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  1. Article: Place in Therapy of the Newly Available Armamentarium for Multi-Drug-Resistant Gram-Negative Pathogens: Proposal of a Prescription Algorithm.

    Volpicelli, Lorenzo / Venditti, Mario / Ceccarelli, Giancarlo / Oliva, Alessandra

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 12

    Abstract: The worldwide propagation of antimicrobial resistance represents one of the biggest threats to global health and development. Multi-drug-resistant organisms (MDROs), including carbapenem-resistant non-fermenting Gram-negatives ... ...

    Abstract The worldwide propagation of antimicrobial resistance represents one of the biggest threats to global health and development. Multi-drug-resistant organisms (MDROs), including carbapenem-resistant non-fermenting Gram-negatives and
    Language English
    Publishing date 2021-11-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10121475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: What are the treatment options for resistant

    Spaziante, Martina / Oliva, Alessandra / Ceccarelli, Giancarlo / Venditti, Mario

    Expert opinion on pharmacotherapy

    2020  Volume 21, Issue 15, Page(s) 1781–1787

    Language English
    Publishing date 2020-06-17
    Publishing country England
    Document type Editorial
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2020.1779221
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5130: Show issues Location:
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  3. Article ; Online: Dysbiosis in SARS-CoV-2-Infected Patients.

    Marazzato, Massimiliano / Ceccarelli, Giancarlo / d'Ettorre, Gabriella

    Gastroenterology

    2020  Volume 160, Issue 6, Page(s) 2195

    MeSH term(s) COVID-19 ; Dysbiosis ; Hospitalization ; Humans ; Mycobiome ; Patient Discharge ; SARS-CoV-2
    Language English
    Publishing date 2020-12-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.12.056
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  4. Article ; Online: Early recognition of a superinfection: This is the problem in the critically ill COVID-19 patients.

    Alessandri, Francesco / d'Ettorre, Gabriella / Ciccozzi, Massimo / Migliara, Giuseppe / Baccolini, Valentina / Pugliese, Francesco / Ceccarelli, Giancarlo

    Journal of medical virology

    2023  Volume 96, Issue 1, Page(s) e29345

    MeSH term(s) Humans ; COVID-19/diagnosis ; Critical Illness ; Superinfection/diagnosis ; SARS-CoV-2
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29345
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    Zs.A 1320: Show issues Location:
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  5. Article ; Online: Infection prevention and control programme and COVID-19 measures: Effects on hospital-acquired infections in patients with cirrhosis.

    Di Cola, Simone / Gazda, Jakub / Lapenna, Lucia / Ceccarelli, Giancarlo / Merli, Manuela

    JHEP reports : innovation in hepatology

    2023  Volume 5, Issue 5, Page(s) 100703

    Abstract: Background & aims: Bacterial infections affect survival of patients with cirrhosis. Hospital-acquired bacterial infections present a growing healthcare problem because of the increasing prevalence of multidrug-resistant organisms. This study aimed to ... ...

    Abstract Background & aims: Bacterial infections affect survival of patients with cirrhosis. Hospital-acquired bacterial infections present a growing healthcare problem because of the increasing prevalence of multidrug-resistant organisms. This study aimed to investigate the impact of an infection prevention and control programme and coronavirus disease 2019 (COVID-19) measures on the incidence of hospital-acquired infections and a set of secondary outcomes, including the prevalence of multidrug-resistant organisms, empiric antibiotic treatment failure, and development of septic states in patients with cirrhosis.
    Methods: The infection prevention and control programme was a complex strategy based on antimicrobial stewardship and the reduction of patient's exposure to risk factors. The COVID-19 measures presented further behavioural and hygiene restrictions imposed by the Hospital and Health Italian Sanitary System recommendations. We performed a combined retrospective and prospective study in which we compared the impact of extra measures against the hospital standard.
    Results: We analysed data from 941 patients. The infection prevention and control programme was associated with a reduction in the incidence of hospital-acquired infections (17
    Conclusions: The infection prevention and control programme decreased the incidence of hospital-acquired infections by nearly 50%. Furthermore, the programme also reduced the prevalence of most of the secondary outcomes. Based on the results of this study, we encourage other liver centres to adopt infection prevention and control programmes.
    Impact and implications: Infections are a life-threatening problem for patients with liver cirrhosis. Moreover, hospital-acquired infections are even more alarming owing to the high prevalence of multidrug-resistant bacteria. This study analysed a large cohort of hospitalised patients with cirrhosis from three different periods. Unlike in the first period, an infection prevention programme was applied in the second period, reducing the number of hospital-acquired infections and containing multidrug-resistant bacteria. In the third period, we imposed even more stringent measures to minimise the impact of the COVID-19 outbreak. However, these measures did not result in a further reduction in hospital-acquired infections.
    Language English
    Publishing date 2023-02-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2023.100703
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  6. Article ; Online: Occupational health surveillance of healthcare workers during COVID 19 pandemic: a narrative review.

    D'Ettorre, Gabriele / Pellicani, Vincenza / Muratore, Massimo / Ceccarelli, Giancarlo

    Acta bio-medica : Atenei Parmensis

    2022  Volume 93, Issue 1, Page(s) e2022007

    Abstract: Background and aims: Current literature has increasingly highlighted the risk of spreading the SARS-COV-2 infection in healthcare settings and showed the need for occupational health surveillance of HCWs during the current epidemiological emergency from ...

    Abstract Background and aims: Current literature has increasingly highlighted the risk of spreading the SARS-COV-2 infection in healthcare settings and showed the need for occupational health surveillance of HCWs during the current epidemiological emergency from COVID-19, as a preventive measure to minimize the spread of the infection. The purpose of this narrative review was to evaluate the literature and discover what the latest developments are about the management of the occupational health surveillance of healthcare workers (HCWs) during COVID-19 pandemic.
    Methods: We searched for publications in MEDLINE, Pubmed and Google Scholar using selected keywords. Each article was reviewed and categorized into one or more of the following three categories based on its subject matter: early diagnosis of COVID-19 in HCWs, detection of worker susceptibility to severe COVID-19, medical examination of HCWs returning to work after COVID-19.
    Results: Selected articles showed the RT-PCR test for Sars-CoV-2 as the gold standard to enable rapid identification of infected HCWs; an effective schedule of occupational health surveillance allows the identification of the susceptibility of the workers to severe Covid-19 and protect HCWs returning to work from the disease.
    Conclusions: The findings of the present narrative review show the need to strenghten the occupational health surveillance of HCWs during the current COVID-19 pandemic, with the aim not only to contain the spread of the infection in healthcare settings, but also to protect HCWs coming back to work after the disease.
    MeSH term(s) COVID-19 ; Health Personnel ; Humans ; Occupational Health ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-03-14
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v93i1.10277
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  7. Article: Joining Forces against Antibiotic Resistance: The One Health Solution.

    Cella, Eleonora / Giovanetti, Marta / Benedetti, Francesca / Scarpa, Fabio / Johnston, Catherine / Borsetti, Alessandra / Ceccarelli, Giancarlo / Azarian, Taj / Zella, Davide / Ciccozzi, Massimo

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: Antibiotic resistance is a significant global health concern that affects both human and animal populations. ... ...

    Abstract Antibiotic resistance is a significant global health concern that affects both human and animal populations. The
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12091074
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  8. Article ; Online: SARS-CoV-2 pandemic, influenza, and influenza-like illness epidemics: Allies or enemies?

    Ceccarelli, Giancarlo / d'Ettorre, Gabriele / Russo, Alessandro / Fabris, Silvia / Ciccozzi, Massimo / d'Ettorre, Gabriella

    Journal of medical virology

    2022  Volume 95, Issue 1, Page(s) e28148

    MeSH term(s) Humans ; SARS-CoV-2 ; Influenza, Human/epidemiology ; Pandemics ; COVID-19/epidemiology ; Virus Diseases ; Epidemics
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28148
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  9. Article ; Online: Post-traumatic stress disorder symptoms in healthcare workers: a ten-year systematic review.

    D'Ettorre, Gabriele / Pellicani, Vincenza / Ceccarelli, Giancarlo

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 12-S, Page(s) e2020009

    Abstract: Background and aims: Healthcare workers (HCWs) employed in hospital settings frequently experience many occupational stressors leading to post-traumatic stress disorder (PTSD) symptoms. Literature has increasingly highlighted PTSD as a major issue that ... ...

    Abstract Background and aims: Healthcare workers (HCWs) employed in hospital settings frequently experience many occupational stressors leading to post-traumatic stress disorder (PTSD) symptoms. Literature has increasingly highlighted PTSD as a major issue that involves both staff and healthcare organizations; the consequences of PTSD may include medication errors and lower standards of care. The current COVID-19 pandemic poses the need for preventing PTSD in HCWs working closely with COVID-19 patients. The purpose of this systematic review was to analyze the latest developments in assessing and managing the occupational risk of PTSD symptoms in hospital HCWs.
    Methods: We searched for publications in MEDLINE/Pubmed using selected keywords. Each article was reviewed and categorized into one or more of the following four categories based on its subject matter: risk assessment, risk management and occurrence rates.
    Results: Our search resulted in a total of 32 publications that matched our inclusion criteria.  Increased years of service, older age, previous year exposure to violence, personality traits (i.e. neuroticism), history of mental disorders, being non-graduates, were found to be workers' pre-trauma factors predicting PTSD symptoms.
    Conclusions: The findings suggest the need to prioritize preventative interventions aimed to anticipate the effects of traumatic exposure by training HCWs in evidence based anticipatory methods of coping with stressful events. With regard to the current COVID-19 pandemic, we found evidence of the need to strength social support and training targeted at psychological skills of medical staff who treated COVID-19 patients.
    MeSH term(s) Age Factors ; Exposure to Violence ; Health Personnel/psychology ; Humans ; Mental Disorders/complications ; Personality ; Risk Factors ; Stress Disorders, Post-Traumatic/etiology
    Language English
    Publishing date 2020-11-30
    Publishing country Italy
    Document type Journal Article ; Systematic Review
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i12-S.9459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Chronic Suppressive Antibiotic Treatment for Staphylococcal Bone and Joint Implant-Related Infections.

    Ceccarelli, Giancarlo / Perciballi, Beatrice / Russo, Alessandro / Martini, Paolo / Marchetti, Francesco / Capparuccia, Marco Rivano / Iaiani, Giancarlo / Fabris, Silvia / Ciccozzi, Massimo / Villani, Ciro / Venditti, Mario / D'Ettorre, Gabriella / De Meo, Daniele

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: Prosthetic joint infection (PJI) and fracture-related infection (FRI) are difficult-to-treat conditions in patients with severe comorbidity or significant surgical risk. In cases not eligible for standard strategy, debridement procedures with the ... ...

    Abstract Prosthetic joint infection (PJI) and fracture-related infection (FRI) are difficult-to-treat conditions in patients with severe comorbidity or significant surgical risk. In cases not eligible for standard strategy, debridement procedures with the retention of prosthesis or internal fixation device, combined with long-term antibiotic treatment and subsequent indefinite chronic oral antimicrobial suppression (COAS), can be the only reasonable choice. The aim of this study was to investigate the role of COAS and its follow-up in the management of these cases. We retrospectively analyzed a cohort of 16 patients with a follow-up of at least 6 months (mean age 75 yo, 9F, 7M, 11 PJI, 5 FRI). All microbiological isolates were tetracycline-susceptible staphylococci and for this reason a minocycline-based COAS was adopted after debridement and 3 months of antibiogram-guided antibiotic treatment. Patient monitoring was carried out on a clinical basis, with bimonthly execution of the inflammation indices and serial radiolabeled leukocyte scintigraphy (LS). The overall median time of COAS follow-up was 15 months (min 6-max 30). Moreover, 62.5% of patients were still taking COAS with no relapse after cure at the last evaluation available. Clinical failure with a relapse of the infection was observed in 37.5% of patients; interestingly, 50% of them had previously stopped COAS due to side effects of the antibiotic used. In the COAS follow-up, a combination of clinical, laboratory and LS evaluation seems to monitor the infection properly. COAS can be considered as an interesting approach in patients not suitable for standard treatments of PJI or FRI but it requires careful monitoring.
    Language English
    Publishing date 2023-05-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12050937
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