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  1. Book ; Online ; E-Book: Trauma induced coagulopathy

    Moore, Hunter B. / Moore, Ernest E. / Neal, Matthew D.

    2021  

    Author's details Hunter B. Moore, Ernest E. Moore, Matthew D. Neal editors
    Language English
    Size 1 Online-Ressource (xix, 802 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020618693
    ISBN 978-3-030-53606-0 ; 9783030536053 ; 3-030-53606-8 ; 303053605X
    DOI 10.1007/978-3-030-53606-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: Trauma induced coagulopathy

    González, Eduardo / Moore, Hunter B. / Moore, Ernest E.

    2016  

    Author's details Eduardo Gonzalez ; Hunter B. Moore ; Ernest E. Moore ed
    Keywords anti-fibrinolytics ; hemorrhage-related mortality ; hemostasis ; plasma transfusion
    Language English
    Size XXXI, 601 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018965997
    ISBN 978-3-319-28306-7 ; 978-3-319-28308-1 ; 3-319-28306-5 ; 3-319-28308-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2016 A 1152 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Fibrinolysis Shutdown and Hypofibrinolysis Are Not Synonymous Terms: The Clinical Significance of Differentiating Low Fibrinolytic States.

    Moore, Hunter B

    Seminars in thrombosis and hemostasis

    2022  Volume 49, Issue 5, Page(s) 433–443

    Abstract: Low fibrinolytic activity has been associated with pathologic thrombosis and multiple-organ failure. Low fibrinolytic activity has two commonly associated terms, hypofibrinolysis and fibrinolysis shutdown. Hypofibrinolysis is a chronic state of lack of ... ...

    Abstract Low fibrinolytic activity has been associated with pathologic thrombosis and multiple-organ failure. Low fibrinolytic activity has two commonly associated terms, hypofibrinolysis and fibrinolysis shutdown. Hypofibrinolysis is a chronic state of lack of ability to generate an appropriate fibrinolytic response when anticipated. Fibrinolysis shutdown is the shutdown of fibrinolysis after systemic activation of the fibrinolytic system. There has been interchanging of these terms to describe critically ill patients in multiple settings. This is problematic in understanding the pathophysiology of disease processes related to these conditions. There is also a lack of research on the cellular mediators of these processes. The purpose of this article is to review the on and off mechanisms of fibrinolysis in the context of low fibrinolytic states to define the importance in differentiating hypofibrinolysis from fibrinolysis shutdown. In many clinical scenarios, the etiology of a low fibrinolytic state cannot be determined due to ambiguity if a preceding fibrinolytic activation event occurred. In this scenario, the term "low fibrinolytic activity" or "fibrinolysis resistance" is a more appropriate descriptor, rather than using assumptive of hypofibrinolysis and fibrinolysis shutdown, particularly in the acute setting of infection, injury, and surgery.
    MeSH term(s) Humans ; Blood Coagulation Disorders/complications ; Clinical Relevance ; Fibrinolysis/physiology ; Thrombolytic Therapy ; Thrombosis/etiology
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0042-1758057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Fibrinolysis Shutdown and Hypofibrinolysis Are Not Synonymous Terms: The Clinical Significance of Differentiating Low Fibrinolytic States

    Moore, Hunter B.

    Seminars in Thrombosis and Hemostasis

    (Editorial Compilation—XIII)

    2022  Volume 49, Issue 05, Page(s) 433–443

    Abstract: Low fibrinolytic activity has been associated with pathologic thrombosis and multiple-organ failure. Low fibrinolytic activity has two commonly associated terms, hypofibrinolysis and fibrinolysis shutdown. Hypofibrinolysis is a chronic state of lack of ... ...

    Series title Editorial Compilation—XIII
    Abstract Low fibrinolytic activity has been associated with pathologic thrombosis and multiple-organ failure. Low fibrinolytic activity has two commonly associated terms, hypofibrinolysis and fibrinolysis shutdown. Hypofibrinolysis is a chronic state of lack of ability to generate an appropriate fibrinolytic response when anticipated. Fibrinolysis shutdown is the shutdown of fibrinolysis after systemic activation of the fibrinolytic system. There has been interchanging of these terms to describe critically ill patients in multiple settings. This is problematic in understanding the pathophysiology of disease processes related to these conditions. There is also a lack of research on the cellular mediators of these processes. The purpose of this article is to review the on and off mechanisms of fibrinolysis in the context of low fibrinolytic states to define the importance in differentiating hypofibrinolysis from fibrinolysis shutdown. In many clinical scenarios, the etiology of a low fibrinolytic state cannot be determined due to ambiguity if a preceding fibrinolytic activation event occurred. In this scenario, the term “low fibrinolytic activity” or “fibrinolysis resistance” is a more appropriate descriptor, rather than using assumptive of hypofibrinolysis and fibrinolysis shutdown, particularly in the acute setting of infection, injury, and surgery.
    Keywords fibrinolysis shutdown ; hypofibrinolysis ; plasminogen activators
    Language English
    Publishing date 2022-11-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0042-1758057
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Commentary on "Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure".

    Boster, Julia M / Adams, Megan A / Moore, Hunter B

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 9, Page(s) 2365–2366

    MeSH term(s) Animals ; Mice ; Acetaminophen/adverse effects ; Liver Failure ; Blood Coagulation ; Blood Coagulation Disorders/chemically induced
    Chemical Substances Acetaminophen (362O9ITL9D)
    Language English
    Publishing date 2023-08-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 295: Show issues

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  6. Article ; Online: Differentiating Pathologic from Physiologic Fibrinolysis: Not as Simple as Conventional Thrombelastography.

    Moore, Hunter B / Barrett, Christopher D / Moore, Ernest E / Pieracci, Fredric M / Sauaia, Angela

    Journal of the American College of Surgeons

    2024  

    Abstract: Background: Conventional rapid-thrombelastography (rTEG) cannot differentiate fibrinolysis shutdown from hypofibrinolysis, as both of these patient populations have low fibrinolytic activity. Tissue plasminogen activator (tPA) TEG can identify depletion ...

    Abstract Background: Conventional rapid-thrombelastography (rTEG) cannot differentiate fibrinolysis shutdown from hypofibrinolysis, as both of these patient populations have low fibrinolytic activity. Tissue plasminogen activator (tPA) TEG can identify depletion of fibrinolytic inhibitors, and its use in combination with rTEG has the potential to differentiate all three pathologic fibrinolytic phenotypes following trauma. We hypothesize tPA-TEG and rapid TEG (rTEG) in combination can further stratify fibrinolysis phenotypes post-injury to better stratify risk for mortality.
    Study design: Adult trauma patients (n=981) with both rTEG and tPA-TEG performed <2 hours post-injury were included. rTEG LY30 was used to initially define fibrinolysis phenotypes (Hyperfibrinolysis >3%, Physiologic 0.9-3%, Shutdown <0.9%), with Youden Index then used to define pathologic extremes of tPA-TEG LY30 [tPA sensitive (depletion of fibrinolytic inhibitors) versus resistant] resulting in 9 groups that were assessed for risk of death.
    Results: The median NISS was 22, 21% were female, 45% had penetrating injury, and overall mortality was 13%. The tPA-TEG LY30 inflection point for increased mortality was>35.5% (tPA sensitive, OR mortality 9.2 P<0.001) and <0.3% (tPA resistance, OR mortality 6.3 p=0.04). Of the nine potential fibrinolytic phenotypes, five were associated with increased mortality. Overall, the 9 phenotypes provided a significantly better prediction of mortality than rTEG or tPA-TEG alone (AUROC=0.80 vs 0.63 and 0.75, respectively, p<0.0001). These could be condensed to three pathologic phenotypes (true hyperfibrinolysis, early fibrinolysis shutdown, and hypofibrinolysis).
    Conclusions: The combination of rTEG and tPA-TEG increases the ability to predict mortality and suggests patient specific strategies for improved outcome.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1097/XCS.0000000000001027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reply to 'The role of tranexamic acid in trauma - a life-saving drug with proven benefit'.

    Moore, Ernest E / Moore, Hunter B / Sauaia, Angela

    Nature reviews. Disease primers

    2022  Volume 8, Issue 1, Page(s) 35

    MeSH term(s) Antifibrinolytic Agents/pharmacology ; Antifibrinolytic Agents/therapeutic use ; Hemorrhage ; Humans ; Tranexamic Acid/therapeutic use
    Chemical Substances Antifibrinolytic Agents ; Tranexamic Acid (6T84R30KC1)
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Letter ; Comment
    ISSN 2056-676X
    ISSN (online) 2056-676X
    DOI 10.1038/s41572-022-00368-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fibrinolysis Resistance After Injury Is a Risk Factor for a Hospital-Acquired Pneumonia-Like Disease Pattern.

    Rodriguez, Ivan E / Saben, Jessica L / Moore, Ernest E / Knudson, M Margaret / Moore, Peter K / Pieracci, Fredric / Sauaia, Angela / Moore, Hunter B

    Surgical infections

    2024  Volume 25, Issue 2, Page(s) 87–94

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Fibrinolysis ; Tissue Plasminogen Activator ; Shock, Hemorrhagic ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Risk Factors ; Hospitals ; Wounds and Injuries
    Chemical Substances Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1440120-4
    ISSN 1557-8674 ; 1096-2964
    ISSN (online) 1557-8674
    ISSN 1096-2964
    DOI 10.1089/sur.2023.257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5617: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Temporal Changes in Fibrinolysis following Injury.

    Moore, Hunter B / Moore, Ernest E

    Seminars in thrombosis and hemostasis

    2020  Volume 46, Issue 2, Page(s) 189–198

    Abstract: Trauma patients present to the emergency department with a spectrum of fibrinolytic activity. This wide variance in fibrinolysis activity is a complex multifactorial process impacted by the degree of hemorrhagic shock and the amount of tissue injury the ... ...

    Abstract Trauma patients present to the emergency department with a spectrum of fibrinolytic activity. This wide variance in fibrinolysis activity is a complex multifactorial process impacted by the degree of hemorrhagic shock and the amount of tissue injury the individual sustains. The fibrinolytic activity of the trauma patient at presentation to the hospital has prognostic and therapeutic implications. Those patients with high fibrinolytic activity (hyperfibrinolysis) are at risk of mortality from hemorrhage, whereas those patients with low fibrinolytic activity (shutdown or hypofibrinolysis) are at an increased risk of delayed mortality from traumatic brain injury or organ failure. These phenotypes of fibrinolysis acutely following injury change with resuscitation, and the majority of trauma patients will transition to a fibrinolytic resistant state several hours after injury. The mechanism for this near-global transition to this acquired fibrinolysis appears to be related to the generation of plasminogen activator inhibitor-1 in the liver. Those patients who do not recover from this fibrinolytic state 24 hours after injury have a poor prognosis. The purpose of this article is to review the different states of fibrinolytic activity following injury and how they change over time following resuscitation and in the intensive care unit.
    MeSH term(s) Fibrinolysis/physiology ; Humans ; Prognosis ; Thrombelastography/methods ; Wounds and Injuries/physiopathology
    Language English
    Publishing date 2020-03-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0039-1701016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: TEG Lysis Shutdown Represents Coagulopathy in Bleeding Trauma Patients: Analysis of the PROPPR Cohort.

    Moore, Hunter B / Moore, Ernest E

    Shock (Augusta, Ga.)

    2019  Volume 52, Issue 6, Page(s) 639–640

    MeSH term(s) Blood Coagulation Disorders ; Cohort Studies ; Hemorrhage ; Humans
    Language English
    Publishing date 2019-03-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/SHK.0000000000001341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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