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  1. Article: Effects of Y

    Yang, Guojian / Sun, Peng / Wang, Yuezhong / Shi, Zitao / Yan, Qingwei / Li, Shasha / Yang, Guoyong / Yang, Ke / Dun, Shijie / Shang, Peng / Deng, Lifen / Li, He / Jiang, Nan

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 22

    Abstract: Sintering aid was very crucial to influence the microstructure and thus the optical property of the sintered optical ceramics. The purpose of this work was to explain the difference between the sintering aids of ... ...

    Abstract Sintering aid was very crucial to influence the microstructure and thus the optical property of the sintered optical ceramics. The purpose of this work was to explain the difference between the sintering aids of Li
    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15228036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neuron-derived neuropeptide Y fine-tunes the splenic immune responses.

    Yu, Jinsong / Xiao, Ke / Chen, Xiaohua / Deng, Lulu / Zhang, Lu / Li, Yue / Gao, Anran / Gao, Junjun / Wu, Chengchao / Yang, Xinmei / Zhou, Qiudi / Yang, Jian / Bao, Chenyu / Jiao, Jiaji / Cheng, Sheng / Guo, Zhiqing / Xu, Weize / Cao, Xiaojian / Guo, Zheng /
    Dai, Jinxia / Hu, Ji / Fu, Zhenfang / Cao, Gang

    Neuron

    2023  Volume 111, Issue 8, Page(s) 1346–1347

    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2023.03.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
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    Zs.MG 92: Show issues

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  3. Article: Protective effect of chicken yolk antibody Y against

    Li, Ziyang / Yan, Jiayi / Bian, Zhaowei / Zhang, Jie / Liu, Yuwen / Deng, Jinping / Deng, Baichuan / Han, Sufang

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1378029

    Abstract: Campylobacter jejuni (C. jejuni) ...

    Abstract Campylobacter jejuni (C. jejuni)
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1378029
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  4. Article ; Online: Neuron-derived neuropeptide Y fine-tunes the splenic immune responses.

    Yu, Jinsong / Xiao, Ke / Chen, Xiaohua / Deng, Lulu / Zhang, Lu / Li, Yue / Gao, Anran / Gao, Junjun / Wu, Chengchao / Yang, Xinmei / Zhou, Qiudi / Yang, Jian / Bao, Chenyu / Jiao, Jiaji / Cheng, Sheng / Guo, Zhiqing / Xu, Weize / Cao, Xiaojian / Guo, Zheng /
    Dai, Jinxia / Hu, Ji / Fu, Zhenfang / Cao, Gang

    Neuron

    2022  Volume 110, Issue 8, Page(s) 1327–1339.e6

    Abstract: The nervous and immune systems are closely entwined to maintain the immune balance in health and disease. Here, we showed that LPS can activate suprarenal and celiac ganglia (SrG-CG) neurons and upregulate NPY expression in rats. Single-cell sequencing ... ...

    Abstract The nervous and immune systems are closely entwined to maintain the immune balance in health and disease. Here, we showed that LPS can activate suprarenal and celiac ganglia (SrG-CG) neurons and upregulate NPY expression in rats. Single-cell sequencing analysis revealed that knockdown of the NPY gene in SrG-CG altered the proliferation and activation of splenic lymphocytes. In a neuron and splenocyte coculture system and in vivo experiments, neuronal NPY in SrG-CG attenuated the splenic immune response. Notably, we demonstrated that neuronal NPF in Drosophila exerted a conservative immunomodulatory effect. Moreover, numerous SNPs in NPY and its receptors were significantly associated with human autoimmune diseases, which was further supported by the autoimmune disease patients and mouse model experiments. Together, we demonstrated that NPY is an ancient language for nervous-immune system crosstalk and might be utilized to alleviate inflammatory storms during infection and to modulate immune balance in autoimmune diseases.
    MeSH term(s) Animals ; Autoimmune Diseases/metabolism ; Humans ; Immunity ; Mice ; Neurons/metabolism ; Neuropeptide Y/genetics ; Neuropeptide Y/metabolism ; Rats ; Receptors, Neuropeptide Y/genetics ; Spleen/metabolism
    Chemical Substances Neuropeptide Y ; Receptors, Neuropeptide Y
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2022.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MG 92: Show issues

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  5. Article ; Online: Nuclear factor Y is a pervasive regulator of neuronal gene expression.

    Moreira, Pedro / Papatheodorou, Paul / Deng, Shuer / Gopal, Sandeep / Handley, Ava / Powell, David R / Pocock, Roger

    Cell reports

    2023  Volume 42, Issue 12, Page(s) 113582

    Abstract: ... we identify the nuclear factor Y (NF-Y) TF as a pervasive direct and indirect regulator of both neuron-type ... specific and pan-neuronal gene expression. Mapping global NF-Y targets reveals direct binding to the cis ...

    Abstract Nervous system function relies on the establishment of complex gene expression programs that provide neuron-type-specific and core pan-neuronal features. These complementary regulatory paradigms are controlled by terminal selector and parallel-acting transcription factors (TFs), respectively. Here, we identify the nuclear factor Y (NF-Y) TF as a pervasive direct and indirect regulator of both neuron-type-specific and pan-neuronal gene expression. Mapping global NF-Y targets reveals direct binding to the cis-regulatory regions of pan-neuronal genes and terminal selector TFs. We show that NFYA-1 controls pan-neuronal gene expression directly through binding to CCAAT boxes in target gene promoters and indirectly by regulating the expression of terminal selector TFs. Further, we find that NFYA-1 regulation of neuronal gene expression is important for neuronal activity and motor function. Thus, our research sheds light on how global neuronal gene expression programs are buffered through direct and indirect regulatory mechanisms.
    MeSH term(s) Transcription Factors/genetics ; Transcription Factors/metabolism ; Regulatory Sequences, Nucleic Acid ; CCAAT-Binding Factor/genetics ; CCAAT-Binding Factor/metabolism ; Neurons/metabolism ; Gene Expression
    Chemical Substances nuclear factor Y ; Transcription Factors ; CCAAT-Binding Factor
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Identification and functional verification of Y-chromosome-specific gene typo-gyf in Bactrocera dorsalis.

    Liu, Peipei / Yu, Shuning / Zheng, Wenping / Zhang, Qiuyuan / Qiao, Jiao / Li, Ziniu / Deng, Zhurong / Zhang, Hongyu

    Insect science

    2024  

    Abstract: Genes on the Y chromosome play important roles in male sex determination and development ... The identification of Y-chromosome-specific genes not only provides a theoretical basis for the study of male ... reproductive development, but also offers genetic control targets for agricultural pests. However, Y-chromosome ...

    Abstract Genes on the Y chromosome play important roles in male sex determination and development. The identification of Y-chromosome-specific genes not only provides a theoretical basis for the study of male reproductive development, but also offers genetic control targets for agricultural pests. However, Y-chromosome genes are rarely characterized due to their high repeatability and high heterochromatinization, especially in the oriental fruit fly. In this study, 1 011 Y-chromosome-specific candidate sequences were screened from 2 to 4 h Bactrocera dorsalis embryo datasets with the chromosome quotient method, 6 of which were identified as Y-chromosome-specific sequences by polymerase chain reaction, including typo-gyf, a 19 126-bp DNA sequence containing a 575-amino acid open reading frame. Testicular deformation and a significant reduction in sperm number were observed after typo-gyf knockdown with RNA interference in embryos. After typo-gyf knockout with clustered regularly interspaced palindromic repeats (CRISPR) / CRISPR-associated protein 9 in the embryonic stage, the sex ratio of the emergent adults was unbalanced, with far more females than males. A genotype analysis of these females with the Y-chromosome gene MoY revealed no sex reversal. Typo-gyf knockout led to the death of XY individuals in the embryonic stage. We conclude that typo-gyf is an essential gene for male survival, and is also involved in testicular development and spermatogenesis. The identification of typo-gyf and its functional verification provide insight into the roles of Y-chromosome genes in male development.
    Language English
    Publishing date 2024-01-08
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2179775-4
    ISSN 1744-7917 ; 1672-9609
    ISSN (online) 1744-7917
    ISSN 1672-9609
    DOI 10.1111/1744-7917.13311
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  7. Article ; Online: Comparative Lysine Acetylome Analysis of Y. pestis YfiQ/CobB Mutants Reveals that Acetylation of SlyA Lys73 Significantly Promotes Biofilm Formation of Y. pestis.

    Tan, Yafang / Liu, Wanbing / Chen, Yuling / Zhou, Yazhou / Song, Kai / Cao, Shiyang / Zhang, Yuan / Song, Yajun / Deng, Haiteng / Yang, Ruifu / Du, Zongmin

    Microbiology spectrum

    2023  Volume 11, Issue 4, Page(s) e0046023

    Abstract: ... unclear. Here, we found more acetylated proteins and a higher degree of acetylation in Y. pestis grown ... of YfiQ and CobB, the major acetyltransferase and deacetylase of Y. pestis, respectively, identified 23 ...

    Abstract Increasing evidence shows that protein lysine acetylation is involved in almost every aspect of cellular physiology in bacteria. Yersinia pestis is a flea-borne pathogen responsible for millions of human deaths in three global pandemics. However, the functional role of lysine acetylation in this pathogen remains unclear. Here, we found more acetylated proteins and a higher degree of acetylation in Y. pestis grown under mammalian host (Mh) conditions than under flea vector (Fv) conditions, suggesting that protein acetylation could significantly change during fleabite transmission. Comparative acetylome analysis of mutants of YfiQ and CobB, the major acetyltransferase and deacetylase of Y. pestis, respectively, identified 23 YfiQ-dependent and 315 CobB-dependent acetylated proteins. Further results demonstrated that acetylation of Lys73 of the SlyA protein, a MarR-family transcriptional regulator, inhibits its binding to the promoter of target genes, including
    MeSH term(s) Animals ; Humans ; Yersinia pestis/metabolism ; Plague/microbiology ; Lysine/metabolism ; Acetylation ; Siphonaptera/microbiology ; Biofilms ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Mammals
    Chemical Substances Lysine (K3Z4F929H6) ; Bacterial Proteins
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00460-23
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  8. Article ; Online: Manipulating Spin Alignments of (Y,Lu)

    Cao, Yili / Lin, Kun / Liu, Zhanning / Hu, Jinyu / Wang, Chin-Wei / Liu, Xinzhi / Tereshina-Chitrova, Evgenia / Kato, Kenichi / Li, Qiang / Deng, Jinxia / Chen, Jun / Zhang, Hongjie / Xing, Xianran

    Inorganic chemistry

    2020  Volume 59, Issue 8, Page(s) 5247–5251

    Abstract: ... we report a new strategy to manipulate the spin alignments of (Y,Lu) ...

    Abstract External pressure has been successfully employed to achieve desirable spin alignments in the field of materials science but is seriously restricted by the difficulty of reaching high pressure with conventional methods. The search for simple and effective ways to apply pressure on the lattice is challenging but intriguing. Here we report a new strategy to manipulate the spin alignments of (Y,Lu)
    Language English
    Publishing date 2020-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.9b03570
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  9. Article ; Online: Microdeletions and vertical transmission of the Y-chromosome azoospermia factor region.

    Deng, Chen-Yao / Zhang, Zhe / Tang, Wen-Hao / Jiang, Hui

    Asian journal of andrology

    2022  Volume 25, Issue 1, Page(s) 5–12

    Abstract: Spermatogenesis is regulated by several Y chromosome-specific genes located in a specific region ... of the long arm of the Y chromosome, the azoospermia factor region (AZF). AZF microdeletions are the main ...

    Abstract Spermatogenesis is regulated by several Y chromosome-specific genes located in a specific region of the long arm of the Y chromosome, the azoospermia factor region (AZF). AZF microdeletions are the main structural chromosomal abnormalities that cause male infertility. Assisted reproductive technology (ART) has been used to overcome natural fertilization barriers, allowing infertile couples to have children. However, these techniques increase the risk of vertical transmission of genetic defects. Despite widespread awareness of AZF microdeletions, the occurrence of de novo deletions and overexpression, as well as the expansion of AZF microdeletion vertical transmission, remains unknown. This review summarizes the mechanism of AZF microdeletion and the function of the candidate genes in the AZF region and their corresponding clinical phenotypes. Moreover, vertical transmission cases of AZF microdeletions, the impact of vertical inheritance on male fertility, and the prospective direction of research in this field are also outlined.
    MeSH term(s) Humans ; Male ; Azoospermia/genetics ; Sex Chromosome Aberrations ; Prospective Studies ; Chromosome Deletion ; Chromosomes, Human, Y/genetics ; Infertility, Male/genetics ; Sertoli Cell-Only Syndrome/genetics ; Oligospermia/genetics
    Language English
    Publishing date 2022-03-08
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2075824-8
    ISSN 1745-7262 ; 1008-682X
    ISSN (online) 1745-7262
    ISSN 1008-682X
    DOI 10.4103/aja2021130
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5739: Show issues Location:
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  10. Article ; Online: Closed or Unclosed Mesentery? A Meta-analysis of Internal Herniation After Laparoscopic Roux-en-Y Gastric Bypass.

    Wu, Qian-Long / Liu, Quan-Zhen / Xi, Ying-Yun / Deng, Xiao-Qing / Xu, Tong-Shan / Xie, Zi-Chun / Chen, Jin-An / Yuan, Yi

    Obesity surgery

    2023  Volume 33, Issue 6, Page(s) 1900–1909

    Abstract: During the laparoscopic Roux-en-Y gastric bypass procedure, closing mesentery or not was still ... of closure versus non-closure of mesenteric defects in laparoscopic Roux-en-Y gastric bypass. Fifteen studies ...

    Abstract During the laparoscopic Roux-en-Y gastric bypass procedure, closing mesentery or not was still controversial according to preexisted studies. So, the current meta-analysis aimed to compare the outcome of closure versus non-closure of mesenteric defects in laparoscopic Roux-en-Y gastric bypass. Fifteen studies were included, enrolling 53,488 patients. Based on the outcome of analysis, regarding internal hernia, Petersen space's IH, jejunal mesenteric's IH, hospital days, and reoperation, closure of the mesentery was better than non-closure. Besides, small bowel obstruction, anastomosis ulcer, stenosis, leakage, bleeding, gastrointestinal perforation, and postoperative BMI of patients show no difference between non-closure and closure.
    MeSH term(s) Humans ; Gastric Bypass/adverse effects ; Gastric Bypass/methods ; Obesity, Morbid/surgery ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Hernia, Abdominal/etiology ; Hernia, Abdominal/surgery ; Laparoscopy/methods ; Mesentery/surgery ; Retrospective Studies
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-023-06594-3
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