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  1. Article: Neuromorphic-P

    Kaiser, Md Abdullah-Al / Datta, Gourav / Wang, Zixu / Jacob, Ajey P / Beerel, Peter A / Jaiswal, Akhilesh R

    Frontiers in neuroinformatics

    2023  Volume 17, Page(s) 1144301

    Abstract: Edge devices equipped with computer vision must deal with vast amounts of sensory data with limited computing resources. Hence, researchers have been exploring different energy-efficient solutions such as near-sensor, in-sensor, and in-pixel processing, ... ...

    Abstract Edge devices equipped with computer vision must deal with vast amounts of sensory data with limited computing resources. Hence, researchers have been exploring different energy-efficient solutions such as near-sensor, in-sensor, and in-pixel processing, bringing the computation closer to the sensor. In particular, in-pixel processing embeds the computation capabilities inside the pixel array and achieves high energy efficiency by generating low-level features instead of the raw data stream from CMOS image sensors. Many different in-pixel processing techniques and approaches have been demonstrated on conventional frame-based CMOS imagers; however, the processing-in-pixel approach for neuromorphic vision sensors has not been explored so far. In this work, for the first time, we propose an asynchronous non-von-Neumann analog processing-in-pixel paradigm to perform convolution operations by integrating
    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452979-5
    ISSN 1662-5196
    ISSN 1662-5196
    DOI 10.3389/fninf.2023.1144301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: P. aeruginosa

    Marogi, Jacob G / Murphy, Coleen T / Myhrvold, Cameron / Gitai, Zemer

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Detecting chemical signals is important for identifying food sources and avoiding harmful agents. Like most animals, ...

    Abstract Detecting chemical signals is important for identifying food sources and avoiding harmful agents. Like most animals,
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.29.569279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: PI(4,5)P

    Mahoney, Jacob P / Bruguera, Elise S / Vasishtha, Mansi / Killingsworth, Lauren B / Kyaw, Saw / Weis, William I

    Science signaling

    2022  Volume 15, Issue 748, Page(s) eabo2820

    Abstract: ... P ...

    Abstract In the Wnt-β-catenin pathway, Wnt binding to Frizzled (Fzd) and LRP5 or LRP6 (LRP5/6) co-receptors inhibits the degradation of the transcriptional coactivator β-catenin by recruiting the cytosolic effector Dishevelled (Dvl). Polymerization of Dvl at the plasma membrane recruits the β-catenin destruction complex, enabling the phosphorylation of LRP5/6, a key step in inhibiting β-catenin degradation. Using purified Fzd proteins reconstituted in lipid nanodiscs, we investigated the factors that promote the recruitment of Dvl to the plasma membrane. We found that the affinity of Fzd for Dvl was not affected by Wnt ligands, in contrast to other members of the GPCR superfamily for which the binding of extracellular ligands affects the affinity for downstream transducers. Instead, Fzd-Dvl binding was enhanced by increased concentration of the lipid PI(4,5)P
    MeSH term(s) Dishevelled Proteins/genetics ; Dishevelled Proteins/metabolism ; Feedback ; Lipids ; Low Density Lipoprotein Receptor-Related Protein-6/genetics ; Low Density Lipoprotein Receptor-Related Protein-6/metabolism ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Wnt Signaling Pathway ; beta Catenin/genetics ; beta Catenin/metabolism
    Chemical Substances Dishevelled Proteins ; Lipids ; Low Density Lipoprotein Receptor-Related Protein-6 ; Phosphoproteins ; Wnt Proteins ; beta Catenin
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.abo2820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Schwarz P-surface via isolated sp

    Ignatchenko, Alexey V / Willower, Jacob P

    Journal of computational chemistry

    2022  Volume 44, Issue 9, Page(s) 954–961

    Abstract: Described are the first two molecular designs of the triply periodic Schwarz P surface using merely ...

    Abstract Described are the first two molecular designs of the triply periodic Schwarz P surface using merely the Schläfli t{3,7} pattern of sp
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1479181-X
    ISSN 1096-987X ; 0192-8651
    ISSN (online) 1096-987X
    ISSN 0192-8651
    DOI 10.1002/jcc.27055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mechanism behind Polysorbates' Inhibitory Effect on P-Glycoprotein.

    Moesgaard, Laust / Reinholdt, Peter / Nielsen, Carsten Uhd / Kongsted, Jacob

    Molecular pharmaceutics

    2022  Volume 19, Issue 7, Page(s) 2248–2253

    Abstract: Much effort has been invested in the search for modulators of membrane transport proteins such as P ... glycoprotein (P-gp) to improve drug bioavailability and reverse multidrug resistance in cancer ... on the molecular level and thereby discover the molecular mechanism of the P-gp inhibition. We show ...

    Abstract Much effort has been invested in the search for modulators of membrane transport proteins such as P-glycoprotein (P-gp) to improve drug bioavailability and reverse multidrug resistance in cancer. Nonionic surfactants, a class of pharmaceutical excipients, are known to inhibit such proteins, but knowledge about the exact mechanism of this inhibition is scarce. Here, we perform multiscale molecular dynamics simulations of one of these surfactants, polysorbate 20 (PS20), to reveal the behavior of such compounds on the molecular level and thereby discover the molecular mechanism of the P-gp inhibition. We show that the amphiphilic headgroup of PS20 is too hydrophobic to partition in the water phase, which drives the binding of PS20 to the amphiphilic drug-binding domain of P-gp and thereby causes the inhibition of the protein. Based on our findings, we conclude that PS20 primarily inhibits P-gp through direct binding to the drug-binding domain (DBD) from the extracellular leaflet.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Excipients/chemistry ; Polysorbates/chemistry ; Surface-Active Agents/chemistry
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Excipients ; Polysorbates ; Surface-Active Agents
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.2c00074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pten, PI3K, and PtdIns(3,4,5)P

    Malin, Jacob / Rosa-Birriel, Christian / Hatini, Victor

    Developmental cell

    2024  

    Abstract: ... of apical contacts between the cells that form its hexagonal lattice. Phosphoinositide PI(3,4,5)P ...

    Abstract Epithelial remodeling of the Drosophila retina depends on the pulsatile contraction and expansion of apical contacts between the cells that form its hexagonal lattice. Phosphoinositide PI(3,4,5)P
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2024.03.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Protonation of P-Stereogenic Phosphiranes: Phospholane Formation via Ring Opening and C-H Activation.

    Tipker, Ryan M / Muldoon, Jake A / Jo, Jacob / Connors, Christopher S / Varga, Balazs R / Hughes, Russell P / Glueck, David S

    ACS omega

    2023  Volume 8, Issue 13, Page(s) 12565–12572

    Abstract: Protonation of cyclopropanes and aziridines is well-studied, but reactions of phosphiranes with acids are rare and have not been reported to result in ring opening. Treatment ... ...

    Abstract Protonation of cyclopropanes and aziridines is well-studied, but reactions of phosphiranes with acids are rare and have not been reported to result in ring opening. Treatment of
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dose dependence of Phasmarhabditis isolates (P. hermaphrodita, P. californica, P. papillosa) on the mortality of adult invasive white garden snails (Theba pisana).

    Schurkman, Jacob / De Ley, Irma Tandingan / Dillman, Adler R

    PloS one

    2022  Volume 17, Issue 7, Page(s) e0270185

    Abstract: ... of Phasmarhabditis species (P. californica, P. papillosa, and P. hermaphrodita) effectively killed juvenile (0.25 ... further showed that the most virulent P. californica did not effectively kill T. pisana at lower doses ...

    Abstract Theba pisana is an invasive snail pest which has established itself in San Diego County and some areas of Los Angeles County, California. The snail has grown to large populations in some areas and mitigation is becoming necessary to stop the spread of the species. In a previous study, three US strains of Phasmarhabditis species (P. californica, P. papillosa, and P. hermaphrodita) effectively killed juvenile (0.25 gram each, 4-6 mm wide) T. pisana in laboratory conditions at 5 times (150 IJs/cm2) the recommended dose. Based on laboratory assays, we demonstrated that the same three US strains of Phasmarhabditis can effectively kill larger adult T. pisana (0.4-1.2 gram, 11.5-15mm wide) in two weeks at the same dose. The strains were more efficient at killing T. pisana than the compared molluscicide Sluggo Plus®. Results further showed that the most virulent P. californica did not effectively kill T. pisana at lower doses of 30 IJs/cm2 and 90 IJs/cm2. Additional research is needed to develop the most efficient means of application of Phasmarhabditis to mitigate T. pisana in the field.
    MeSH term(s) Animals ; Rhabditoidea ; Snails
    Language English
    Publishing date 2022-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0270185
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  9. Article: Pten, Pi3K and PtdIns(3,4,5)P

    Malin, Jacob / Rosa Birriel, Christian / Hatini, Victor

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... of apical contacts between the cells that form its hexagonal lattice. Phosphoinositide PI(3,4,5)P ...

    Abstract Epithelial remodeling of the Drosophila retina depends on the pulsatile contraction and expansion of apical contacts between the cells that form its hexagonal lattice. Phosphoinositide PI(3,4,5)P
    Language English
    Publishing date 2023-04-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.17.533017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Essential role of P-glycoprotein in the mechanism of action of oliceridine.

    Ventriglia, Emilya / Rizzo, Arianna / Gomez, Juan L / Friedman, Jacob / Lam, Sherry / Solís, Oscar / Rais, Rana / Bonaventura, Jordi / Michaelides, Michael

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2022  Volume 48, Issue 5, Page(s) 831–842

    Abstract: Mu opioid receptor (MOR) agonists comprise the most effective analgesics, but their therapeutic utility is limited by adverse effects. One approach for limiting such effects has been to develop "biased" MOR agonists that show preference for activating G ... ...

    Abstract Mu opioid receptor (MOR) agonists comprise the most effective analgesics, but their therapeutic utility is limited by adverse effects. One approach for limiting such effects has been to develop "biased" MOR agonists that show preference for activating G protein over β-Arrestin signaling. However, the notion of biased agonism has been challenged by recent studies. Oliceridine (Olinvyk
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Analgesics, Opioid/therapeutic use ; GTP-Binding Proteins ; ATP Binding Cassette Transporter, Subfamily B ; beta-Arrestins ; Receptors, Opioid, mu/agonists
    Chemical Substances ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Analgesics, Opioid ; GTP-Binding Proteins (EC 3.6.1.-) ; ATP Binding Cassette Transporter, Subfamily B ; beta-Arrestins ; Receptors, Opioid, mu
    Language English
    Publishing date 2022-11-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-022-01507-x
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