach to diabetes prevention. This review identifies key priorities to optimize the population-level delivery of diabetes prevention based on a consensus-based evaluation of the current evidence among experts in global translational programs; key priorities identified include (1) participant eligibility, (2) intervention intensity, (3) delivery components, (4) behavioral economics, (5) technology, and (6) the role of pharmacotherapy. We offer a conceptual framework for a broader, person-centered approach to better address an individual's risk, readiness, barriers, and digital competency.
    MeSH term(s) Adult ; Humans ; Health Promotion ; Pandemics ; Diabetes Mellitus, Type 2/prevention & control ; COVID-19/epidemiology ; COVID-19/prevention & control ; Life Style
    Language English
    Publishing date 2022-12-05
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2022.110195
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  8. Article ; Online: Revolutions in Lipid Isomer Resolution: Application of Ultrahigh-Resolution Ion Mobility to Reveal Lipid Diversity.

    Poad, Berwyck L J / Jekimovs, Lachlan J / Young, Reuben S E / Wongsomboon, Puttandon / Marshall, David L / Hansen, Felicia K M / Fulloon, Therese / Pfrunder, Michael C / Dodgen, Tyren / Ritchie, Mark / Wong, Stephen C C / Blanksby, Stephen J

    Analytical chemistry

    2023  Volume 95, Issue 43, Page(s) 15917–15923

    Abstract: Many families of lipid isomers remain unresolved by contemporary liquid chromatography-mass spectrometry approaches, leading to a significant underestimation of the structural diversity within the lipidome. While ion mobility coupled to mass spectrometry ...

    Abstract Many families of lipid isomers remain unresolved by contemporary liquid chromatography-mass spectrometry approaches, leading to a significant underestimation of the structural diversity within the lipidome. While ion mobility coupled to mass spectrometry has provided an additional dimension of lipid isomer resolution, some isomers require a resolving power beyond the capabilities of conventional platforms. Here, we present the application of high-resolution traveling-wave ion mobility for the separation of lipid isomers that differ in (i) the location of a single carbon-carbon double bond, (ii) the stereochemistry of the double bond (
    MeSH term(s) Isomerism ; Mass Spectrometry/methods ; Phosphatidylcholines/analysis ; Chromatography, Liquid ; Carbon
    Chemical Substances Phosphatidylcholines ; Carbon (7440-44-0)
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c02658
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  9. Article ; Online: The needs of family caregivers of persons living with dementia cared for in primary care practices.

    Vetter, Michael / Donelan, Karen / Guzikowski, Sophia / Michael, Carie / Ritchie, Christine S / Vogeli, Christine / Forester, Brent P

    Journal of evaluation in clinical practice

    2023  Volume 29, Issue 8, Page(s) 1243–1246

    Abstract: Rationale: The informal caregivers who provide unpaid support for persons living with dementia (PLWD) are often unprepared to appropriately manage symptoms and navigate health services to support themselves or the PLWD.: Aim: To understand informal ... ...

    Abstract Rationale: The informal caregivers who provide unpaid support for persons living with dementia (PLWD) are often unprepared to appropriately manage symptoms and navigate health services to support themselves or the PLWD.
    Aim: To understand informal caregivers' perceived capabilities of handling dementia symptomology and perceived support from providers.
    Methods: We identified and surveyed caregivers of primary care patients in the Mass General Brigham health system. We included a self-efficacy questionnaire to assess caregivers' ability and confidence in access to dementia care, symptom management, and provider support.
    Results: Respondents indicated that although their provider had knowledge of dementia and memory care, they were least likely to agree (39.2%) that their provider helped them with these challenging symptoms. Those who live with the care recipient were least likely to receive advice about common symptoms (43.6%) and to access community services (63.8%), and in general felt moderately knowledgeable about the progression of the disease (47.9%).
    Conclusions: The findings imply that caregivers are aware of disease progression, dementia symptoms, and do not feel supported by their providers in managing care or accessing support services. There is opportunity to support informal caregivers in a primary care setting by appropriately uptraining providers in dementia care.
    MeSH term(s) Humans ; Caregivers ; Dementia/therapy ; Health Services ; Primary Health Care
    Language English
    Publishing date 2023-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1327355-3
    ISSN 1365-2753 ; 1356-1294
    ISSN (online) 1365-2753
    ISSN 1356-1294
    DOI 10.1111/jep.13919
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  10. Article ; Online: The Year in Thoracic Anesthesia: Selected Highlights From 2021.

    Boisen, Michael L / Fernando, Rohesh J / Alfaras-Melainis, Konstantinos / Hoffmann, Paul J / Kolarczyk, Lavinia M / Teeter, Emily / Schisler, Travis / Ritchie, Peter J / La Colla, Luca / Rao, Vidya K / Gelzinis, Theresa A

    Journal of cardiothoracic and vascular anesthesia

    2022  Volume 36, Issue 12, Page(s) 4252–4265

    MeSH term(s) Humans ; Anesthesia ; Anesthesiology ; Thoracic Surgical Procedures ; One-Lung Ventilation
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2022.08.007
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