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  1. Article ; Online: Discussion.

    de Perrot, Marc

    The Journal of thoracic and cardiovascular surgery

    2022  Volume 166, Issue 6, Page(s) 1541

    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2022.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.104: Show issues Location:
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  2. Article ; Online: Role of extracorporeal membrane oxygenation and surgical embolectomy in acute pulmonary embolism.

    de Perrot, Marc

    Current opinion in pulmonary medicine

    2022  Volume 28, Issue 5, Page(s) 384–390

    Abstract: Purpose of review: Surgery is an important option to consider in patients with massive and submassive pulmonary emboli. Earlier intervention, better patient selection, improved surgical techniques and the use of veno-arterial extracorporeal membrane ... ...

    Abstract Purpose of review: Surgery is an important option to consider in patients with massive and submassive pulmonary emboli. Earlier intervention, better patient selection, improved surgical techniques and the use of veno-arterial extracorporeal membrane oxygenation (VA ECMO) have contributed to improve the safety of surgery for pulmonary emboli.
    Recent findings: VA ECMO is rapidly changing the initial management of patients with massive pulmonary emboli, providing an opportunity for stabilization and optimization before intervention. The early and long-term consequences of acute pulmonary emboli are better understood, in particular with regard to the risks of chronic thromboembolic pulmonary hypertension (CTEPH), an entity that should be identified in the acute setting as much as possible. The presence of chronic thromboembolic pulmonary disease can be associated with persistent haemodynamic instability despite removal of the acute thrombi, particularly if pulmonary hypertension is established. The pulmonary embolism response team (PERT) is an important component in the management of massive and submassive acute pulmonary emboli to determine the best treatment options for each patient depending on their clinical presentation.
    Summary: Three types of surgery can be performed for pulmonary emboli depending on the extent and degree of organization of the thrombi (pulmonary embolectomy, pulmonary thrombo-embolectomy and pulmonary thrombo-endarterectomy). Other treatment options in the context of acute pulmonary emboli include thrombolysis and catheter-directed embolectomy. Future research should determine how best to integrate VA ECMO as a bridging strategy to recovery or intervention in the treatment algorithm of patients with acute massive pulmonary emboli.
    MeSH term(s) Acute Disease ; Embolectomy/methods ; Endarterectomy ; Extracorporeal Membrane Oxygenation/methods ; Humans ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/surgery ; Pulmonary Embolism/complications ; Pulmonary Embolism/surgery
    Language English
    Publishing date 2022-07-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Omics Overview of the SPARC Gene in Mesothelioma.

    Wu, Licun / de Perrot, Marc

    Biomolecules

    2023  Volume 13, Issue 7

    Abstract: The SPARC gene plays multiple roles in extracellular matrix synthesis and cell shaping, associated with tumor cell migration, invasion, and metastasis. The SPARC gene is also involved in the epithelial-mesenchymal transition (EMT) process, which is a ... ...

    Abstract The SPARC gene plays multiple roles in extracellular matrix synthesis and cell shaping, associated with tumor cell migration, invasion, and metastasis. The SPARC gene is also involved in the epithelial-mesenchymal transition (EMT) process, which is a critical phenomenon leading to a more aggressive cancer cell phenotype. SPARC gene overexpression has shown to be associated with poor survival in the mesothelioma (MESO) cohort from the TCGA database, indicating that this gene may be a powerful prognostic factor in MESO. Its overexpression is correlated with the immunosuppressive tumor microenvironment. Here, we summarize the omics advances of the SPARC gene, including the summary of SPARC gene expression associated with prognosis in pancancer and MESO, the immunosuppressive microenvironment, and cancer cell stemness. In addition, SPARC might be targeted by microRNAs. Notably, despite the controversial functions on angiogenesis, SPARC may directly or indirectly contribute to tumor angiogenesis in MESO. In conclusion, SPARC is involved in tumor invasion, metastasis, immunosuppression, cancer cell stemness, and tumor angiogenesis, eventually impacting patient survival. Strategies targeting this gene may provide novel therapeutic approaches to the treatment of MESO.
    MeSH term(s) Humans ; Cell Line, Tumor ; Mesothelioma/genetics ; MicroRNAs/genetics ; Mesothelioma, Malignant/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Tumor Microenvironment/genetics ; Osteonectin/genetics ; Osteonectin/metabolism
    Chemical Substances MicroRNAs ; SPARC protein, human ; Osteonectin
    Language English
    Publishing date 2023-07-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13071103
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  4. Article ; Online: Prognostic Role of PD-L1 in Malignant Pleural Mesothelioma: Unraveling the Complexity of the Tumor Microenvironment in Mesothelioma.

    de Perrot, Marc

    The Annals of thoracic surgery

    2021  Volume 112, Issue 5, Page(s) 1583–1584

    MeSH term(s) B7-H1 Antigen ; Humans ; Mesothelioma ; Mesothelioma, Malignant ; Pleural Neoplasms ; Prognosis ; Tumor Microenvironment
    Chemical Substances B7-H1 Antigen
    Language English
    Publishing date 2021-01-29
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2020.12.052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
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  5. Article ; Online: Commentary: Is thoracic cage volume a new parameter for clinical staging in mesothelioma?

    de Perrot, Marc

    The Journal of thoracic and cardiovascular surgery

    2020  Volume 159, Issue 6, Page(s) 2520–2521

    MeSH term(s) Humans ; Lung Neoplasms ; Mesothelioma ; Rib Cage
    Language English
    Publishing date 2020-01-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2019.12.048
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  6. Article ; Online: Commentary: Biomarkers in chronic thromboembolic pulmonary hypertension-The clot thickens.

    de Perrot, Marc

    The Journal of thoracic and cardiovascular surgery

    2020  Volume 161, Issue 4, Page(s) 1544–1545

    MeSH term(s) Biomarkers ; C-Reactive Protein ; Endarterectomy ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Thrombosis
    Chemical Substances Biomarkers ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2020-01-31
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2020.01.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: When You Cannot

    Beale, Anna Louise / Mok, Kwang How / de Perrot, Marc / Granton, John T / Mak, Susanna

    Annals of the American Thoracic Society

    2023  Volume 20, Issue 5, Page(s) 749–755

    MeSH term(s) Humans ; Cardiology ; Cardiovascular System ; Diagnostic Imaging ; Hemodynamics
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202212-1012CC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5828: Show issues Location:
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  8. Article ; Online: Commentary: Innovative strategies in lobar lung transplantation.

    Donahoe, Laura L / de Perrot, Marc

    JTCVS techniques

    2020  Volume 3, Page(s) 392–393

    Language English
    Publishing date 2020-08-15
    Publishing country United States
    Document type Editorial
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2020.08.033
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  9. Article ; Online: Commentary: Solitary Fibrous Tumor of the Esophagus-Rare but With Typical Characteristics.

    Yeung, Jonathan / de Perrot, Marc

    Seminars in thoracic and cardiovascular surgery

    2019  Volume 32, Issue 1, Page(s) 179–180

    MeSH term(s) Esophagus ; Humans ; Solitary Fibrous Tumors
    Language English
    Publishing date 2019-08-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1038278-1
    ISSN 1532-9488 ; 1043-0679
    ISSN (online) 1532-9488
    ISSN 1043-0679
    DOI 10.1053/j.semtcvs.2019.08.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Timing of surgery for pulmonary embolism: An evolving paradigm.

    de Perrot, Marc

    The Journal of thoracic and cardiovascular surgery

    2017  Volume 155, Issue 3, Page(s) 1091–1092

    MeSH term(s) Embolectomy ; Humans ; Pulmonary Embolism
    Language English
    Publishing date 2017-10-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2017.10.011
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