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Article: Editorial: Current advances in genetic presentations of dementia and aging, volume II.

Xu, Yuzhen / Gomez-Pinedo, Ulises / Liu, Jun / Hong, Daojun / Xu, Jun

2023 Volume 15, Page(s) 1202532

Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1202532
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: Current advances in genetic dementia and aging.

Xu, Yuzhen / Hong, Daojun / Gomez-Pinedo, Ulises / Liu, Jun / Xu, Jun

Frontiers in aging neuroscience

2022 Volume 14, Page(s) 1020547

Language	English
Publishing date	2022-09-14
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2022.1020547
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: The Use of Biomaterials With Stem and Precursor Cells in Diseases of the Central Nervous System; A Step to Clinical Trials.

Ramos-Zúñiga, Rodrigo / Guerrero-Cázares, Hugo / Gómez-Pinedo, Ulises / Matias-Guiu, Jorge

Frontiers in neurology

2021 Volume 12, Page(s) 654890

Language	English
Publishing date	2021-03-30
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.654890
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chitosan-Hydroxycinnamic Acids Conjugates: Emerging Biomaterials with Rising Applications in Biomedicine.

Ojeda-Hernández, Doddy Denise / Canales-Aguirre, Alejandro A / Matias-Guiu, Jordi A / Matias-Guiu, Jorge / Gómez-Pinedo, Ulises / Mateos-Díaz, Juan Carlos

International journal of molecular sciences

2022 Volume 23, Issue 20

Abstract: Over the past thirty years, research has shown the huge potential of chitosan in biomedical applications such as drug delivery, tissue engineering and regeneration, cancer therapy, and antimicrobial treatments, among others. One of the major advantages ... ...

Abstract	Over the past thirty years, research has shown the huge potential of chitosan in biomedical applications such as drug delivery, tissue engineering and regeneration, cancer therapy, and antimicrobial treatments, among others. One of the major advantages of this interesting polysaccharide is its modifiability, which facilitates its use in tailor-made applications. In this way, the molecular structure of chitosan has been conjugated with multiple molecules to modify its mechanical, biological, or chemical properties. Here, we review the conjugation of chitosan with some bioactive molecules: hydroxycinnamic acids (HCAs); since these derivatives have been probed to enhance some of the biological effects of chitosan and to fine-tune its characteristics for its application in the biomedical field. First, the main characteristics of chitosan and HCAs are presented; then, the currently employed conjugation strategies between chitosan and HCAs are described; and, finally, the studied biomedical applications of these derivatives are discussed to present their limitations and advantages, which could lead to proximal therapeutic uses.
MeSH term(s)	Chitosan/chemistry ; Biocompatible Materials/chemistry ; Coumaric Acids/therapeutic use ; Tissue Engineering ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Anti-Infective Agents/chemistry
Chemical Substances	Chitosan (9012-76-4) ; Biocompatible Materials ; Coumaric Acids ; Anti-Infective Agents
Language	English
Publishing date	2022-10-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232012473
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: COVID-19 in CNS and PNS: Basic and Clinical Focus on the Mechanisms of Infection and New Tools for the Therapeutic Approach.

Matias-Guiu, Jorge / Matias-Guiu, Jordi A / Garrido, Carmen / Pimienta, Genaro / Reyes, Patricio F / Baig, Abdul Mannan / Gomez-Pinedo, Ulises

Frontiers in neurology

2022 Volume 13, Page(s) 838227

Language	English
Publishing date	2022-03-03
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.838227
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies.

Gómez-Pinedo, Ulises / Matías-Guiu, Jordi A / Ojeda-Hernandez, Denise / de la Fuente-Martin, Sarah / Kamal, Ola Mohamed-Fathy / Benito-Martin, Maria Soledad / Selma-Calvo, Belen / Montero-Escribano, Paloma / Matías-Guiu, Jorge

Cells

2023 Volume 12, Issue 11

Abstract: The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or ... ...

Abstract	The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or differentiate into myelin-forming oligodendrocytes. One essential issue is the creation of administration protocols and determining which factors need to be well established. There is controversy around whether these cells may be implanted simultaneously with corticosteroid treatment, which is widely used in many clinical situations. This study assesses the influence of corticosteroids on the capacity for proliferation and differentiation and the survival of human oligodendroglioma cells. Our findings show that corticosteroids reduce the capacity of these cells to proliferate and to differentiate into oligodendrocytes and decrease cell survival. Thus, their effect does not favour remyelination; this is consistent with the results of studies with rodent cells. In conclusion, protocols for the administration of oligodendrocyte lineage cells with the aim of repopulating oligodendroglial niches or repairing demyelinated axons should not include corticosteroids, given the evidence that the effects of these drugs may undermine the objectives of cell transplantation.
MeSH term(s)	Humans ; Methylprednisolone/pharmacology ; Oligodendroglia ; Myelin Sheath ; Axons ; Cell Differentiation
Chemical Substances	Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12111515
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Article ; Online: Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1

Fernández-Beltrán, Luis C / Ali, Zeinab / Larrad-Sanz, Angélica / Lopez-Carbonero, Juan I / Godoy-Corchuelo, Juan M / Jimenez-Coca, Irene / Garcia-Toledo, Irene / Bentley, Liz / Gomez-Pinedo, Ulises / Matias-Guiu, Jordi A / Gil-Moreno, Maria Jose / Matias-Guiu, Jorge / Corrochano, Silvia

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2671

Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by significant metabolic disruptions, including weight loss and hypermetabolism in both patients and animal models. Leptin, an adipose-derived hormone, displays ... ...

Abstract	Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by significant metabolic disruptions, including weight loss and hypermetabolism in both patients and animal models. Leptin, an adipose-derived hormone, displays altered levels in ALS. Genetically reducing leptin levels (Lepob/+) to maintain body weight improved motor performance and extended survival in female SOD1G93A mice, although the exact molecular mechanisms behind these effects remain elusive. Here, we corroborated the sexual dimorphism in circulating leptin levels in ALS patients and in SOD1G93A mice. We reproduced a previous strategy to generate a genetically deficient leptin SOD1G93A mice (SOD1G93ALepob/+) and studied the transcriptomic profile in the subcutaneous adipose tissue and the spinal cord. We found that leptin deficiency reduced the inflammation pathways activated by the SOD1G93A mutation in the adipose tissue, but not in the spinal cord. These findings emphasize the importance of considering sex-specific approaches in metabolic therapies and highlight the role of leptin in the systemic modulation of ALS by regulating immune responses outside the central nervous system.
MeSH term(s)	Animals ; Female ; Humans ; Male ; Mice ; Adipose Tissue/metabolism ; Amyotrophic Lateral Sclerosis/metabolism ; Disease Models, Animal ; Haploinsufficiency ; Leptin/metabolism ; Mice, Transgenic ; Spinal Cord/metabolism ; Superoxide Dismutase/metabolism ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/metabolism
Chemical Substances	Leptin ; SOD1 protein, human ; Superoxide Dismutase (EC 1.15.1.1) ; Superoxide Dismutase-1 (EC 1.15.1.1) ; Lep protein, mouse ; Sod1 protein, mouse (EC 1.15.1.1)
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52439-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Multimodal neuroimaging in post-COVID syndrome and correlation with cognition.

Díez-Cirarda, María / Yus, Miguel / Gómez-Ruiz, Natividad / Polidura, Carmen / Gil-Martínez, Lidia / Delgado-Alonso, Cristina / Jorquera, Manuela / Gómez-Pinedo, Ulises / Matias-Guiu, Jorge / Arrazola, Juan / Matias-Guiu, Jordi A

Brain : a journal of neurology

2022 Volume 146, Issue 5, Page(s) 2142–2152

Abstract: Brain changes have been reported in the first weeks after SARS-CoV-2 infection. However, limited literature exists about brain alterations in post-COVID syndrome, a condition increasingly associated with cognitive impairment. The present study aimed to ... ...

Abstract	Brain changes have been reported in the first weeks after SARS-CoV-2 infection. However, limited literature exists about brain alterations in post-COVID syndrome, a condition increasingly associated with cognitive impairment. The present study aimed to evaluate brain functional and structural alterations in patients with post-COVID syndrome, and assess whether these brain alterations were related to cognitive dysfunction. Eighty-six patients with post-COVID syndrome and 36 healthy controls were recruited and underwent neuroimaging acquisition and a comprehensive neuropsychological assessment. Cognitive and neuroimaging examinations were performed 11 months after the first symptoms of SARS-CoV-2. Whole-brain functional connectivity analysis was performed. Voxel-based morphometry was performed to evaluate grey matter volume, and diffusion tensor imaging was carried out to analyse white-matter alterations. Correlations between cognition and brain changes were conducted and Bonferroni corrected. Post-COVID syndrome patients presented with functional connectivity changes, characterized by hypoconnectivity between left and right parahippocampal areas, and between bilateral orbitofrontal and cerebellar areas compared to controls. These alterations were accompanied by reduced grey matter volume in cortical, limbic and cerebellar areas, and alterations in white matter axial and mean diffusivity. Grey matter volume loss showed significant associations with cognitive dysfunction. These cognitive and brain alterations were more pronounced in hospitalized patients compared to non-hospitalized patients. No associations with vaccination status were found. The present study shows persistent structural and functional brain abnormalities 11 months after the acute infection. These changes are associated with cognitive dysfunction and contribute to a better understanding of the pathophysiology of the post-COVID syndrome.
MeSH term(s)	Humans ; Diffusion Tensor Imaging/methods ; Magnetic Resonance Imaging/methods ; COVID-19 ; SARS-CoV-2 ; Brain ; Neuroimaging/methods ; Cognition/physiology ; Gray Matter ; White Matter ; Syndrome
Language	English
Publishing date	2022-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awac384
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis.

Ojeda-Hernández, Doddy Denise / Hernández-Sapiéns, Mercedes A / Reza-Zaldívar, Edwin E / Canales-Aguirre, Alejandro / Matías-Guiu, Jordi A / Matías-Guiu, Jorge / Mateos-Díaz, Juan Carlos / Gómez-Pinedo, Ulises / Sancho-Bielsa, Francisco

Life (Basel, Switzerland)

2022 Volume 12, Issue 9

Abstract: Current efforts to find novel treatments that counteract multiple sclerosis (MS) have pointed toward immunomodulation and remyelination. Currently, cell therapy has shown promising potential to achieve this purpose. However, disadvantages such as poor ... ...

Abstract	Current efforts to find novel treatments that counteract multiple sclerosis (MS) have pointed toward immunomodulation and remyelination. Currently, cell therapy has shown promising potential to achieve this purpose. However, disadvantages such as poor survival, differentiation, and integration into the target tissue have limited its application. A series of recent studies have focused on the cell secretome, showing it to provide the most benefits of cell therapy. Exosomes are a key component of the cell secretome, participating in the transfer of bioactive molecules. These nano-sized vesicles offer many therapeutical advantages, such as the capacity to cross the blood-brain barrier, an enrichable cargo, and a customizable membrane. Moreover, integrating of biomaterials into exosome therapy could lead to new tissue-specific therapeutic strategies. In this work, the use of exosomes and their integration with biomaterials is presented as a novel strategy in the treatment of MS.
Language	English
Publishing date	2022-09-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12091417
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In Vitro Effects of Methylprednisolone over Oligodendroglial Cells

Ulises Gómez-Pinedo / Jordi A. Matías-Guiu / Denise Ojeda-Hernandez / Sarah de la Fuente-Martin / Ola Mohamed-Fathy Kamal / Maria Soledad Benito-Martin / Belen Selma-Calvo / Paloma Montero-Escribano / Jorge Matías-Guiu

Cells, Vol 12, Iss 1515, p

Foresight to Future Cell Therapies

2023 Volume 1515

Abstract	The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or differentiate into myelin-forming oligodendrocytes. One essential issue is the creation of administration protocols and determining which factors need to be well established. There is controversy around whether these cells may be implanted simultaneously with corticosteroid treatment, which is widely used in many clinical situations. This study assesses the influence of corticosteroids on the capacity for proliferation and differentiation and the survival of human oligodendroglioma cells. Our findings show that corticosteroids reduce the capacity of these cells to proliferate and to differentiate into oligodendrocytes and decrease cell survival. Thus, their effect does not favour remyelination; this is consistent with the results of studies with rodent cells. In conclusion, protocols for the administration of oligodendrocyte lineage cells with the aim of repopulating oligodendroglial niches or repairing demyelinated axons should not include corticosteroids, given the evidence that the effects of these drugs may undermine the objectives of cell transplantation.
Keywords	multiple sclerosis ; HOG cells ; oligodendrocyte precursor cells ; oligodendrocytes ; corticosteroids ; demyelination ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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