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  1. Article ; Online: Correction to: Highlights of the 34th EANM Annual Congress 2021, 2nd virtual edition: "FROM HAMBURG WITH LOVE".

    Albert, Nathalie L / Burger, Irene A

    European journal of nuclear medicine and molecular imaging

    2022  Volume 49, Issue 9, Page(s) 3302

    Language English
    Publishing date 2022-05-23
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-022-05811-y
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  2. Article ; Online: Highlights of the 34th EANM Annual Congress 2021, 2nd virtual edition: "FROM HAMBURG WITH LOVE".

    Albert, Nathalie L / Burger, Irene A

    European journal of nuclear medicine and molecular imaging

    2022  Volume 49, Issue 5, Page(s) 1435–1441

    MeSH term(s) Humans ; Nuclear Medicine
    Language English
    Publishing date 2022-02-28
    Publishing country Germany
    Document type Editorial
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-022-05724-w
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  3. Article ; Online: Is There a Role of Interim PSMA PET in Chemotherapy of Prostate Cancer?

    Laudicella, Riccardo / Bauckneht, Matteo / Burger, Irene A

    Seminars in nuclear medicine

    2023  Volume 54, Issue 1, Page(s) 87–96

    Abstract: While RECIST 1.1 is well established in radiological response assessment, it is of limited use in prostate cancer (PCa) considering that the disease is often seen only as sclerotic bone changes on conventional imaging. Therefore, a molecular imaging- ... ...

    Abstract While RECIST 1.1 is well established in radiological response assessment, it is of limited use in prostate cancer (PCa) considering that the disease is often seen only as sclerotic bone changes on conventional imaging. Therefore, a molecular imaging-based response assessment including bone scans has been proposed and used in clinical trials, however, due to the flare phenomenon on bone scans this assessment leads to substantial delays in the detection of progression. Indeed, a robust and reliable imaging tool to assess response to chemotherapy in PCa is still warranted. Whether Positron Emission Tomography (PET) targeting the Prostate-Specific Membrane Antigen (PSMA) could achieve this, is still controversial. In this review, we summarized the available data on cytotoxic agents and their impact on PSMA expression, as well as the available data on PSMA PET imaging for response assessment.
    MeSH term(s) Male ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Molecular Imaging ; Gallium Radioisotopes
    Chemical Substances Gallium Radioisotopes
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2023.07.006
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  4. Article ; Online: Correction to: Highlights of the 35th EANM Annual Congress 2022, onsite edition in Barcelona, Spain: "FROM BARCELONA WITH LOVE".

    Albert, Nathalie L / Garrigue, Philippe / Guillet, Benjamin / Burger, Irene A

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 13, Page(s) 4114

    Language English
    Publishing date 2023-09-29
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06419-6
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  5. Article ; Online: Highlights of the 35th EANM Annual Congress 2022, onsite edition in Barcelona, Spain: "FROM BARCELONA WITH LOVE".

    Albert, Nathalie L / Garrigue, Philippe / Guillet, Benjamin / Burger, Irene A

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 11, Page(s) 3168–3176

    MeSH term(s) Humans ; Spain ; Nuclear Medicine ; Societies, Medical
    Language English
    Publishing date 2023-07-11
    Publishing country Germany
    Document type Editorial
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06306-0
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  6. Article ; Online: Whole-Body 18 F-FDG PET/CT Patlak Parametric Imaging of Hepatic Alveolar Echinococcosis.

    Maurer, Alexander / Kotasidis, Fotis / Deibel, Ansgar / Burger, Irene A / Huellner, Martin W

    Clinical nuclear medicine

    2023  Volume 48, Issue 12, Page(s) 1089–1090

    Abstract: Abstract: We present dynamic 18 F-FDG PET/CT acquisition in a 52-year-old old woman with histologically proven hepatic alveolar echinococcosis (AE). Metabolic rate of FDG images generated with traditional and relative Patlak analysis show the AE ... ...

    Abstract Abstract: We present dynamic 18 F-FDG PET/CT acquisition in a 52-year-old old woman with histologically proven hepatic alveolar echinococcosis (AE). Metabolic rate of FDG images generated with traditional and relative Patlak analysis show the AE manifestation in the liver significantly better the static SUV images. Dynamic PET may thus have the potential to increase sensitivity in the assessment of hepatic AE manifestations. Such parametric images may offer complementary qualitative information and quantification superior to SUV images.
    MeSH term(s) Female ; Humans ; Middle Aged ; Positron Emission Tomography Computed Tomography/methods ; Echinococcosis, Hepatic ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography/methods
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004878
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  7. Article ; Online: Prostate Cancer: Prostate-specific Membrane Antigen Positron-emission Tomography/Computed Tomography or Positron-emission Tomography/Magnetic Resonance Imaging for Staging.

    Ferraro, Daniela A / Burger, Irene A

    Topics in magnetic resonance imaging : TMRI

    2020  Volume 29, Issue 1, Page(s) 59–66

    Abstract: Positron-emission tomography (PET) with prostate-specific membrane antigen (PSMA) has been increasingly used to image prostate cancer in the last decade. In the staging setting several studies have already been published suggesting PSMA PET can be a ... ...

    Abstract Positron-emission tomography (PET) with prostate-specific membrane antigen (PSMA) has been increasingly used to image prostate cancer in the last decade. In the staging setting several studies have already been published suggesting PSMA PET can be a valuable tool. They, however, did not translate into recommendations by guidelines. Both PSMA PET/computed tomography (CT) and PET/magnetic resonance imaging have been investigated in the staging setting, showing higher detection rate of prostate cancer lesions over the conventional imaging work-up and some studies already showed an impact on disease management. The aim of this review is to provide an overview of the existing published data regarding PSMA PET for staging prostate cancer, with emphasis on PET/magnetic resonance imaging. Despite the fact that PSMA is a relatively new tool and not officially recommended for staging yet, there are >50 original studies in the literature assessing PSMA PET performance in the staging setting of prostate cancer, and some meta-analyses.
    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Male ; Multimodal Imaging/methods ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2020-02-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1112716-8
    ISSN 1536-1004 ; 0899-3459
    ISSN (online) 1536-1004
    ISSN 0899-3459
    DOI 10.1097/RMR.0000000000000229
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    Zs.A 3430: Show issues Location:
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  8. Article ; Online: The Role of Molecular Imaging in the Assessment of Cardiac Amyloidosis: State-of-the-Art.

    Popescu, Cristina / Burger, Irene A

    Current radiopharmaceuticals

    2020  Volume 14, Issue 3, Page(s) 228–241

    Abstract: Cardiac amyloidosis is a progressive infiltrative disease for which new treatments are now available. As therapy should be started as early as possible to avoid complications such as restrictive cardiomyopathy, arrhythmias and heart failure, a prompt and ...

    Abstract Cardiac amyloidosis is a progressive infiltrative disease for which new treatments are now available. As therapy should be started as early as possible to avoid complications such as restrictive cardiomyopathy, arrhythmias and heart failure, a prompt and reliable diagnosis by means of non-invasive tests would be highly warranted. Electrocardiography, echocardiography and cardiac magnetic resonance imaging are all used in the evaluation of cardiac amyloidosis with varying diagnostic and prognostic accuracy, but none of these modalities can effectively differentiate the cardiac amyloid subtypes. We aim to highlight the most relevant findings in the literature of molecular imaging in the assessment of patients with cardiac amyloidosis and to underline future clinical perspective. We performed multiple searches using Pub-Med databases in order to find important original articles on the role of molecular imaging in the assessment of patients affected by CA. Several search terms were used, such as "cardiac amyloidosis"; "Light-chain amyloidosis"; "Transthyretin amyloid cardiomyopathy"; "bone scintigraphy"; "single photon emission tomography" or "SPECT"; "Positron emission tomography or PET", and "cardiac imaging". All radiopharmaceuticals tracing cardiac amyloidosis were also included. Several studies about the role of SPECT with bone-seeking tracer (47 articles) and innervation tracer (9 articles) in the work-up of CA, as well as new PET amyloid-binding (14 articles) and bone radiotracer (4 articles) have been reviewed and discussed. Molecular imaging represents a sensitive tool for early assessment of both amyloid burden and cardiac innervation, to differentiate between subtypes and to monitor disease burden, disease progression, and potential response to therapy.
    MeSH term(s) Amyloidosis/diagnostic imaging ; Cardiomyopathies/diagnostic imaging ; Disease Progression ; Humans ; Molecular Imaging/trends ; Radiopharmaceuticals
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2020-06-10
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 1874-4729
    ISSN (online) 1874-4729
    DOI 10.2174/1874471013666200611105856
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  9. Article ; Online: PSMA-positive prostatic volume prediction with deep learning based on T2-weighted MRI.

    Laudicella, Riccardo / Comelli, Albert / Schwyzer, Moritz / Stefano, Alessandro / Konukoglu, Ender / Messerli, Michael / Baldari, Sergio / Eberli, Daniel / Burger, Irene A

    La Radiologia medica

    2024  

    Abstract: Purpose: High PSMA expression might be correlated with structural characteristics such as growth patterns on histopathology, not recognized by the human eye on MRI images. Deep structural image analysis might be able to detect such differences and ... ...

    Abstract Purpose: High PSMA expression might be correlated with structural characteristics such as growth patterns on histopathology, not recognized by the human eye on MRI images. Deep structural image analysis might be able to detect such differences and therefore predict if a lesion would be PSMA positive. Therefore, we aimed to train a neural network based on PSMA PET/MRI scans to predict increased prostatic PSMA uptake based on the axial T2-weighted sequence alone.
    Material and methods: All patients undergoing simultaneous PSMA PET/MRI for PCa staging or biopsy guidance between April 2016 and December 2020 at our institution were selected. To increase the specificity of our model, the prostatic beds on PSMA PET scans were dichotomized in positive and negative regions using an SUV threshold greater than 4 to generate a PSMA PET map. Then, a C-ENet was trained on the T2 images of the training cohort to generate a predictive prostatic PSMA PET map.
    Results: One hundred and fifty-four PSMA PET/MRI scans were available (133 [
    Conclusion: Increased prostatic PSMA uptake on PET might be estimated based on T2 MRI alone. Further investigation with larger cohorts and external validation is needed to assess whether PSMA uptake can be predicted accurately enough to help in the interpretation of mpMRI.
    Language English
    Publishing date 2024-05-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-024-01820-z
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  10. Article ; Online: Histology of the pleural rind at [

    Soltermann, Alex / Opitz, Isabelle / Burger, Irene A

    Pathology, research and practice

    2021  Volume 228, Page(s) 153660

    Abstract: The role of 2-deoxy-2-[ ...

    Abstract The role of 2-deoxy-2-[
    MeSH term(s) Female ; Fluorodeoxyglucose F18 ; Humans ; Induction Chemotherapy/methods ; Male ; Mesothelioma/diagnostic imaging ; Mesothelioma/pathology ; Mesothelioma/therapy ; Neoadjuvant Therapy/methods ; Neoplasm Staging/methods ; Pleura/diagnostic imaging ; Pleura/pathology ; Pleural Neoplasms/diagnostic imaging ; Pleural Neoplasms/pathology ; Pleural Neoplasms/therapy ; Pleurodesis/methods ; Positron Emission Tomography Computed Tomography/methods ; Radiopharmaceuticals ; Talc/therapeutic use ; Treatment Outcome
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Talc (14807-96-6)
    Language English
    Publishing date 2021-10-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2021.153660
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