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  1. Article ; Online: Value of stimulated pre-ablation thyroglobulin as a prognostic marker in patients with differentiated thyroid carcinoma treated with radioiodine.

    Nóbrega, Giulliana / Cavalcanti, Milena / Leite, Verônica / Vilar, Lúcio / Brandão, Simone Cristina Soares

    Endocrine

    2022  Volume 76, Issue 3, Page(s) 642–647

    Abstract: Objective: To determine which Thyroglobulin (Tg) level after levothyroxine (LT: Methods: A chart review was performed in which 375 patients with DTC treated with RAIT were included. The sTg was measured in all patients prior to treatment with I: ... ...

    Abstract Objective: To determine which Thyroglobulin (Tg) level after levothyroxine (LT
    Methods: A chart review was performed in which 375 patients with DTC treated with RAIT were included. The sTg was measured in all patients prior to treatment with I
    Results: Incomplete response to treatment was found in 122 patients (32.5%), this group had a mean sTg of 23.2 ng/mL. ROC curve showed that the optimal cut-off sTg level was 4.4 ng/mL. (sensitivity: 72.1%; specificity: 72.3%; accuracy: 72.2%; positive predictive value of 55.7%; and negative predictive value: 84.3%).
    Conclusion: sTg pre-ablation is a valuable predictor of DTC incomplete response to treatment one year after RAIT. Levels of 4.4 ng/ml or more showed higher accuracy to predict this outcome.
    MeSH term(s) Adenocarcinoma/surgery ; Humans ; Iodine Radioisotopes/therapeutic use ; Prognosis ; Retrospective Studies ; Thyroglobulin ; Thyroid Neoplasms/radiotherapy ; Thyroid Neoplasms/surgery ; Thyroidectomy
    Chemical Substances Iodine Radioisotopes ; Thyroglobulin (9010-34-8)
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-022-03021-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Progression of Myocardial 18F-FDG Uptake in a Patient with Cardiotoxicity.

    Berenguer, Diego Rafael Freitas / de Moraes Chaves Becker, Monica / de Oliveira Buril, Roberto / Bertão, Paula Araruna / Markman Filho, Brivaldo / Brandão, Simone Cristina Soares

    Arquivos brasileiros de cardiologia

    2024  Volume 121, Issue 2, Page(s) e20230276

    Abstract: The objective of this case report was to present the progression of chemotherapy-induced cardiotoxicity in a patient with lymphoma, highlighting the importance of myocardial fluor-18-fluorodeoxyglucose (18F-FDG) uptake by positron emission tomography ... ...

    Title translation Evolução da Captação Miocárdica de 18F-FDG em Paciente com Diagnóstico de Cardiotoxicidade.
    Abstract The objective of this case report was to present the progression of chemotherapy-induced cardiotoxicity in a patient with lymphoma, highlighting the importance of myocardial fluor-18-fluorodeoxyglucose (18F-FDG) uptake by positron emission tomography coupled with computed tomography (PET/CT). 43-year-old female patient with uterine lymphoma, who underwent hysterectomy followed by three chemotherapy regimens and radiotherapy. The patient had episodes of acute heart failure two years after chemotherapy. Echocardiogram revealed a reduction in left ventricular ejection fraction (LVEF). A retrospective analysis of 18F-FDG PET/CT showed an increase in myocardial uptake in all tests performed during oncologic treatment. Despite disease remission, the patient developed heart failure with reduced LVEF. During chemotherapy, there was a diffuse, significant increase in myocardial 18F-FDG uptake, which preceded the decrease in myocardial performance and seemed to reflect metabolic changes in cardiomyocytes, related to cardiotoxicity. Would an analysis of myocardial 18F-FDG uptake yield a different cardiac outcome in this patient? This question is relevant, considering that other patients may benefit from the use of PET as an early marker of cardiotoxicity. Imaging tests are essential in the follow-up of patients at risk of cardiotoxicity. Although echocardiography remains the main imaging test in the diagnosis of cardiotoxicity, 18F-FDG PET/CT may be a powerful tool for the early diagnosis of this condition.
    MeSH term(s) Female ; Humans ; Adult ; Fluorodeoxyglucose F18/metabolism ; Positron Emission Tomography Computed Tomography/methods ; Cardiotoxicity/diagnostic imaging ; Cardiotoxicity/etiology ; Stroke Volume ; Retrospective Studies ; Ventricular Function, Left ; Lymphoma ; Heart Failure/chemically induced ; Heart Failure/diagnostic imaging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2024-02-23
    Publishing country Brazil
    Document type Case Reports ; Letter
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.36660/abc.20230276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Does Valved Holding Chamber Improve Aerosol Lung Deposition with a Jet Nebulizer? A Randomized Crossover Study.

    Alcoforado, Luciana / Paiva, Dulciane Nunes / Ari, Arzu / Barcelar, Jacqueline de Melo / Brandão, Simone Cristina Soares / Fink, James B / Dornelas de Andrade, Armele

    Pharmaceutics

    2022  Volume 14, Issue 3

    Abstract: Using valved holding chambers (VHC) during aerosol therapy has been reported to improve the inhaled dose with various aerosol devices, including vibrating mesh nebulizers. The aim of this study was to quantify the pulmonary deposition of a jet nebulizer ( ...

    Abstract Using valved holding chambers (VHC) during aerosol therapy has been reported to improve the inhaled dose with various aerosol devices, including vibrating mesh nebulizers. The aim of this study was to quantify the pulmonary deposition of a jet nebulizer (JN) with and without a VHC, and a mesh nebulizer (MN) with a VHC in a randomized cross-over trial with seven healthy consenting adults. Our hypothesis was that the use of a VHC would improve deposition with the JN. Diethylnitriaminopentacetic acid with technetium (DTPA-Tc99m), with the activity of 1 mC with 0.9% saline solution was nebulized. The radiolabeled aerosol was detected by 2D planar scintigraphy after administration. The pulmonary deposition was greater with a JN with a VHC (4.5%) than a JN alone (3.2%; p = 0.005. However, an MN with a VHC (30.0%) was six-fold greater than a JN or JN with a VHC (p < 0.001). The extrapulmonary deposition was higher in the JN group without a VHC than in the other two modalities (p < 0.001). Deposition in the device was greater with a JN + VHC than an MN+/VHC (p < 0.001). Lower residual drug at the end of the dose was detected with an MN than either JN configuration. The exhaled dose was greater with a JN alone than either an MN or JN with VHC (p < 0.001). In conclusion, the addition of the VHC did not substantially improve the efficiency of aerosol lung deposition over a JN alone.
    Language English
    Publishing date 2022-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14030566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Value of18F-FDG PET/CT in the Diagnosis and Assessment of Response to Treatment of Lupus Myocarditis.

    Perazzo, Alvaro M / Andrade, Larissa G F / Venancio, Leonardo G A / Gouveia, Pedro Alves da Cruz / Galvão, Mariana Feitosa Ramalho / Lins, Esdras M / Moraes Neto, Fernando / Brandão, Simone Cristina Soares

    Arquivos brasileiros de cardiologia

    2022  Volume 118, Issue 6, Page(s) 1150–1152

    Title translation Valor do 18F-FDG PET/CT no Diagnóstico e Avaliação de Resposta ao Tratamento da Miocardite Lúpica.
    MeSH term(s) Fluorodeoxyglucose F18 ; Humans ; Myocarditis/diagnostic imaging ; Myocarditis/drug therapy ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiopharmaceuticals
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language Portuguese
    Publishing date 2022-06-10
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.36660/abc.20210523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Endothelial function, arterial stiffness and heart rate variability of patients with cardiovascular diseases hospitalized due to COVID-19.

    Araújo, Cláudia Regina da Silva / Fernandes, Juliana / Caetano, Débora Sidrônio / Barros, Ana Eugênia Vasconcelos do Rêgo / de Souza, Juliana Andrade Ferreira / Machado, Maria da Glória Rodrigues / de Aguiar, Maria Inês Remígio / Brandão, Simone Cristina Soares / Campos, Shirley Lima / de Andrade, Armele de Fatima Dornelas / Brandão, Daniella Cunha

    Heart & lung : the journal of critical care

    2023  Volume 58, Page(s) 210–216

    Abstract: Background: The novel coronavirus disease (COVID-19) may cause vascular (e.g., endothelial dysfunction, and arterial stiffness), cardiac, autonomic (e.g., heart rate variability [HRV]), and systemic inflammatory response via direct viral attack, hypoxia- ...

    Abstract Background: The novel coronavirus disease (COVID-19) may cause vascular (e.g., endothelial dysfunction, and arterial stiffness), cardiac, autonomic (e.g., heart rate variability [HRV]), and systemic inflammatory response via direct viral attack, hypoxia-induced injury, or immunological dysregulation, especially in those patients with pre-existing cardiovascular diseases (CVD). However, to date, no study has shown prevalence of endothelial dysfunction, arterial stiffness and heart rate variability assessed by bedside peripheral arterial tonometry in patients with previous CVD hospitalized in the acute phase of COVID-19.
    Objective: This study aimed to assess the prevalence of endothelial dysfunction, arterial stiffness, and altered HRV in patients with CVD hospitalized due to COVID-19.
    Methods: This cross-sectional study was conducted from July 2020 to February 2021. Included male and female adult patients aged 40 to 60 years with previous CVD and diagnosed with COVID-19. Anthropometric data, comorbidities, and blood tests were analyzed. Endothelial function, arterial stiffness, and HRV were assessed using peripheral arterial tonometry (PAT), and the statistical significance was set at 5%.
    Results: Fourteen (51.8%) patients presented endothelial dysfunction (reactive hyperemia index = 1.2 ± 0.3) and enhancement in the high-frequency component of HRV (p < 0.05). There was a high prevalence of endothelial dysfunction, especially in patients with chronic heart failure (10 (71.4%)). Patients with preserved endothelial function showed a high augmentation index normalized to a heart rate of 75 bpm (p < 0.01), suggesting arterial stiffness.
    Conclusion: Patients with CVD hospitalized due to COVID-19 presented endothelial dysfunction assessed using PAT, which could be used as a biomarker for arterial stiffness and altered HRV. The possibility of detecting vascular and autonomic changes during phase II of COVID-19 may help to prevent possible long-term complications.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Cardiovascular Diseases ; Heart Rate ; Vascular Stiffness/physiology ; Cross-Sectional Studies ; Endothelium, Vascular ; COVID-19/complications
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 193129-5
    ISSN 1527-3288 ; 0147-9563
    ISSN (online) 1527-3288
    ISSN 0147-9563
    DOI 10.1016/j.hrtlng.2022.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cardiac Malignant Peripheral Nerve Sheath Tumor Accessed By

    Soares Brandão, Simone Cristina / Dompieri, Luca Terracini / Tonini, Romero Carlos / Grativvol, Petherson Susano / Gama, Juliano Dallapicula / Calado, Eveline Barros / Monteiro Pedroti, Fátima Cristina

    The Canadian journal of cardiology

    2020  Volume 36, Issue 6, Page(s) 967.e17–967.e19

    Abstract: This is a case report of a patient presenting an extremely rare cardiac malignancy: malignant peripheral nerve sheath tumour. ... ...

    Abstract This is a case report of a patient presenting an extremely rare cardiac malignancy: malignant peripheral nerve sheath tumour. The
    MeSH term(s) Drug Therapy/methods ; Echocardiography/methods ; Electrocardiography/methods ; Fatal Outcome ; Fluorodeoxyglucose F18/pharmacology ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/pathology ; Heart Neoplasms/physiopathology ; Heart Neoplasms/therapy ; Heart Septum/diagnostic imaging ; Heart Septum/pathology ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasm Staging ; Neurofibrosarcoma/diagnosis ; Neurofibrosarcoma/pathology ; Neurofibrosarcoma/physiopathology ; Neurofibrosarcoma/therapy ; Positron Emission Tomography Computed Tomography/methods ; Radiopharmaceuticals/pharmacology ; Tomography, X-Ray Computed/methods
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2020-01-24
    Publishing country England
    Document type Case Reports
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2019.12.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: COVID19 e coração

    Brandão, Simone Cristina Soares / Andrade, Andresson W. / Feitosa, Audes Diógenes de Magalhães

    manual prático de condutas

    2020  

    Abstract: Objetiva mostrar de forma clara e concisa, quais os aspectos mais relevantes, descobertos e recomendados até o momento, sobre COVID-19 e coração. ...

    Abstract Objetiva mostrar de forma clara e concisa, quais os aspectos mais relevantes, descobertos e recomendados até o momento, sobre COVID-19 e coração.
    Keywords Infecções por Coronavirus ; COVID-19 ; Coração ; SARS-CoV-2 ; covid19
    Language Portuguese
    Publishing date 2020-04-20
    Publisher Os Autores
    Publishing country br
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Ultrasound findings in severe COVID-19: a deeper look through the carotid arteries.

    Bezerra, Camila Silva / Leite, Alice Abath / da Costa, Thaís Ramos / Lins, Esdras Marques / Godoi, Emmanuelle Tenório Albuquerque Madruga / Cordeiro, Lúcia Helena de Oliveira / Raposo, Maria Cristina Falcão / Brandão, Simone Cristina Soares

    Radiologia brasileira

    2022  Volume 55, Issue 6, Page(s) 329–336

    Abstract: Objective: To investigate vascular and perivascular abnormalities in the carotid arteries using ultrasound, as well as to evaluate their association with mortality and clinical variables in hospitalized patients with coronavirus disease 2019 (COVID-19).! ...

    Abstract Objective: To investigate vascular and perivascular abnormalities in the carotid arteries using ultrasound, as well as to evaluate their association with mortality and clinical variables in hospitalized patients with coronavirus disease 2019 (COVID-19).
    Materials and methods: This was a prospective study in which 53 hospitalized patients with severe COVID-19 were evaluated and underwent carotid ultrasound. We documented the carotid ultrasound findings in these patients. Clinical, demographic, laboratory, and imaging features were analyzed and compared by statistical analysis to detect correlations between them.
    Results: Carotid ultrasound demonstrated luminal surface irregularity in 29 patients (55%), carotid plaques in 30 (57%), perivascular infiltration in four (8%), and increased intima-media thickness (IMT) in 31 (58%). Of the 31 patients with increased IMT, 19 (61%) died, and the association between increased IMT and COVID-19-related mortality was significant (
    Conclusion: In hospitalized patients with severe COVID-19, carotid ultrasound can show increased IMT, luminal surface irregularity, carotid plaques, and perivascular infiltrates. The combination of increased IMT and kidney damage appears to increase the risk of death in such patients.
    Language English
    Publishing date 2022-11-29
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2078806-X
    ISSN 1678-7099 ; 0100-3984
    ISSN (online) 1678-7099
    ISSN 0100-3984
    DOI 10.1590/0100-3984.2022.0012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Role of the Endothelium in Severe COVID-19.

    Brandão, Simone Cristina Soares / Godoi, Emmanuelle Tenório Albuquerque Madruga / Ramos, Júlia de Oliveira Xavier / Melo, Leila Maria Magalhães Pessoa de / Dompieri, Luca Terracini / Brindeiro Filho, Djair Falcão / Sarinho, Emanuel Sávio Cavalcanti

    Arquivos brasileiros de cardiologia

    2021  Volume 115, Issue 6, Page(s) 1184–1189

    Title translation Papel do Endotélio na COVID-19 Grave.
    MeSH term(s) COVID-19 ; Endothelium ; Endothelium, Vascular ; Humans ; SARS-CoV-2
    Language Portuguese
    Publishing date 2021-01-20
    Publishing country Brazil
    Document type Letter
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.36660/abc.20200643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Severe COVID-19: understanding the role of immunity, endothelium, and coagulation in clinical practice.

    Brandão, Simone Cristina Soares / Godoi, Emmanuelle Tenório Albuquerque Madruga / Ramos, Júlia de Oliveira Xavier / de Melo, Leila Maria Magalhães Pessoa / Sarinho, Emanuel Sávio Cavalcanti

    Jornal vascular brasileiro

    2020  Volume 19, Page(s) e20200131

    Abstract: SARS-CoV-2 is responsible for the COVID-19 pandemic. The immune system is a determinant factor in defense against viral infections. Thus, when it acts in a balanced and effective manner the disease is self-limited and benign. Nevertheless, in a ... ...

    Abstract SARS-CoV-2 is responsible for the COVID-19 pandemic. The immune system is a determinant factor in defense against viral infections. Thus, when it acts in a balanced and effective manner the disease is self-limited and benign. Nevertheless, in a significant proportion of the population, the immune response is exaggerated. When infected, patients with diabetes, hypertension, obesity, and cardiovascular disease are more likely to progress to severe forms. These diseases are related to chronic inflammation and endothelial dysfunction. Toll-like receptors are expressed on immune cells and play an important role in the physiopathology of cardiovascular and metabolic diseases. When activated, they can induce release of inflammatory cytokines. Hypercoagulability, hyperinflammation, platelet hyperresponsiveness, and endothelial dysfunction occur in immune system hyperactivity caused by viral activity, thereby increasing the risk of arterial and venous thrombosis. We discuss the interactions between COVID-19, immunity, the endothelium, and coagulation, as well as why cardiometabolic diseases have a negative impact on COVID-19 prognosis.
    Language English
    Publishing date 2020-11-16
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2571403-X
    ISSN 1677-7301 ; 1677-7301
    ISSN (online) 1677-7301
    ISSN 1677-7301
    DOI 10.1590/1677-5449.200131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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