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Article ; Online: Intestinal bacteria associated with irritable bowel syndrome and chronic fatigue.

El-Salhy, Magdy

2023 Volume 35, Issue 9, Page(s) e14621

Abstract: The etiology of irritable bowel syndrome (IBS) is unknown. Abnormal intestinal bacterial profiles and low bacterial diversity appear to play important roles in the pathophysiology of IBS. This narrative review was designed to present recent observations ... ...

Abstract	The etiology of irritable bowel syndrome (IBS) is unknown. Abnormal intestinal bacterial profiles and low bacterial diversity appear to play important roles in the pathophysiology of IBS. This narrative review was designed to present recent observations made relating to fecal microbiota transplantation (FMT), which implicate possible roles of 11 intestinal bacteria in the pathophysiology of IBS. The intestinal abundances of nine of these bacteria increased after FMT in patients with IBS, and these increases were inversely correlated with IBS symptoms and fatigue severity. These bacteria were Alistipes spp., Faecalibacterium prausnitzii, Eubacterium biforme, Holdemanella biformis, Prevotella spp., Bacteroides stercoris, Parabacteroides johnsonii, Bacteroides zoogleoformans, and Lactobacillus spp. The intestinal abundances of two bacteria were decreased in patients with IBS after FMT and were correlated with the severity of IBS symptoms and fatigue (Streptococcus thermophilus and Coprobacillus cateniformis). Ten of these bacteria are anaerobic and one (Streptococcus thermophilus) is facultative anaerobic. Several of these bacteria produce short-chain fatty acids, especially butyrate, which is used as an energy source by large intestine epithelial cells. Moreover, it modulates the immune response and hypersensitivity of the large intestine and decreases intestinal cell permeability and intestinal motility. These bacteria could be used as probiotics to improve these conditions. Protein-rich diets could increase the intestinal abundance of Alistipes, and plant-rich diet could increase the intestinal abundance of Prevotella spp., and consequently improve IBS and fatigue.
MeSH term(s)	Humans ; Irritable Bowel Syndrome/therapy ; Fatigue Syndrome, Chronic/therapy ; Butyrates ; Epithelial Cells
Chemical Substances	Butyrates
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.14621
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Article ; Online: Factors Underlying the Difference in Response to Fecal Microbiota Transplantation Between IBS Patients with Severe and Moderate Symptoms.

El-Salhy, Magdy / Hatlebakk, Jan Gunnar

Digestive diseases and sciences

2024 Volume 69, Issue 4, Page(s) 1336–1344

Abstract: Background: Previous studies showed that patients with Severe IBS respond better to fecal microbiota transplantation (FMT) than do those with Moderate IBS.: Aims: The present study aimed to determine the effects of the transplant dose, route of ... ...

Abstract	Background: Previous studies showed that patients with Severe IBS respond better to fecal microbiota transplantation (FMT) than do those with Moderate IBS. Aims: The present study aimed to determine the effects of the transplant dose, route of administering it and repeating FMT on this difference. Methods: This study included 186 patients with IBS randomized 1:1:1 into groups with a 90-g transplant administered once to the colon (LI), once to the duodenum (SI), or twice to the distal duodenum twice (repeated SI). The patients provided a fecal sample and were asked to complete three questionnaires at baseline and at 3, 6, and 12 months after FMT. The fecal bacteria composition and Dysbiosis index were analyzed using 16 S rRNA gene PCR DNA amplification/probe hybridization covering regions V3-V9. Results: There was no difference in the response rates between severe IBS and moderate IBS for SI and repeated SI at all observation intervals after FMT. In the LI group, the response rate at 3 months after FMT was higher for moderate IBS than for severe IBS. The levels of Dorea spp. were higher and those of Streptococcus salivarius subsp. Thermophilus, Alistipes spp., Bacteroides and Prevotella spp., Parabacteroides johnsoni and Parabacteroides spp. were lower in moderate IBS than in severe IBS. Conclusions: There was no difference in the response to FMT between severe and moderate IBS when a 90-g transplant was administered to the small intestine. The difference in the bacterial profile between severe and moderate IBS may explain the difference in symptoms between these patients. ( www. Clinicaltrials: gov : NCT04236843).
MeSH term(s)	Humans ; Fecal Microbiota Transplantation ; Irritable Bowel Syndrome/diagnosis ; Gastrointestinal Microbiome/physiology ; Feces/microbiology ; Duodenum ; Treatment Outcome
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-024-08369-x
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Book: Understanding and controlling the irritable bowel

El-Salhy, Magdy / Hatlebakk, Jan Gunnar / Hausken, Trygve

2015

Author's details	Magdy El-Salhy ; Jan Gunnar Hatlebakk ; Trygve Hausken
Keywords	Irritable Bowel Syndrome ; Controlling IBS ; Dietary guidance ; Clinical expertise ; Treatment options
Language	English
Size	XV, 85 S. : Ill., graph. Darst.
Publisher	Springer
Publishing place	Cham u.a.
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT018648887
ISBN	978-3-319-15641-5 ; 3-319-15641-1 ; 9783319156422 ; 331915642X
Database	Catalogue ZB MED Medicine, Health

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2015 A 1856	available for loan (reading room)	Lesesaal EG

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Article ; Online: FMT in IBS: how cautious should we be?

El-Salhy, Magdy

Gut

2020 Volume 70, Issue 3, Page(s) 626–628

MeSH term(s)	Fecal Microbiota Transplantation ; Gastrointestinal Microbiome ; Humans ; Irritable Bowel Syndrome/therapy
Language	English
Publishing date	2020-07-14
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2020-322038
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Article ; Online: Letter: A step forward towards a standard FMT protocol for IBS.

El-Salhy, Magdy / Gilja, Odd Helge / Hatlebakk, Jan Gunnar

Alimentary pharmacology & therapeutics

2023 Volume 58, Issue 10, Page(s) 1115–1116

MeSH term(s)	Humans ; Irritable Bowel Syndrome/diagnosis ; Irritable Bowel Syndrome/therapy ; Fecal Microbiota Transplantation/methods ; Feces ; Antineoplastic Combined Chemotherapy Protocols ; Treatment Outcome
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17749
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Article ; Online: Increasing the transplant dose and repeating faecal microbiota transplantation results in the responses of male patients with IBS reaching those of females.

El-Salhy, Magdy / Gilja, Odd Helge / Hatlebakk, Jan Gunnar

Scandinavian journal of gastroenterology

2023 Volume 59, Issue 4, Page(s) 391–400

Abstract: Background: Faecal microbiota transplantation (FMT) performed with a proper protocol is a safe treatment for IBS that has high efficacy and durable effects. Females have been reported to respond better than males to FMT. The present study aimed at ... ...

Abstract	Background: Faecal microbiota transplantation (FMT) performed with a proper protocol is a safe treatment for IBS that has high efficacy and durable effects. Females have been reported to respond better than males to FMT. The present study aimed at determining whether increasing the transplant dose or repeating FMT improve the responses of males to FMT. Methods: This study included 186 IBS patients (131 females and 55 males) who were randomized at a 1:1:1 ratio to receive 90 g of donor faeces once into the large intestine, once into the small intestine or twice into the small intestine. Patients completed five questionnaires that assessed their symptoms and quality of life, and provided faecal samples at baseline and at 3, 6 and 12 months after FMT. The faecal bacterial profile and dysbiosis index were determined using 16S rRNA gene PCR DNA amplification covering variable genes V3-V9. Results: The response rates to FMT at all observation times did not differ significantly between females and males regardless of the transplant administration route or whether it was repeated. Faecal Conclusions: Increasing the transplant dose and repeating FMT results in the responses of male IBS patients to FMT reaching those of females regardless of the administration route.
MeSH term(s)	Humans ; Male ; Female ; Fecal Microbiota Transplantation/methods ; Irritable Bowel Syndrome/diagnosis ; Quality of Life ; RNA, Ribosomal, 16S ; Gastrointestinal Microbiome ; Feces/microbiology ; Treatment Outcome
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2023.2292479
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Article ; Online: Factors affecting the outcome of fecal microbiota transplantation for patients with irritable bowel syndrome.

El-Salhy, Magdy / Gilja, Odd Helge / Hatlebakk, Jan Gunnar

Neurogastroenterology and motility

2023 Volume 36, Issue 1, Page(s) e14641

Abstract: Background: A previous study that introduced a Fecal microbiota transplantation (FMT) protocol with a high efficacy applied a combination of favorable factors.: Aims: The present study aimed to evaluate some of these factors.: Methods: This study ... ...

Abstract	Background: A previous study that introduced a Fecal microbiota transplantation (FMT) protocol with a high efficacy applied a combination of favorable factors. Aims: The present study aimed to evaluate some of these factors. Methods: This study included 186 patients with IBS randomized 1:1:1 into transplant administered to the colon (single LI), to the duodenum (single SI), or to the duodenum twice with a 1-week interval (repeated SI). The patients provided a fecal sample and were asked to complete five questionnaires at baseline and at 3, 6, and 12 months after FMT. The fecal bacteria composition and dysbiosis index (DI) were analyzed using 16S rRNA gene PCR DNA amplification/probe hybridization covering regions V3-V9. Results: The response rate was significantly higher in single SI than in single LI at 12 months after FMT. Symptoms and quality of life improved in all the treated groups at all time intervals after FMT. The abdominal symptoms were significantly reduced and the quality of life improved for repeated SI compared with for single SI. DI significantly decreased in all the treated groups at all observation times after FMT. The bacterial profiles changed in all groups at all observation intervals. However, these changes differed between single LI and single SI/repeated SI. Conclusion: Administrating transplant to the small intestine had a long-term higher response rate than that administrated to the large intestine, and led to long-term colonization of beneficial bacteria. Repeating FMT had more effect on symptoms and quality of life than a single FMT. (www. Clinicaltrials: gov: NCT04236843).
MeSH term(s)	Humans ; Fecal Microbiota Transplantation/methods ; Irritable Bowel Syndrome/diagnosis ; Quality of Life ; RNA, Ribosomal, 16S ; Treatment Outcome ; Gastrointestinal Microbiome/physiology ; Feces/microbiology ; Dysbiosis/microbiology ; Bacteria
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.14641
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Article ; Online: Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome.

El-Salhy, Magdy

World journal of gastroenterology

2020 Volume 26, Issue 13, Page(s) 1427–1438

Abstract: The pathophysiology of irritable bowel syndrome (IBS) is not completely understood. However, several factors are known to play a role in pathophysiology of IBS such as genetics, diet, gut microbiota, gut endocrine cells, stress and low-grade inflammation. ...

Abstract	The pathophysiology of irritable bowel syndrome (IBS) is not completely understood. However, several factors are known to play a role in pathophysiology of IBS such as genetics, diet, gut microbiota, gut endocrine cells, stress and low-grade inflammation. Understanding the pathophysiology of IBS may open the way for new treatment approaches. Low density of intestinal stem cells and low differentiation toward enteroendocrine cells has been reported recently in patients with IBS. These abnormalities are believed to be the cause of the low density of enteroendocrine cells seen in patients with IBS. Enteroendocrine cells regulate gastrointestinal motility, secretion, absorption and visceral sensitivity. Gastrointestinal dysmotility, abnormal absorption/secretion and visceral hypersensitivity are all seen in patients with IBS and haven been attributed to the low density the intestinal enteroendocrine cells in these patients. The present review conducted a literature search in Medline (PubMed) covering the last ten years until November 2019, where articles in English were included. Articles about the intestinal stem cells and their possible role in the pathophysiology of IBS are discussed in the present review. The present review discusses the assumption that intestinal stem cells play a central role in the pathophysiology of IBS and that the other factors known to contribute to the pathophysiology of IBS such as genetics, diet gut microbiota, stress, and low-grade inflammation exert their effects through affecting the intestinal stem cells. It reports further the data that support this assumption on genetics, diet, gut microbiota, stress with depletion of glutamine, and inflammation.
MeSH term(s)	Cell Differentiation ; Enteroendocrine Cells/physiology ; Gastrointestinal Motility/physiology ; Humans ; Intestines/cytology ; Irritable Bowel Syndrome/physiopathology ; Stem Cells/physiology
Language	English
Publishing date	2020-04-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v26.i13.1427
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Article ; Online: Nutritional Management of Gastrointestinal Diseases and Disorders.

El-Salhy, Magdy

Nutrients

2019 Volume 11, Issue 12

Abstract: Diet not only provides the nutrition necessary for energy and body growth and repair, but also affects and regulates several important functions of the body [ ... ]. ...

Abstract	Diet not only provides the nutrition necessary for energy and body growth and repair, but also affects and regulates several important functions of the body [...].
MeSH term(s)	Diet ; Gastrointestinal Diseases/diet therapy ; Gastrointestinal Diseases/physiopathology ; Humans ; Irritable Bowel Syndrome/diet therapy ; Irritable Bowel Syndrome/physiopathology ; Nutritional Status ; Nutritional Support ; Probiotics/administration & dosage
Language	English
Publishing date	2019-12-10
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu11123013
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Article ; Online: Changes in colonic enteroendocrine cells of patients with irritable bowel syndrome following fecal microbiota transplantation.

Mazzawi, Tarek / Hausken, Trygve / El-Salhy, Magdy

Scandinavian journal of gastroenterology

2022 Volume 57, Issue 7, Page(s) 792–796

Abstract: Objectives: The aim was to investigate the effect of fecal microbiota transplantation (FMT) on colonic enteroendocrine cells densities in patients with irritable bowel syndrome (IBS).: Materials and methods: This study is connected to the REFIT study, ...

Abstract	Objectives: The aim was to investigate the effect of fecal microbiota transplantation (FMT) on colonic enteroendocrine cells densities in patients with irritable bowel syndrome (IBS). Materials and methods: This study is connected to the REFIT study, a double-blinded placebo-controlled trial to investigate using FMT for IBS treatment. Eighty-three subjects received either donor-FMT or placebo FMT (own feces) by colonoscope to cecum. Biopsies were obtained from sigmoid colon. Ten responders and ten non-responders consented to new biopsy one-year after FMT. Sixteen patients received donor-FMT and four received placebo FMT. Biopsies were immunostained for all of the colonic enteroendocrine cells and were quantified using computerized image analysis.Allocation sequence was revealed after obtaining re-biopsies and cells quantification. Results: Scores for IBS-SSS (mean ± SEM) of responders (eight of 10 patients who received donor FMT) and non-responders changed from baseline to one year after FMT (297 ± 11 and 81 ± 16, Conclusion: This study shows that colonic enteroendocrine cells densities significantly change in responders group that received donor-FMT. The mechanisms for the cross talks between gut microbiota and colonic enteroendocrine cells remain to be investigated.
MeSH term(s)	Adult ; Aged ; Double-Blind Method ; Enteroendocrine Cells ; Fecal Microbiota Transplantation/methods ; Feces ; Female ; Gastrointestinal Microbiome ; Humans ; Irritable Bowel Syndrome/therapy ; Male ; Middle Aged ; Treatment Outcome
Language	English
Publishing date	2022-02-14
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2022.2036809
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