Article ; Online: Value of stimulated pre-ablation thyroglobulin as a prognostic marker in patients with differentiated thyroid carcinoma treated with radioiodine.
2022 Volume 76, Issue 3, Page(s) 642–647
Abstract: Objective: To determine which Thyroglobulin (Tg) level after levothyroxine (LT: Methods: A chart review was performed in which 375 patients with DTC treated with RAIT were included. The sTg was measured in all patients prior to treatment with I: ... ...
Abstract | Objective: To determine which Thyroglobulin (Tg) level after levothyroxine (LT Methods: A chart review was performed in which 375 patients with DTC treated with RAIT were included. The sTg was measured in all patients prior to treatment with I Results: Incomplete response to treatment was found in 122 patients (32.5%), this group had a mean sTg of 23.2 ng/mL. ROC curve showed that the optimal cut-off sTg level was 4.4 ng/mL. (sensitivity: 72.1%; specificity: 72.3%; accuracy: 72.2%; positive predictive value of 55.7%; and negative predictive value: 84.3%). Conclusion: sTg pre-ablation is a valuable predictor of DTC incomplete response to treatment one year after RAIT. Levels of 4.4 ng/ml or more showed higher accuracy to predict this outcome. |
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MeSH term(s) | Adenocarcinoma/surgery ; Humans ; Iodine Radioisotopes/therapeutic use ; Prognosis ; Retrospective Studies ; Thyroglobulin ; Thyroid Neoplasms/radiotherapy ; Thyroid Neoplasms/surgery ; Thyroidectomy |
Chemical Substances | Iodine Radioisotopes ; Thyroglobulin (9010-34-8) |
Language | English |
Publishing date | 2022-03-02 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 1194484-5 |
ISSN | 1559-0100 ; 1355-008X ; 0969-711X |
ISSN (online) | 1559-0100 |
ISSN | 1355-008X ; 0969-711X |
DOI | 10.1007/s12020-022-03021-y |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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