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  1. Article: Muscle-Specific Pyruvate Kinase Isoforms, Pkm1 and Pkm2, Regulate Mammalian SWI/SNF Proteins and Histone 3 Phosphorylation During Myoblast Differentiation.

    Olea-Flores, Monserrat / Sharma, Tapan / Verdejo-Torres, Odette / DiBartolomeo, Imaru / Thompson, Paul R / Padilla-Benavides, Teresita / Imbalzano, Anthony N

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Pyruvate kinase is a glycolytic enzyme that converts phosphoenolpyruvate and ADP into pyruvate and ATP. There are two genes that encode pyruvate kinase in vertebrates; ...

    Abstract Pyruvate kinase is a glycolytic enzyme that converts phosphoenolpyruvate and ADP into pyruvate and ATP. There are two genes that encode pyruvate kinase in vertebrates;
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.10.588959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Stimulation of Pro-inflammatory Cytokines in Mixed Cultures of Peripheral Blood Mononuclear Cells and Anaerobic Bacteria.

    Torres, Anthony R / Morris, Shayne / Benson, Michael / Wilkinson, Craig / Lyon, Rachael

    Cureus

    2023  Volume 15, Issue 12, Page(s) e50586

    Abstract: In the last couple of decades, much progress has been made in studying bacteria living in humans. However, there is much more to learn about bacteria immune cell interactions. Here, we show that anaerobic bacteria do not grow when cultured overnight with ...

    Abstract In the last couple of decades, much progress has been made in studying bacteria living in humans. However, there is much more to learn about bacteria immune cell interactions. Here, we show that anaerobic bacteria do not grow when cultured overnight with human cells under atmospheric air. Air contains about 18% oxygen, which inhibits the growth of these bacteria while supporting the cultivation of human cells. The bacteria cultured with human peripheral blood mononuclear cells (PBMCs) inflamed with phytohemagglutinin (PHA) greatly increased the production of proinflammatory cytokines like tumor necrosis factor-alpha (TNFα) while inhibiting the production of monocyte chemoattractant protein-1 (MCP-1), an important chemokine.
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.50586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Levetiracetam induced rhabdomyolysis

    Anthony C. Torres / Madan R. Joshi / W. P. Vernon Chan

    Cogent Medicine, Vol 8, Iss

    2021  Volume 1

    Abstract: Abstract: Thirty-three-year-old Caucasian male underwent initiation of levetiracetam following witnessed generalized seizure activity at the same time presenting with a right MCA territory ischemic stroke. He then developed elevated CPK and myalgias are ... ...

    Abstract Abstract: Thirty-three-year-old Caucasian male underwent initiation of levetiracetam following witnessed generalized seizure activity at the same time presenting with a right MCA territory ischemic stroke. He then developed elevated CPK and myalgias are highly suspicious for rhabdomyolysis following levetiracetam. Subsequent improvement noted following complete cessation of medication. At follow-up patient reported complete resolution of hemiparesis and myalgias and no new neurological deficits while tolerating valproic acid. This case exemplifies potential rare adverse effect of levetiracetam. Levetiracetam is an antiepileptic medication effective for both generalized and focal types of epilepsy by affecting a broad spectrum of neurotransmitter release via calcium channels GABA receptors and synaptic vessel protein 2A (SV2A). Typical adverse effects include mild dizziness, headache, nausea, somnolence and sometimes hostility. This case provides further evidence of a rare and potentially life-threatening adverse effect of rhabdomyolysis. Further study is needed to possibly detect the exact mechanism resulting in this rare and dangerous adverse effect.
    Keywords levetiracetam induced rhabdomyolysis ; Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: Hydrogen reactions with dopants and impurities in solar silicon from first principles

    Coutinho, José / Gomes, Diana / Torres, Vitor J. B. / Fattah, Tarek O. Abdul / Markevich, Vladimir P. / Peaker, Anthony R.

    2024  

    Abstract: We present a theoretical account of some of the most likely hydrogen-related reactions with impurities in n-type and p-type solar-grade silicon. These include reactions with dopants and carbon, which are relevant in the context of life-time degradation ... ...

    Abstract We present a theoretical account of some of the most likely hydrogen-related reactions with impurities in n-type and p-type solar-grade silicon. These include reactions with dopants and carbon, which are relevant in the context of life-time degradation of silicon solar cells, most notably of light and elevated temperature degradation (LeTID) of the cells. Among the problems addressed, we highlight a comparative study of acceptor-enhanced dissociation of hydrogen molecules in B- and Ga-doped material, their subsequent reaction steps toward formation of acceptor-hydrogen pairs, the proposal of mechanisms which explain the observed kinetics of photo-/carrier-induced dissociation of PH and CH pairs in n-type Si, analysis of reactions involving direct interactions between molecules with P and C, and the assignment of several electron and hole traps with detailed atomistic- and wavefunction-resolved models.
    Keywords Condensed Matter - Materials Science
    Subject code 540
    Publishing date 2024-02-01
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Spatially-resolved transcriptomics of human dentate gyrus across postnatal lifespan reveals heterogeneity in markers for proliferation, extracellular matrix, and neuroinflammation.

    Ramnauth, Anthony D / Tippani, Madhavi / Divecha, Heena R / Papariello, Alexis R / Miller, Ryan A / Pattie, Elizabeth A / Kleinman, Joel E / Maynard, Kristen R / Collado-Torres, Leonardo / Hyde, Thomas M / Martinowich, Keri / Hicks, Stephanie C / Page, Stephanie C

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The dentate gyrus of the anterior hippocampus is important for many human cognitive functions, including regulation of learning, memory, and mood. However, the postnatal development and aging of the dentate gyrus throughout the human lifespan has yet to ... ...

    Abstract The dentate gyrus of the anterior hippocampus is important for many human cognitive functions, including regulation of learning, memory, and mood. However, the postnatal development and aging of the dentate gyrus throughout the human lifespan has yet to be fully characterized in the same molecular and spatial detail as other species. Here, we generated a spatially-resolved molecular atlas of the dentate gyrus in postmortem human tissue using the 10x Genomics Visium platform to retain extranuclear transcripts and identify changes in molecular topography across the postnatal lifespan. We found enriched expression of extracellular matrix markers during infancy and increased expression of GABAergic cell-type markers
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.20.567883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Risk Behaviours Associated with Dating and Relationship Violence among 11-16 Year Olds in Wales: Results from the 2019 Student Health and Wellbeing Survey.

    Couturiaux, Danielle V R / Young, Honor / Anthony, Rebecca E / Page, Nicholas / Lowthian, Emily / Melendez-Torres, G J / Hewitt, Gillian / Moore, Graham F

    International journal of environmental research and public health

    2021  Volume 18, Issue 3

    Abstract: 1) Background: This study examines the associations between risk behaviours and adolescent emotional and physical dating and relationship violence (DRV) victimisation and perpetration, and how these vary by gender. The risk behaviours explored include ... ...

    Abstract (1) Background: This study examines the associations between risk behaviours and adolescent emotional and physical dating and relationship violence (DRV) victimisation and perpetration, and how these vary by gender. The risk behaviours explored include bullying, cyberbullying, sexting, alcohol, and cannabis use; (2) Methods: Cross-sectional self-report data from the School Health Research Network (SHRN) 2019 Student Health Wellbeing (SHW) survey of 48,397 students aged 11-16 from 149 schools across Wales were analysed using single and multiple-behaviour logistic regression models to explore the associations between each risk behaviour and emotional and physical DRV victimisation and perpetration; (3) Results: Bivariate analyses revealed a statistically significant association between DRV and all risk behaviours. In multivariate analyses, students who reported bullying, cyberbullying, sexting, and substance use, compared to those that had not, had significantly higher odds of experiencing and perpetrating emotional and physical DRV; and (4) Conclusions: Future studies on DRV should consider a mixed-methods approach to explore the context in which DRV and risk behaviours interrelate. Results from this study indicate the possibility that prevention and intervention programmes in school settings that seek to develop healthy school environments and peer-to-peer relationships, could inadvertently reduce the occurrence of future DRV and associated risk behaviours.
    MeSH term(s) Adolescent ; Adolescent Behavior ; Bullying ; Child ; Crime Victims ; Cross-Sectional Studies ; Humans ; Risk-Taking ; Schools ; Students ; Violence ; Wales/epidemiology
    Language English
    Publishing date 2021-01-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18031192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Impact of Mode of Delivery on Maternal and Neonatal Outcomes during Periviable Birth (22-25 Weeks).

    Roeckner, Jared T / Peterson, Erica / Rizzo, Jennifer / Flores-Torres, Jaime / Odibo, Anthony O / Duncan, Jose R

    American journal of perinatology

    2022  Volume 39, Issue 12, Page(s) 1269–1278

    Abstract: Objective: The objective of our study was to compare the maternal and neonatal complications of periviable birth by the delivery route.: Study design: A retrospective cohort study of periviable deliveries (22: Results: After exclusion, 230 ... ...

    Abstract Objective: The objective of our study was to compare the maternal and neonatal complications of periviable birth by the delivery route.
    Study design: A retrospective cohort study of periviable deliveries (22
    Results: After exclusion, 230 deliveries were included in the cohort. Maternal characteristics were similar between cohorts. For the primary outcome, cesarean delivery was associated with a trend toward increased maternal morbidity (22.6 vs. 10.7%, RR = 2.11 [1.03-4.43], aRR = 1.95 [0.94-4.03],
    Conclusion: Periviable birth has a high rate of maternal morbidity with a trend toward the highest risk among women undergoing cesarean delivery. These risks should be included in shared decision-making.
    Key points: · Periviable birth has high maternal morbidity (19%) and is highest after cesarean delivery (23%).. · Route of delivery does not impact neonatal survival or intact neonatal survival.. · Head entrapment is rare during vaginal breech delivery..
    MeSH term(s) Bronchopulmonary Dysplasia/epidemiology ; Delivery, Obstetric ; Ductus Arteriosus, Patent ; Enterocolitis, Necrotizing/epidemiology ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Resuscitation ; Retinopathy of Prematurity ; Retrospective Studies
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/a-1788-5802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Site-tropism of streptococci in the oral microbiome.

    McLean, Anthony R / Torres-Morales, Julian / Dewhirst, Floyd E / Borisy, Gary G / Mark Welch, Jessica L

    Molecular oral microbiology

    2022  Volume 37, Issue 6, Page(s) 229–243

    Abstract: A detailed understanding of where bacteria localize is necessary to advance microbial ecology and microbiome-based therapeutics. The site-specialist hypothesis predicts that most microbes in the human oral cavity have a primary habitat type within the ... ...

    Abstract A detailed understanding of where bacteria localize is necessary to advance microbial ecology and microbiome-based therapeutics. The site-specialist hypothesis predicts that most microbes in the human oral cavity have a primary habitat type within the mouth where they are most abundant. We asked whether this hypothesis accurately describes the distribution of the members of the genus Streptococcus, a clinically relevant taxon that dominates most oral sites. Prior analysis of 16S rRNA gene sequencing data indicated that some oral Streptococcus clades are site-specialists while others may be generalists. However, within complex microbial populations composed of numerous closely related species and strains, such as the oral streptococci, genome-scale analysis is necessary to provide the resolution to discriminate closely related taxa with distinct functional roles. Here, we assess whether individual species within this genus are specialists using publicly available genomic sequence data that provide species-level resolution. We chose a set of high-quality representative genomes for human oral Streptococcus species. Onto these genomes, we mapped shotgun metagenomic sequencing reads from supragingival plaque, tongue dorsum, and other sites in the oral cavity. We found that every abundant Streptococcus species in the healthy human oral cavity showed strong site-tropism and that even closely related species such as S. mitis, S. oralis, and S. infantis specialized in different sites. These findings indicate that closely related bacteria can have distinct habitat distributions in the absence of dispersal limitation and under similar environmental conditions and immune regimes. Substantial overlap between the core genes of these three species suggests that site-specialization is determined by subtle differences in genomic content.
    MeSH term(s) Humans ; RNA, Ribosomal, 16S/genetics ; Streptococcus/genetics ; Microbiota/genetics ; Metagenome ; Bacteria/genetics ; Mouth/microbiology ; Tropism ; Phylogeny
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-10-11
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2537726-7
    ISSN 2041-1014 ; 2041-1006
    ISSN (online) 2041-1014
    ISSN 2041-1006
    DOI 10.1111/omi.12387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2199: Show issues Location:
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  9. Article ; Online: Negligible risk of rabies importation in dogs thirty days after demonstration of adequate serum antibody titer.

    Smith, Todd G / Fooks, Anthony R / Moore, Susan M / Freuling, Conrad M / Müller, Thomas / Torres, Gregorio / Wallace, Ryan M

    Vaccine

    2021  Volume 39, Issue 18, Page(s) 2496–2499

    MeSH term(s) Animals ; Antibodies, Viral ; Dog Diseases ; Dogs ; Immunologic Tests ; Rabies/prevention & control ; Rabies/veterinary ; Rabies Vaccines ; Vaccination
    Chemical Substances Antibodies, Viral ; Rabies Vaccines
    Language English
    Publishing date 2021-04-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.03.064
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    Zs.MO 458: Show issues

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  10. Article: Quorum-sensing

    Podkowik, Magdalena / Perault, Andrew I / Putzel, Gregory / Pountain, Andrew / Kim, Jisun / Dumont, Ashley / Zwack, Erin / Ulrich, Robert J / Karagounis, Theodora K / Zhou, Chunyi / Haag, Andreas F / Shenderovich, Julia / Wasserman, Gregory A / Kwon, Junbeom / Chen, John / Richardson, Anthony R / Weiser, Jeffrey N / Nowosad, Carla R / Lun, Desmond S /
    Parker, Dane / Pironti, Alejandro / Zhao, Xilin / Drlica, Karl / Yanai, Itai / Torres, Victor J / Shopsin, Bo

    bioRxiv : the preprint server for biology

    2024  

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.08.544038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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