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Article ; Online: Revisiting the role of ischaemia in familial cardiomyopathy: insights from an NRAP gene-related cardiomyopathy.

AbdelMassih, Antoine Fakhry / Al Ali, Alyaa / Musleh, Afnan Sameer / Ramsi, Musaab

BMJ case reports

2023 Volume 16, Issue 9

MeSH term(s)	Humans ; Cardiomyopathies/genetics ; Ischemia ; Muscle Proteins
Chemical Substances	NRAP protein, human ; Muscle Proteins
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-256111
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Article ; Online: RSV-induced LV dysfunction, what can be the underlying cause?

AbdelMassih, Antoine Fakhry / Ismail, Habiba-Allah / Nabil, Fatima Mohamed / Mabrouk, Aliaa Ibrahim / Abdel Aziz, Faten

Pediatric pulmonology

2022 Volume 58, Issue 4, Page(s) 991–995

MeSH term(s)	Humans ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology ; Ventricular Function, Left ; Reproducibility of Results
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26290
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Article ; Online: JAK out of the Box; The Rationale behind Janus Kinase Inhibitors in the COVID-19 setting, and their potential in obese and diabetic populations.

Menshawey, Rahma / Menshawey, Esraa / Alserr, Ayman H K / Abdelmassih, Antoine Fakhry

Cardiovascular endocrinology & metabolism

2020 Volume 10, Issue 2, Page(s) 80–88

Abstract: The adaptive use of Janus kinase (JAK)-inhibitors has been suggested by rheumatology experts in the management of COVID-19. We recount the rationale behind their use in this setting, and the current evidence for and against their use in this review. JAK- ... ...

Abstract	The adaptive use of Janus kinase (JAK)-inhibitors has been suggested by rheumatology experts in the management of COVID-19. We recount the rationale behind their use in this setting, and the current evidence for and against their use in this review. JAK-inhibitors role in COVID-19 infection appears to be multifaceted, including preventing viral endocytosis and dampening the effect of excessive chemokines. This drug class may be able to achieve these effects at already preapproved dosages. Concerns arise regarding reactivation of latent viral infections and the feasibility of their use in those with severe disease. Most interestingly, JAK-Inhibitors may also have an additional advantage for diabetic and obese populations, where the dysregulation of JAK-signal transducer and activator of transcription pathway may be responsible for their increased risk of poor outcomes. Targeting this pathway may provide a therapeutic advantage for these patient groups.
Language	English
Publishing date	2020-10-15
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2574-0954
ISSN (online)	2574-0954
DOI	10.1097/XCE.0000000000000237
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Article ; Online: Low iron mitigates viral survival: insights from evolution, genetics, and pandemics-a review of current hypothesis.

Menshawey, Rahma / Menshawey, Esraa / Alserr, Ayman H K / Abdelmassih, Antoine Fakhry

The Egyptian journal of medical human genetics

2020 Volume 21, Issue 1, Page(s) 75

Abstract: Background: Upon re-examination of our human history, evolutionary perspectives, and genetics, a prevailing iron deficiency phenotype appears to have evolved to protect the human race from extinction.: Body: In this review, we summarize the ... ...

Abstract	Background: Upon re-examination of our human history, evolutionary perspectives, and genetics, a prevailing iron deficiency phenotype appears to have evolved to protect the human race from extinction. Body: In this review, we summarize the evolutionary and genetic perspectives pointing towards the hypothesis that low iron mitigates infection. The presence of infection promotes the generation of resistance alleles, and there are some evolutionary and genetic clues that suggest the presence of an iron deficiency phenotype that may have developed to protect against infection. Examples include the relative paucity of iron overload genes given the essential role of iron, as well as the persistence of iron deficiency among populations in spite of public health efforts to treat it. Additional examination of geographic areas with severe iron deficiency in the setting of pandemics including H1N1, SARS, and COVID-19 reveals that areas with higher prevalence of iron deficiency are less affected. RNA viruses have several evolutionary adaptations which suggest their absolute need for iron, and this dependency may be exploited during treatment. Conclusion: RNA viruses pose a unique challenge to modern healthcare, with an average of 2-3 new pathogens being discovered yearly. Their overarching requirements for iron, along with human evolutionary and genetic adaptations which favored an iron deficiency phenotype, ultimately suggest the potential need for iron control in these infections.
Language	English
Publishing date	2020-12-16
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2515357-2
ISSN	2090-2441 ; 2090-2441
ISSN (online)	2090-2441
ISSN	2090-2441
DOI	10.1186/s43042-020-00114-z
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Article ; Online: Advanced Echocardiography Techniques: The Future Stethoscope of Systemic Diseases.

Iskander, John / Kelada, Peter / Rashad, Lara / Massoud, Doaa / Afdal, Peter / Abdelmassih, Antoine Fakhry

Current problems in cardiology

2021 Volume 47, Issue 6, Page(s) 100847

Abstract: Cardiovascular disease (CVD) has been showing patterns of extensive rise in prevalence in the contemporary era, affecting the quality of life of millions of people and leading the causes of death worldwide. It has been a provocative challenge for modern ... ...

Abstract	Cardiovascular disease (CVD) has been showing patterns of extensive rise in prevalence in the contemporary era, affecting the quality of life of millions of people and leading the causes of death worldwide. It has been a provocative challenge for modern medicine to diagnose CVD in its crib, owing to its etiological factors being attributed to a large array of systemic diseases, as well as its non-binary hideous nature that gradually leads to functional disability. Novel echocardiography techniques have enabled the cardiac ultrasound to provide a comprehensive analysis of the heart in an objective, feasible, time- and cost-effective manner. Speckle tracking echocardiography, contrast echocardiography, and 3D echocardiography have shown the highest potential for widespread use. The uses of novel modalities have been elaborately demonstrated in this study as a proof of concept that echocardiography has a place in routine general practice with supportive evidence being as recent as its role in the concurrent COVID-19 pandemic. Despite such evidence, many uses remain off-label and unexploited in practice. Generalization of echocardiography at the point of care can become a much-needed turning point in the clinical approach to case management. To actualize such aspirations, we recommend further prospective and interventional studies to examine the effect of implementing advanced techniques at the point of care on the decision-making process and evaluate their effectiveness in prevention of cardiovascular morbidities and mortalities.
MeSH term(s)	COVID-19 ; Cardiovascular Diseases/diagnostic imaging ; Echocardiography/methods ; Humans ; Pandemics ; Quality of Life ; Stethoscopes
Language	English
Publishing date	2021-03-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2021.100847
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Article: Intensity of inflammation as the most important predictor of myocardial involvement in JIA. A 3D echocardiographic study.

AbdelMassih, Antoine Fakhry / Salem, Amr / Arabi, Salma / Malak, Lauris / Marzouk, Huda

Acta reumatologica portuguesa

2020 Volume 44, Issue 4, Page(s) 296–302

Abstract: Introduction: Myocardial dysfunction is an important complication in the context of juvenile idiopathic arthritis (JIA). Several mechanisms might be involved in the induction of myocardial injury in such a disabling disease. Among several factors ... ...

Title translation	Intensity of inflammation as the most important predictor of myocardial involvement in JIA. A 3D echocardiographic study.
Abstract	Introduction: Myocardial dysfunction is an important complication in the context of juvenile idiopathic arthritis (JIA). Several mechanisms might be involved in the induction of myocardial injury in such a disabling disease. Among several factors involved, myocardial inflammation and cardiotoxic drugs were thought to be the most incriminated factors. The aim of this paper was to determine the most important factors that implicated myocardial injury in JIA and to weigh whether the severity of inflammation varies significantly among the several subtypes or not. Methods: Sixty JIA patients as well as sixty, age and surface area, matched controls were subjected to conventional Echocardiography, 3D Speckle tracking and the disease activity was measured as by Juvenile Arthritis Disease Score 27 (JADAS 27). Results: JIA cases showed statistically significant systolic and diastolic dysfunction when compared to controls. Global longitudinal strain (GLS) (index of systolic function) was lower in cases compared to controls (JIA: 16.1±6.7 vs Controls: 23.9±1.4, P < 0.0001), Left Ventricular ratio of early diastolic mitral inflow velocity to average of early diastolic velocities of the mitral annulus and basal septum (LV E/E') (index of diastolic function) was higher in cases compared to controls (JIA: 14.8±7 vs. Controls: 5.9±1.3). There was no statistically significant difference in echocardiographic parameters as well as JADAS 27 between subtypes of JIA patients. Multivariate analysis showed that the best predictor of both systolic and diastolic involvement of the myocardium in JIA patients was the severity of inflammation rather than the duration or the type of medications used. Conclusion: This study points out the potential of inflammation as an important inducer of myocardial injury in JIA. It also underlines the fact that this inflammation does not differ significantly according to the disease subtype.
MeSH term(s)	Arthritis, Juvenile/complications ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/etiology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Echocardiography, Three-Dimensional ; Female ; Humans ; Inflammation/complications ; Male ; Severity of Illness Index
Language	English
Publishing date	2020-04-01
Publishing country	Portugal
Document type	Journal Article
ZDB-ID	442031-7
ISSN	0303-464X
ISSN	0303-464X
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Article ; Online: Low iron mitigates viral survival

Rahma Menshawey / Esraa Menshawey / Ayman H. K. Alserr / Antoine Fakhry Abdelmassih

Egyptian Journal of Medical Human Genetics, Vol 21, Iss 1, Pp 1-

insights from evolution, genetics, and pandemics—a review of current hypothesis

2020 Volume 14

Abstract: Abstract Background Upon re-examination of our human history, evolutionary perspectives, and genetics, a prevailing iron deficiency phenotype appears to have evolved to protect the human race from extinction. Body In this review, we summarize the ... ...

Abstract	Abstract Background Upon re-examination of our human history, evolutionary perspectives, and genetics, a prevailing iron deficiency phenotype appears to have evolved to protect the human race from extinction. Body In this review, we summarize the evolutionary and genetic perspectives pointing towards the hypothesis that low iron mitigates infection. The presence of infection promotes the generation of resistance alleles, and there are some evolutionary and genetic clues that suggest the presence of an iron deficiency phenotype that may have developed to protect against infection. Examples include the relative paucity of iron overload genes given the essential role of iron, as well as the persistence of iron deficiency among populations in spite of public health efforts to treat it. Additional examination of geographic areas with severe iron deficiency in the setting of pandemics including H1N1, SARS, and COVID-19 reveals that areas with higher prevalence of iron deficiency are less affected. RNA viruses have several evolutionary adaptations which suggest their absolute need for iron, and this dependency may be exploited during treatment. Conclusion RNA viruses pose a unique challenge to modern healthcare, with an average of 2–3 new pathogens being discovered yearly. Their overarching requirements for iron, along with human evolutionary and genetic adaptations which favored an iron deficiency phenotype, ultimately suggest the potential need for iron control in these infections.
Keywords	Iron deficiency anemia ; RNA viruses ; COVID-19 ; Hyperferritinemia ; Hepcidin ; Ferroptosis ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
Subject code	570
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Insulin resistance linked to subtle myocardial dysfunction in normotensive Turner syndrome young patients without structural heart diseases.

AbdelMassih, Antoine Fakhry / Attia, Mona / Ismail, Mohamed M / Samir, Mohamed

Journal of pediatric endocrinology & metabolism : JPEM

2018 Volume 31, Issue 12, Page(s) 1355–1361

Abstract: Background Turner syndrome (TS) patients have increased cardiovascular risk. This cardiovascular risk is famously attributed to structural abnormalities of the left side of the heart such as aortic stenosis and aortic coarctation. However, due to insulin ...

Abstract	Background Turner syndrome (TS) patients have increased cardiovascular risk. This cardiovascular risk is famously attributed to structural abnormalities of the left side of the heart such as aortic stenosis and aortic coarctation. However, due to insulin resistance and subsequent pathogenic mechanisms, normotensive TS patients without structural abnormalities may develop varying degrees of myocardial dysfunction. The aim of this research was to examine the role of speckle tracking echocardiography in early detection of Turner cardiomyopathy and to correlate this myocardial dysfunction with measures of insulin resistance. Methods This cross-sectional case control study included 30 children with TS and 30 age-matched healthy controls. TS patients were excluded if: hypertensive, with major structural abnormalities of the heart or other systemic diseases that may affect myocardial function. Conventional speckle tracking echocardiography and glucose-insulin ratio were performed for all study subjects. Results Routine echocardiographic parameters of left ventricular systolic function were similar in cases and controls while global longitudinal and circumferential strain (GLS and GCS) were lower in patients with TS than controls: (-13.2±1.1 vs. -18.3±2.4, p-value<0.000) and (-11.3±1.1 vs. -16.3±2.1, p-value<0.000), respectively. Fasting glucose:insulin ratio (FGIR) proved to be the best predictor of myocardial dysfunction in TS patients by multivariate analysis. Conclusions This study points towards the potential role of two-dimensional (2D) speckle tracking echocardiography in early detection of subtle systolic myocardial dysfunction in TS patients. It also points towards the implication of insulin resistance in precipitation of the observed dysfunction in TS patients.
MeSH term(s)	Blood Glucose ; Cardiomyopathies/blood ; Cardiomyopathies/complications ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/physiopathology ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Echocardiography ; Female ; Heart/physiopathology ; Humans ; Insulin/blood ; Insulin Resistance/physiology ; Turner Syndrome/blood ; Turner Syndrome/complications ; Turner Syndrome/diagnostic imaging ; Turner Syndrome/physiopathology
Chemical Substances	Blood Glucose ; Insulin
Language	English
Publishing date	2018-11-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2018-0207
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Article ; Online: Discrepancy in patterns of myocardial involvement in beta-thalassaemia vs. sickle cell anaemia.

AbdelMassih, Antoine Fakhry / Salama, Khaled M / Ghobrial, Carolyne / Haroun, Basma / Rahman, Mohamed Abdel

Acta cardiologica

2019 Volume 75, Issue 5, Page(s) 442–449

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Adult ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/diagnosis ; Anemia, Sickle Cell/metabolism ; Anemia, Sickle Cell/physiopathology ; Correlation of Data ; Echocardiography, Three-Dimensional/methods ; Egypt/epidemiology ; Endocardium/metabolism ; Endocardium/pathology ; Female ; Ferritins/blood ; Hemoglobins/analysis ; Humans ; Iron Overload/complications ; Iron Overload/metabolism ; L-Lactate Dehydrogenase/blood ; Male ; Microcirculation ; Pericardium/metabolism ; Pericardium/pathology ; Stroke Volume ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/epidemiology ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/metabolism ; beta-Thalassemia/complications ; beta-Thalassemia/diagnosis ; beta-Thalassemia/metabolism ; beta-Thalassemia/physiopathology
Chemical Substances	Hemoglobins ; Ferritins (9007-73-2) ; L-Lactate Dehydrogenase (EC 1.1.1.27)
Language	English
Publishing date	2019-06-05
Publishing country	England
Document type	Journal Article
ZDB-ID	390197-x
ISSN	1784-973X ; 0001-5385
ISSN (online)	1784-973X
ISSN	0001-5385
DOI	10.1080/00015385.2019.1610836
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Article: Biventricular reverse remodeling and relationship with mitral valve prolapse after transcatheter closure of ASD secundum, a 3D echocardiographic study.

El-Sisi, Amal / Dabour, Shaheen / Fattouh, Aya M / Assar, Effat / Naguib, Rasha / AbdelMassih, Antoine Fakhry

Journal of cardiovascular and thoracic research

2019 Volume 12, Issue 1, Page(s) 15–19

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2019-12-23
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2654729-6
ISSN	2008-6830 ; 2008-5117
ISSN (online)	2008-6830
ISSN	2008-5117
DOI	10.34172/jcvtr.2020.03
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