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  1. Article ; Online: Clap if you believe in Batman The Dark Knight Christopher Nolan (director).

    Dreyer, Randolph

    Perspectives in psychiatric care

    2009  Volume 45, Issue 1, Page(s) 80–81

    MeSH term(s) Antisocial Personality Disorder/nursing ; Antisocial Personality Disorder/psychology ; Attitude ; Grief ; Humans ; Motion Pictures ; Nurse Practitioners ; Nurse's Role ; Psychiatric Nursing ; Suicide/psychology
    Language English
    Publishing date 2009-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391097-0
    ISSN 1744-6163 ; 0031-5990
    ISSN (online) 1744-6163
    ISSN 0031-5990
    DOI 10.1111/j.1744-6163.2009.00206.x
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  2. Article: Composite neurocognitive endpoints in Alzheimer's disease clinical trials: A commentary.

    Randolph, Christopher

    Alzheimer's & dementia (Amsterdam, Netherlands)

    2020  Volume 12, Issue 1, Page(s) e12010

    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832898-X
    ISSN 2352-8729
    ISSN 2352-8729
    DOI 10.1002/dad2.12010
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  3. Article ; Online: Remember the null hypothesis?

    Randolph, Christopher

    Journal of neurology, neurosurgery, and psychiatry

    2020  Volume 91, Issue 6, Page(s) 571

    MeSH term(s) Brain Concussion ; Chronic Traumatic Encephalopathy ; Dementia ; Humans ; Mental Recall
    Language English
    Publishing date 2020-04-24
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2019-322310
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  4. Article ; Online: The Utility of Episodic Memory Cut-Off Scores for Inclusion in Clinical Trials for Early Symptomatic Alzheimer Disease.

    Randolph, Christopher

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    2019  Volume 27, Issue 12, Page(s) 1428–1432

    Abstract: Correctly diagnosing early symptomatic Alzheimer disease in the context of multinational clinical trials poses a significant challenge. Subjective complaints of memory are fairly ubiquitous in an older population, and establishing the presence of ... ...

    Abstract Correctly diagnosing early symptomatic Alzheimer disease in the context of multinational clinical trials poses a significant challenge. Subjective complaints of memory are fairly ubiquitous in an older population, and establishing the presence of definitive cognitive decline from clinical assessments is difficult. Most such trials have adopted the use of standardized episodic memory measures as an inclusion criterion, typically setting the cutoff at one standard deviation below age normal means. This is useful in terms of establishing the presence of an objective impairment of memory, thereby excluding subjects with purely subjective complaints and increasing the probability that clinical outcome measures will be sensitive to disease progression. Further demographic adjustments are unnecessary as other demographic variables are not strongly associated with memory performance, are difficult to equate across cultures, and will not eventuate in reduced screen fail rates and would be challenging to implement. Not all episodic memory measures are equivalent for this purpose, however, and existing data suggest significant variability in terms of specificity for identifying true (i.e., amyloid positive) early symptomatic AD.
    MeSH term(s) Alzheimer Disease ; Cognition ; Cognitive Dysfunction ; Humans ; Memory, Episodic ; Neuropsychological Tests
    Language English
    Publishing date 2019-08-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1016/j.jagp.2019.08.012
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  5. Article ; Online: An Exploratory Study of the Mpox Media Consumption, Attitudes, and Preferences of Sexual and Gender Minority People Assigned Male at Birth in the United States.

    Owens, Christopher / Hubach, Randolph D

    LGBT health

    2023  Volume 10, Issue 5, Page(s) 401–407

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Infant, Newborn ; Humans ; Male ; United States ; Sexual and Gender Minorities ; Homosexuality, Male ; Cross-Sectional Studies ; Mpox (monkeypox) ; Sexual Behavior ; Gender Identity ; Attitude
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2727303-9
    ISSN 2325-8306 ; 2325-8292
    ISSN (online) 2325-8306
    ISSN 2325-8292
    DOI 10.1089/lgbt.2022.0251
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  6. Article ; Online: Chronic traumatic encephalopathy is not a real disease.

    Randolph, Christopher

    Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

    2018  Volume 33, Issue 5, Page(s) 644–648

    Abstract: There was a long-lasting debate during the first half of the 1900s about whether boxers suffered from a condition called "dementia pugilistica". This included arguments as to whether there was such a distinct clinical condition, whether it was static or ... ...

    Abstract There was a long-lasting debate during the first half of the 1900s about whether boxers suffered from a condition called "dementia pugilistica". This included arguments as to whether there was such a distinct clinical condition, whether it was static or progressive, and whether boxers were actually at any increased risk of any neurological issues at all. The debate was never resolved, but was resuscitated in 2005 with the speculation that a similar condition, dubbed "chronic traumatic encephalopathy (CTE)" existed in retired National Football League (NFL) players. A specific pattern of p-tau deposition has been identified in the brains of NFL retirees, and also identifiable in the brains of at least a percentage of individuals exposed to contact sports in general. Advocates of CTE as a disease describe it as presenting with behavioral disturbance, increased suicidality and neurodegeneration leading to dementia. The evidence to date, however, does not rise to the level of a verifiable disease, and remains at the level of case report. To assume that CTE pathology represents a neurodegenerative disease flies in the face of a number of facts, including that traumatic brain injury does not cause neurodegeneration, protein deposits in the brain are a poor predictor of behavioral symptoms, p-tau is not necessarily toxic or self-propagating, and retired NFL players are actually much physically and mentally healthier than men of their demographic background. They have an all-cause mortality rate that is 50% of that expected, and a suicide rate that is 40% of that expected. The most parsimonious explanation of the evidence to date is that repetitive head trauma may result in p-tau deposition, but that this isoform of p-tau is inert and has no toxic or self-propagating effects.
    MeSH term(s) Boxing ; Brain Injuries ; Chronic Traumatic Encephalopathy/complications ; Chronic Traumatic Encephalopathy/pathology ; Chronic Traumatic Encephalopathy/psychology ; Football ; Humans ; Neurodegenerative Diseases/etiology ; Neuropsychological Tests
    Language English
    Publishing date 2018-08-31
    Publishing country United States
    Document type Editorial
    ZDB-ID 632972-x
    ISSN 1873-5843 ; 0887-6177
    ISSN (online) 1873-5843
    ISSN 0887-6177
    DOI 10.1093/arclin/acy063
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    Zs.B 2993: Show issues Location:
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  7. Article ; Online: Rural‐urban differences in monkeypox behaviors and attitudes among men who have sex with men in the United States

    Owens, Christopher / Hubach, Randolph D.

    The Journal of Rural Health. 2023 Mar., v. 39, no. 2 p.508-515

    2023  

    Abstract: PURPOSE: An outbreak of the monkeypox virus has been documented in the United States with most cases occurring among gay, bisexual, and other men who have sex with men (MSM). As monkeypox cases increase among relatively rural states, current public ... ...

    Abstract PURPOSE: An outbreak of the monkeypox virus has been documented in the United States with most cases occurring among gay, bisexual, and other men who have sex with men (MSM). As monkeypox cases increase among relatively rural states, current public health messaging may not resonate with rural at‐risk populations. Given this, there is a need to assess potential rural‐urban differences in monkeypox behaviors and attitudes among MSM. METHODS: A total of 582 eligible MSM completed an online cross‐sectional survey between August 6 and 15, 2022. Participants answered questions about their demographics, sexual behaviors, monkeypox testing and vaccination behaviors, monkeypox media consumption and attitudes, and their intention and attitudes found in the Health Belief Model of getting the monkeypox vaccine. Rural‐urban differences in behaviors and attitudes were assessed with a chi‐square test of independence. Differences in intention to get vaccinated and Health Belief Model factors were assessed with a Mann‐Whitney U test. FINDINGS: Rural MSM, in comparison to their urban counterparts, were found to be less likely to report modifying their behaviors to decrease monkeypox exposure, being susceptible to monkeypox, or perceiving severe consequences acquiring monkeypox. Similarly, rural MSM had a lower intention to get vaccinated for monkeypox. CONCLUSIONS: As vaccination uptake among rural populations for vaccine‐preventable diseases remains suboptimal, results from this novel study can inform the development of monkeypox prevention, testing, and vaccination messaging campaigns geared toward rural MSM and other at‐risk populations. It will be important to ensure that monkeypox prevention, testing, and vaccination interventions are available and accessible in rural areas.
    Keywords Monkeypox virus ; chi-square distribution ; cross-sectional studies ; demographic statistics ; health beliefs ; models ; rural health ; vaccination ; vaccines
    Language English
    Dates of publication 2023-03
    Size p. 508-515.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 639160-6
    ISSN 0890-765X
    ISSN 0890-765X
    DOI 10.1111/jrh.12726
    Database NAL-Catalogue (AGRICOLA)

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    Zs.B 3102: Show issues Location:
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  8. Article ; Online: Findings on the Monkeypox Exposure Mitigation Strategies Employed by Men Who Have Sex with Men and Transgender Women in the United States.

    Hubach, Randolph D / Owens, Christopher

    Archives of sexual behavior

    2022  Volume 51, Issue 8, Page(s) 3653–3658

    MeSH term(s) Male ; United States ; Female ; Humans ; Homosexuality, Male ; Transgender Persons ; Mpox (monkeypox) ; Sexual and Gender Minorities ; Transsexualism ; HIV Infections
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Letter
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-022-02423-3
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    Zs.A 1106: Show issues Location:
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  9. Article ; Online: Features in Backgrounds of Microscopy Images Introduce Biases in Machine Learning Analyses.

    Greenblott, David N / Johann, Florian / Snell, Jared R / Gieseler, Henning / Calderon, Christopher P / Randolph, Theodore W

    Journal of pharmaceutical sciences

    2024  

    Abstract: Subvisible particles may be encountered throughout the processing of therapeutic protein formulations. Flow imaging microscopy (FIM) and backgrounded membrane imaging (BMI) are techniques commonly used to record digital images of these particles, which ... ...

    Abstract Subvisible particles may be encountered throughout the processing of therapeutic protein formulations. Flow imaging microscopy (FIM) and backgrounded membrane imaging (BMI) are techniques commonly used to record digital images of these particles, which may be analyzed to provide particle size distributions, concentrations, and identities. Although both techniques record digital images of particles within a sample, FIM analyzes particles suspended in flowing liquids, whereas BMI records images of dry particles after collection by filtration onto a membrane. This study compared the performance of convolutional neural networks (CNNs) in classifying images of subvisible particles recorded by both imaging techniques. Initially, CNNs trained on BMI images appeared to provide higher classification accuracies than those trained on FIM images. However, attribution analyses showed that classification predictions from CNNs trained on BMI images relied on features contributed by the membrane background, whereas predictions from CNNs trained on FIM features were based largely on features of the particles. Segmenting images to minimize the contributions from image backgrounds reduced the apparent accuracy of CNNs trained on BMI images but caused minimal reduction in the accuracy of CNNs trained on FIM images. Thus, the seemingly superior classification accuracy of CNNs trained on BMI images compared to FIM images was an artifact caused by subtle features in the backgrounds of BMI images. Our findings emphasize the importance of examining machine learning algorithms for image analysis with attribution methods to ensure the robustness of trained models and to mitigate potential influence of artifacts within training data sets.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2024.03.003
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  10. Article ; Online: Seasonality of asthma: a retrospective population study.

    Randolph, Christopher

    Pediatrics

    2014  Volume 134 Suppl 3, Page(s) S165–6

    Language English
    Publishing date 2014-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2014-1817DDD
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