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Article ; Online: Kültür koşullarında Nil Tilapyası ve Melez Kırmızı Tilapya (Cichlidae, Oreochromis spp.)’da görülen gaz kabarcığı hastalığı

Sema Midilli / Deniz Çoban / Mehmet Güler / Semra Küçük

Su Ürünleri Dergisi, Vol 36, Iss 3, Pp 1-

2019 Volume 1

Abstract: ... açabilmekte ve bu durum ölümle sonuçlanabilmektedir. Bu çalışmada Nil tilapyası (Oreochromis niloticus) ve ...

Abstract	Su içerisinde çözünebilen gazların süpersature olması balıklarda gaz kabarcığı hastalığına yol açabilmekte ve bu durum ölümle sonuçlanabilmektedir. Bu çalışmada Nil tilapyası (Oreochromis niloticus) ve melez kırmızı tilapyada (Oreochromis sp.), gaz süpersaturasyonu sonucu gelişen gaz kabarcığı hastalığı vakaları incelenmiştir. Elde edilen makroskobik ve histolojik bulgular kültür koşulları ile birlikte ele alınarak balık yetiştiriciliğinde sıklıkla görülebilen bu hastalık hakkındaki bilgilerin çeşitlendirilmesi amaçlanmıştır. Çalışma, deneysel olarak kültürü yapılan balıklar üzerinden; yaz (Ağustos) ve kış (Aralık) aylarında olmak üzere iki adımlı olarak yürütülmüştür. Klinik ve histolojik incelemesi yapılan balıkların genelinde dorsal, pektoral ve kaudal yüzgeçte gaz kabarcıkları, ayrıca pektoral, dorsal, kaudal yüzgeç ve solungaç kapağı çevresinde peteşiyal tip kanamalar olduğu tespit edilmiştir. Nekropside özellikle mide ve bağırsakların gaz kabarcıkları ile dolu olduğu ve solungaçların da kanamalı olduğu izlenmiştir. Histolojik bulgularda solungaçlarda hiperplazi ve ödem, karaciğer ve dalakta kanama, mide ve bağırsak mukozasında yıkımlanmalar izlenmiştir. Birkaç özel durum dışında her iki balıktan elde edilen klinik bulgular benzer olup süpersaturasyonun etkilerinin her iki balık türü için de ağır olduğu gözlenmiştir.
Keywords	Nile tilapia ; hybrid red tilapia ; gas bubble disease ; histology ; tank culture ; Gas supersaturation ; Nil tilapyası ; melez kırmızı tilapya ; histoloji ; tank üretimi ; Gaz süpersaturasyonu ; gaz kabarcığı hastalığı ; Aquaculture. Fisheries. Angling ; SH1-691 ; Ecology ; QH540-549.5
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	Ege University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Kültür koşullarında Nil Tilapyası ve Melez Kırmızı Tilapya (Cichlidae, Oreochromis spp.)’da görülen gaz kabarcığı hastalığı

Semra Küçük / Mehmet Güler / Deniz Çoban / Sema Midilli

Su Ürünleri Dergisi, Vol 36, Iss 3, Pp 285-

2019 Volume 291

Abstract: ... açabilmekte ve bu durum ölümle sonuçlanabilmektedir. Bu çalışmada Nil tilapyası (Oreochromis niloticus) ve ...

Abstract	Su içerisinde çözünebilen gazların süpersature olması balıklarda gaz kabarcığı hastalığına yol açabilmekte ve bu durum ölümle sonuçlanabilmektedir. Bu çalışmada Nil tilapyası (Oreochromis niloticus) ve melez kırmızı tilapyada (Oreochromis sp.), gaz süpersaturasyonu sonucu gelişen gaz kabarcığı hastalığı vakaları incelenmiştir. Elde edilen makroskobik ve histolojik bulgular kültür koşulları ile birlikte ele alınarak balık yetiştiriciliğinde sıklıkla görülebilen bu hastalık hakkındaki bilgilerin çeşitlendirilmesi amaçlanmıştır. Çalışma, deneysel olarak kültürü yapılan balıklar üzerinden; yaz (Ağustos) ve kış (Aralık) aylarında olmak üzere iki adımlı olarak yürütülmüştür. Klinik ve histolojik incelemesi yapılan balıkların genelinde dorsal, pektoral ve kaudal yüzgeçte gaz kabarcıkları, ayrıca pektoral, dorsal, kaudal yüzgeç ve solungaç kapağı çevresinde peteşiyal tip kanamalar olduğu tespit edilmiştir. Nekropside özellikle mide ve bağırsakların gaz kabarcıkları ile dolu olduğu ve solungaçların da kanamalı olduğu izlenmiştir. Histolojik bulgularda solungaçlarda hiperplazi ve ödem, karaciğer ve dalakta kanama, mide ve bağırsak mukozasında yıkımlanmalar izlenmiştir. Birkaç özel durum dışında her iki balıktan elde edilen klinik bulgular benzer olup süpersaturasyonun etkilerinin her iki balık türü için de ağır olduğu gözlenmiştir.
Keywords	nile tilapia ; hybrid red tilapia ; gas bubble disease ; histology ; tank culture ; gas supersaturation ; nil tilapyası ; melez kırmızı tilapya ; histoloji ; tank üretimi ; gaz süpersaturasyonu ; gaz kabarcığı hastalığı ; Aquaculture. Fisheries. Angling ; SH1-691 ; Ecology ; QH540-549.5
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	Ege University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: GDF11 level and its effect on prognosis in patients with acute myeloid leukemia.

Aslan, Nevin Alayvaz / Avcı, Esin / Şenol, Hande / Güler, Nil

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

2024 Volume 72, Issue 4, Page(s) 341–348

Abstract: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the proliferation of CD34 positive self-renewing malignant hematopoietic stem cells. Previous studies have shown that the transforming growth factor beta (TGFβ) pathway plays a ... ...

Abstract	Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the proliferation of CD34 positive self-renewing malignant hematopoietic stem cells. Previous studies have shown that the transforming growth factor beta (TGFβ) pathway plays a role in AML pathogenesis, especially by affecting the microenvironment. Growth differentiation factor 11 (GDF11) is a member of the TGFβ superfamily, involved in embryological development and known as rejuvenating factor. In this study, our aim was to determine the serum GDF11 level in patients with AML, to compare it with the control group, to determine its relationship with follistatin, vimentin, and E-cadherin levels, and to determine whether GDF11 influences AML prognosis. Serum GDF11, vimentin, follistatin, and E-cadherin levels of newly diagnosed or relapsed/refractory AML patients and age- and gender-matched control group were measured by enzyme-linked immunosorbent assay. Serum GDF11 level was higher in the patient group (263.87 ± 126.54 ng/L) compared to the control group (211.54 ± 61.47 ng/L; p = 0.035). GDF11 level did not change according to age, gender, hemoglobin level, and bone marrow blast rate. No correlation was found between GDF11 level, response rates, and survival status of the patients. A positive correlation was detected between GDF11, E-cadherin, and vimentin levels. As a conclusion, increased serum GDF11 levels in AML patients may be linked to the regeneration ability of leukemic stem cells. There is a need for studies investigating GDF11 expression in myeloblasts.
MeSH term(s)	Humans ; Follistatin ; Vimentin ; Leukemia, Myeloid, Acute/pathology ; Prognosis ; Transforming Growth Factor beta ; Growth Differentiation Factors ; Cadherins ; Tumor Microenvironment ; Bone Morphogenetic Proteins
Chemical Substances	Follistatin ; Vimentin ; Transforming Growth Factor beta ; Growth Differentiation Factors ; Cadherins ; GDF11 protein, human ; Bone Morphogenetic Proteins
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1217870-6
ISSN	1708-8267 ; 0009-9279 ; 1081-5589
ISSN (online)	1708-8267
ISSN	0009-9279 ; 1081-5589
DOI	10.1177/10815589241238218
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Zs.A 307: Show issues

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Article ; Online: Bosutinib-induced massive pleural effusion: Cross-intolerance with all tyrosine kinase inhibitors.

Aslan, Nevin Alayvaz / Hıncal, Hande Oğul / Elver, Özde / Erol, Veysel / Güler, Nil

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2022 Volume 29, Issue 2, Page(s) 511–516

Abstract: Background: The discovery of tyrosine kinase inhibitors provided a breakthrough in the treatment of chronic myeloid leukemia. Nowadays, the management of tyrosine kinase inhibitor-related side effects is one of the important problems in chronic myeloid ... ...

Abstract	Background: The discovery of tyrosine kinase inhibitors provided a breakthrough in the treatment of chronic myeloid leukemia. Nowadays, the management of tyrosine kinase inhibitor-related side effects is one of the important problems in chronic myeloid leukemia treatment. Grades 3-4 pulmonary toxicity; especially pleural effusion is mostly seen with dasatinib treatment but rarely seen with nilotinib and bosutinib. Development of cross-intolerance due to pleural effusion is not an expected situation. Pleural effusion related to tyrosine kinase inhibitors is mostly exudative in nature with abundant lymphocytes. Case report: Massive pleural effusion developed in a 59-year-old male patient with chronic myeloid leukemia, who was being treated with bosutinib. In the past, the patient had experienced massive pleural effusion also with dasatinib and nilotinib. The evaluation for differential diagnosis of pleural effusion did not reveal any additional malignancy. Management and outcome: After discontinuation of bosutinib and initiation of prednisolone, pleural effusion was totally resolved. Prednisolone was gradually discontinued and third-generation tyrosine kinase inhibitor ponatinib was started. After 12 months of follow-up, massive pleural effusion occurred again, leading to discontinuation of ponatinib. Discussion: Cross-intolerance is an important problem in the tyrosine kinase inhibitor era. The significance of this case is the development of cross-intolerance to all second-generation tyrosine kinase inhibitors and furthermore to a third-generation tyrosine kinase inhibitor. Management strategies for pleural effusion and close follow-up are important.
MeSH term(s)	Male ; Humans ; Middle Aged ; Dasatinib/adverse effects ; Tyrosine Kinase Inhibitors ; Protein Kinase Inhibitors/adverse effects ; Pyrimidines/adverse effects ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Pleural Effusion/chemically induced ; Prednisolone/therapeutic use
Chemical Substances	Dasatinib (RBZ1571X5H) ; bosutinib (5018V4AEZ0) ; Tyrosine Kinase Inhibitors ; Protein Kinase Inhibitors ; Pyrimidines ; Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	2022-07-12
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/10781552221114070
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Zs.A 4488: Show issues

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Article: Radiation exposure in acute myeloid leukaemia, diffuse large B-cell lymphoma, and multiple myeloma patients in the first year following diagnosis.

Koluman, Başak Ünver / Arslan, Muhammet / Şenol, Hande / Hacıoğlu, Sibel Kabukçu / Çağlıyan, Gülsüm Akgün / Güler, Nil / Türk, Nilay Şen

Polish journal of radiology

2023 Volume 88, Page(s) e75–e79

Abstract: Purpose: Radiological examinations are critical in the evaluation of patients with haematological malignancies for diagnosis and treatment. Any dose of radiation has been shown in studies to be harmful. In this regard, we assessed the radiation exposure ...

Abstract	Purpose: Radiological examinations are critical in the evaluation of patients with haematological malignancies for diagnosis and treatment. Any dose of radiation has been shown in studies to be harmful. In this regard, we assessed the radiation exposure of 3 types of haematological malignancies (diffuse large B-cell lymphoma [DLBCL], acute myeloid leukaemia [AML], and multiple myeloma [MM]) in our centre during the first year after diagnosis. Material and methods: In the first year after diagnosis we retrospectively reviewed the radiation exposure data of 3 types of haematological malignancies (DLBCL, AML, and MM). The total and median CED value (cumulative effective radiation dose in millisieverts [mSv]) of each patient was used. Each patient's total and median estimated CED value was calculated using a web-based calculator and recorded in millisieverts (mSv). Results: The total radiation doses in one year after diagnosis (CED value) were 46.54 ± 37.12 (median dose: 36.2) in the AML group; 63.00 ± 42.05 (median dose: 66.4) in the DLBCL group; and 28.04 ± 19.81 (median dose: 26.0) in the MM group ( Conclusions: In all 3 haematological malignancies, the radiation exposure was significant, especially in the DBLCL group, within the first year of diagnosis. It is critical to seek methods to reduce these dosage levels. In diagnostic radiology, reference values must be established to increase awareness and self-control and reduce patient radiation exposure. This paper is also the first to offer thorough details on the subject at hand, and we think it can serve as a guide for further investigation.
Language	English
Publishing date	2023-02-03
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2675143-4
ISSN	1899-0967 ; 1733-134X
ISSN (online)	1899-0967
ISSN	1733-134X
DOI	10.5114/pjr.2023.125008
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Article ; Online: Is the Reason of Increased D-Dimer Levels in COVID-19 Because of ACE-2-Induced Apoptosis in Endothelium?

Guler, Nil / Siddiqui, Fakiha / Fareed, Jawed

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

2020 Volume 26, Page(s) 1076029620935526

MeSH term(s)	Alphacoronavirus/pathogenicity ; Angiotensin II/pharmacology ; Animals ; Apoptosis/drug effects ; Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; Caspase Inhibitors/pharmacology ; Caspase Inhibitors/therapeutic use ; Chikungunya virus/pathogenicity ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Endothelium, Vascular/enzymology ; Endothelium, Vascular/pathology ; Endothelium, Vascular/virology ; Fibrin Fibrinogen Degradation Products/metabolism ; Host-Pathogen Interactions ; Humans ; Models, Cardiovascular ; Orthomyxoviridae/pathogenicity ; Pandemics ; Peptidyl-Dipeptidase A/physiology ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Receptors, Virus/physiology ; Swine ; Thrombophilia/blood ; Thrombophilia/etiology ; Virus Replication ; Zika Virus/pathogenicity
Chemical Substances	Caspase Inhibitors ; Fibrin Fibrinogen Degradation Products ; Receptors, Virus ; fibrin fragment D ; Angiotensin II (11128-99-7) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; angiotensin converting enzyme 2 (EC 3.4.17.-)
Keywords	covid19
Language	English
Publishing date	2020-07-10
Publishing country	United States
Document type	Letter
ZDB-ID	1237357-6
ISSN	1938-2723 ; 1076-0296
ISSN (online)	1938-2723
ISSN	1076-0296
DOI	10.1177/1076029620935526
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Zs.A 4370: Show issues

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Article ; Online: Retrospective Analysis of Patients with Immune Thrombocytopenic Purpura

Nil Guler / Mehmet Turgut / Düzgün Özatlı / Şengül Aksakal

Journal of Contemporary Medicine, Vol 10, Iss 2, Pp 196-

2020 Volume 200

Abstract: Aim: We evaluated the clinical feature and the responses to treatments in patients diagnosed and/or followed as chronic immune thrombocytopenic purpura (ITP). Methods: Medical charts of 150 patients diagnosed and/or followed as ITP at Ondokuz Mayıs ... ...

Abstract	Aim: We evaluated the clinical feature and the responses to treatments in patients diagnosed and/or followed as chronic immune thrombocytopenic purpura (ITP). Methods: Medical charts of 150 patients diagnosed and/or followed as ITP at Ondokuz Mayıs Medical Faculty between 2003 and 2011 were analyzed retrospectively. As first-line treatments, steroids based treatment and IVIg were used as medical therapy. In patients, who had no response to first and second courses treatments, splenectomy was performed. Results: The median follow-up of 150 patients was 15 months (range 2-83 months). Thrombocytopenia was incidentally detected in 51(34%) of the cases. During the study period, 21(14%) the patients were followed up without treatment. First line medical therapy were given to 129(86%) patients. Of them, complete response (CR) were seen in 93(72%) patients, partial response (PR) in 14(11%) patients and none response (NR) in 22 (17%) patients. There was no significant benefit of high dose steroid therapy over the standard dose therapy (p=0.59). Of the 107 patients who had response to the treatment, relapse were observed in 48(45%) within 2,5 years. Of 40 patients, there were CR in 15(38%) patients, PR in 9(22%) patients and NR in 16(40%) patients. Splenectomy was performed in 38 patients. Of the 48 patients, CR was achieved in 32(84%) patients, PR in 2(%5) patients and NR in 4(16%) patients. Relapse was observed in 12(35%) patients. Conclusion: This study showed that steroids based treatment and splenectomy are very effective treatment in ITP patients. Only 13(8.6%) patients in our study needed further treatment.
Keywords	immune thrombocytopenic purpura ; bleeding ; corticosteroid ; splenectomy ; i̇mmün trombositopenik purpura ; kanama ; kortikosteroid ; splenektomi ; Medicine ; R
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Rabia Yılmaz
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Is the Reason of Increased D-Dimer Levels in COVID-19 Because of ACE-2-Induced Apoptosis in Endothelium?

Guler, Nil / Siddiqui, Fakiha / Fareed, Jawed

Clin Appl Thromb Hemost

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #643163
Database	COVID19

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Article ; Online: Is the Reason of Increased D-Dimer Levels in COVID-19 Because of ACE-2-Induced Apoptosis in Endothelium?

Guler, Nil / Siddiqui, Fakiha / Fareed, Jawed

Clinical and Applied Thrombosis/Hemostasis

2020 Volume 26, Page(s) 107602962093552

Keywords	Hematology ; General Medicine ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	1237357-6
ISSN	1076-0296
ISSN	1076-0296
DOI	10.1177/1076029620935526
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Serum Hepcidin and Prohepcidin Levels in Nonfebrile and Febrile Neutropenia.

Koluman, Basak Unver / Avci, Esin / Guler, Nil / Cagliyan, Gulsum Akgun / Senol, Hande

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2021 Volume 31, Issue 11, Page(s) 1303–1307

Abstract: Objective: To compare the prohepcidin and hepcidin levels in the afebrile neutropenic period and neutropenic fever in patients with hematological malignancy.: Study design: Descriptive study.: Place and duration of study: Department of Hematology, ...

Abstract	Objective: To compare the prohepcidin and hepcidin levels in the afebrile neutropenic period and neutropenic fever in patients with hematological malignancy. Study design: Descriptive study. Place and duration of study: Department of Hematology, Pamukkale University Hospital, Denizli, Turkey, between January 2018 and December 2019. Methodology: Neutropenic patients were compared with a healthy control group. Prohepcidin and hepcidin serum levels were to be measured in neutropenic and control groups. When fever occurred in neutropenic group, serum was taken again and the same values were compared, in addition to procalcitonin and CRP values. Results: Prohepcidin and hepcidin levels were found to be significantly higher in the neutropenic group (n = 53) than the control group [n = 44, (med:166.65 ng/ml, IQR:147.66 - 187.38 ng/ml vs. med:47.49 ng/ml, IQR:15.61 - 82.51 ng/ml; p <0.001); (med:315 ng/ml, IQR:314.92 - 315 ng/ml vs. med:26.61 ng/ml, IQR:4.69 - 66.83 ng/ml; p <0.001)]. No significant difference was found in terms of these two analyses (167.29 ± 29.31 ng/ml vs. 167.15 ± 27.61 ng/ml; p = 0.979; 296.21 ± 37.19 ng/ml vs 299.16 ± 37.68 ng/ml; p= 0.629) in the neutropenic fever period compared to the afebrile neutropenic period. In neutropenic fever patients, procalcitonin and CRP (C-reactive protein) were found significantly higher than the afebnile neutropenic group (0.7 ± 1.2 ng/ml vs. 0.25 ± 0.76 ng/ml; p = 0.034; 10.27 ± 9.93 mg/dl vs 2.61 ± 2.78 mg/dl; p <0.001). Conclusion: Although there was no significant difference between afebnile neutropenia and neutropenic fever in patients in terms of hepcidin and prohepcidin levels, higher levels were found in both groups compared to the control group. Key Words: Hepcidin, Prohepcidin, Neutropenia, Febrile neutropenia.
MeSH term(s)	C-Reactive Protein ; Febrile Neutropenia ; Hepcidins ; Humans ; Procalcitonin ; Protein Precursors
Chemical Substances	Hepcidins ; Procalcitonin ; Protein Precursors ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-10-23
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2021.11.1303
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