Article ; Online: Is SARS-CoV-2 Spike glycoprotein impairing macrophage function via α7-nicotinic acetylcholine receptors?
2021 Volume 152, Page(s) 112184
Abstract: The innate immune cells play an important role in handling early infections, and can eliminate them completely up to a certain threshold. Beyond that threshold they take up their role in "The Resolution of Inflammation". The recognition of the SARS-CoV-2 ...
| Abstract | The innate immune cells play an important role in handling early infections, and can eliminate them completely up to a certain threshold. Beyond that threshold they take up their role in "The Resolution of Inflammation". The recognition of the SARS-CoV-2 antigen triggers an eicosanoid storm and initiates a robust inflammatory response. This establishes a positive feedback loop which develops into a sustained cytokine storm which interferes with the activation of adaptive immune cells. The mechanism of this interaction, and hence the pathogenesis of the virus with the immune system, is yet to be determined. In silico studies predict a direct SARS-CoV-2 spike glycoprotein interaction with nicotinic acetylcholine receptors, which could impair macrophage function and initiate the cascade of events in severe infections. We here, add to the hypothesis that immune dysregulation can be caused by the interaction of the SARS-CoV-2 spike glycoprotein via a cryptic epitope with the α7-nAChR in Type-1 macrophages, discuss its implications for the treatment of COVID-19 patients, and present better prospects for the design and dissemination of more effective vaccines and their importance. |
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| MeSH term(s) | COVID-19/immunology ; Epitopes ; Humans ; Macrophages/virology ; Spike Glycoprotein, Coronavirus/immunology ; alpha7 Nicotinic Acetylcholine Receptor/immunology | |||||
| Chemical Substances | Epitopes ; Spike Glycoprotein, Coronavirus ; alpha7 Nicotinic Acetylcholine Receptor ; spike protein, SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2021-04-08 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 782617-5 | |||||
| ISSN | 1873-6351 ; 0278-6915 | |||||
| ISSN (online) | 1873-6351 | |||||
| ISSN | 0278-6915 | |||||
| DOI | 10.1016/j.fct.2021.112184 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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