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  1. Article ; Online: Airway Occlusion Pressure (P0.1) and Dyspnea During Mechanical Ventilation: Giving Words to the Pleas of the Respiratory Centers.

    Pérez, Joaquin / Telias, Irene

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202402-0384ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Potentially Injurious Patient-Ventilator Interactions, Challenges Beyond Excess Stress and Strain.

    Castellví-Font, Andrea / Rodrigues, Antenor / Telias, Irene

    Critical care medicine

    2024  Volume 52, Issue 5, Page(s) 850–853

    MeSH term(s) Humans ; Ventilators, Mechanical/adverse effects
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Measuring patient's effort on the ventilator.

    Cornejo, Rodrigo / Telias, Irene / Brochard, Laurent

    Intensive care medicine

    2024  Volume 50, Issue 4, Page(s) 573–576

    MeSH term(s) Humans ; Ventilators, Mechanical ; Respiration, Artificial/adverse effects
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07352-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bedside-available strategies to minimise P-SILI and VILI during ARDS.

    Roca, Oriol / Telias, Irene / Grieco, Domenico L

    Intensive care medicine

    2024  Volume 50, Issue 4, Page(s) 597–601

    MeSH term(s) Humans ; Respiration, Artificial ; Ventilator-Induced Lung Injury ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07366-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reverse Triggering, the Rhythm Dyssynchrony: Potential Implications for Lung and Diaphragm Protection.

    Telias, Irene / Beitler, Jeremy R

    American journal of respiratory and critical care medicine

    2020  Volume 203, Issue 1, Page(s) 5–6

    MeSH term(s) Diaphragm/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; Phenotype ; Respiratory Distress Syndrome ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2020-08-04
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202008-3172ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The oesophageal balloon for respiratory monitoring in ventilated patients: updated clinical review and practical aspects.

    Jonkman, Annemijn H / Telias, Irene / Spinelli, Elena / Akoumianaki, Evangelia / Piquilloud, Lise

    European respiratory review : an official journal of the European Respiratory Society

    2023  Volume 32, Issue 168

    Abstract: There is a well-recognised importance for personalising mechanical ventilation settings to protect the lungs and the diaphragm for each individual patient. Measurement of oesophageal pressure ( ...

    Abstract There is a well-recognised importance for personalising mechanical ventilation settings to protect the lungs and the diaphragm for each individual patient. Measurement of oesophageal pressure (
    MeSH term(s) Humans ; Respiration, Artificial/adverse effects ; Lung ; Respiratory Mechanics/physiology ; Ventilators, Mechanical ; Monitoring, Physiologic
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0186-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Added Benefit of Noninvasive Ventilation to High-Flow Nasal Oxygen to Prevent Reintubation in Higher-Risk Patients.

    Telias, Irene / Ferguson, Niall D

    JAMA

    2019  Volume 322, Issue 15, Page(s) 1455–1457

    Language English
    Publishing date 2019-10-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2019.14609
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  8. Article ; Online: Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients.

    Coiffard, Benjamin / Dianti, Jose / Telias, Irene / Brochard, Laurent J / Slutsky, Arthur S / Beck, Jennifer / Sinderby, Christer / Ferguson, Niall D / Goligher, Ewan C

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 107

    Abstract: Background: Pre-clinical studies suggest that dyssynchronous diaphragm contractions during mechanical ventilation may cause acute diaphragm dysfunction. We aimed to describe the variability in diaphragm contractile loading conditions during mechanical ... ...

    Abstract Background: Pre-clinical studies suggest that dyssynchronous diaphragm contractions during mechanical ventilation may cause acute diaphragm dysfunction. We aimed to describe the variability in diaphragm contractile loading conditions during mechanical ventilation and to establish whether dyssynchronous diaphragm contractions are associated with the development of impaired diaphragm dysfunction.
    Methods: In patients receiving invasive mechanical ventilation for pneumonia, septic shock, acute respiratory distress syndrome, or acute brain injury, airway flow and pressure and diaphragm electrical activity (Edi) were recorded hourly around the clock for up to 7 days. Dyssynchronous post-inspiratory diaphragm loading was defined based on the duration of neural inspiration after expiratory cycling of the ventilator. Diaphragm function was assessed on a daily basis by neuromuscular coupling (NMC, the ratio of transdiaphragmatic pressure to diaphragm electrical activity).
    Results: A total of 4508 hourly recordings were collected in 45 patients. Edi was low or absent (≤ 5 µV) in 51% of study hours (median 71 h per patient, interquartile range 39-101 h). Dyssynchronous post-inspiratory loading was present in 13% of study hours (median 7 h per patient, interquartile range 2-22 h). The probability of dyssynchronous post-inspiratory loading was increased with reverse triggering (odds ratio 15, 95% CI 8-35) and premature cycling (odds ratio 8, 95% CI 6-10). The duration and magnitude of dyssynchronous post-inspiratory loading were associated with a progressive decline in diaphragm NMC (p < 0.01 for interaction with time).
    Conclusions: Dyssynchronous diaphragm contractions may impair diaphragm function during mechanical ventilation.
    Trial registration: MYOTRAUMA, ClinicalTrials.gov NCT03108118. Registered 04 April 2017 (retrospectively registered).
    MeSH term(s) Humans ; Respiration, Artificial/adverse effects ; Diaphragm ; Ventilators, Mechanical ; Respiratory Distress Syndrome ; Thorax
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-024-04894-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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  9. Article ; Online: Sleep and Circadian Rhythm in Critical Illness.

    Telias, Irene / Wilcox, Mary Elizabeth

    Critical care (London, England)

    2019  Volume 23, Issue 1, Page(s) 82

    Abstract: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2019 . Further information about the ... ...

    Abstract This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2019 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901 .
    MeSH term(s) Circadian Rhythm/drug effects ; Circadian Rhythm/physiology ; Critical Illness/psychology ; Critical Illness/therapy ; Humans ; Intensive Care Units/organization & administration ; Noise/adverse effects ; Sleep/drug effects ; Sleep/physiology ; Sleep Wake Disorders/complications ; Sleep Wake Disorders/physiopathology
    Language English
    Publishing date 2019-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-019-2366-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reverse Triggering during Controlled Ventilation: From Physiology to Clinical Management.

    Rodrigues, Antenor / Telias, Irene / Damiani, L Felipe / Brochard, Laurent

    American journal of respiratory and critical care medicine

    2022  Volume 207, Issue 5, Page(s) 533–543

    Abstract: Reverse triggering dyssynchrony is a frequent phenomenon recently recognized in sedated critically ill patients under controlled ventilation. It occurs in at least 30-55% of these patients and often occurs in the transition from fully passive to assisted ...

    Abstract Reverse triggering dyssynchrony is a frequent phenomenon recently recognized in sedated critically ill patients under controlled ventilation. It occurs in at least 30-55% of these patients and often occurs in the transition from fully passive to assisted mechanical ventilation. During reverse triggering, patient inspiratory efforts start after the passive insufflation by mechanical breaths. The most often referred mechanism is the entrainment of the patient's intrinsic respiratory rhythm from the brainstem respiratory centers to periodic mechanical insufflations from the ventilator. However, reverse triggering might also occur because of local reflexes without involving the respiratory rhythm generator in the brainstem. Reverse triggering is observed during the acute phase of the disease, when patients may be susceptible to potential deleterious consequences of injurious or asynchronous efforts. Diagnosing reverse triggering might be challenging and can easily be missed. Inspection of ventilator waveforms or more sophisticated methods, such as the electrical activity of the diaphragm or esophageal pressure, can be used for diagnosis. The occurrence of reverse triggering might have clinical consequences. On the basis of physiological data, reverse triggering might be beneficial or injurious for the diaphragm and the lung, depending on the magnitude of the inspiratory effort. Reverse triggering can cause breath-stacking and loss of protective lung ventilation when triggering a second cycle. Little is known about how to manage patients with reverse triggering; however, available evidence can guide management on the basis of physiological principles.
    MeSH term(s) Humans ; Respiration, Artificial ; Respiration ; Ventilators, Mechanical ; Lung ; Diaphragm
    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202208-1477CI
    Database MEDical Literature Analysis and Retrieval System OnLINE

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