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Article ; Online: Application of metagenomic next-generation sequencing in patients with infective endocarditis.

Li, Shao-Lin / Zhao, Xi / Tao, Jun-Zhong / Yue, Zhen-Zhen / Zhao, Xiao-Yan

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1107170

Abstract: Objectives: Metagenomic next-generation sequencing (mNGS) technology is helpful for the early diagnosis of infective endocarditis, especially culture-negative infective endocarditis, which may guide clinical treatment. The purpose of this study was to ... ...

Abstract	Objectives: Metagenomic next-generation sequencing (mNGS) technology is helpful for the early diagnosis of infective endocarditis, especially culture-negative infective endocarditis, which may guide clinical treatment. The purpose of this study was to compare the presence of culture-negative infective endocarditis pathogens versus culture-positive ones, and whether mNGS test results could influence treatment regimens for patients with routine culture-negative infective endocarditis. Methods: The present study enrolled patients diagnosed with infective endocarditis and tested for mNGS in the First Affiliated Hospital of Zhengzhou University from February 2019 to February 2022 continuously. According to the culture results, patients were divided into culture-negative group (Group CN, n=18) and culture-positive group (Group CP, n=32). The baseline characteristics, clinical data, pathogens, 30 day mortality and treatment regimen of 50 patients with infective endocarditis were recorded and analyzed. Results: Except for higher levels of PCT in the Group CN [0.33 (0.16-2.74) ng/ml Conclusions: Culture-negative infective endocarditis should be tested for mNGS for early diagnosis and to guide clinical antibiotic regimen.
MeSH term(s)	Humans ; Endocarditis, Bacterial/complications ; Endocarditis/diagnosis ; Mitral Valve ; High-Throughput Nucleotide Sequencing ; Metagenomics ; Anti-Bacterial Agents
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1107170
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Article ; Online: Surgical treatment of severe benign tracheal stenosis.

Feng, Yong-Geng / Tao, Shao-Lin / Mei, Long-Yong / Dai, Fu-Qiang / Tan, Qun-You / Wang, Ru-Wen / Zhou, Jing-Hai / Deng, Bo

Journal of cardiothoracic surgery

2023 Volume 18, Issue 1, Page(s) 293

Abstract: Objective: To present clinical experiences regarding surgical treatment of patients with severe cicatricial tracheal stenosis.: Patients and methods: From January 2008 to March 2020, 14 patients underwent tracheal resection and reconstruction under ... ...

Abstract	Objective: To present clinical experiences regarding surgical treatment of patients with severe cicatricial tracheal stenosis. Patients and methods: From January 2008 to March 2020, 14 patients underwent tracheal resection and reconstruction under general anesthesia. Nine cases had cervical tracheal stenosis and five cases had thoracic tracheal stenosis. The mean diameter and length of strictured trachea was 0 - 8 mm with a mean of 4.5 ± 2.4 mm and 1 - 3 cm with a mean of 1.67 ± 0.63 cm, respectively. General anesthesia and mechanical ventilation were performed in ten cases and four patients underwent femoral arteriovenous bypass surgery due to severe stenosis. End-to-end anastomosis of trachea was performed in 13 cases and the anastomosis between trachea and cricothyroid membrane was performed in one case. Absorbable and unabsorbable sutures were used for the anterior and posterior anastomoses, respectively. Postoperative neck anteflexion was maintained by a suture between the chin and superior chest wall. The relevant data of the 14 patients were retrospectively reviewed, and the operation time, blood loss, postoperative hospital stay, postoperative complications and follow-up were retrieved. Results: There was no intraoperative death. The length of resected trachea ranged from 1.5 to 4.5 cm with a mean of 1.67 ± 0.63 cm. Operation time ranged from 50 - 450 min with a mean of 142.8 ± 96.6 min and intraoperative hemorrhage ranged from 10 - 300 ml with a mean of 87.8 ± 83.6 ml. Follow-up period ranged from 5 to 43 months with a mean of 17.9 ± 10.6 months. None of the patients had recurrent laryngeal nerve paralysis during postoperative follow-up. Ten cases were discharged uneventfully. Anastomosis stenosis occurred in three cases who received interventional therapies. Bronchopleurocutaneous fistula occurred in one patient after 6 days postoperatively and further treatment was declined. Conclusion: The strategies of anesthesia, mechanical ventilation, identification of stenosis lesion, the "hybrid" sutures and postoperative anteflexion are critical to be optimized for successful postoperative recovery.
MeSH term(s)	Humans ; Tracheal Stenosis/surgery ; Tracheal Stenosis/etiology ; Constriction, Pathologic/complications ; Retrospective Studies ; Trachea/surgery ; Larynx/surgery ; Anastomosis, Surgical/adverse effects ; Treatment Outcome
Language	English
Publishing date	2023-10-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02369-0
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Article: Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina.

Tan, Jian / Xiao, Ang / Yang, Lin / Tao, Yu-Lin / Shao, Yi / Zhou, Qiong

World journal of diabetes

2024 Volume 15, Issue 3, Page(s) 519–529

Abstract: Background: Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, leading to visual impairment. Retinal pigment epithelium (RPE) injury is a key component of the outer blood retinal barrier, and its damage is an important ... ...

Abstract	Background: Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, leading to visual impairment. Retinal pigment epithelium (RPE) injury is a key component of the outer blood retinal barrier, and its damage is an important indicator of DR. Receptor for activated C kinase 1 (RACK1) activates protein kinase C-ε (PKC-ε) to promote the generation of reactive oxygen species (ROS) in RPE cells, leading to apoptosis. Therefore, we hypothesize that the activation of RACK1 under hypoxic/high-glucose conditions may promote RPE cell apoptosis by modulating PKC-ε/ROS, thereby disrupting the barrier effect of the outer blood retinal barrier and contributing to the progression of DR. Aim: To investigate the role and associated underlying mechanisms of RACK1 in the development of early DR. Methods: In this study, Sprague-Dawley rats and adult RPE cell line-19 (ARPE-19) cells were used as Results: Streptozotocin-induced diabetic rats showed increased apoptosis and up-regulated expression of RACK1 and PKC-ε proteins in RPE cells following a prolonged modeling. Similarly, ARPE-19 cells exposed to high glucose and hypoxia displayed elevated mRNA and protein levels of RACK1 and PKC-ε, accompanied by an increases in ROS production, apoptosis rate, and monolayer permeability. However, silencing RACK1 significantly downregulated the expression of PKC-ε and ROS, reduced cell apoptosis and permeability, and protected barrier function. Conclusion: RACK1 plays a significant role in the development of early DR and might serve as a potential therapeutic target for DR by regulating RPE apoptosis and barrier function.
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2583471-X
ISSN	1948-9358
ISSN	1948-9358
DOI	10.4239/wjd.v15.i3.519
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Article ; Online: Development of membrane-targeting TPP

Li, Tao / He, Xiaoli / Tao, Wenlan / Zhang, Ruixue / He, Qiaolin / Gong, Hongzhi / Liu, Ye / Luo, Dong / Zhang, Maojie / Zou, Cheng / Zhang, Shao-Lin / He, Yun

European journal of medicinal chemistry

2023 Volume 264, Page(s) 115973

Abstract: Infections caused by drug-resistant bacteria have become a new challenge in infection treatment, gravely endangering public health. Chloramphenicol (CL) is a well-known antibiotic which has lost its efficacy due to bacterial resistance. To address this ... ...

Abstract	Infections caused by drug-resistant bacteria have become a new challenge in infection treatment, gravely endangering public health. Chloramphenicol (CL) is a well-known antibiotic which has lost its efficacy due to bacterial resistance. To address this issue, herein we report the design, synthesis and biological evaluations of novel triphenylphosphonium chloramphenicol conjugates (TPP
MeSH term(s)	Animals ; Mice ; Chloramphenicol/pharmacology ; Methicillin-Resistant Staphylococcus aureus ; Microbial Sensitivity Tests ; Anti-Bacterial Agents ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology
Chemical Substances	Chloramphenicol (66974FR9Q1) ; triphenylphosphonium ; Anti-Bacterial Agents
Language	English
Publishing date	2023-11-27
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2023.115973
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Article ; Online: Effect of preoperative pulmonary artery pressure on the prognosis of end-stage heart failure patients after heart transplantation.

Zhou, Wei / Du, Zhen / Tao, Yun / Zhang, Guan-Xin / Xu, Zhi-Yun / Han, Lin / Ma, Shao-Lin / Hu, Dao-Xi / Fan, Xing-Li / Li, Bai-Ling

Journal of cardiothoracic surgery

2023 Volume 18, Issue 1, Page(s) 154

Abstract: Objective: To evaluate the effect of preoperative pulmonary artery pressure on perioperative outcome of end-stage heart failure patients undergoing heart transplantation.: Methods: Retrospective analysis was undertaken on the clinical data of ... ...

Abstract	Objective: To evaluate the effect of preoperative pulmonary artery pressure on perioperative outcome of end-stage heart failure patients undergoing heart transplantation. Methods: Retrospective analysis was undertaken on the clinical data of patients receiving heart transplantation in the Department of Cardiovascular Surgery of our hospital from March 2017 to March 2022. A ROC curve analysis was developed between mean pulmonary artery pressure (mPAP) and postoperative mortality using mPAP as diagnostic criteria. Patients were divided into groups based on this threshold to determine the best mPAP threshold value for predicting postoperative nosocomial mortality, and the differences in preoperative and intraoperative data, postoperative complications, and clinical prognosis of patients in the two groups were compared. Patients were followed up to draw the survival curve of patients in the two groups. Results: The study enlisted the participation of 105 patients. ROC curve research revealed that preoperative pulmonary artery pressure was substantially linked with death following heart transplantation, with mPAP = 30.5mmHg being the best threshold. The group with mPAP ≥ 30.5mmHg had a greater incidence of postoperative ECMO support (28.2% vs. 10.6%, P = 0.021) and a higher incidence of in-hospital mortality (15.4% vs. 1.5%, P = 0.019) than the group with mPAP < 30.5mmHg. The postoperative survival rates of 105 patients were 91.3%, 88.7%, 81.6%, and 77.5% at 1, 2, 3, and 4 years, respectively, however, there was no significant difference between the two groups of patients in the postoperative intermediate-far survival rate (P = 0.431). Conclusions: Preoperative pulmonary artery pressure in patients with end-stage heart failure is intimately correlated with perioperative prognosis of heart transplant recipients. The optimal cut-off mPAP value in predicting perioperative prognosis of heart transplant recipients is 30.5mmHg. In the high mPAP group, perioperative ECMO support rate and perioperative mortality rate are high, which do not affect the medium and long-term prognosis of the recipients undergoing heart transplantation.
MeSH term(s)	Humans ; Hypertension, Pulmonary/complications ; Retrospective Studies ; Pulmonary Artery ; Prognosis ; Heart Transplantation ; Heart Failure/surgery ; Heart Failure/complications
Language	English
Publishing date	2023-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02253-x
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Article ; Online: Design and synthesis of TPP<sup>+</sup>-Mitomycin C conjugate with reduced toxicity.

Huang, Ding / Zhang, Maojie / Zhang, Haiyan / Cui, Zhiying / Luo, Dong / Li, Tao / Li, Xuemin / He, Yun / Zhang, Shao-Lin

Bioorganic & medicinal chemistry letters

2022 Volume 77, Page(s) 129036

Abstract: Mitomycin C (MMC) is a class of alkylating anticancer drug, which non-specifically interacts with nuclear DNA and cross-links guanine and cytosine of DNA, thereby affecting DNA replication and synthesis. However, toxic effects largely impeded MMC's ... ...

Abstract	Mitomycin C (MMC) is a class of alkylating anticancer drug, which non-specifically interacts with nuclear DNA and cross-links guanine and cytosine of DNA, thereby affecting DNA replication and synthesis. However, toxic effects largely impeded MMC's clinical applications. In this study, triphenylphosphine groups (TPP<sup>+</sup>) were attached to MMC via the active aziridine amine with the aim to reduce its toxicity. MTT assay suggested that 5 possessed a good anticancer activity (IC<sub>50</sub> = 1.09 μM, A549) with negligible effects on human normal cells (IC<sub>50</sub> > 20 μM, L02 and HUVEC), while MMC exhibited IC<sub>50</sub> values of less than 2.5 μM on the tested human normal cells. Dose range-finding experiments suggested that 5 had little effect on the body weight and tissues in mouse at a dose of 20 mg/kg, indicating significantly reduced toxicity as compared to MMC (LD<sub>50</sub> < 2.5 mg/kg). Collectively, these data suggested that TPP<sup>+</sup> group could be an effective vector to reduce toxicity of MMC.
MeSH term(s)	Mice ; Humans ; Animals ; Mitomycin/pharmacology ; DNA
Chemical Substances	Mitomycin (50SG953SK6) ; DNA (9007-49-2)
Language	English
Publishing date	2022-10-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2022.129036
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Article: Lysobacter enzymogenes

Lin, Long / Yang, Zixiang / Tao, Min / Shen, Danyu / Cui, Chuanbin / Wang, Pingping / Wang, Limin / Jing, Maofeng / Qian, Guoliang / Shao, Xiaolong

Frontiers in plant science

2023 Volume 14, Page(s) 1116147

Abstract: ... ...

Abstract	The
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1116147
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Article: The α2δ-1-NMDA receptor complex and its potential as a therapeutic target for ischemic stroke.

Wu, Tao / Chen, Shao-Rui / Pan, Hui-Lin / Luo, Yi

Frontiers in neurology

2023 Volume 14, Page(s) 1148697

Abstract: ... ...

Abstract	N
Language	English
Publishing date	2023-04-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1148697
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Article ; Online: Citrus fruit intake and incidence of renal cell carcinoma: A meta-analysis of observational studies.

Sheng, Tao / Shen, Rui-Lin / Shao, Huan / Ma, Tian-Hong

Asia-Pacific journal of clinical oncology

2023 Volume 20, Issue 2, Page(s) 143–151

Abstract: Observational studies on the association between citrus fruit intake and risk of renal cell carcinoma (RCC) have reported inconsistent results. We quantitatively assessed this association by conducting a meta-analysis. PubMed and Embase databases search ... ...

Abstract	Observational studies on the association between citrus fruit intake and risk of renal cell carcinoma (RCC) have reported inconsistent results. We quantitatively assessed this association by conducting a meta-analysis. PubMed and Embase databases search was conducted including relevant studies published up to January, 2020. We included epidemiological studies that reported relative risks (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) for the association between citrus fruit intake and RCC risk. A total of eight epidemiological studies consisting of five cohort and three case-control studies were included. The overall analysis showed a significantly reduced risk of RCC for high intake of citrus fruit (OR = 0.84, 95% CI 0.73-0.95). No heterogeneity was detected among the included studies (p = 0.497 for heterogeneity; I
MeSH term(s)	Humans ; Carcinoma, Renal Cell/epidemiology ; Incidence ; Citrus ; Cohort Studies ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/prevention & control ; Risk Factors ; Fruit
Language	English
Publishing date	2023-01-19
Publishing country	Australia
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	2187409-8
ISSN	1743-7563 ; 1743-7555
ISSN (online)	1743-7563
ISSN	1743-7555
DOI	10.1111/ajco.13925
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Article ; Online: Combined effects of the earthworm casts application and fallow time on runoff and sediment loss by raindrop splashing in the Loess Plateau, China.

Shao, Fanfan / Tao, Wanghai / Wu, Junhu / Lin, Shudong / Wang, Quanjiu

Journal of environmental management

2022 Volume 325, Issue Pt A, Page(s) 116472

Abstract: The importing of sources of exogenous organic carbon is an effective method for the prevention of soil degradation in sloping soils. Earthworm casts (ECs) have been recognised as a contributor to long-term carbon protection, but relatively few studies ... ...

Abstract	The importing of sources of exogenous organic carbon is an effective method for the prevention of soil degradation in sloping soils. Earthworm casts (ECs) have been recognised as a contributor to long-term carbon protection, but relatively few studies have examined the temporal impact ECs have on the achievement of this goal and its efficacy in the mitigation of soil erosion challenges in the Loess Plateau region in China. This study conducted field simulated rainfall experiments as a means of investigating the effects of five ECs (0, 200, 400, 600 and 800 g/m
MeSH term(s)	Animals ; Oligochaeta ; Rain ; Soil ; Carbon/analysis ; Water ; China ; Geologic Sediments
Chemical Substances	Soil ; Carbon (7440-44-0) ; Water (059QF0KO0R)
Language	English
Publishing date	2022-10-12
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2022.116472
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