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  1. Book ; Online ; E-Book: Echocardiography

    Demetrescu, Camelia / Hothi, Sandeep S. / Chambers, John / Rimington, Helen

    a practical guide for reporting and interpretation

    2024  

    Author's details Camelia Demetrescu, Sandeep S Hothi, John Chambers
    Language English
    Size 1 Online-Ressource (xviii, 250 Seiten), Illustrationen, Diagramme
    Edition Fourth edition
    Publisher CRC Press, Taylor & Francis Group
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030660808
    ISBN 978-1-000-85571-5 ; 978-1-003-24278-9 ; 9781032151601 ; 9781032151588 ; 1-000-85571-6 ; 1-003-24278-2 ; 1032151609 ; 1032151587
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Shock at the millennium II. Walter B. Cannon and Lawrence J. Henderson.

    Chambers, N K / Buchman, T G

    Shock (Augusta, Ga.)

    2000  Volume 16, Issue 4, Page(s) 278–284

    Abstract: Walter B. Cannon and Lawrence J. Henderson, students of shock in the early twentieth century, were ...

    Abstract Walter B. Cannon and Lawrence J. Henderson, students of shock in the early twentieth century, were contemporaries for four decades in the Harvard Department of Physiology. While their discoveries continue to have important clinical applications, both men established complementary methods of scientific investigation and description. Both men were inspired by Claude Bernard, hewing to his principle of the stability of the milieu intérieur. Cannon, the traditional experimentalist, employed a reductionist approach by holding constant the confounding variables of his experiments; in contrast, Henderson, the strategist of theoretical analysis, deduced patterns and relationships from less constrained models, focusing on complexity using mathematics and graphs. In delineation, Cannon described mechanisms; Henderson described the organization of systems. Cannon's emphasis on homeostasis with the identification of feedback arcs dominated shock research for the balance of the twentieth century. Henderson's perspective designating the importance of organization to those restorative mechanisms could well reemerge to dominate the twenty-first.
    MeSH term(s) History, 20th Century ; Humans ; Research/history ; Research Design ; Shock/history ; Shock/physiopathology ; Shock/therapy ; United States
    Language English
    Publishing date 2000-11-16
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/00024382-200116040-00008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3985: Show issues Location:
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  3. Book ; Online ; E-Book: CBT for managing non-cardiac chest pain

    Marks, Elizabeth / Hunter, Myra / Chambers, John

    an evidence-based guide

    2017  

    Author's details Elizabeth Marks, Myra Hunter and John Chambers
    Keywords Chest Pain / therapy ; Cognitive Therapy / methods ; Evidence-Based Medicine / methods
    Language English
    Size 1 Online-Ressource (x, 232 Seiten), Illustrationen
    Publisher Routledge, Taylor & Francis Group
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019273926
    ISBN 978-1-317-24348-9 ; 978-1-315-62925-4 ; 9781138119000 ; 9781138119017 ; 1-317-24348-X ; 1-315-62925-9 ; 1138119008 ; 1138119016
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: The positioning of ceftobiprole in the treatment of Staphylococcus aureus bacteremia.

    Minter, Daniel J / Appa, Ayesha / Chambers, Henry F / Doernberg, Sarah B

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae126
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    Zs.MO 480: Show issues

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  5. Article ; Online: Executive Summary: State-of-The-Art Review: Contemporary Management of Staphylococcus aureus Bacteremia: Controversies in Clinical Practice.

    Minter, Daniel J / Appa, Ayesha / Chambers, Henry F / Doernberg, Sarah B

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 11, Page(s) 1489–1491

    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad525
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  6. Article ; Online: Contemporary Management of Staphylococcus aureus Bacteremia-Controversies in Clinical Practice.

    Minter, Daniel J / Appa, Ayesha / Chambers, Henry F / Doernberg, Sarah B

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 11, Page(s) e57–e68

    Abstract: Staphylococcus aureus bacteremia (SAB) carries a high risk for excess morbidity and mortality. Despite its prevalence, significant practice variation continues to permeate clinical management of this syndrome. Since the publication of the 2011 Infectious ...

    Abstract Staphylococcus aureus bacteremia (SAB) carries a high risk for excess morbidity and mortality. Despite its prevalence, significant practice variation continues to permeate clinical management of this syndrome. Since the publication of the 2011 Infectious Diseases Society of America (IDSA) guidelines on management of methicillin-resistant Staphylococcus aureus infections, the field of SAB has evolved with the emergence of newer diagnostic strategies and therapeutic options. In this review, we seek to provide a comprehensive overview of the evaluation and management of SAB, with special focus on areas where the highest level of evidence is lacking to inform best practices.
    MeSH term(s) Humans ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcus aureus ; Anti-Bacterial Agents/therapeutic use ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Bacteremia/epidemiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Acute medicine

    Sprigings, David / Chambers, John

    a practical guide to the management of medical emergencies

    2008  

    Author's details David Sprigings ; John Chambers
    Keywords Emergency Treatment / methods ; Emergencies
    Language English
    Size X, 662 S. : Ill., graph. Darst.
    Edition 4. ed.
    Publisher Blackwell
    Publishing place Malden, Mass. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015905007
    ISBN 978-1-4051-2962-6 ; 1-4051-2962-X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 1693 order for loan Magazin

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  8. Article ; Online: The in silico identification of novel broad-spectrum antidotes for poisoning by organophosphate anticholinesterases.

    Habiballah, Sohaib / Chambers, Janice / Meek, Edward / Reisfeld, Brad

    Journal of computer-aided molecular design

    2023  Volume 37, Issue 12, Page(s) 755–764

    Abstract: Owing to their potential to cause serious adverse health effects, significant efforts have been made to develop antidotes for organophosphate (OP) anticholinesterases, such as nerve agents. To be optimally effective, antidotes must not only reactivate ... ...

    Abstract Owing to their potential to cause serious adverse health effects, significant efforts have been made to develop antidotes for organophosphate (OP) anticholinesterases, such as nerve agents. To be optimally effective, antidotes must not only reactivate inhibited target enzymes, but also have the ability to cross the blood-brain barrier (BBB). Progress has been made toward brain-penetrating acetylcholinesterase reactivators through the development of a new group of substituted phenoxyalkyl pyridinium oximes. To help in the selection and prioritization of compounds for future synthesis and testing within this class of chemicals, and to identify candidate broad-spectrum molecules, an in silico framework was developed to systematically generate structures and screen them for reactivation efficacy and BBB penetration potential.
    MeSH term(s) Antidotes/pharmacology ; Antidotes/chemistry ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Reactivators/pharmacology ; Cholinesterase Reactivators/chemistry ; Organophosphates ; Acetylcholinesterase/chemistry ; Oximes/chemistry
    Chemical Substances Antidotes ; Cholinesterase Inhibitors ; Cholinesterase Reactivators ; Organophosphates ; Acetylcholinesterase (EC 3.1.1.7) ; Oximes
    Language English
    Publishing date 2023-10-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 808166-9
    ISSN 1573-4951 ; 0920-654X
    ISSN (online) 1573-4951
    ISSN 0920-654X
    DOI 10.1007/s10822-023-00537-x
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    Zs.A 2625: Show issues Location:
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  9. Article: The in silico identification of novel broad-spectrum antidotes for poisoning by organophosphate anticholinesterases.

    Habiballah, Sohaib / Chambers, Janice / Meek, Edward / Reisfeld, Brad

    Research square

    2023  

    Abstract: Because of their potential to cause serious adverse health effects, significant efforts have been made to develop antidotes for organophosphate (OP) anticholinesterases, such as nerve agents. To be optimally effective, antidotes must not only reactivate ... ...

    Abstract Because of their potential to cause serious adverse health effects, significant efforts have been made to develop antidotes for organophosphate (OP) anticholinesterases, such as nerve agents. To be optimally effective, antidotes must not only reactivate inhibited target enzymes, but also have the ability to cross the blood brain barrier (BBB). Progress has been made toward brain-penetrating acetylcholinesterase reactivators through the development of a new group of substituted phenoxyalkyl pyridinium oximes. To help in the selection and prioritization of compounds for future synthesis and testing within this class of chemicals, and to identify candidate broad-spectrum molecules, an in silico framework was developed to systematically generate structures and screen them for reactivation efficacy and BBB penetration potential.
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3163943/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Wound healing complications following folded flap palatoplasty in brachycephalic dogs.

    Khoo, T-X / Yates, G / Chambers, B / Ng, J

    Australian veterinary journal

    2022  

    Abstract: Objective: To determine the incidence and characteristics of wound healing complications after folded flap palatoplasty (FFP).: Methods: Prospective study of 25 dogs that underwent FFP as a component of corrective multilevel surgery for ... ...

    Abstract Objective: To determine the incidence and characteristics of wound healing complications after folded flap palatoplasty (FFP).
    Methods: Prospective study of 25 dogs that underwent FFP as a component of corrective multilevel surgery for brachycephalic obstructive airway syndrome. Oropharyngeal re-examination was conducted after a minimum of 28 days post-operatively, unless indicated earlier by the onset of clinical signs.
    Results: Wound healing complications occurred in nine dogs (36%). Minor and major wound complications were diagnosed at a median of 36 days (1.5-51 days) post-operatively. Eight dogs had major wound complications, four of which showed no associated clinical signs. Two patterns of major wound complications were observed: incisional dehiscence (ID) with caudal retraction of the soft palate mucosa and development of a full-thickness defect (FTD) in the centre of the soft palate. Revision of the soft palate surgery was performed in five dogs, failing again in one dog with ID. Clinical signs resolved in symptomatic dogs after revision surgery to close FTD.
    Conclusion: In this study, wound healing complications were common after FFP and were not associated with significant clinical deterioration. Further research is necessary to determine the value and timing of routine post-operative oropharyngeal examination for assessment of soft palate healing after FFP as well as the indication for and success of approaches to the management of wound healing complications. The two distinct patterns of FFP failure recognised may provide insight into the underlying causes and lead to refinements in folded flap palatoplasty technique.
    Language English
    Publishing date 2022-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 41542-x
    ISSN 1751-0813 ; 0005-0423
    ISSN (online) 1751-0813
    ISSN 0005-0423
    DOI 10.1111/avj.13204
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