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  1. Book: Remodelling of the heart and vessels in experimental hypertension

    Simko, Fedor

    advances in protection

    (Journal of hypertension ; 28, Suppl. 1)

    2010  

    Author's details ed.: Fedor Simko
    Series title Journal of hypertension ; 28, Suppl. 1
    Collection
    Language English
    Size S62 S. : graph. Darst.
    Publisher Wolters Kluwer Health Lippincott Williams & Wilkins
    Publishing place Hagerstown, Md
    Publishing country United States
    Document type Book
    HBZ-ID HT016556041
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1885 -28,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Book: Recent trends in hypertension treatment

    Simko, Fedor

    perspectives from animal studies

    (Journal of hypertension ; 27, Suppl. 6)

    2009  

    Author's details ed.: Fedor Simko
    Series title Journal of hypertension ; 27, Suppl. 6
    Collection
    Language English
    Size S52 S. : graph. Darst.
    Publisher Wolters Kluwer Health Lippincott Williams & Wilkins
    Publishing place Hagerstown, Md
    Publishing country United States
    Document type Book
    HBZ-ID HT016068321
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1885 -27,Suppl.6- not available for loan Zeitschriften-Lesesaal

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  3. Book: The importance of nitric oxide in the hemodynamically overloaded circulation

    Simko, Fedor

    (Physiological research ; 56, Suppl. 2)

    2007  

    Author's details guest ed. F. Šimko
    Series title Physiological research ; 56, Suppl. 2
    Collection
    Language English
    Publisher Inst. of Physiology
    Publishing place Prague
    Publishing country Czech Republic
    Document type Book
    HBZ-ID HT015402942
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 228 -56,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  4. Article: Chronotherapy of cardiovascular pathologies: a hopeful strategy.

    Simko, Fedor / Baka, Tomas

    Therapeutic advances in chronic disease

    2022  Volume 13, Page(s) 20406223221092372

    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/20406223221092372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Commentary: Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells.

    Simko, Fedor / Baka, Tomas

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 842512

    Language English
    Publishing date 2022-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.842512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Ivabradine and Blood Pressure Reduction: Underlying Pleiotropic Mechanisms and Clinical Implications.

    Simko, Fedor / Baka, Tomas

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 607998

    Language English
    Publishing date 2021-02-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.607998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Monitoring Non-dipping Heart Rate by Consumer-Grade Wrist-Worn Devices: An Avenue for Cardiovascular Risk Assessment in Hypertension.

    Baka, Tomas / Simko, Fedor

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 711417

    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.711417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Correction in article by Baka et al. "Consideration of nondipping heart rate during ambulatory blood pressure monitoring to improve cardiovascular risk assessment", Rev Esp Cardiol. 2022;75:355-356.

    Baka, Tomas / Domínguez-Rodríguez, Alberto / Simko, Fedor

    Revista espanola de cardiologia (English ed.)

    2022  Volume 75, Issue 11, Page(s) 974

    Language Spanish
    Publishing date 2022-09-27
    Publishing country Spain
    Document type Published Erratum
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2022.07.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure.

    Reiter, Russel J / Sharma, Ramaswamy / Chuffa, Luiz Gustavo de Almeida / Simko, Fedor / Dominguez-Rodriguez, Alberto

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 1

    Abstract: Cardiovascular disease is the cause of physical infirmity and thousands of deaths annually. Typically, during heart failure, cardiomyocyte mitochondria falter in terms of energy production and metabolic processing. Additionally, inflammation and the ... ...

    Abstract Cardiovascular disease is the cause of physical infirmity and thousands of deaths annually. Typically, during heart failure, cardiomyocyte mitochondria falter in terms of energy production and metabolic processing. Additionally, inflammation and the accumulation of non-contractile fibrous tissue contribute to cardiac malfunction. Melatonin, an endogenously produced molecule, experimentally reduces the initiation and progression of atherosclerotic lesions, which are often the basis of coronary artery disease. The current review critically analyzes published data related to the experimental use of melatonin to forestall coronary artery pathologies. Collectively, these studies document melatonin's anti-atherosclerotic actions in reducing LDL oxidation and triglyceride levels, lowering endothelial malfunction, limiting adhesion molecule formation, preventing macrophage polarization to the M1 pro-inflammatory phenotype, changing cellular metabolism, scavenging destructive reactive oxygen species, preventing the proliferation and invasion of arterial smooth muscle cells into the lesioned area, restricting the ingrowth of blood vessels from the vasa vasorum, and solidifying the plaque cap to reduce the chance of its rupture. Diabetic hyperglycemia, which aggravates atherosclerotic plaque formation, is also inhibited by melatonin supplementation in experimental animals. The potential value of non-toxic melatonin as a possible inhibitor of cardiac pathology in humans should be seriously considered by performing clinical trials using this multifunctional molecule.
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14010088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?

    Simko, Fedor / Baka, Tomas

    Clinical science (London, England : 1979)

    2021  Volume 135, Issue 8, Page(s) 1009–1014

    Abstract: Angiotensin-converting enzyme 2 (ACE2) is the leading player of the protective renin-angiotensin system (RAS) pathway but also the entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RAS inhibitors seemed to interfere with ... ...

    Abstract Angiotensin-converting enzyme 2 (ACE2) is the leading player of the protective renin-angiotensin system (RAS) pathway but also the entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RAS inhibitors seemed to interfere with the ACE2 receptor, and their safety was addressed in COVID-19 patients. Pedrosa et al. (Clin. Sci. (Lond.) (2021), 135, 465-481) showed in rats that captopril and candesartan up-regulated ACE2 expression and the protective RAS pathway in lung tissue. In culture of pneumocytes, the captopril/candesartan-induced ACE2 up-regulation was associated with inhibition of ADAM17 activity, counterbalancing increased ACE2 expression, which was associated with reduced SARS-CoV-2 spike protein entry. If confirmed in humans, these results could become the pathophysiological background for justifying RAS inhibitors as cornerstone cardiovascular protectives even during COVID-19 pandemic.
    MeSH term(s) Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Benzimidazoles ; Biphenyl Compounds ; COVID-19 ; Captopril/pharmacology ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Rats ; Renin-Angiotensin System ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Tetrazoles
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Benzimidazoles ; Biphenyl Compounds ; Spike Glycoprotein, Coronavirus ; Tetrazoles ; spike protein, SARS-CoV-2 ; Captopril (9G64RSX1XD) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; candesartan (S8Q36MD2XX)
    Language English
    Publishing date 2021-04-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20210182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.220: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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