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  1. Book: The antiphospholipid syndrome / 2

    Asherson, Ronald A.

    2002  

    Author's details ed.: Ronald A. Asherson
    Collection The antiphospholipid syndrome
    Language English
    Size XVII, 457 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    Note Includes index
    HBZ-ID HT013451867
    ISBN 0-444-50987-9 ; 978-0-444-50987-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 5311 order for loan Magazin

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  2. Book: Vascular manifestations of systemic autoimmune diseases

    Asherson, Ronald A.

    2001  

    Author's details ed. by Ronald A. Asherson
    Keywords Autoimmune Disease / complications ; Vascular Diseases / etiology
    Language English
    Size 601 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT012953577
    ISBN 0-8493-1335-X ; 978-0-8493-1335-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  3. Book: The antiphospholipid syndrome / [1]

    Asherson, Ronald A.

    1996  

    Author's details ed.: Ronald A. Asherson
    Collection The antiphospholipid syndrome
    Keywords Anti-Phospholipid-Antikörper ; Thrombozytenaggregation
    Subject APL-AK
    Language English
    Size 339 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographies and index
    HBZ-ID HT007439728
    ISBN 0-8493-9423-6 ; 978-0-8493-9423-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 1695 order for loan Magazin

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  4. Book ; Collection: The antiphospholipid syndrome

    Asherson, Ronald A.

    1996  

    Author's details ed.: Ronald A. Asherson
    Keywords Antibodies, Antiphospholipid ; Antiphospholipid Syndrome / pathology ; Antiphospholipid Syndrome / diagnosis ; Antiphospholipid Syndrome / therapy ; Lupus Coagulation Inhibitor
    Language English
    Dates of publication 1996-9999
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Collection (display volumes)
    Note Bd. [1] im Verl. CRC Press, Boca Raton erschienen
    HBZ-ID HT013500396
    Database Catalogue ZB MED Medicine, Health

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  5. Article: The primary, secondary, catastrophic, and seronegative variants of the antiphospholipid syndrome: a personal history long in the making.

    Asherson, Ronald A

    Seminars in thrombosis and hemostasis

    2008  Volume 34, Issue 3, Page(s) 227–235

    Abstract: Although many of the clinical features accompanying lupus anticoagulant positivity were documented in the early 1960s and many "non-lupus patients" were also published, it was not until the discovery of antibodies to cardiolipin in the 1980s that the ... ...

    Abstract Although many of the clinical features accompanying lupus anticoagulant positivity were documented in the early 1960s and many "non-lupus patients" were also published, it was not until the discovery of antibodies to cardiolipin in the 1980s that the existence and true ramifications of a distinct antiphospholipid syndrome was defined. A primary syndrome was in fact recognized in 1985 by the author while at the Hammersmith Hospital and comprised 25 patients who conformed to this new subset of disease, which has now overtaken lupus-associated (secondary) antiphospholipid syndromes in frequency. However, publication of this important milestone was in fact prevented, because of the purveying dogma at that time that "these patients were all suffering from 'lupus,'" which history has since proved to be incorrect. The syndrome was therefore only clearly defined AND published in 1988. Subsequently, in the following year, a new and more comprehensive multicenter series comprising 70 patients was documented (including the original 25 patients from 1985) as well as two smaller series by other units. The catastrophic variant of the syndrome with distinct triggering factors, clinical features, and a generally poor prognosis was then defined in 1992, with more than 300 patients with this devastating condition now summarized on the University of Barcelona online registry. The existence of a seronegative syndrome has also been suggested, but whether this is related to the presence of undetectable antiphospholipid antibodies or perhaps represents a similar type of vasculopathy or endotheliopathy is unclear at the present time. This article documents a personal account of the events that took place in relation to the description of these syndromes.
    MeSH term(s) Abortion, Habitual/etiology ; Antibodies, Antiphospholipid/blood ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/etiology ; Antiphospholipid Syndrome/history ; Female ; History, 20th Century ; Humans ; Lupus Coagulation Inhibitor/blood ; Lupus Erythematosus, Systemic/complications ; Male ; Neoplasms/complications ; Neoplasms/immunology ; Pregnancy ; Pregnancy Complications, Hematologic/immunology ; Thrombophilia/etiology ; Venous Thrombosis/etiology
    Chemical Substances Antibodies, Antiphospholipid ; Lupus Coagulation Inhibitor
    Language English
    Publishing date 2008-04
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0028-1082266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1259: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The catastrophic antiphospholipid (Asherson's) syndrome.

    Asherson, Ronald A

    Autoimmunity reviews

    2006  Volume 6, Issue 2, Page(s) 64–67

    Abstract: The catastrophic antiphospholipid syndrome (CAPS, Asherson's syndrome) develops rapidly following an identifiable triggering factor (eg infection, trauma, inadequate coagulation neoplasia, obstetric) in antiphospholipid antibody positive patients. It is ... ...

    Abstract The catastrophic antiphospholipid syndrome (CAPS, Asherson's syndrome) develops rapidly following an identifiable triggering factor (eg infection, trauma, inadequate coagulation neoplasia, obstetric) in antiphospholipid antibody positive patients. It is most frequently encountered in patients with a primary antiphospholipid syndrome or systemic lupus erythematosus (SLE) or "lupus-like" disease (LLD). It manifests mainly with small vessel thromboses affecting organs (gastrointestinal tract, brain, heart), large vessel occlusions in one-third, manifestations of the systemic inflammatory response syndrome (SIRS), particularly the acute respiratory distress syndrome (ARDS). The mortality is high, although with early and effective therapies, including full parenteral anticoagulation, corticosteroids, plasma exchanges and IV globulins, an improvement in this high death rate has been noted recently.
    MeSH term(s) Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/physiopathology ; Antiphospholipid Syndrome/therapy ; Catastrophic Illness ; Humans
    Language English
    Publishing date 2006-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1568-9972
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2006.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: New subsets of the antiphospholipid syndrome in 2006: "PRE-APS" (probable APS) and microangiopathic antiphospholipid syndromes ("MAPS").

    Asherson, Ronald A

    Autoimmunity reviews

    2006  Volume 6, Issue 2, Page(s) 76–80

    Abstract: The concept of "probable" antiphospholipid syndrome (APS) is almost identical with several conditions which may presage the development of the APS with its major complications of large vessel thromboses resulting in deep vein occlusions in the lower ... ...

    Abstract The concept of "probable" antiphospholipid syndrome (APS) is almost identical with several conditions which may presage the development of the APS with its major complications of large vessel thromboses resulting in deep vein occlusions in the lower limbs (DVT) particularly and strokes. These conditions comprising livedo reticularis, chorea, thrombocytopenia, fetal loss and valve lesions. These conditions, comprising livedo reticularis, chorea, thrombocytopenia, fetal loss and valve lesions may be followed, often years later by diagnosable APS. The issue whether these patients should be more aggressively treated on presentation in order to prevent the thrombotic complications. A new subset of the APS is proposed viz. microangiopathic antiphospholipid syndrome ("MAPS") comprising those patients presenting with thrombotic microangiopathy and demonstrable antiphospholipid antibodies who may share common although not identical provoking factors (e.g. infections, drugs), clinical manifestations and haematological manifestations (severe thrombocytopenia, hemolytic anaemia) and treatments viz. plasma exchange. Patients without large vessel occlusions may be included in the MAPS subset. These conditions include thrombotic thrombocytopenic purpura (TTP), hemolytic-uremic syndrome (HUS), and the HELLP syndrome. Patients with catastrophic antiphospholipid syndrome (CAPS) who do not demonstrate large vessel occlusions also fall into this group. Disseminated intravascular coagulation (DIC) has also been reported with demonstrable antiphospholipid antibodies and also manifests severe thrombocytopenia and small vessel occlusions. It may cause problems in differential diagnosis.
    MeSH term(s) Abortion, Spontaneous/physiopathology ; Antiphospholipid Syndrome/classification ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Chorea/complications ; Diagnosis, Differential ; Disseminated Intravascular Coagulation/physiopathology ; Female ; HELLP Syndrome/physiopathology ; Heart Valve Diseases/complications ; Humans ; Pregnancy ; Purpura, Thrombotic Thrombocytopenic/complications ; Skin Diseases, Vascular/complications ; Thrombocytopenia/complications
    Language English
    Publishing date 2006-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1568-9972
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2006.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5913: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: The catastrophic antiphospholipid (Asherson's) syndrome in 2004--a review.

    Asherson, Ronald A

    Autoimmunity reviews

    2005  Volume 4, Issue 1, Page(s) 48–54

    Abstract: ... Antiphospholipid Syndrome (CAPS) in 1992 by Asherson is described. The condition may arise "de-novo" in a patient previously ...

    Abstract An unusual variant of the antiphospholipid syndrome (APS) termed the Catastrophic Antiphospholipid Syndrome (CAPS) in 1992 by Asherson is described. The condition may arise "de-novo" in a patient previously not suspected of having an APS or during the course of a "Primary" APS or Secondary APS (most commonly SLE). The patient may already be on therapy. "Trigger" factors (infections most commonly) have been identified in 45% of patients but in the majority, they remain unidentified. Clinically, the patients present with small vessel occlusions involving organs (e.g. bowel, brain, heart, kidney) but large vessels occlusions do occur. Unusual organs are involved and the clinical features depend on which organs are affected. Because of tissue necrosis, the Systemic Inflammatory Response ensues ("SIRS") and many patients develop ARDS. Despite seemingly adequate therapy (parenteral heparin, steroids, antibiotics), the mortality remains high (approximately 50%).
    MeSH term(s) Antiphospholipid Syndrome/immunology ; Antiphospholipid Syndrome/microbiology ; Antiphospholipid Syndrome/physiopathology ; Antiphospholipid Syndrome/therapy ; Antiphospholipid Syndrome/virology ; Communicable Diseases/immunology ; Humans
    Language English
    Publishing date 2005-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1568-9972
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2004.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5913: Show issues Location:
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  9. Article: Multiorgan failure and antiphospholipid antibodies: the catastrophic antiphospholipid (Asherson's) syndrome.

    Asherson, Ronald A

    Immunobiology

    2005  Volume 210, Issue 10, Page(s) 727–733

    Abstract: A review of 250 patients with the catastrophic antiphospholipid (Asherson's) syndrome (CAPS) taken from the web site organized by the Europhospholipid Group (http://www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) is presented in this paper. A short historical ... ...

    Abstract A review of 250 patients with the catastrophic antiphospholipid (Asherson's) syndrome (CAPS) taken from the web site organized by the Europhospholipid Group (http://www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) is presented in this paper. A short historical overview of the antiphospholipid syndrome (APS) is followed by a description of the "triggering" factors, associated autoimmune diseases, clinical presentation, presumed pathogenesis, prognosis, mode of death and suggested therapies. Triggering factors are present in approximately 50% of patients and consist predominantly of infections, trauma, including minor surgical procedures such as biopsies, obstetric-related multiorgan failure and malignancy-associated CAPS. The patients present mainly with multiorgan failure resulting from predominantly small vessel occlusions affecting mainly intra-abdominal organs such as bowel, liver, pancreas, and adrenals, although large vessel occlusions do occur and comprise mainly deep vein thromboses (DVT) of the veins of the lower limbs and arterial occlusions causing strokes and peripheral gangrene. They do not however dominate the clinical picture. The condition differs considerably from the simple/classic APS in several respects, viz. the rapid development of multiorgan failure following the above-mentioned identifiable precipitating factors, the involvement of unusual organs such as bowel, reproductive organs, and bone marrow, complicating features of disseminated intravascular coagulation in 20% of cases, the acute (adult) respiratory distress syndrome (ARDS) in one third of patients, and severe thrombocytopenia; these not being encountered in the simple/classic APS. Treatment consisting of regular and repeated plasma exchanges using fresh frozen plasma, and IV immunoglobulins in addition to parenteral steroids and anticoagulation are necessary to improve the survival in a condition where the mortality is still of the order of 50%. Treatment may have to be continued for several weeks. Parenteral antibiotics may be indicated where an underlying infection is suspected. Antifungal therapy may also be indicated with prolonged treatment and the use of the monoclonal anti-CD20 molecule, Rituximab, has proven useful in those patients where thrombocytopenia poses a major risk of hemorrhage.
    MeSH term(s) Antibodies, Antiphospholipid ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/etiology ; Antiphospholipid Syndrome/therapy ; Humans ; Multiple Organ Failure/etiology ; Thrombosis ; Treatment Outcome
    Chemical Substances Antibodies, Antiphospholipid
    Language English
    Publishing date 2005
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 563292-4
    ISSN 1878-3279 ; 0171-2985
    ISSN (online) 1878-3279
    ISSN 0171-2985
    DOI 10.1016/j.imbio.2005.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.32: Show issues Location:
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  10. Article: Acute respiratory distress syndrome and other unusual manifestations of the catastrophic antiphospholipid (Asherson's) syndrome.

    Asherson, Ronald A

    The Israel Medical Association journal : IMAJ

    2004  Volume 6, Issue 6, Page(s) 360–363

    MeSH term(s) Adrenal Glands/pathology ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/physiopathology ; Bone Marrow/pathology ; Catastrophic Illness ; Humans ; Necrosis ; Respiratory Distress Syndrome, Adult/etiology ; Respiratory Distress Syndrome, Adult/pathology
    Language English
    Publishing date 2004-06
    Publishing country Israel
    Document type Journal Article ; Review
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
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