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  1. Article: [Preface].

    Sato, Kaoru

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2020  Volume 155, Issue 5, Page(s) 283

    Language Japanese
    Publishing date 2020-11-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj20057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: The Conventional and Breakthrough Tool for the Study of L-Glutamate Transporters.

    Takahashi, Kanako / Sato, Kaoru

    Membranes

    2024  Volume 14, Issue 4

    Abstract: In our recent report, we clarified the direct interaction between the excitatory amino acid transporter (EAAT) 1/2 and polyunsaturated fatty acids (PUFAs) by applying electrophysiological and molecular biological techniques to Xenopus oocytes. Xenopus ... ...

    Abstract In our recent report, we clarified the direct interaction between the excitatory amino acid transporter (EAAT) 1/2 and polyunsaturated fatty acids (PUFAs) by applying electrophysiological and molecular biological techniques to Xenopus oocytes. Xenopus oocytes have a long history of use in the scientific field, but they are still attractive experimental systems for neuropharmacological studies. We will therefore summarize the pharmacological significance, advantages (especially in the study of EAAT2), and experimental techniques that can be applied to Xenopus oocytes; our new findings concerning L-glutamate (L-Glu) transporters and PUFAs; and the significant outcomes of our data. The data obtained from electrophysiological and molecular biological studies of Xenopus oocytes have provided us with further important questions, such as whether or not some PUFAs can modulate EAATs as allosteric modulators and to what extent docosahexaenoic acid (DHA) affects neurotransmission and thereby affects brain functions. Xenopus oocytes have great advantages in the studies about the interactions between molecules and functional proteins, especially in the case when the expression levels of the proteins are small in cell culture systems without transfections. These are also proper to study the mechanisms underlying the interactions. Based on the data collected in Xenopus oocyte experiments, we can proceed to the next step, i.e., the physiological roles of the compounds and their significances. In the case of EAAT2, the effects on the neurotransmission should be examined by electrophysiological approach using acute brain slices. For new drug development, pharmacokinetics pharmacodynamics (PKPD) data and blood brain barrier (BBB) penetration data are also necessary. In order not to miss the promising candidate compounds at the primary stages of drug development, we should reconsider using Xenopus oocytes in the early phase of drug development.
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes14040077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: β-adrenergic receptor regulates embryonic epithelial extensibility through actomyosin inhibition.

    Mizoguchi, Yohei / Nakashima, Kaoru / Sato, Ayato / Shindo, Asako

    iScience

    2023  Volume 26, Issue 12, Page(s) 108469

    Abstract: During morphogenesis, epithelial tissues reshape and expand to cover the body and organs. The molecular mechanisms of this deformability remain elusive. Here, we investigate the role of the β-adrenergic receptor (ADRB) in orchestrating actomyosin ... ...

    Abstract During morphogenesis, epithelial tissues reshape and expand to cover the body and organs. The molecular mechanisms of this deformability remain elusive. Here, we investigate the role of the β-adrenergic receptor (ADRB) in orchestrating actomyosin contractility, pivotal for epithelial extensibility. Chemical screens on
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Experiences of Game-Based Learning and Reviewing History of the Experience Using Player's Emotions.

    Sumi, Kaoru / Sato, Shusuke

    Frontiers in artificial intelligence

    2022  Volume 5, Page(s) 874106

    Abstract: In this paper, we discuss whether the history of a learning experience, containing action and emotion information, is useful for review of the experience in game-based learning using virtual space. We developed a game-based story generation system that ... ...

    Abstract In this paper, we discuss whether the history of a learning experience, containing action and emotion information, is useful for review of the experience in game-based learning using virtual space. We developed a game-based story generation system that automatically generates scripts in real time by using a player's emotions and actions. The system has two functions: a game-based experiential learning environment and automatic story generation. The system provides the player with a virtual world and a virtual tool operated by using a hand controller and a display. The system recognizes the player's real-time emotions through facial expressions, and it outputs reactions based on these emotions and actions
    Language English
    Publishing date 2022-07-15
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2624-8212
    ISSN (online) 2624-8212
    DOI 10.3389/frai.2022.874106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Incarcerated Small Bowel Herniation in a Stoma Mimicking Sigmoid End Colostomy Prolapse.

    Abe, Kaoru / Yamai, Daisuke / Katsumi, Chihiro / Oyamatsu, Manabu / Sato, Kenji

    Case reports in gastroenterology

    2024  Volume 18, Issue 1, Page(s) 21–27

    Abstract: Introduction: A stoma prolapse is easy to diagnose by visual examination, and it rarely incarcerates. Therefore, manual reduction is usually performed as soon as the diagnosis is made. In this report, we describe a case of stoma prolapse that could not ... ...

    Abstract Introduction: A stoma prolapse is easy to diagnose by visual examination, and it rarely incarcerates. Therefore, manual reduction is usually performed as soon as the diagnosis is made. In this report, we describe a case of stoma prolapse that could not be reduced manually and ruptured because an incarcerated parastomal hernia occurred in the stoma, mimicking stoma prolapse.
    Case presentation: A 66-year-old woman underwent total hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymphadenectomy, omentectomy, resection of dissemination, and low anterior resection with formation of a sigmoid end colostomy for endometrial cancer with infiltration of the rectum. Fourteen months after the initial operation, she presented with stoma prolapse and multiple episodes of vomiting. The prolapsed stoma was 20 cm in length, appeared swollen and edematous, and was somewhat firm. Although it looked viable, some of the mucosa was darkish red, indicating congestion. Therefore, the diagnosis was sigmoid end colostomy prolapse with an ischemic component. An attempt at manual reduction resulted in rupture, so an emergency laparotomy was performed. Intraoperatively, we found that the ileum was incarcerated in the aperture created where the colostomy had been formed. When the incarcerated ileum was released, the stoma prolapse could be reduced easily. The end colostomy was refashioned in the left upper quadrant of the abdomen.
    Conclusion: An incarcerated parastomal hernia can mimic stoma prolapse. If the findings differ from those of typical stoma prolapse, imaging should be performed to confirm whether another clinical entity is involved in the stoma prolapse.
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2440540-1
    ISSN 1662-0631
    ISSN 1662-0631
    DOI 10.1159/000535988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Consideration for future in vitro BBB models - technical development to investigate the drug delivery to the CNS].

    Sato, Kaoru

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2018  Volume 152, Issue 6, Page(s) 287–294

    Abstract: Blood vessels in the central nervous system (CNS) limit the material exchange between blood and parenchyma by blood brain barrier (BBB). At present, no appropriate in vitro BBB models are available for the investigation whether or not the candidate ... ...

    Abstract Blood vessels in the central nervous system (CNS) limit the material exchange between blood and parenchyma by blood brain barrier (BBB). At present, no appropriate in vitro BBB models are available for the investigation whether or not the candidate compounds for new drugs could be delivered to the CNS. This causes huge difficulties of the development of CNS drugs and prediction of CNS adverse effects. In this review, I first outline the structures and functions of BBB, together with the parameters used for the quantification of BBB functions. I also introduce the history of in vitro BBB models used in the drug development so far, i.e., the transition from non-cell models to the models using primary culture of rodent cells, porcine, bovine, cell lines, etc. More recently, the application of human cells differentiated from human induced pluripotent stem cells and microfluidic engineering have already started. BBB is essential for the maintenance of brain homeostasis and the mechanisms of the BBB development will be clarified by reproducing functional BBB on the dish. The new in vitro models and the data may provide accurate prediction of drug delivery to the CNS and the improvement of the evaluation system for toxicity and safety, thereby leading to successful launch of new drugs on the market.
    MeSH term(s) Animals ; Blood-Brain Barrier ; Brain ; Cattle ; Central Nervous System Agents ; Drug Delivery Systems ; Humans ; Induced Pluripotent Stem Cells ; Swine
    Chemical Substances Central Nervous System Agents
    Language Japanese
    Publishing date 2018-12-05
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.152.287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Under the Covers: A Sharp Foreign Body Buried Within the Lumen.

    Kanno, Masaki / Unoura, Shingo / Tanahashi, Yota / Sato, Hisaho / Ishida, Kaoru / Noda, Hironobu / Kojika, Masahiro / Fujino, Yasuhisa / Mase, Tomohiko / Sasaki, Akira

    The American journal of gastroenterology

    2024  

    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002697
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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: β-adrenergic receptor regulates embryonic epithelial extensibility through actomyosin inhibition

    Yohei Mizoguchi / Kaoru Nakashima / Ayato Sato / Asako Shindo

    iScience, Vol 26, Iss 12, Pp 108469- (2023)

    2023  

    Abstract: Summary: During morphogenesis, epithelial tissues reshape and expand to cover the body and organs. The molecular mechanisms of this deformability remain elusive. Here, we investigate the role of the β-adrenergic receptor (ADRB) in orchestrating ... ...

    Abstract Summary: During morphogenesis, epithelial tissues reshape and expand to cover the body and organs. The molecular mechanisms of this deformability remain elusive. Here, we investigate the role of the β-adrenergic receptor (ADRB) in orchestrating actomyosin contractility, pivotal for epithelial extensibility. Chemical screens on Xenopus laevis embryos pinpointed ADRB2 as a principal regulator. ADRB2 promotes actomyosin relaxation, facilitating apical cell area expansion during body elongation. In contrast, ADRB2 knockdown results in heightened cell contraction, marked by synchronous oscillation of F-actin and myosin, impeding body elongation. ADRB2 mutants with reduced affinity for ligand binding lack the function to induce cellular relaxation, highlighting the ligand’s essential roles even in the developing epidermis. Our findings unveil ADRB2’s critical contribution to extensibility of the epidermis and subsequent body elongation during development. This study also offers insights into the physiology of mature epithelial organs deformed by the smooth muscle response to the adrenergic autonomic nervous system.
    Keywords Bioengineering ; Tissue engineering ; Science ; Q
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Stress granules sequester Alzheimer's disease-associated gene transcripts and regulate disease-related neuronal proteostasis.

    Sato, Kaoru / Takayama, Ken-Ichi / Inoue, Satoshi

    Aging

    2023  Volume 15, Issue 10, Page(s) 3984–4011

    Abstract: Environmental and physiological stresses can accelerate Alzheimer's disease (AD) pathogenesis. Under stress, a cytoplasmic membraneless structure termed a stress granule (SG) is formed and is associated with various neurodegenerative disorders, including ...

    Abstract Environmental and physiological stresses can accelerate Alzheimer's disease (AD) pathogenesis. Under stress, a cytoplasmic membraneless structure termed a stress granule (SG) is formed and is associated with various neurodegenerative disorders, including AD. SGs contain translationally arrested mRNAs, suggesting that impaired RNA metabolism in neurons causes AD progression; however, the underlying mechanism remains unclear. Here, we identified numerous mRNAs and long non-coding RNAs that are directly targeted by the SG core proteins G3BP1 and G3BP2. They redundantly target RNAs before and after stress conditions. We further identified RNAs within SGs, wherein AD-associated gene transcripts accumulated, suggesting that SGs can directly regulate AD development. Furthermore, gene-network analysis revealed a possible link between the sequestration of RNAs by SGs and the impairment of protein neurohomeostasis in AD brains. Together, our study provides a comprehensive RNA regulatory mechanism involving SGs, which could be targeted therapeutically to slow AD progression mediated by SGs.
    MeSH term(s) Humans ; Carrier Proteins/genetics ; DNA Helicases/metabolism ; Poly-ADP-Ribose Binding Proteins/genetics ; Poly-ADP-Ribose Binding Proteins/metabolism ; RNA Recognition Motif Proteins/genetics ; RNA Recognition Motif Proteins/metabolism ; RNA Helicases/genetics ; RNA Helicases/metabolism ; Proteostasis ; Alzheimer Disease/genetics ; Stress Granules ; RNA/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Stress, Physiological/genetics ; Neurons/metabolism
    Chemical Substances Carrier Proteins ; DNA Helicases (EC 3.6.4.-) ; Poly-ADP-Ribose Binding Proteins ; RNA Recognition Motif Proteins ; RNA Helicases (EC 3.6.4.13) ; RNA (63231-63-0) ; RNA, Messenger ; G3BP1 protein, human (EC 3.6.4.12)
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Expression and function of estrogen receptors and estrogen-related receptors in the brain and their association with Alzheimer's disease.

    Sato, Kaoru / Takayama, Ken-Ichi / Inoue, Satoshi

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1220150

    Abstract: While estrogens are well known for their pivotal role in the female reproductive system, they also play a crucial function in regulating physiological processes associated with learning and memory in the brain. Moreover, they have neuroprotective effects ...

    Abstract While estrogens are well known for their pivotal role in the female reproductive system, they also play a crucial function in regulating physiological processes associated with learning and memory in the brain. Moreover, they have neuroprotective effects in the pathogenesis of Alzheimer's disease (AD). Importantly, AD has a higher incidence in older and postmenopausal women than in men, and estrogen treatment might reduce the risk of AD in these women. In general, estrogens bind to and activate estrogen receptors (ERs)-mediated transcriptional machineries, and also stimulate signal transduction through membrane ERs (mERs). Estrogen-related receptors (ERRs), which share homologous sequences with ERs but lack estrogen-binding capabilities, are widely and highly expressed in the human brain and have also been implicated in AD pathogenesis. In this review, we primarily provide a summary of ER and ERR expression patterns in the human brain. In addition, we summarize recent studies on their role in learning and memory. We then review and discuss research that has elucidated the functions and importance of ERs and ERRs in AD pathogenesis, including their role in Aβ clearance and the reduction of phosphorylated tau levels. Elucidation of the mechanisms underlying ER- and ERR-mediated transcriptional machineries and their functions in healthy and diseased brains would provide new perspectives for the diagnosis and treatment of AD. Furthermore, exploring the potential role of estrogens and their receptors, ERs, in AD will facilitate a better understanding of the sex differences observed in AD, and lead to novel sex-specific therapeutic approaches.
    MeSH term(s) Female ; Humans ; Male ; Aged ; Receptors, Estrogen/metabolism ; Alzheimer Disease/genetics ; Alzheimer Disease/drug therapy ; Estrogens/metabolism ; Brain/metabolism ; Neuroprotective Agents/therapeutic use
    Chemical Substances Receptors, Estrogen ; Estrogens ; Neuroprotective Agents
    Language English
    Publishing date 2023-07-04
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1220150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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