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Article ; Online: Enhancement of aerodynamic performance of a bristled wing by elliptic cylinders.

Zhang, Wanqiu / Liang, Daxing / Tan, Dongwen / Mei, Yaochen / Zhou, Xinping

2024 Volume 19, Issue 2

Abstract: Enhancing the aerodynamic performance of bristled wings is an important topic for small flying robotics. This paper numerically investigates this situation at very low Reynolds numbers by using elliptic cylinders as the bristles instead of circular ... ...

Abstract	Enhancing the aerodynamic performance of bristled wings is an important topic for small flying robotics. This paper numerically investigates this situation at very low Reynolds numbers by using elliptic cylinders as the bristles instead of circular cylinders. Optimal configuration of the bristled wing with five elliptic cylinders is obtained, which corresponds to the maximum lift. The results show that, compared with the case of circular cylindrical bristles, the aerodynamic performance of the elliptical bristles can be enhanced effectively. The enhancement can be more significant as the aspect ratio of the ellipses increases and the gap width decreases. The bristled wing generates more lift compared to a flat-plate wing with a length five times that of the major axis of an ellipse. For the cases that the attack angle
MeSH term(s)	Animals ; Biomechanical Phenomena ; Flight, Animal ; Models, Biological ; Wings, Animal ; Robotics
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2235670-8
ISSN	1748-3190 ; 1748-3182
ISSN (online)	1748-3190
ISSN	1748-3182
DOI	10.1088/1748-3190/ad2115
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Article ; Online: Corrigendum to "Sevoflurane up-regulates miR-7a to protect against ischemic brain injury in rats by down-regulating ATG7 and reducing neuronal autophagy" [Brain Res. Bull. 188 (2022) 214-222].

Wu, Zhiguo / Tan, Jian / Lin, Lichang / Zhang, Wenting / Yuan, Wanqiu

Brain research bulletin

2022 Volume 192, Page(s) 80–82

Language	English
Publishing date	2022-11-14
Publishing country	United States
Document type	Published Erratum
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2022.11.004
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Article ; Online: The emergence of COVID-19 over-concern immediately after the cancelation of the measures adopted by the dynamic zero-COVID policy in China

Fengyi Hao / Zhisong Zhang / Sam S. S. Lau / Soon-Kiat Chiang / Dewen Zhou / Wanqiu Tan / Xiangdong Tang / Roger Ho

Frontiers in Public Health, Vol

2024 Volume 11

Abstract: BackgroundThis study aimed to report the prevalence of COVID-19 over-concern and its associated factors after the relaxation of the health-protective measures in China.MethodsA team of seven experts in psychiatry and psychology specializing in COVID-19 ... ...

Abstract	BackgroundThis study aimed to report the prevalence of COVID-19 over-concern and its associated factors after the relaxation of the health-protective measures in China.MethodsA team of seven experts in psychiatry and psychology specializing in COVID-19 mental health research from China, Hong Kong, and overseas reached a consensus on the diagnostic criteria for COVID-19 over-concern. Individuals had to meet at least five of the following criteria: (1) at least five physical symptoms; (2) stocking up at least five items related to protecting oneself during the COVID-19 pandemic; (3) obsessive-compulsive symptoms related to the COVID-19 pandemic; (4) illness anxiety related to the COVID-19 pandemic; (5) post-traumatic stress symptoms; (6) depression; (7) anxiety; (8) stress and (9) insomnia. An online survey using snowball sampling collected data on demographics, medical history, views on COVID-19 policies, and symptoms of COVID-19 over-concern. Multivariate linear regression was performed using significant variables from the previous regressions as independent variables against the presence of COVID-19 over-concern as the dependent variable. Breush-Pagan test was used to assess each regression model for heteroskedasticity of residuals.Results1,332 respondents from 31 regions in China participated in the study for 2 weeks from December 25 to 27, 2022, after major changes in the zero-COVID policy. After canceling measures associated with the dynamic zero-COVID policy, 21.2% of respondents fulfilled the diagnostic criteria for COVID-19 over-concern. Factors significantly associated with COVID-19 over-concern were poor self-rated health status (β = 0.07, p < 0.001), concerns about family members getting COVID-19 (β = 0.06, p < 0.001), perceived usefulness of COVID-19 vaccine (β = 0.03, p = 0.012), impact on incomes, employment and studies (β = 0.045, p < 0.001) and impact on families (β = 0.03, p = 0.01).ConclusionAfter removing measures associated with the dynamic zero-COVID policy in China, approximately ...
Keywords	COVID-19 ; overconcern ; China ; dynamic zero-COVID ; illness anxiety ; depression ; Public aspects of medicine ; RA1-1270
Subject code	310
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: The emergence of COVID-19 over-concern immediately after the cancelation of the measures adopted by the dynamic zero-COVID policy in China.

Hao, Fengyi / Zhang, Zhisong / Lau, Sam S S / Chiang, Soon-Kiat / Zhou, Dewen / Tan, Wanqiu / Tang, Xiangdong / Ho, Roger

Frontiers in public health

2024 Volume 11, Page(s) 1319906

Abstract: Background: This study aimed to report the prevalence of COVID-19 over-concern and its associated factors after the relaxation of the health-protective measures in China.: Methods: A team of seven experts in psychiatry and psychology specializing in ... ...

Abstract	Background: This study aimed to report the prevalence of COVID-19 over-concern and its associated factors after the relaxation of the health-protective measures in China. Methods: A team of seven experts in psychiatry and psychology specializing in COVID-19 mental health research from China, Hong Kong, and overseas reached a consensus on the diagnostic criteria for COVID-19 over-concern. Individuals had to meet at least five of the following criteria: (1) at least five physical symptoms; (2) stocking up at least five items related to protecting oneself during the COVID-19 pandemic; (3) obsessive-compulsive symptoms related to the COVID-19 pandemic; (4) illness anxiety related to the COVID-19 pandemic; (5) post-traumatic stress symptoms; (6) depression; (7) anxiety; (8) stress and (9) insomnia. An online survey using snowball sampling collected data on demographics, medical history, views on COVID-19 policies, and symptoms of COVID-19 over-concern. Multivariate linear regression was performed using significant variables from the previous regressions as independent variables against the presence of COVID-19 over-concern as the dependent variable. Breush-Pagan test was used to assess each regression model for heteroskedasticity of residuals. Results: 1,332 respondents from 31 regions in China participated in the study for 2 weeks from December 25 to 27, 2022, after major changes in the zero-COVID policy. After canceling measures associated with the dynamic zero-COVID policy, 21.2% of respondents fulfilled the diagnostic criteria for COVID-19 over-concern. Factors significantly associated with COVID-19 over-concern were poor self-rated health status ( Conclusion: After removing measures associated with the dynamic zero-COVID policy in China, approximately one-fifth of respondents met the diagnostic criteria for COVID-19 over-concern.
MeSH term(s)	Humans ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Vaccines ; Pandemics ; China/epidemiology ; Policy
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1319906
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Article ; Online: Sevoflurane up-regulates miR-7a to protect against ischemic brain injury in rats by down-regulating ATG7 and reducing neuronal autophagy.

Wu, Zhiguo / Tan, Jian / Lin, Lichang / Zhang, Wenting / Yuan, Wanqiu

Brain research bulletin

2022 Volume 188, Page(s) 214–222

Abstract: The current study aimed to elucidate the effects of Sevoflurane on neuronal autophagy and ischemic brain injury by regulating miR-7a/ATG7 axis. The rat model of middle cerebral artery occlusion (MCAO) was established by thread embolization. The ... ...

Abstract	The current study aimed to elucidate the effects of Sevoflurane on neuronal autophagy and ischemic brain injury by regulating miR-7a/ATG7 axis. The rat model of middle cerebral artery occlusion (MCAO) was established by thread embolization. The expression pattern of microRNA-7a (miR-7a) and autophagy-related gene 7 (ATG7) was subsequently determined in Sevoflurane-treated MCAO rats with their relation and effects on neuronal autophagy and ischemic brain injury further analyzed. Bioinformatics analysis confirmed that miR-7a could target to inhibit ATG7 in ischemic brain injury samples. Sevoflurane could alleviate ischemic brain injury in rats by reducing the level of neuronal autophagy-related factors. The expression of miR-7a was up-regulated and ATG7 was down-regulated in the brain tissues of MCAO rats after Sevoflurane treatment. ATG7 was found to induce neuronal autophagy during autophagy in the brain tissues of MCAO rats. In summary, Sevoflurane exerts protective effects on ischemic brain injury via inhibiting autophagy of neurons and microglia through the miR-7a-mediated downregulation of ATG7.
MeSH term(s)	Animals ; Autophagy ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Brain Injuries ; Down-Regulation ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Rats ; Sevoflurane/pharmacology
Chemical Substances	Atg7 protein, rat ; MicroRNAs ; Sevoflurane (38LVP0K73A) ; Autophagy-Related Protein 7 (EC 6.2.1.45)
Language	English
Publishing date	2022-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2022.07.003
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Article: microRNA-140-3p protects hippocampal neuron against pyroptosis to attenuate sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of HTR2A/ERK/Nrf2 axis by targeting DNMT1.

Wu, Zhiguo / Tan, Jian / Lin, Lichang / Zhang, Wenting / Yuan, Wanqiu

Cell death discovery

2022 Volume 8, Issue 1, Page(s) 290

Abstract: The incidence of post-operative cognitive dysfunction (POCD) remains a relatively prevalent complication in the elderly after surgery, especially in those receiving sevoflurane (Sevo) anesthesia. microRNA (miR)-140-3p has been demonstrated to orchestrate ...

Abstract	The incidence of post-operative cognitive dysfunction (POCD) remains a relatively prevalent complication in the elderly after surgery, especially in those receiving sevoflurane (Sevo) anesthesia. microRNA (miR)-140-3p has been demonstrated to orchestrate neuroinflammation and neuron apoptosis. However, the role of miR-140-3p in POCD remains largely unknown. In this context, this research was designed to explore whether miR-140-3p mediated Sevo inhalation-induced POCD in rats. A POCD rat model was established by Sevo inhalation, and a Sevo cell model was constructed in primary hippocampal neurons isolated from rats, followed by detection of miR-140-30 and HTR2A expression. Then, gain- and loss-of-function assays were implemented in rats and neurons. In rats, the cognitive function was evaluated by Water maze test and step-through test, and neuron apoptosis by TUNEL staining. In neurons, cell viability, apoptosis, and pyroptosis-related factors were tested by MTT, flow cytometry, and Western blot analysis respectively. Interaction between HTR2A and DNMT1 was assessed by MSP, and ChIP assay, and interaction between miR-140-3p and DNMT1 by dual-luciferase reporter assay, RIP and RNA pull-down. HTR2A and miR-140-3p were downregulated in POCD rats and Sevo-treated hippocampal neurons. Mechanistically, miR-140-3p negatively targeted DNMT1 to decrease HTR2A promoter methylation, thus upregulation HTR2A to activate ERK/Nrf2 pathway. miR-140-3p or HTR2A overexpression or activation of ERK/Nrf2 pathway elevated neuron viability and diminished their apoptosis and pyroptosis while alleviating Sevo-induced POCD in rats. Collectively, miR-140-3p might repress neuron pyroptosis to alleviate Sevo inhalation-induced POCD in rats via DNMT1/HTR2A/ERK/Nrf2 axis.
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Journal Article
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-022-01068-4
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Article ; Online: Identification of serum MiRNAs as candidate biomarkers for non-small cell lung cancer diagnosis.

Zhang, Xintong / Tan, Jinjing / Chen, Yan / Ma, Shang / Bai, Wanqiu / Peng, Yanjing / Shi, Guangli

BMC pulmonary medicine

2022 Volume 22, Issue 1, Page(s) 479

Abstract: Background: Lung cancer is one of the most common solid tumors worldwide and the leading cause of cancer-associated death. Non-small cell lung cancer (NSCLC) is accounts for approximately 85% of all the lung cancers and lung squamous carcinoma (SCC) and ...

Abstract	Background: Lung cancer is one of the most common solid tumors worldwide and the leading cause of cancer-associated death. Non-small cell lung cancer (NSCLC) is accounts for approximately 85% of all the lung cancers and lung squamous carcinoma (SCC) and adenocarcinoma (ADC) are the main subtypes of NSCLC. Early diagnose using serum biomarkers could improve the overall survival of patients. In this study, we aimed to identify miRNAs from serum with clinical utility in the diagnosis of NSCLC. Methods: Ten patients with SCC, ten patients with ADC and five noncancerous individuals were enrolled in the screening cohort. miRNA expression levels in serum were measured by microarray analysis. Candidate miRNAs were validated by real-time quantitative polymerase chain reaction analysis in a validation cohort of 78 NSCLC patients and 44 noncancerous individuals. Receiver operating characteristic curves were used to assess the diagnostic performance of serum miRNAs for NSCLC. Logistic regression was used to evaluate the diagnostic value of the combination of markers. Results: Six candidate miRNAs were differentially expressed between NSCLC patients and noncancerous individuals in the screening set (fold change > 2, p < 0.05). Among them, expression levels of miR-3149 and miR-4769.3p were confirmed to be significantly increased in tumor serum in the validation set. The area under the curve values of miR-3149 and miR-4769.3p in distinguishing NSCLC patients from noncancerous controls were 0.830 and 0.735, respectively. When combined with tumor markers CEA and Cyfra21-1, the joint diagnostic model increased the area under the curve to 0.898. Conclusion: Serum miRNAs miR-3149 and miR-4769.3p were up-regulated in NSCLC and may be potential biomarkers for early diagnosis of lung cancer.
Language	English
Publishing date	2022-12-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-022-02267-6
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Article ; Online: Reply to letter.

Tam, Wilson / Ho, Roger / Ho, Cyrus / Hao, Fengyi / Tan, Wanqiu

Brain, behavior, and immunity

2020 Volume 93, Page(s) 426–427

MeSH term(s)	Anxiety ; COVID-19 ; Case-Control Studies ; Communicable Disease Control ; Humans ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2020-12-24
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2020.12.019
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Article ; Online: A Comparative Study of Estimating Auroral Electron Energy from Ground-Based Hyperspectral Imagery and DMSP-SSJ5 Particle Data

Wanqiu Kong / Zejun Hu / Jiaji Wu / Tan Qu / Gwanggil Jeon

Remote Sensing, Vol 12, Iss 2259, p

2020 Volume 2259

Abstract: Aurora, the spectacular phenomenon commonly occurring in high latitudes, is caused by the precipitation of energetic particles penetrating the Earth’s atmosphere. Being the result of solar-terrestrial interactions, electron precipitation significantly ... ...

Abstract	Aurora, the spectacular phenomenon commonly occurring in high latitudes, is caused by the precipitation of energetic particles penetrating the Earth’s atmosphere. Being the result of solar-terrestrial interactions, electron precipitation significantly contributes to auroral production. To evaluate its magnitude, a physical quantity describing the characteristics of precipitating auroral electrons—their characteristic energy—is adopted. In this paper, this quantity is derived from joint data observed by the ground-based auroral spectroscopic imager located in Antarctica Zhongshan Station and the particle detectors “Special Sensor J5 (SSJ5)” on the Defense Meteorological Satellite Program (DMSP) satellites. A postprocessing scheme of ground-based spectral data is proposed to infer the characteristic energy that successively uses classical brute-force, recursive brute-force and self-consistent approximation strategies for step-up speed improvement. Then, the inferred characteristic energies are compared to the average energies calibrated from the relevant electron data detected by SSJ5 to confirm whether this inference is valid. Regarding DMSP F18/SSJ5, these two energy estimations about auroral electrons deviate slightly from each other and show a strong linear relationship. It sheds light on further applications of the valuable aurora spectral data.
Keywords	aurora ; atmospheric electron transport ; auroral energy ; hyperspectral data ; DMSP SSJ5 ; Science ; Q
Subject code	541
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: The isocitrate dehydrogenase 1 is a potential prognostic indicator for non-small cell lung cancer patients.

Zhang, Xintong / Ma, Shang / Chen, Yan / Yin, Yanjun / Bai, Wanqiu / Tan, Jinjing / Shi, Guangli

The International journal of biological markers

2021 Volume 36, Issue 4, Page(s) 27–35

Abstract: Background: The serum isocitrate dehydrogenase 1(IDH1) level is significantly elevated in patients with non-small cell lung cancer (NSCLC) and has important clinical value as a marker for early diagnosis. This study examined the dynamic changes of serum ...

Abstract	Background: The serum isocitrate dehydrogenase 1(IDH1) level is significantly elevated in patients with non-small cell lung cancer (NSCLC) and has important clinical value as a marker for early diagnosis. This study examined the dynamic changes of serum IDH1 levels of patients with NSCLC undergoing surgery or medical treatment, to evaluate its potential prognostic value. Methods: The study cohort included 83 NSCLC patients who underwent surgery, 37 NSCLC patients who underwent medical treatment, 50 healthy controls, and 52 disease controls. Serum levels of IDH1 were assayed by enzyme-linked immunoassay. Tumor biomarkers including carcinoembryonic antigen, squamous cell carcinoma, neuron-specific enolase, CYFRA21-1, and pro-gastrin-releasing peptide-which are currently used in clinical practice-were measured by automatic immunoanalyzers. Results: Serum IDH1 was significantly higher in patients with NSCLC compared with healthy people or patients with benign lung diseases ( Conclusion: IDH1 has potential prognostic value and may be used as a marker for the monitoring of treatment efficacy.
MeSH term(s)	Antigens, Neoplasm ; Biomarkers, Tumor ; Carcinoembryonic Antigen ; Carcinoma, Non-Small-Cell Lung/genetics ; Humans ; Isocitrate Dehydrogenase/genetics ; Keratin-19/genetics ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Prognosis
Chemical Substances	Antigens, Neoplasm ; Biomarkers, Tumor ; Carcinoembryonic Antigen ; Keratin-19 ; antigen CYFRA21.1 ; Isocitrate Dehydrogenase (EC 1.1.1.41)
Language	English
Publishing date	2021-11-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	645113-5
ISSN	1724-6008 ; 0393-6155
ISSN (online)	1724-6008
ISSN	0393-6155
DOI	10.1177/17246008211052571
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