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  1. Article: The Relationship Between Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels and Treatment Response in Patients With Glomerulonephritis: A Single-Center Experience.

    İşsever, Kubilay / Dheir, Hamad

    Cureus

    2023  Volume 15, Issue 10, Page(s) e47473

    Abstract: Aim Soluble urokinase-type plasminogen activator receptor (suPAR) is an important protein that is reported to increase in a broad range of inflammatory processes. We aimed to determine whether suPAR is a significant biomarker in glomerulonephritis for ... ...

    Abstract Aim Soluble urokinase-type plasminogen activator receptor (suPAR) is an important protein that is reported to increase in a broad range of inflammatory processes. We aimed to determine whether suPAR is a significant biomarker in glomerulonephritis for distinguishing patients with treatment response from patients without treatment response in our study. Materials and methods This was a prospective study in which 117 patients with biopsy-proven glomerulonephritis and 54 healthy individuals without a known chronic disease (control group) were enrolled. A total of 117 patients were divided into two groups: "treatment responsive" and "treatment nonresponsive." Blood samples were collected from the patients upon their outpatient clinic visits, and the demographical and lab parameters were compared between the groups. Results For the patient group consisting of 117 individuals, 56.4% were male, the mean age was 49.6 years, and the mean follow-up duration was 32.2 months. The most commonly diagnosed glomerular disease was focal segmental glomerulosclerosis (FSGS), followed by IgA nephropathy and membranoproliferative glomerulonephritis, respectively. While suPAR levels were significantly higher in the patient group (166.06 ± 127.66 vs. 119.67 ± 70.53 pg/ml, p = 0.001) (suPAR level ± standard deviation), no significant relationship was found between suPAR levels, treatment response status, and disease severity. Besides, there was no significant relationship between suPAR levels and proteinuria levels, BMI of the patients, and the type of immunosuppressive agent used in the treatment and BMI. Conclusion Our study showed that suPAR levels could distinguish a patient with glomerulonephritis from a healthy individual, whereas it has no value in predicting the disease progression and treatment responsiveness.
    Language English
    Publishing date 2023-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.47473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Experience with Hemodialysis Patients in the COVID-19 Pandemic in Sakarya, Turkey.

    Sipahi, Savaş / Dheir, Hamad / Tocoglu, Aysel / Karabay, Oguz

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2020  Volume 30, Issue 10, Page(s) 138

    MeSH term(s) Ambulatory Care Facilities ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Humans ; Infection Control/methods ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Renal Dialysis ; Risk Factors ; SARS-CoV-2 ; Turkey/epidemiology
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-10-29
    Publishing country Pakistan
    Document type Letter
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2020.supp2.138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Thorax Magnetic Resonance Imaging Findings in Patients with Coronavirus Disease (COVID-19).

    Ates, Omer Faruk / Taydas, Onur / Dheir, Hamad

    Academic radiology

    2020  Volume 27, Issue 10, Page(s) 1373–1378

    Abstract: Rationale and objectives: The aim of this study was to compare the findings found in thorax computed tomography (CT), which is increasingly used in the diagnosis of the important public health problem of coronavirus disease (COVID-19), and the findings ... ...

    Abstract Rationale and objectives: The aim of this study was to compare the findings found in thorax computed tomography (CT), which is increasingly used in the diagnosis of the important public health problem of coronavirus disease (COVID-19), and the findings of magnetic resonance imaging (MRI) as an important diagnostic alternative.
    Materials and methods: Thirty-two patients diagnosed with COVID-19 who underwent thorax CT for COVID pneumonia and MRI for any reason within 24 hours after CT were included in the study. The number of lobes affected, number of lobes containing ground-glass opacities and consolidation, number of nodules, distribution of lesions (central, peripheral, or diffuse), lobes with centrilobular nodular pattern, and the presence of pleural effusion were recorded separately for both imaging methods.
    Results: Seventeen of the patients were female (53%) and 15 were male (47%). The mean age of the patients was 60.5 (range, 20-85) years. A total of 31 patients (96%) had signs of pneumonia on CT. The most common finding in CT was ground-glass opacities in 29 patients (90.6%), followed by consolidation in 14 patients (43.75%). Both consolidation and ground-glass opacities were also observed in MRI in all of these patients. Nodules were detected in 12 patients (37.5%) on CT and 11 patients (34.4%) on MRI. The sensitivity and specificity of MRI in nodule detection were calculated as 91.67% and 100%, respectively.
    Conclusion: Although thorax CT is widely used in the imaging of COVID-19 infection, due to its advantages, MRI can also be used as an alternative diagnostic tool.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnostic imaging ; Female ; Humans ; Lung ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; SARS-CoV-2 ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2020.08.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Differences in clinical outcomes of COVID-19 among vaccinated and unvaccinated kidney transplant recipients.

    Demir, Erol / Dheir, Hamad / Safak, Seda / Serra Artan, Ayse / Sipahi, Savas / Turkmen, Aydin

    Vaccine

    2022  Volume 40, Issue 24, Page(s) 3313–3319

    Abstract: Introduction: The remarkable efficacy and effectiveness of COVID-19 vaccines have been described in healthy individuals, but kidney transplant recipients have been excluded from these studies. Therefore, real-world evidence of these vaccines can guide ... ...

    Abstract Introduction: The remarkable efficacy and effectiveness of COVID-19 vaccines have been described in healthy individuals, but kidney transplant recipients have been excluded from these studies. Therefore, real-world evidence of these vaccines can guide clinicians in predicting complications in kidney transplant recipients and how many doses of vaccines are protective. In this study, we aimed to investigate the impact of the COVID-19 vaccines on kidney transplant recipients with SARS-CoV-2 infection.
    Material and method: This matched case-control study included vaccinated kidney transplant recipients with COVID-19 from two centers between 1 May and 1 October 2021. All patients in the vaccinated group received a minimum of two doses of the vaccine and were diagnosed with COVID-19 at least one month after the last dose. Each vaccinated patient was matched with an unvaccinated kidney transplant recipient diagnosed with COVID. The endpoints were all-cause mortality, hospitalization, intensive care unit admission, acute kidney injury, cytokine storm, and acute respiratory distress syndrome.
    Results: The median age of vaccinated seventy-two participants was 45 years, and 41 of the participants were men in the vaccinated group. Four patients in the vaccinated group and nine patients in the control group died during follow-up (p = 0.247). Seventeen patients in the vaccinated group, thirty-four participants in the control group were hospitalized (p = 0.004); five vaccinated patients and ten unvaccinated patients were followed-up in the ICU during follow-up (p = 0.168). Thirteen of the vaccinated and twelve unvaccinated patients developed acute kidney injury (p = 0.16). The occurrence of cytokine storm (n = 4 vs. n = 11; p = 0.061) and acute respiratory distress syndrome (n = 5 vs. n = 10; p = 0.168) was higher in the patient group compared to the control group.
    Conclusion: COVID-19 remains a fatal disease despite advancing treatment modalities and preventive strategies. COVID-19 vaccines can't prevent death in all kidney transplant recipients, but they decrease hospitalization rate and duration in most patients.
    MeSH term(s) Acute Kidney Injury ; COVID-19/prevention & control ; COVID-19 Vaccines ; Case-Control Studies ; Cytokine Release Syndrome ; Female ; Humans ; Kidney Transplantation ; Male ; Middle Aged ; Respiratory Distress Syndrome ; SARS-CoV-2 ; Transplant Recipients ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-04-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.04.066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Does Monocyte Chemoattractant Protein-1 Levels Determine the Prognosis of Covid-19 Disease in Kidney Transplant Recipients?

    Akin, Emrah / Karabay, Oguz / Tocoglu, Aysel / Pinar, Musa / Toptan, Hande / Kose, Elif / Firat, Necattin / Islam, Mahmud / Altintoprak, Fatih / Dheir, Hamad

    Transplantation proceedings

    2023  Volume 55, Issue 5, Page(s) 1121–1124

    Abstract: Background: In the normal population, a high monocyte chemoattractant protein (MCP-1) level is an important biomarker for the progression of COVID-19. This study investigated whether MCP-1 level can determine the disease prognosis in kidney transplant ( ... ...

    Abstract Background: In the normal population, a high monocyte chemoattractant protein (MCP-1) level is an important biomarker for the progression of COVID-19. This study investigated whether MCP-1 level can determine the disease prognosis in kidney transplant (KT) patients with COVID-19.
    Methods: A total of 89 patients, including 49 KT patients (group 1) diagnosed with COVID-19 who required hospitalization, and 40 KT patients who did not have COVID-19 disease (group 2), were included. Demographic characteristics and laboratory results of the patients were recorded. The serum reserved for MCP-1 was stored at -80°C and studied blindly by a single microbiologist at the end of the study.
    Results: While the mean age of the patients was 51.0 years (40.0-59.50) in group 1, it was 48.0 years (40.75-54.75) in group 2 (P > .05). In terms of the female sex, it was 36 (73.5%) and 27 (67.5%) in group 1 and group 2, respectively (P > .05). Similarly, there was no significant difference between the 2 groups regarding primary disease and basal graft function (P > .05). There was a statistically significant difference in inflammation indicators in group 1 compared with group 2 (P < .05). A correlation was found between inflammation indicators and COVID-19 (P < .05). However, no significant correlation was detected between COVID-19 disease and MCP-1 levels in both groups (P > .05). Also, according to basal MCP-1 levels, we did not find a significant difference between survival and nonsurvival patients (164.0 pg/mL [146.0-202.0] vs 156.0 pg/mL [143.0-173.0], respectively (P > .05).
    Conclusion: Monocyte chemoattractant protein, an indicator of inflammation, was not found to predict the prognosis of COVID-19 disease in kidney recipients.
    MeSH term(s) Humans ; Female ; Middle Aged ; Chemokine CCL2/metabolism ; Kidney Transplantation/adverse effects ; COVID-19 ; Prognosis ; Monocyte Chemoattractant Proteins ; Inflammation ; Transplant Recipients
    Chemical Substances Chemokine CCL2 ; Monocyte Chemoattractant Proteins
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.03.033
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  6. Article: Experience with Hemodialysis Patients in the COVID-19 Pandemic in Sakarya, Turkey

    Sipahi, Savas / Dheir, Hamad / Tocoglu, Aysel / Karabay, Oguz

    J Coll Physicians Surg Pak

    Abstract: Null. ...

    Abstract Null.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #895893
    Database COVID19

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  7. Article ; Online: Thorax Magnetic Resonance Imaging Findings in Patients with Coronavirus Disease (COVID-19)

    Ates, Omer Faruk / Taydas, Onur / Dheir, Hamad

    Academic Radiology

    2020  Volume 27, Issue 10, Page(s) 1373–1378

    Keywords Radiology Nuclear Medicine and imaging ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1355509-1
    ISSN 1076-6332
    ISSN 1076-6332
    DOI 10.1016/j.acra.2020.08.009
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The levels of inflammatory biomarkers in hemodialysis and peritoneal dialysis patients.

    Yildirim, Mehmet / Acikgoz, Seyyid Bilal / Genc, Ahmed Bilal / Yaylaci, Selçuk / Dheir, Hamad / Sipahi, Sava S

    Revista da Associacao Medica Brasileira (1992)

    2021  Volume 67, Issue 5, Page(s) 718–723

    Abstract: Objective: In this study, we aimed to determine fibroblast growth factor 23, soluble alpha klotho, osteocalcin, indoxyl sulphate, sclerostin, Procollagen 1 N Terminal Propeptide, and beta-CrossLaps levels in hemodialysis and peritoneal dialysis patients, ...

    Abstract Objective: In this study, we aimed to determine fibroblast growth factor 23, soluble alpha klotho, osteocalcin, indoxyl sulphate, sclerostin, Procollagen 1 N Terminal Propeptide, and beta-CrossLaps levels in hemodialysis and peritoneal dialysis patients, and to compare the levels of these markers among hemodialysis and peritoneal dialysis patients, as well as healthy individuals.
    Methods: The study included 30 hemodialysis and 23 peritoneal dialysis patients who were followed-up for at least six months at the Sakarya University Hospital, besides 30 healthy volunteers.
    Results: The participants were divided into three groups with similar characteristics in terms of age, gender and body mass index. Fibroblast growth factor 23, soluble alpha klotho, indoxyl sulphate, beta-CrossLaps, and Procollagen 1 N Terminal Propeptide levels were significantly higher in patients of both the hemodialysis and peritoneal dialysis groups than in the healthy volunteers' group. There was no difference in levels of these molecules between hemodialysis and peritoneal dialysis groups.
    Conclusions: Fibroblast growth factor 23, sclerostin, indoxyl sulphate, beta-CrossLaps, and Paclitaxel-induced neuropathic pain levels were higher in patients of both groups as inflammatory markers. In our study, we found higher soluble alpha klotho levels in patients of both groups than in the healthy volunteers' group, suggesting that blood soluble alpha klotho levels may not correlate with renal klotho levels.
    MeSH term(s) Biomarkers ; Humans ; Kidney ; Kidney Failure, Chronic/therapy ; Peritoneal Dialysis/adverse effects ; Renal Dialysis/adverse effects
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-09-20
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.20210056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Predictors of Mortality in Patients with COVID-19 Infection-associated Acute Kidney Injury.

    Tocoglu, Aysel / Dheir, Hamad / Bektas, Melike / Acikgoz, Seyyid Bilal / Karabay, Oguz / Sipahi, Savas

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2021  Volume 31, Issue 1, Page(s) S60–S65

    Abstract: Objective: To determine clinical characteristics, renal replacement therapy (RRT) requirements, and predictors of mortality in critically ill patients with COVID-19 associated AKI.: Study design: Descriptive study.: Place and duration of study: ... ...

    Abstract Objective: To determine clinical characteristics, renal replacement therapy (RRT) requirements, and predictors of mortality in critically ill patients with COVID-19 associated AKI.
    Study design: Descriptive study.
    Place and duration of study: Sakarya University Education and Training Hospital, Sakarya, Turkey, between April 1 and 30, 2020.
    Methodology: The study included 55 patients who were admitted with diagnosis of COVID-19, and whose illnesses showed a critical course that leads to AKI. The variables were studied as per objective.
    Results: During the follow-up, 43 out of 55 patients (78.2%) died and 12 (21.8%) were discharged with recovery. The mortality was higher in patients at stage 3 (88.9% mortality) compared to stage 2 (53.8% mortality) (p=0.014). In the nonsurvivor group, RDW (red cell distribution width) and albumin levels were lower at admission; whereas, the LDH levels and CRP/albumin ratios were higher. On regression analysis, low albumin level (OR: 12.793, p = 0.010), high LDH level (OR: 8.454, p = 0.026), and presence of stage 3 AKI (OR: 10.268, p = 0.020) were found as independent risk factors for mortality in COVID-19 patients, who developed AKI.
    Conclusion: In critically ill patients with COVID-19 pneumonia, who developed AKI, it was seen that the presence of low albumin, high LDH, and stage 3 AKI at the time of admission could be used as predictors of mortality. Moreover,, it was shown for the first time that in these patients, the high CRP/albumin ratio and low RDW could be associated with mortality. Key Words: Acute kidney injury, Mortality, COVID-19.
    Language English
    Publishing date 2021-09-17
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2021.Supp1.S60
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  10. Article ; Online: Predictors of Mortality in Patients with COVID-19 Infection-associated Acute Kidney Injury.

    Tocoglu, Aysel / Dheir, Hamad / Bektas, Melike / Acikgoz, Seyyid Bilal / Karabay, Oguz / Sipahi, Savas

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2021  Volume 31, Issue 1, Page(s) S60–S65

    Abstract: Objective: To determine clinical characteristics, renal replacement therapy (RRT) requirements, and predictors of mortality in critically ill patients with COVID-19 associated AKI.: Study design: Descriptive study.: Place and duration of study: ... ...

    Abstract Objective: To determine clinical characteristics, renal replacement therapy (RRT) requirements, and predictors of mortality in critically ill patients with COVID-19 associated AKI.
    Study design: Descriptive study.
    Place and duration of study: Sakarya University Education and Training Hospital, Sakarya, Turkey, between April 1 and 30, 2020.
    Methodology: The study included 55 patients who were admitted with diagnosis of COVID-19, and whose illnesses showed a critical course that leads to AKI. The variables were studied as per objective.
    Results: During the follow-up, 43 out of 55 patients (78.2%) died and 12 (21.8%) were discharged with recovery. The mortality was higher in patients at stage 3 (88.9% mortality) compared to stage 2 (53.8% mortality) (p=0.014). In the nonsurvivor group, RDW (red cell distribution width) and albumin levels were lower at admission; whereas, the LDH levels and CRP/albumin ratios were higher. On regression analysis, low albumin level (OR: 12.793, p = 0.010), high LDH level (OR: 8.454, p = 0.026), and presence of stage 3 AKI (OR: 10.268, p = 0.020) were found as independent risk factors for mortality in COVID-19 patients, who developed AKI.
    Conclusion: In critically ill patients with COVID-19 pneumonia, who developed AKI, it was seen that the presence of low albumin, high LDH, and stage 3 AKI at the time of admission could be used as predictors of mortality. Moreover,, it was shown for the first time that in these patients, the high CRP/albumin ratio and low RDW could be associated with mortality. Key Words: Acute kidney injury, Mortality, COVID-19.
    MeSH term(s) Acute Kidney Injury/etiology ; Acute Kidney Injury/mortality ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/epidemiology ; Critical Illness/mortality ; Female ; Follow-Up Studies ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Survival Rate/trends ; Turkey/epidemiology
    Language English
    Publishing date 2021-02-26
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2021.01.S60
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