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  1. Article ; Online: Is the HScore useful in COVID-19?

    Leverenz, David L / Tarrant, Teresa K

    Lancet (London, England)

    2020  Volume 395, Issue 10236, Page(s) e83

    MeSH term(s) Betacoronavirus ; COVID-19 ; Calcinosis ; Coronavirus Infections ; Cytokines ; Heart Valve Diseases ; Humans ; Immune Tolerance ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31057-6
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  3. Article ; Online: Is the HScore useful in COVID-19?

    Leverenz, David L / Tarrant, Teresa K

    The Lancet

    2020  Volume 395, Issue 10236, Page(s) e83

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)31057-6
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: RheumMadness: Creating an Online Community of Inquiry in Rheumatology.

    Leverenz, David L / Garren, Akrithi U / Katz, Guy / Saygin, Didem / Witt, Allen / Harper, Robert / Sparks, Matthew A / Criscione-Schreiber, Lisa

    Arthritis care & research

    2023  Volume 75, Issue 11, Page(s) 2248–2258

    Abstract: Objective: To evaluate the educational impact of RheumMadness, an online tournament of rheumatology concepts grounded in social constructivist theory, as viewed through the community of inquiry (CoI) framework.: Methods: The curricular scaffold of ... ...

    Abstract Objective: To evaluate the educational impact of RheumMadness, an online tournament of rheumatology concepts grounded in social constructivist theory, as viewed through the community of inquiry (CoI) framework.
    Methods: The curricular scaffold of RheumMadness was a bracket of 16 rheumatology concepts competing as "teams" in a tournament. Participants could create and review "scouting reports" about each team, listen to a RheumMadness podcast, discuss on social media, and submit a bracket predicting tournament outcomes according to the perceived importance of each team. Engagement was measured with direct analytics and through self-report on a survey. The survey also assessed participants' educational experience using an adapted 34-item CoI survey, which describes the cognitive, social, and teaching presences in a learning activity.
    Results: One hundred brackets were submitted. On average, each scouting report was viewed 92 times, each podcast episode was downloaded 163 times, and 486 tweets were sent about #RheumMadness from 105 users. The survey received 58 of 107 responses (54%). Respondent agreement with prompts related to each CoI presence was: 70.3% cognitive, 61.7% social, 84.9% teaching. Reported engagement in RheumMadness correlated strongly with overall CoI survey scores (r = 0.72, P < 0.001).
    Conclusion: RheumMadness created an online CoI that fostered social constructivist learning about rheumatology.
    MeSH term(s) Humans ; Rheumatology ; Surveys and Questionnaires ; Self Report
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.25108
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  5. Article ; Online: The Role of T Helper Type 2 (Th2) Cytokines in the Pathogenesis of Eosinophilic Granulomatosis with Polyangiitis (eGPA): an Illustrative Case and Discussion.

    Milne, Megan E / Kimball, Jack / Tarrant, Teresa K / Al-Rohil, Rami N / Leverenz, David L

    Current allergy and asthma reports

    2022  Volume 22, Issue 11, Page(s) 141–150

    Abstract: Purposeof review: The pathogenesis of eosinophilic granulomatosis with polyangiitis (eGPA) is driven largely by CD4 + type 2 helper T cells (Th2), B cells, and eosinophils. Interleukin (IL)-4 and IL-13 are critical cytokines in Th2 cell-mediated ... ...

    Abstract Purposeof review: The pathogenesis of eosinophilic granulomatosis with polyangiitis (eGPA) is driven largely by CD4 + type 2 helper T cells (Th2), B cells, and eosinophils. Interleukin (IL)-4 and IL-13 are critical cytokines in Th2 cell-mediated inflammation; however, inhibition of IL-4 and IL-13 does not reduce serum eosinophil counts and has even been associated with hypereosinophilia. This review explores the role of IL-4, IL-5, and IL-13 in Th2-mediated inflammation to consider the potential clinical consequences of inhibiting these individual cytokines in eGPA.
    Recent findings: Treatments for eosinophilic granulomatosis with polyangiitis (eGPA) are rapidly evolving through using biologic therapies to modulate the Th2 inflammatory response via eosinophil inhibition. While IL-4, IL-5, IL-13, and IL-25 can all affect eosinophils, only IL-5 inhibition has demonstrated therapeutic benefit to-date. In this review, we report a clinical vignette of a patient with adult-onset asthma who developed severe manifestations of eGPA after switching from mepolizumab (an IL-5 inhibitor) to dupilumab (an inhibitor of IL-4 and IL-13). By understanding the role of IL-4, IL-5, and IL-13 in Th2-mediated vasculitis, we can start to understand how eGPA might respond differently to focused cytokine inhibition.
    MeSH term(s) Adult ; Churg-Strauss Syndrome/complications ; Churg-Strauss Syndrome/drug therapy ; Cytokines ; Granulomatosis with Polyangiitis/drug therapy ; Humans ; Inflammation ; Interleukin-13/therapeutic use ; Interleukin-4/therapeutic use ; Interleukin-5 ; Th2 Cells
    Chemical Substances Cytokines ; Interleukin-13 ; Interleukin-5 ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-022-01039-w
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  6. Article ; Online: A single center pilot study: assessing resident needs and faculty perceptions to improve training in rheumatology.

    He, Lauren / Saygin, Didem / Leverenz, David / Quimson, Laarni / Martin, Shannon K / Ko, Kichul

    BMC medical education

    2023  Volume 23, Issue 1, Page(s) 351

    Abstract: Background: Internal medicine (IM) residents lack confidence in rheumatology. Due to the wide variety of topics in rheumatology, identifying the most important subjects to learn during training is vital to create future interventions to increase ... ...

    Abstract Background: Internal medicine (IM) residents lack confidence in rheumatology. Due to the wide variety of topics in rheumatology, identifying the most important subjects to learn during training is vital to create future interventions to increase confidence and knowledge. The preferred teaching modality for both attendings/fellows and residents is not known.
    Methods: An electronic survey was distributed to all IM residents, rheumatology fellows, and rheumatology faculty at the University of Chicago during the 2020-2021 academic year. Residents reported self-confidence levels on 10 rheumatology topics, while rheumatology attendings/fellows were asked to rank these from most to least important to learn during IM residency. All groups were asked preferred teaching modality.
    Results: Median confidence level [interquartile range] among residents for caring for patients with rheumatological conditions was 6 [3.6-7.5] for inpatient and 5 [3.7-6.5] for outpatient settings (10 being very confident). Attendings and fellows identified the most important topics to learn during the rheumatology rotation as ordering and interpreting autoimmune serologies and musculoskeletal exam. Both attendings/fellows and residents preferred bedside teaching in the inpatient setting and case-based learning in the outpatient setting.
    Conclusions: While some disease-specific topics such as autoimmune serologies were identified as important rheumatology topics for IM residents to learn, more practical topics like musculoskeletal exam skills were also deemed important. This highlights the need for comprehensive interventions that focus on more than standardized exam topics alone to improve rheumatology confidence in IM residents. There are different preferences of teaching styles in various clinical settings.
    MeSH term(s) Humans ; Rheumatology/education ; Internship and Residency ; Education, Medical, Graduate ; Pilot Projects ; Faculty ; Clinical Competence
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-023-04336-8
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  7. Article ; Online: A Fuzzy Cause of Hip Pain.

    Leverenz, David L / Criscione-Schreiber, Lisa G

    The American journal of medicine

    2019  Volume 133, Issue 5, Page(s) 580–581

    MeSH term(s) Adult ; Arthralgia/diagnostic imaging ; Arthralgia/etiology ; Calcinosis/complications ; Calcinosis/diagnosis ; Calcinosis/pathology ; Female ; Hip Joint/diagnostic imaging ; Hip Joint/pathology ; Humans ; Magnetic Resonance Imaging ; Periarthritis/complications ; Periarthritis/diagnosis ; Periarthritis/pathology ; Radiography
    Language English
    Publishing date 2019-11-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2019.10.026
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  8. Article ; Online: The Impact of the COVID-19 Pandemic and Telemedicine Implementation on Practice Patterns and Electronic Health Record Utilization in an Academic Rheumatology Practice.

    Maheswaranathan, Mithu / Chu, Philip / Johannemann, Andrew / Criscione-Schreiber, Lisa / Clowse, Megan / Leverenz, David L

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2021  Volume 28, Issue 2, Page(s) e612–e615

    MeSH term(s) COVID-19 ; Electronic Health Records ; Humans ; Pandemics ; Rheumatology ; SARS-CoV-2 ; Telemedicine
    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001751
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  9. Article ; Online: Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren's syndrome.

    Leverenz, David L / St Clair, E William

    F1000Research

    2019  Volume 8

    Abstract: Primary Sjögren's syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren's syndrome also have extraglandular ... ...

    Abstract Primary Sjögren's syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren's syndrome also have extraglandular systemic complications, some of which can be organ- or life-threatening. Over the last decade, numerous targeted immunomodulatory therapies for primary Sjögren's syndrome have failed to show a benefit in clinical trials, and as yet no disease-modifying therapy has been approved for this disease. Herein, we provide an updated review of the clinical trial landscape for primary Sjögren's syndrome and the numerous efforts to move the field forward, including the development of new classification criteria and outcome measures, the results of recent clinical trials in this field, the challenges faced in the search for effective therapies, and the expanding pipeline of novel therapies under development.
    MeSH term(s) Clinical Trials as Topic ; Humans ; Immunotherapy ; Quality of Life ; Sjogren's Syndrome/therapy
    Language English
    Publishing date 2019-08-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.19842.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: What do internal medicine residents know about rheumatology? A needs assessment for curriculum design.

    Leverenz, David L / Eudy, Amanda M / Criscione-Schreiber, Lisa G

    Clinical rheumatology

    2020  Volume 40, Issue 5, Page(s) 2021–2026

    Abstract: We sought to determine if analyzing internal medicine (IM) resident performance on the in-training exam (ITE) might reveal curricular needs in rheumatology education beyond those intuitive to learners and educators from their perceptions and experience. ... ...

    Abstract We sought to determine if analyzing internal medicine (IM) resident performance on the in-training exam (ITE) might reveal curricular needs in rheumatology education beyond those intuitive to learners and educators from their perceptions and experience. We analyzed ITE scores of post-graduate year (PGY) 2 IM residents at our institution from 2010 to 2017. We sorted rheumatology-related educational objectives on the ITEs into 10 disease categories and calculated average scores. We then surveyed our IM residents' self-reported confidence and rheumatology educators' perceptions of IM resident proficiency in the 10 categories on a 10-point Likert scale. Finally, we tallied diagnoses in each category encountered by IM residents in rheumatology clinic. Pearson's correlation coefficients were calculated for the relationship between these data. The ITEs exposed 402 residents to 63 rheumatology-related educational objectives in the 10 categories; 24 objectives were categorized as "other." Survey respondents included 38 residents and 22 educators. There was no correlation between ITE scores in the 10 categories and resident confidence (r = - 0.226, p = 0.530), educator perception (r = - 0.274, p = 0.445), or diagnoses encountered (r = - 0.310, p = 0.383). There was a strong positive correlation between resident confidence and educator perception (r = 0.934, p < 0.001). ITE performance was low in crystalline arthritis and osteoarthritis despite high resident confidence, educator perception, and number of diagnoses seen. Our analysis of IM resident ITE performance identified curricular gaps not apparent in surveys of learner and educator perceptions or an assessment of learner experience. Key Points • In this study, we demonstrate how a systematic analysis of internal medicine resident performance on the in-training exam can identify important curricular gaps in rheumatology education that are not apparent in assessments of learners and educator perceptions or learner experience in rheumatology clinic. • In-training exam performance was low in crystalline arthritis and osteoarthritis despite high resident confidence, educator perception of proficiency, and number of diagnoses seen in these categories. • When rheumatology curricula for internal medicine residents are developed solely on the basis of learner and educator perceptions, common disorders traditionally considered "easy" may be overlooked.
    MeSH term(s) Clinical Competence ; Curriculum ; Humans ; Internal Medicine/education ; Internship and Residency ; Needs Assessment ; Rheumatology/education
    Language English
    Publishing date 2020-11-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-020-05506-5
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