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  1. Article ; Online: Is stratified shielding from covid-19 feasible and ethical?

    Petersen, Irene

    BMJ (Clinical research ed.)

    2020  Volume 370, Page(s) m2660

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Risk Assessment ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Is stratified shielding from covid-19 feasible and ethical?

    Petersen, Irene

    2020  

    Keywords LETTERS ; covid19
    Language English
    Publishing date 2020-07-07 09:09:51.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Is stratified shielding from covid-19 feasible and ethical?

    Petersen, Irene

    BMJ

    2020  , Page(s) m2660

    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2660
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The case-crossover design for studying sudden events.

    Lewer, Dan / Petersen, Irene / Maclure, Malcolm

    BMJ medicine

    2022  Volume 1, Issue 1, Page(s) e000214

    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article
    ISSN 2754-0413
    ISSN (online) 2754-0413
    DOI 10.1136/bmjmed-2022-000214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Association of Recent Fatherhood With Antidepressant Treatment Initiation Among Men in the United Kingdom.

    Smith, Holly Christina / Petersen, Irene / Schartau, Patricia

    JAMA network open

    2023  Volume 6, Issue 5, Page(s) e2316105

    Abstract: Importance: There is some evidence that men may be at higher risk of depression directly following the birth of their child and that approximately 1 in 10 men will experience depression in the year after birth, but less is known about men's ... ...

    Abstract Importance: There is some evidence that men may be at higher risk of depression directly following the birth of their child and that approximately 1 in 10 men will experience depression in the year after birth, but less is known about men's antidepressant treatment during this time. Likewise, few direct comparisons have been made with antidepressant treatment in men who have not recently become fathers.
    Objectives: To determine whether recently having a child was associated with increased odds of antidepressant treatment in men.
    Design, setting, and participants: This cohort study used UK primary care electronic health records from the IQVIA Medical Research Database. Participants included men aged 15 to 55 years who had had a child in the previous year, from January 2007 to December 2016, and compared with up to 5 men who did not have a child in the same calendar year. Data were analyzed from January 2022 to March 2023.
    Exposure: A record of having a child in the previous year was identified through linked primary care records using a family identification number.
    Main outcomes and measures: The main outcome was antidepressant initiation in the year after childbirth or in the year after this index date for men who did not have a child. Random-effects Poisson regression was used to determine associations of cohort, age group, social deprivation, history of antidepressant treatment, and calendar year with having an antidepressant prescription in the year after index date using prevalence risk rates (PPRs).
    Results: Analysis included 90 736 men who had had a child in the previous year and 453 632 men in the comparison cohort. Most men in the study (463 879 men [85.2%]) were aged between 25 and 44 years, and there were more men living in the least deprived areas (130 277 men [23.9%]) than the most deprived areas (72 268 men [13.3%]). Overall, 4439 men (4.9%) had at least 1 antidepressant prescription in the year after they had a child, compared with 26 646 men (5.9%) who did not have a child in the same year. However, after adjustment there was no difference in antidepressant treatment between groups (adjusted PRR [aPRR], 1.01; 95% CI, 0.98-1.04). In fathers, those who had recently received antidepressant treatment were much more likely to receive antidepressant treatment after childbirth compared with fathers with no history of antidepressant treatment (aPRR, 32.31; 95% CI, 30.37-34.38). Fathers living in the most deprived areas were 18% more likely to have an antidepressant prescription compared with fathers living in the least deprived areas (aPRR, 1.18; 95% CI, 1.07-1.30).
    Conclusions and relevance: These findings suggest that recently having a child was not associated with an increase in antidepressant treatment among men, but previous antidepressant treatment in fathers was strongly associated with treatment after childbirth. Further research is needed to determine whether antidepressant treatment or experiencing depression can be a barrier to fatherhood and whether fatherhood is a barrier to receiving antidepressant treatment.
    MeSH term(s) Male ; Pregnancy ; Female ; Humans ; Adult ; Cohort Studies ; Antidepressive Agents/therapeutic use ; Parturition ; United Kingdom/epidemiology ; Delivery, Obstetric
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.16105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Maternal Postnatal Depression and Completion of Infant Immunizations: A UK Cohort Study of 196,329 Mother-Infant Pairs, 2006-2015.

    Smith, Holly C / Saxena, Sonia / Petersen, Irene

    The Journal of clinical psychiatry

    2022  Volume 83, Issue 4

    Abstract: Objective:: Methods:: Results:: Conclusions: ...

    Abstract Objective:
    Methods:
    Results:
    Conclusions:
    MeSH term(s) Antidepressive Agents/therapeutic use ; Child ; Cohort Studies ; Depression, Postpartum/epidemiology ; Depression, Postpartum/prevention & control ; Female ; Haemophilus Vaccines ; Humans ; Infant ; Mothers ; United Kingdom/epidemiology ; Vaccination
    Chemical Substances Antidepressive Agents ; Haemophilus Vaccines
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.20m13575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Risk of Parkinson's disease in people with New Onset Anxiety over 50 years - Incidence and Associated Features.

    Bazo-Alvarez, Juan Carlos / Nimmons, Danielle / Walters, Kate / Petersen, Irene / Schrag, Anette

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2024  

    Abstract: Background: Anxiety has been identified as a prodromal feature of Parkinson's disease (PD). The prospective risk of PD in those newly presenting with anxiety and factors that increase the risk of PD in patients with anxiety have not been investigated.!## ...

    Abstract Background: Anxiety has been identified as a prodromal feature of Parkinson's disease (PD). The prospective risk of PD in those newly presenting with anxiety and factors that increase the risk of PD in patients with anxiety have not been investigated.
    Aim: To investigate the incidence of PD in people with anxiety above the age 50 years and clinical features associated with later diagnosis of PD in people with anxiety.
    Design and setting: Retrospective cohort study using UK primary care data of people between 2008 and 2018 who had new onset anxiety over the age of 50 years.
    Method: We fitted Weibull survival regression models and estimated hazard ratios (HR) for modelling time-to-PD in those with and without anxiety and when determining the risk of developing PD in those with anxiety. Results were adjusted for sociodemographic and lifestyle factors and relevant physical and mental health conditions.
    Results: The risk of PD was increased 2-fold compared to the non-anxiety group after adjustment for age, sex, social deprivation, lifestyle factors, severe mental illness, head trauma and dementia HR 2.1 (CI: 1.9-2.4). In those with anxiety, the presence of depression, hypotension, tremor, rigidity, balance impairment, constipation, sleep disturbance, fatigue, and cognitive impairment were associated with an increased risk of developing PD.
    Conclusion: The risk of developing PD was at least doubled in people with anxiety compared to those without. The clinical features of those who developed PD can help identify patients presenting with anxiety who are in the prodromal phase of PD.
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/BJGP.2023.0423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Quantifying the impact of unmeasured confounding in observational studies with the E value.

    Gaster, Tobias / Eggertsen, Christine Marie / Støvring, Henrik / Ehrenstein, Vera / Petersen, Irene

    BMJ medicine

    2023  Volume 2, Issue 1, Page(s) e000366

    Abstract: The E value method deals with unmeasured confounding, a key source of bias in observational studies. The E value method is described and its use is shown in a worked example of a meta-analysis examining the association between the use of antidepressants ... ...

    Abstract The E value method deals with unmeasured confounding, a key source of bias in observational studies. The E value method is described and its use is shown in a worked example of a meta-analysis examining the association between the use of antidepressants in pregnancy and the risk of miscarriage.
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article
    ISSN 2754-0413
    ISSN (online) 2754-0413
    DOI 10.1136/bmjmed-2022-000366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Prevalence of Perinatal Depression and Anxiety in Both Parents: A Systematic Review and Meta-analysis.

    Smythe, Kara L / Petersen, Irene / Schartau, Patricia

    JAMA network open

    2022  Volume 5, Issue 6, Page(s) e2218969

    Abstract: Importance: New and expectant parents experience perinatal mood disorders, with consequences to parenting ability, bonding with the neonate, interpersonal relationships, and health and well-being of parents. Research shows that maternal and paternal ... ...

    Abstract Importance: New and expectant parents experience perinatal mood disorders, with consequences to parenting ability, bonding with the neonate, interpersonal relationships, and health and well-being of parents. Research shows that maternal and paternal perinatal mood disorders are associated, but no recent systematic review has addressed the prevalence of perinatal mood disorders in both mothers and fathers (parental dyad).
    Objective: To examine the prevalence of perinatal mood disorders in parental dyads and identify factors associated with perinatal mood disorders in parental dyads.
    Data sources: Ovid (MEDLINE, Embase, and PsycINFO) and Web of Science were searched from January 1, 1990, to June 8, 2021, for observational studies reporting on the prevalence of perinatal depression or anxiety in a parental dyad.
    Study selection: Studies reporting the prevalence of anxiety or depression in both members of a parental dyad were included, with diagnosis according to established criteria (Diagnostic and Statistical Manual of Mental Disorders [Fifth Edition], International Classification of Diseases, 11th Revision) or use of validated screening tools.
    Data extraction and synthesis: Prevalence data were extracted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data were analyzed in subgroups: antenatal depression, early postnatal depression (0-12 weeks), late postnatal depression (3-12 months), and perinatal anxiety. Pooled prevalence was calculated using a random-effects meta-analysis model. Quality assessment was performed using Joanna Briggs Institute Appraisal Checklist for Studies Reporting Prevalence Data. Data were analyzed in June 2021.
    Main outcomes and measures: Prevalence of perinatal anxiety and perinatal depression in parental dyads.
    Results: Twenty-three studies were included, with data from 29 286 couples. The pooled prevalence of antenatal depression in both parents was 1.72% (95% CI, 0.96%-2.48%; P < .001). The prevalence of early postnatal depression (up to 12 weeks post partum) was 2.37% (95% CI, 1.66%-3.08%; P < .001) and the prevalence of late postnatal depression (3-12 months post partum) was 3.18% (95% CI, 2.3-4.05; P < .001). Only 3 studies reported on perinatal anxiety in both parents, precluding a quantitative analysis.
    Conclusions and relevance: In up to 3.18% of couples, both parents may concurrently experience perinatal depression. Perinatal health care must consider the mental health needs of parents, both as individuals and as a parental dyad. Further research is needed to examine outcomes in families where both parents experience perinatal mood disorders.
    MeSH term(s) Anxiety/epidemiology ; Anxiety/psychology ; Depression/epidemiology ; Depression, Postpartum ; Female ; Humans ; Infant, Newborn ; Parents ; Pregnancy ; Prevalence
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.18969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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