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Article: First record of

Zhang, Zhengkun / Tian, Yifan / Sui, Li / Lu, Yang / Cheng, Ke / Zhao, Yu / Li, Qiyun / Shi, Wangpeng

2024 Volume 14, Page(s) 1284276

Abstract: Introduction: Aspergillus nomiae: Methods: A strain of EPF was isolated and identified from diseased larvae of : Results: The isolated EPF strain AnS1Gzl-1 was identified as : Discussion: This is the first record of a natural infection ... ...

Abstract	Introduction: Aspergillus nomiae Methods: A strain of EPF was isolated and identified from diseased larvae of Results: The isolated EPF strain AnS1Gzl-1 was identified as Discussion: This is the first record of a natural infection of
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1284276
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Article ; Online: A Newborn with "Black Spots".

Shi, Qiyun / Kurada, Sravanti

NeoReviews

2019 Volume 20, Issue 8, Page(s) e482–e485

MeSH term(s)	Diagnosis, Differential ; Humans ; Infant, Newborn ; Male ; Nevus, Pigmented/congenital ; Nevus, Pigmented/diagnosis ; Nevus, Pigmented/therapy
Language	English
Publishing date	2019-08-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	1526-9906
ISSN (online)	1526-9906
DOI	10.1542/neo.20-8-e482
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Article ; Online: Pyrotinib-based therapeutic approaches for HER2-positive breast cancer: the time is now.

Qi, Xiaowei / Shi, Qiyun / Xuhong, Juncheng / Zhang, Yi / Jiang, Jun

Breast cancer research : BCR

2023 Volume 25, Issue 1, Page(s) 113

Abstract: Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) is a highly aggressive subtype associated with poor prognosis. The advent of HER2-targeted drugs, including monoclonal antibodies, tyrosine-kinase inhibitors (TKIs) and antibody- ... ...

Abstract	Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) is a highly aggressive subtype associated with poor prognosis. The advent of HER2-targeted drugs, including monoclonal antibodies, tyrosine-kinase inhibitors (TKIs) and antibody-drug conjugates, has yielded improved prognosis for patients. Compared with widely used monoclonal antibodies, small-molecule TKIs have unique advantages including oral administration and favorable penetration of blood-brain barrier for brain metastatic BC, and reduced cardiotoxicity. Pyrotinib is an irreversible TKI of the pan-ErbB receptor, and has recently been shown to be clinically effective for the treatment of HER2-positive BC in metastatic and neoadjuvant settings. This review highlights the development on the application of pyrotinib-based therapeutic approaches in the clinical settings of HER2-positive BC.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Receptor, ErbB-2/metabolism ; Aminoquinolines/therapeutic use ; Acrylamides/therapeutic use ; Antibodies, Monoclonal
Chemical Substances	pyrotinib ; Receptor, ErbB-2 (EC 2.7.10.1) ; Aminoquinolines ; Acrylamides ; Antibodies, Monoclonal
Language	English
Publishing date	2023-10-03
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2015059-3
ISSN	1465-542X ; 1465-5411
ISSN (online)	1465-542X
ISSN	1465-5411
DOI	10.1186/s13058-023-01694-5
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Zs.A 5494: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Metarhizium rileyi with broad-spectrum insecticidal ability confers resistance against phytopathogens and insect pests as a phytoendophyte.

Zhang, Zhengkun / Sui, Li / Tian, Yifan / Lu, Yang / Xia, Xinyao / Liu, Wende / Cheng, Ke / Li, Qiyun / Shi, Wangpeng

Pest management science

2024

Abstract: Background: Entomophagous fungi (EPF) not only directly kill insect pests, but also colonize plants and improve their resistance against pests. However, most previous research has focused on Beauveria bassiana and Metarhizium anisopliae, and there are ... ...

Abstract	Background: Entomophagous fungi (EPF) not only directly kill insect pests, but also colonize plants and improve their resistance against pests. However, most previous research has focused on Beauveria bassiana and Metarhizium anisopliae, and there are few reports on whether other EPF can enhance resistance against pests via endogenous colonization. Herein, an EPF strain was isolated from diseased larvae of Spodoptera litura in a soybean field, and subjected to genome-wide sequencing at the chromosomal level. The pathogenicity of the isolate toward various pest insects was evaluated, and the ability to colonize plants and induce resistance against phytopathogens and insect pests was tested. Results: The purified isolate was identified as M. rileyi and designated MrS1Gz1-1. Biological assays revealed its strong pathogenicity toward five insect pests belonging to Lepidoptera and Hemiptera. Furthermore, the strain inhibited the growth of soil-borne plant disease caused by Sclerotinia sclerotiorum in vitro. It colonized plants as an endophyte via soil application, thereby inducing plant resistance-related genes against phytopathogen infection, and it disrupted the feeding selectivity of S. litura larvae. Conclusion: M. rileyi MrS1Gz1-1 has potential as a broad-spectrum microbial control agent that can induce resistance against phytopathogens and insect pests feeding as an endotype. The complete genome provides a valuable resource for exploring host interactions. © 2024 Society of Chemical Industry.
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.8027
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Z 2731: Show issues

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Article ; Online: High-performance sono-piezoelectric nanocomposites enhanced by interfacial coupling effects for implantable nanogenerators and actuators.

Chen, Yingxin / Shi, Jingchao / Yang, Guowei / Zhu, Ning / Zhang, Lei / Yang, Dexin / Yao, Ni / Zhang, Wentao / Li, Yongshuang / Guo, Qiyun / Wang, Yuxiang / Wang, Yan / Yang, Tao / Liu, Xiaolian / Zhang, Jian

Materials horizons

2024 Volume 11, Issue 4, Page(s) 995–1007

Abstract: Transcutaneous energy-harvesting technology based on ultrasound-driven piezoelectric nanogenerators is the most promising technology in medical and industrial applications. Based on ultrasonic coupling effects at the interfaces, the interfacial ... ...

Abstract	Transcutaneous energy-harvesting technology based on ultrasound-driven piezoelectric nanogenerators is the most promising technology in medical and industrial applications. Based on ultrasonic coupling effects at the interfaces, the interfacial architecture is a critical parameter to attain desirable electromechanical properties of nanocomposites. Herein, we successfully synthesized core-conductive shell-structured BaTiO
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2744250-0
ISSN	2051-6355 ; 2051-6347
ISSN (online)	2051-6355
ISSN	2051-6347
DOI	10.1039/d3mh01355c
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Article ; Online: Transcriptome and small RNA analysis unveils novel insights into the C

Hua, Xiuting / Li, Zhen / Dou, Meijie / Zhang, Yanqing / Zhao, Dongxu / Shi, Huihong / Li, Yihan / Li, Shuangyu / Huang, Yumin / Qi, Yiying / Wang, Baiyu / Wang, Qiyun / Wang, Qiaoyu / Gao, Ruiting / Ming, Ray / Tang, Haibao / Yao, Wei / Zhang, Muqing / Zhang, Jisen

Planta

2024 Volume 259, Issue 5, Page(s) 120

Abstract: Main conclusion: This study reveals miRNA indirect regulation of ... ...

Abstract	Main conclusion: This study reveals miRNA indirect regulation of C
MeSH term(s)	Transcriptome/genetics ; Saccharum/genetics ; Transcription Factors/genetics ; Gene Regulatory Networks ; MicroRNAs/genetics
Chemical Substances	Transcription Factors ; MicroRNAs
Language	English
Publishing date	2024-04-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	208909-9
ISSN	1432-2048 ; 0032-0935 ; 1866-2749
ISSN (online)	1432-2048
ISSN	0032-0935 ; 1866-2749
DOI	10.1007/s00425-024-04390-6
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Z 46/303: Show issues

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Article: Transcriptomic analysis of entomopathogenic fungus Beauveria bassiana infected by a hypervirulent polymycovirus BbPmV-4.

Kang, Qin / Ning, Siyu / Sui, Li / Lu, Yang / Zhao, Yu / Shi, Wangpeng / Li, Qiyun / Zhang, Zhengkun

Fungal biology

2023 Volume 127, Issue 3, Page(s) 958–967

Abstract: Polymycoviridae is a recently established family of mycoviruses. Beauveria bassiana polymycovirus 4 (BbPmV-4) was previously reported. However, the effect of the virus on host fungus B. bassiana was not clarified. Here, a comparison between virus-free ... ...

Abstract	Polymycoviridae is a recently established family of mycoviruses. Beauveria bassiana polymycovirus 4 (BbPmV-4) was previously reported. However, the effect of the virus on host fungus B. bassiana was not clarified. Here, a comparison between virus-free and virus-infected isogenic lines of B. bassiana revealed that BbPmV-4 infection of B. bassiana changes morphology and could lead to decreases in conidiation and increases in virulence against Ostrinia furnacalis larvae. The differential expression of genes between virus-free and virus-infected strains was compared by RNA-Seq and was consistent with the phenotype of B. bassiana. The enhanced pathogenicity may be related to the significant up-regulation of genes encoding mitogen activated protein kinase, cytochrome P450, and polyketide synthase. The results enable studies of the mechanism of interaction between BbPmV-4 and B. bassiana.
MeSH term(s)	Animals ; Transcriptome ; Beauveria ; Gene Expression Profiling ; Moths/microbiology ; Virulence
Language	English
Publishing date	2023-02-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2532164-X
ISSN	1878-6162 ; 1878-6146
ISSN (online)	1878-6162
ISSN	1878-6146
DOI	10.1016/j.funbio.2023.02.003
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Article ; Online: The Role of Innate Immunity in Osteoarthritis and the Connotation of "Immune-joint" Axis: A Narrative Review.

Kuang, Gaoyan / Tan, Xuyi / Liu, Xin / Li, Naping / Yi, Nanxing / Mi, Yilin / Shi, Qiyun / Zeng, Fan / Xie, Xinjun / Lu, Min / Xu, Xiaotong

Combinatorial chemistry & high throughput screening

2024

Abstract: Osteoarthritis (OA) is a degenerative disease that results in constriction of the joint space due to the gradual deterioration of cartilage, alterations in subchondral bone, and synovial membrane. Recently, scientists have found that OA involves lesions ... ...

Abstract	Osteoarthritis (OA) is a degenerative disease that results in constriction of the joint space due to the gradual deterioration of cartilage, alterations in subchondral bone, and synovial membrane. Recently, scientists have found that OA involves lesions in the whole joint, in addition to joint wear and tear and cartilage damage. Osteoarthritis is often accompanied by a subclinical form of synovitis, which is a chronic, relatively low-grade inflammatory response mainly mediated by the innate immune system. The "immune-joint" axis refers to an interaction of an innate immune response with joint inflammation and the whole joint range. Previous studies have underestimated the role of the immune-joint axis in OA, and there is no related research. For this reason, this review aimed to evaluate the existing evidence on the influence of innate immune mechanisms on the pathogenesis of OA. The innate immune system is the body's first line of defense. When the innate immune system is triggered, it instantly activates the downstream inflammatory signal pathway, causing an inflammatory response, while also promoting immune cells to invade joint synovial tissue and accelerate the progression of OA. We have proposed the concept of the "immune-joint" axis and explored it from two aspects of Traditional Chinese Medicine (TCM) theory and modern medical research, such as the innate immunity and OA, macrophages and OA, complement and OA, and other cells and OA, to enrich the scientific connotation of the "immune-joint" axis.
Language	English
Publishing date	2024-01-18
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073264389231101190637
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Zs.A 5577: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Dramatic Response to Pyrotinib and T-DM1 in HER2-Negative Metastatic Breast Cancer With 2 Activating HER2 Mutations.

Tian, Hao / Qu, Man / Zhang, Guozhi / Yuan, Long / Shi, Qiyun / Wang, Yinhuan / Yang, Ying / Zhang, Yi / Qi, Xiaowei

The oncologist

2023 Volume 28, Issue 7, Page(s) e534–e541

Abstract: HER2 signaling is activated in response to somatic HER2 mutations, which are often found in invasive lobular breast cancer (ILC) and are associated with poor prognosis. Tyrosine kinase inhibitors (TKIs) have demonstrated considerable antitumor activity ... ...

Abstract	HER2 signaling is activated in response to somatic HER2 mutations, which are often found in invasive lobular breast cancer (ILC) and are associated with poor prognosis. Tyrosine kinase inhibitors (TKIs) have demonstrated considerable antitumor activity in patients with HER2-mutated advanced breast cancer (BC). Further, several clinical trials have indicated that HER2-targeted antibody-drug conjugates (ADCs) exhibit promising efficacy in lung cancer with HER2 mutations, and the efficacy of ADCs against HER2-mutated BC is currently being evaluated. Several preclinical studies have demonstrated that the therapeutic efficacy of ADCs in HER2-mutated cancer can be enhanced by the addition of irreversible TKIs, but the potential of such a combined treatment regimen for the treatment of HER2-mutated BC has not been reported. Herein, we describe a case in which a patient with estrogen receptor-positive/HER2-negative metastatic ILC with 2 activating HER2 mutations (D769H and V777L) exhibited a significant and durable response to anti-HER2 treatment with pyrotinib (an irreversible TKI) in combination with ado-trastuzumab emtansine, which was administered after multiple lines of therapy that had resulted in disease progression. Further, based on the evidence from the present case, TKI plus ADC seems to be a promising combination anti-HER2 regimen for patients with HER2-negative/HER2-mutated advanced BC, although further rigorous studies are warranted to confirm these findings.
MeSH term(s)	Humans ; Female ; Ado-Trastuzumab Emtansine/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Trastuzumab/therapeutic use ; Receptor, ErbB-2/therapeutic use ; Mutation
Chemical Substances	Ado-Trastuzumab Emtansine (SE2KH7T06F) ; Trastuzumab (P188ANX8CK) ; pyrotinib ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2023-04-29
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1093/oncolo/oyad122
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Zs.A 4845: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 494: Show issues

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Article ; Online: Case Report: Four cases of SARS-CoV-2-associated Guillain-Barré Syndrome with SARS-CoV-2-positive cerebrospinal fluid detected by metagenomic next-generation sequencing: a retrospective case series from China.

Guan, Yalin / Yu, Changshen / Fei, Yunhan / Wang, Qiushi / Wang, Pan / Zuo, Wenchao / Wu, Hao / Qi, Xuemei / Shi, Qiyun

Frontiers in immunology

2023 Volume 14, Page(s) 1258579

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often absent or at low levels in the cerebrospinal fluid (CSF) of patients with previous SARS-CoV-2-associated Guillain-Barré syndrome (GBS). This has led to speculation that SARS-CoV-2- ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often absent or at low levels in the cerebrospinal fluid (CSF) of patients with previous SARS-CoV-2-associated Guillain-Barré syndrome (GBS). This has led to speculation that SARS-CoV-2-associated GBS is more likely mediated by post-infectious immunity or a parainfection. This understanding has influenced the development of treatment regimens for SARS-CoV-2-associated GBS. This paper reports our experience with four Chinese patients with SARS-CoV-2-associated GBS who tested positive for SARS-CoV-2 RNA in the CSF. They developed symptoms of peripheral nerve damage 4-15 days after fever and confirmed SARS-CoV-2 infection, all of whom presented with progressive weakness of both lower limbs; three with autonomic nerve function impairment such as constipation and urination disorder; and one with polycranial neuritis and Miller-Fisher syndrome. Three patients were tested for anti-ganglioside antibodies, and one tested positive for GD1a-IgG. Four patients recovered well after treatment with anti-viral drugs combined with intravenous immunoglobulin. The present results showed that SARS-CoV-2 RNA can be detected via mNGS in the CSF of some patients with SARS-CoV-2-associated GBS, suggesting that SARS-CoV-2-associated GBS may have multiple pathogeneses.
MeSH term(s)	Humans ; SARS-CoV-2 ; Guillain-Barre Syndrome/diagnosis ; RNA, Viral/genetics ; Retrospective Studies ; COVID-19/complications ; COVID-19/diagnosis ; China ; High-Throughput Nucleotide Sequencing
Chemical Substances	RNA, Viral
Language	English
Publishing date	2023-08-28
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1258579
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