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Article ; Online: Correction for Piepenbrink et al., "Highly Cross-Reactive and Protective Influenza A Virus H3N2 Hemagglutinin- and Neuraminidase-Specific Human Monoclonal Antibodies".

Piepenbrink, Michael / Oladunni, Fatai / Nogales, Aitor / Khalil, Ahmed M / Fitzgerald, Theresa / Hilimire, Thomas A / Basu, Madhubanti / Fucile, Christopher / Topham, David J / Rosenberg, Alexander F / Martinez-Sobrido, Luis / Kobie, James J

Microbiology spectrum

2024 Volume 12, Issue 3, Page(s) e0338923

Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.03389-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Alzheimer's disease heterogeneity revealed by neuroanatomical normative modeling.

Loreto, Flavia / Verdi, Serena / Kia, Seyed Mostafa / Duvnjak, Aleksandar / Hakeem, Haneen / Fitzgerald, Anna / Patel, Neva / Lilja, Johan / Win, Zarni / Perry, Richard / Marquand, Andre F / Cole, James H / Malhotra, Paresh

Alzheimer's & dementia (Amsterdam, Netherlands)

2024 Volume 16, Issue 1, Page(s) e12559

Abstract: Introduction: Overlooking the heterogeneity in Alzheimer's disease (AD) may lead to diagnostic delays and failures. Neuroanatomical normative modeling captures individual brain variation and may inform our understanding of individual differences in AD- ... ...

Abstract	Introduction: Overlooking the heterogeneity in Alzheimer's disease (AD) may lead to diagnostic delays and failures. Neuroanatomical normative modeling captures individual brain variation and may inform our understanding of individual differences in AD-related atrophy. Methods: We applied neuroanatomical normative modeling to magnetic resonance imaging from a real-world clinical cohort with confirmed AD ( Results: The superior temporal sulcus contained the highest proportion of outliers (60%). Elsewhere, overlap between patient atrophy patterns was low. Mean total outlier count was higher in patients who were non-amnestic, at more advanced disease stages, and without depressive symptoms. Amyloid burden was negatively associated with outlier count. Discussion: Brain atrophy in AD is highly heterogeneous and neuroanatomical normative modeling can be used to explore anatomo-clinical correlations in individual patients.
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832898-X
ISSN	2352-8729
ISSN	2352-8729
DOI	10.1002/dad2.12559
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Article ; Online: Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome.

Mansfield, Christopher R / Quan, Baiyi / Chirgwin, Michael E / Eduful, Benjamin / Hughes, Philip F / Neveu, Gaëlle / Sylvester, Kayla / Ryan, Daniel H / Kafsack, Björn F C / Haystead, Timothy A J / Leahy, James W / Fitzgerald, Michael C / Derbyshire, Emily R

Cell chemical biology

2024 Volume 31, Issue 4, Page(s) 729–742.e13

Abstract: The molecular chaperone heat shock protein 90 (Hsp90) has an essential but largely undefined role in maintaining proteostasis in Plasmodium falciparum, the most lethal malaria parasite. Herein, we identify BX-2819 and XL888 as potent P. falciparum (Pf) ... ...

Abstract	The molecular chaperone heat shock protein 90 (Hsp90) has an essential but largely undefined role in maintaining proteostasis in Plasmodium falciparum, the most lethal malaria parasite. Herein, we identify BX-2819 and XL888 as potent P. falciparum (Pf)Hsp90 inhibitors. Derivatization of XL888's scaffold led to the development of Tropane 1, as a PfHsp90-selective binder with nanomolar affinity. Hsp90 inhibitors exhibit anti-Plasmodium activity against the liver, asexual blood, and early gametocyte life stages. Thermal proteome profiling was implemented to assess PfHsp90-dependent proteome stability, and the proteasome-the main site of cellular protein recycling-was enriched among proteins with perturbed stability upon PfHsp90 inhibition. Subsequent biochemical and cellular studies suggest that PfHsp90 directly promotes proteasome hydrolysis by chaperoning the active 26S complex. These findings expand our knowledge of the PfHsp90-dependent proteome and protein quality control mechanisms in these pathogenic parasites, as well as further characterize this chaperone as a potential antimalarial drug target.
MeSH term(s)	Plasmodium falciparum/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Proteome/metabolism ; Antimalarials/chemistry ; HSP90 Heat-Shock Proteins ; Molecular Chaperones/metabolism
Chemical Substances	ATP dependent 26S protease (EC 3.4.99.-) ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Proteome ; Antimalarials ; HSP90 Heat-Shock Proteins ; Molecular Chaperones
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ISSN	2451-9448
ISSN (online)	2451-9448
DOI	10.1016/j.chembiol.2024.02.008
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Article ; Online: Variation of prescription drug prices in community pharmacies: A national cross-sectional study.

Larkin, James / Moriarty, Frank / McGuinness, Shane / Finucane, Karl / Fitzgerald, Karen / Smith, Susan M / O'Mahony, James F

Research in social & administrative pharmacy : RSAP

2022 Volume 18, Issue 10, Page(s) 3736–3743

Abstract: Background; There is evidence of significant variation of prescription drug prices in community pharmacies in several countries. Prescription drugs are a major source of expenditure for patients. High prices can lead to cost-related non-adherence and ... ...

Abstract	Background; There is evidence of significant variation of prescription drug prices in community pharmacies in several countries. Prescription drugs are a major source of expenditure for patients. High prices can lead to cost-related non-adherence and adverse health outcomes. Objective; This study's aim was to establish the variation and availability of prescription drug prices in community pharmacies in Ireland. Methods; Using a cross-sectional design, prices were sought in community pharmacies using phone, email and website enquiries. A purposive sample of 12 prescription drugs was included. The prescription drugs were selected from the top 100 medications by dispensing frequency in 2017 on Ireland's main state drug scheme. For each pharmacy, the price was checked for three drugs only. Researchers sought to contact 1,500 pharmacies by phone and 320 by email, as well as consult the website of 370 pharmacies. Results; In total, 1,529 pharmacies responded to queries, 1,362 by telephone and 167 by email. Overall, 88.5% (N = 1,353) of pharmacies who answered queries, provided prices. For each drug, the average price quoted to researchers was higher than the price paid by the state for patients who can access subsidised medicines. The ratio of 90th to 10th percentile prices ranged from 1.3 to 2.0 for the twelve drugs. A Welch's t-test found that for nine of the 12 drugs, the price was significantly higher (p < .05) for chain pharmacies compared to independent pharmacies. Conclusions; Evidence was found of significant price variation in community pharmacies. There was also evidence that some community pharmacies were not following regulatory guidance on drug pricing transparency. Policy measures such as mandated price transparency, or fixed prescription drug prices could help address these price issues.
MeSH term(s)	Cross-Sectional Studies ; Drug Costs ; Humans ; Pharmacies ; Pharmacy ; Prescription Drugs ; Prescriptions
Chemical Substances	Prescription Drugs
Language	English
Publishing date	2022-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2192059-X
ISSN	1934-8150 ; 1551-7411
ISSN (online)	1934-8150
ISSN	1551-7411
DOI	10.1016/j.sapharm.2022.05.007
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Article ; Online: Mediterranean diet is linked to less objective disability in multiple sclerosis.

Katz Sand, Ilana / Levy, Sarah / Fitzgerald, Kathryn / Sorets, Tali / Sumowski, James F

Multiple sclerosis (Houndmills, Basingstoke, England)

2022 Volume 29, Issue 2, Page(s) 248–260

Abstract: Background: The multiple sclerosis (MS) community is highly interested in diet as a potential protective factor against disability, but empirical evidence remains limited.: Objective: Evaluate associations between patient-reported Mediterranean diet ... ...

Abstract	Background: The multiple sclerosis (MS) community is highly interested in diet as a potential protective factor against disability, but empirical evidence remains limited. Objective: Evaluate associations between patient-reported Mediterranean diet alignment and objective disability in a real-world MS cohort. Methods: Data were analyzed from persons with MS, aged 18-65, who completed the Mediterranean Diet Adherence Screener (MEDAS), MS Functional Composite (MSFC; primary disability metric), and patient-reported outcomes (PROs; disability, gait disturbance, fatigue, anxiety, and depression) as part of our Comprehensive Annual Assessment Program. Multiple regression predicted MSFC (and PROs) with MEDAS after adjusting for demographic (age, sex, race, ethnicity, and socioeconomic status) and health-related (body mass index (BMI), exercise, sleep disturbance, hypertension, diabetes, hyperlipidemia, and smoking) covariates. Results: Higher MEDAS independently predicted better outcomes across MSFC ( Conclusion: With robust control for potential confounds, higher Mediterranean diet alignment predicted lower objective and patient-reported disability. Findings lay the necessary groundwork for longitudinal and interventional studies to guide clinical recommendations in MS.
MeSH term(s)	Humans ; Multiple Sclerosis ; Diet, Mediterranean ; Smoking ; Social Class
Language	English
Publishing date	2022-10-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1290669-4
ISSN	1477-0970 ; 1352-4585
ISSN (online)	1477-0970
ISSN	1352-4585
DOI	10.1177/13524585221127414
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Article ; Online: Changes in Brain Network Connections After Exposure and Response Prevention Therapy for Obsessive-Compulsive Disorder in Adolescents and Adults.

Becker, Hannah C / Beltz, Adriene M / Himle, Joseph A / Abelson, James L / Block, Stefanie Russman / Taylor, Stephan F / Fitzgerald, Kate D

Biological psychiatry. Cognitive neuroscience and neuroimaging

2023 Volume 9, Issue 1, Page(s) 70–79

Abstract: Background: Functional alterations of tripartite neural networks during cognitive control (i.e., frontoparietal network [FPN], cingulo-opercular network, and default mode network) occur in patients with obsessive-compulsive disorder (OCD) and may ... ...

Abstract	Background: Functional alterations of tripartite neural networks during cognitive control (i.e., frontoparietal network [FPN], cingulo-opercular network, and default mode network) occur in patients with obsessive-compulsive disorder (OCD) and may contribute to illness expression. However, the degree to which changes in these networks are elicited by gold standard treatment (e.g., exposure and response prevention [EX/RP]) remains unknown. Understanding how EX/RP modulates network connectivity in adolescent versus adult patients with OCD may aid the identification of developmentally sensitive treatment targets that enhance cognitive control. Methods: Data from a total of 169 adolescents (13-17 years) and adults (25-40 years; 57% female) were analyzed, including healthy control participants (n = 58) and patients with OCD (n = 111) who were randomized to either EX/RP or an active control therapy (stress management training). Participants performed a flanker task during functional magnetic resonance imaging pre- and posttreatment. To retain sensitivity to individual differences in connectivity, group iterative multiple model estimation was used to assess functional connectivity (i.e., density) within and between brain networks. Results: Significant increases in FPN density and decreases in FPN-default mode network density were observed from pre- to posttreatment in patients who received EX/RP. The opposite patterns of change occurred in patients who received stress management training. These treatment-related changes in network density did not differ across age group. Conclusions: Results suggest EX/RP-specific changes in task-based connectivity in patients with OCD. Given baseline differences between healthy control participants and patients by age group, these treatment-related changes may indicate restoration of healthy FPN and default mode network development across patients, providing targets for improving response to EX/RP.
MeSH term(s)	Adult ; Humans ; Adolescent ; Female ; Male ; Brain ; Brain Mapping ; Obsessive-Compulsive Disorder ; Magnetic Resonance Imaging ; Healthy Volunteers
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2879089-3
ISSN	2451-9030 ; 2451-9022
ISSN (online)	2451-9030
ISSN	2451-9022
DOI	10.1016/j.bpsc.2023.09.009
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Article ; Online: Depression symptoms and cognition in multiple sclerosis: Longitudinal evidence of a specific link to executive control.

Anderson, Jordyn R / Fitzgerald, Kathryn C / Murrough, James W / Katz Sand, Ilana B / Sorets, Tali R / Krieger, Stephen C / Riley, Claire S / Fabian, Michelle T / Sumowski, James F

Multiple sclerosis (Houndmills, Basingstoke, England)

2023 Volume 29, Issue 13, Page(s) 1632–1645

Abstract: Background: Depression symptoms are prevalent in multiple sclerosis (MS) and associated with poorer cognition in cross-sectional studies; it is unknown whether changes in depression symptoms track with cognitive changes longitudinally.: Objective: ... ...

Abstract	Background: Depression symptoms are prevalent in multiple sclerosis (MS) and associated with poorer cognition in cross-sectional studies; it is unknown whether changes in depression symptoms track with cognitive changes longitudinally. Objective: Investigate whether changes in depression symptoms correspond with cognitive changes over time in MS, and identify specific cognitive functions related to depression symptoms. Method: Persons with early relapse-onset MS ( Results: Change in depression symptoms was related to change in executive control ( Conclusions: Executive control tracks with depression symptoms, raising hope that management of mood may improve executive control. The specific link between executive control and anhedonia implicates dysfunctional reward processing as a key component of MS depression.
MeSH term(s)	Humans ; Executive Function ; Multiple Sclerosis/complications ; Multiple Sclerosis/psychology ; Depression ; Cross-Sectional Studies ; Neuropsychological Tests ; Cognition
Language	English
Publishing date	2023-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1290669-4
ISSN	1477-0970 ; 1352-4585
ISSN (online)	1477-0970
ISSN	1352-4585
DOI	10.1177/13524585231198746
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Article ; Online: Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption.

Bhattarai, Shakti K / Du, Muxue / Zeamer, Abigail L / M Morzfeld, Benedikt / Kellogg, Tasia D / Firat, Kaya / Benjamin, Anna / Bean, James M / Zimmerman, Matthew / Mardi, Gertrude / Vilbrun, Stalz Charles / Walsh, Kathleen F / Fitzgerald, Daniel W / Glickman, Michael S / Bucci, Vanni

Science translational medicine

2024 Volume 16, Issue 730, Page(s) eadi9711

Abstract: Despite their therapeutic benefits, antibiotics exert collateral damage on the microbiome and promote antimicrobial resistance. However, the mechanisms governing microbiome recovery from antibiotics are poorly understood. Treatment ... ...

Abstract	Despite their therapeutic benefits, antibiotics exert collateral damage on the microbiome and promote antimicrobial resistance. However, the mechanisms governing microbiome recovery from antibiotics are poorly understood. Treatment of
MeSH term(s)	Humans ; Animals ; Mice ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Resilience, Psychological ; Drug Resistance, Bacterial/genetics ; Microbiota ; Gastrointestinal Microbiome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.adi9711
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Article ; Online: Lentil grain quality and segregation opportunities in‐field using remote sensing

Nuttall, James G. / Wallace, Ashley J. / Delahunty, Audrey J. / Perry, Eileen M. / Clancy, Alexander B. / Panozzo, Joe F. / Fitzgerald, Glenn J. / Walker, Cassandra K.

Agronomy Journal. 2024 , v. 116, no. 1 p.121-140

2024

Abstract: For broad‐acre crops grown in Mediterranean‐type environments, variation in lentil (Lens culinaris) yield and quality occurs due to seasonal abiotic and biotic stresses. Because grain quality affects the price paid to growers, in‐season assessment of ... ...

Abstract	For broad‐acre crops grown in Mediterranean‐type environments, variation in lentil (Lens culinaris) yield and quality occurs due to seasonal abiotic and biotic stresses. Because grain quality affects the price paid to growers, in‐season assessment of likely final quality using remote sensing technologies could limit economic losses by informing spatial management at harvest. For a survey of lentil crops grown in southern Australia, in 2019 and 2020, Moran's I analysis identified significant field spatial autocorrelation for the grain quality traits of grain protein concentration (GPC), grain size, and grain brightness (CIE L, where CIE is International Commission on Illumination), indicating an opportunity for zoning at harvest. Partial least squares calibration models of observed grain quality and proximal reflectance spectra were successfully derived for grain weight (R² = 0.80), GPC (R² = 0.80), and CIE L (R² = 0.86). For late senescence, Sentinel‐2 satellite canopy reflectance, grain size was best predicted (R² = 0.79) and GPC was poorer (R² = 0.42). Spatial maps of fields for grain size, informed by models, could be derived and determined that for the market critical threshold (38 mg), field area that exceeded this threshold ranged between 30% and 94%. Overall, we determined that sensing technologies had utility for mapping lentil grain quality across fields, providing a potential tool for growers to selectively harvest to achieve best aggregate price based on grain quality targets. Further calibration and validation with multiple years and locations is also needed to test model stability and application to varying environments.
Keywords	Lens culinaris ; agronomy ; autocorrelation ; grain protein ; grain quality ; leaf reflectance ; lentils ; lighting ; markets ; models ; prices ; reflectance ; satellites ; surveys ; Australia
Language	English
Dates of publication	2024-01
Size	p. 121-140.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	410332-4
ISSN	1435-0645 ; 0002-1962
ISSN (online)	1435-0645
ISSN	0002-1962
DOI	10.1002/agj2.21507
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A brainstem integrator for self-location memory and positional homeostasis in zebrafish.

Yang, En / Zwart, Maarten F / James, Ben / Rubinov, Mikail / Wei, Ziqiang / Narayan, Sujatha / Vladimirov, Nikita / Mensh, Brett D / Fitzgerald, James E / Ahrens, Misha B

Cell

2022 Volume 185, Issue 26, Page(s) 5011–5027.e20

Abstract: To track and control self-location, animals integrate their movements through space. Representations of self-location are observed in the mammalian hippocampal formation, but it is unknown if positional representations exist in more ancient brain regions, ...

Abstract	To track and control self-location, animals integrate their movements through space. Representations of self-location are observed in the mammalian hippocampal formation, but it is unknown if positional representations exist in more ancient brain regions, how they arise from integrated self-motion, and by what pathways they control locomotion. Here, in a head-fixed, fictive-swimming, virtual-reality preparation, we exposed larval zebrafish to a variety of involuntary displacements. They tracked these displacements and, many seconds later, moved toward their earlier location through corrective swimming ("positional homeostasis"). Whole-brain functional imaging revealed a network in the medulla that stores a memory of location and induces an error signal in the inferior olive to drive future corrective swimming. Optogenetically manipulating medullary integrator cells evoked displacement-memory behavior. Ablating them, or downstream olivary neurons, abolished displacement corrections. These results reveal a multiregional hindbrain circuit in vertebrates that integrates self-motion and stores self-location to control locomotor behavior.
MeSH term(s)	Animals ; Zebrafish/physiology ; Neurons/physiology ; Rhombencephalon/physiology ; Brain/physiology ; Swimming/physiology ; Homeostasis ; Mammals
Language	English
Publishing date	2022-12-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2022.11.022
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