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  1. Article ; Online: Building a global immune system.

    Lipkin, W I / Briese, T

    Human vaccines & immunotherapeutics

    2022  Volume 18, Issue 4, Page(s) 2036069

    Abstract: The COVID-19 pandemic exposed global vulnerabilities to emerging infectious diseases, heralded by earlier outbreaks, that did not result in appropriate investments in surveillance, international collaboration, and response. We propose specific steps that ...

    Abstract The COVID-19 pandemic exposed global vulnerabilities to emerging infectious diseases, heralded by earlier outbreaks, that did not result in appropriate investments in surveillance, international collaboration, and response. We propose specific steps that should be taken to reduce future risks to public health, economic and political stability, and food security.
    MeSH term(s) COVID-19/epidemiology ; Global Health ; Humans ; Immune System ; International Cooperation ; Pandemics/prevention & control
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2022.2036069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6967: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature.

    Komaroff, Anthony L / Lipkin, W Ian

    Frontiers in medicine

    2023  Volume 10, Page(s) 1187163

    Abstract: Some patients remain unwell for months after "recovering" from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms ... ...

    Abstract Some patients remain unwell for months after "recovering" from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms that greatly interfere with their ability to function and that can leave some people housebound and disabled. The illness (Long COVID) is similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well as to persisting illnesses that can follow a wide variety of other infectious agents and following major traumatic injury. Together, these illnesses are projected to cost the U.S. trillions of dollars. In this review, we first compare the
    Language English
    Publishing date 2023-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1187163
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  3. Article ; Online: Regional histomorphology of cancellous bone in Macaca fascicularis.

    Lipkin, Edward W

    American journal of primatology

    2019  Volume 39, Issue 3, Page(s) 179–187

    Abstract: The structural and dynamic characteristics of cancellous bone from biopsy sites representing different degrees of weight bearing were quantified following double fluorochrome labeling of adult male Macaca fascicularis. A strong correlation of bone ... ...

    Abstract The structural and dynamic characteristics of cancellous bone from biopsy sites representing different degrees of weight bearing were quantified following double fluorochrome labeling of adult male Macaca fascicularis. A strong correlation of bone formation rate was found between the humerus, tibia, and iliac crest within the same individual. There was no significant correlation between differing biopsy sites for the structural measures of bone. The coefficient of variation for bone formation rate at different sites from the same animal was comparable to the coefficient of variation for different animals measured at the same biopsy site. The present study suggests that any accessible site of cancellous bone will yield a representative measure of bone formation rate, but that structural measures are not generalizable between different sites. © 1996 Wiley-Liss, Inc.
    Language English
    Publishing date 2019-12-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1495834-X
    ISSN 1098-2345 ; 0275-2565
    ISSN (online) 1098-2345
    ISSN 0275-2565
    DOI 10.1002/(SICI)1098-2345(1996)39:3<179::AID-AJP3>3.0.CO;2-W
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  4. Article ; Online: Cohort-guided insights into gene-environment interactions in autism spectrum disorders.

    Lipkin, W Ian / Bresnahan, Michaeline / Susser, Ezra

    Nature reviews. Neurology

    2023  Volume 19, Issue 2, Page(s) 118–125

    Abstract: Prospective birth cohorts offer unprecedented opportunities to investigate the pathogenesis of complex disorders such as autism, in which gene-environment interactions must be appreciated in a temporal context. This Perspective article considers the ... ...

    Abstract Prospective birth cohorts offer unprecedented opportunities to investigate the pathogenesis of complex disorders such as autism, in which gene-environment interactions must be appreciated in a temporal context. This Perspective article considers the history of autism research, including missteps that reflected an incomplete understanding of the epidemiology of autistic spectrum disorders, the effects of advocacy and philanthropy on the trajectory of scientific inquiry, and the current and future roles of prospective birth cohort research in illuminating the pathology of these and other complex disorders wherein exposures during gestation might not manifest until later in life.
    MeSH term(s) Humans ; Autism Spectrum Disorder/epidemiology ; Autism Spectrum Disorder/genetics ; Gene-Environment Interaction ; Prospective Studies ; Autistic Disorder
    Language English
    Publishing date 2023-01-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-022-00764-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6257: Show issues Location:
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    Zs.MG 88: Show issues

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  5. Article ; Online: Maternal prenatal Tdap not associated with autism development in the child.

    Lipkin, W Ian

    The Journal of pediatrics

    2018  Volume 204, Page(s) 320–323

    MeSH term(s) Autism Spectrum Disorder ; Autistic Disorder ; Child ; Diphtheria ; Female ; Humans ; Pregnancy ; Tetanus ; Vaccination ; Whooping Cough
    Language English
    Publishing date 2018-12-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2018.10.074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.116: Show issues Location:
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  6. Article ; Online: Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome.

    Komaroff, Anthony L / Lipkin, W Ian

    Trends in molecular medicine

    2021  Volume 27, Issue 9, Page(s) 895–906

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause chronic and acute disease. Postacute sequelae of SARS-CoV-2 infection (PASC) include injury to the lungs, heart, kidneys, and brain that may produce a variety of symptoms. PASC also ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause chronic and acute disease. Postacute sequelae of SARS-CoV-2 infection (PASC) include injury to the lungs, heart, kidneys, and brain that may produce a variety of symptoms. PASC also includes a post-coronavirus disease 2019 (COVID-19) syndrome ('long COVID') with features that can follow other acute infectious diseases and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Here we summarize what is known about the pathogenesis of ME/CFS and of 'acute' COVID-19, and we speculate that the pathogenesis of post-COVID-19 syndrome in some people may be similar to that of ME/CFS. We propose molecular mechanisms that might explain the fatigue and related symptoms in both illnesses, and we suggest a research agenda for both ME/CFS and post-COVID-19 syndrome.
    MeSH term(s) COVID-19/complications ; COVID-19/etiology ; COVID-19/physiopathology ; Energy Metabolism ; Fatigue Syndrome, Chronic/etiology ; Fatigue Syndrome, Chronic/physiopathology ; Gastrointestinal Microbiome ; Humans ; Nervous System/physiopathology ; Post-Acute COVID-19 Syndrome
    Language English
    Publishing date 2021-06-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2021.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4345: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Discovery and Surveillance of Tick-Borne Pathogens.

    Tokarz, Rafal / Lipkin, W Ian

    Journal of medical entomology

    2020  Volume 58, Issue 4, Page(s) 1525–1535

    Abstract: Within the past 30 yr molecular assays have largely supplanted classical methods for detection of tick-borne agents. Enhancements provided by molecular assays, including speed, throughput, sensitivity, and specificity, have resulted in a rapid increase ... ...

    Abstract Within the past 30 yr molecular assays have largely supplanted classical methods for detection of tick-borne agents. Enhancements provided by molecular assays, including speed, throughput, sensitivity, and specificity, have resulted in a rapid increase in the number of newly characterized tick-borne agents. The use of unbiased high throughput sequencing has enabled the prompt identification of new pathogens and the examination of tick microbiomes. These efforts have led to the identification of hundreds of new tick-borne agents in the last decade alone. However, little is currently known about the majority of these agents beyond their phylogenetic classification. Our article outlines the primary methods involved in tick-borne agent discovery and the current status of our understanding of tick-borne agent diversity.
    MeSH term(s) Animals ; Arachnid Vectors/microbiology ; High-Throughput Nucleotide Sequencing ; Polymerase Chain Reaction ; Ticks/microbiology ; Virome
    Language English
    Publishing date 2020-12-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 410635-0
    ISSN 1938-2928 ; 0022-2585
    ISSN (online) 1938-2928
    ISSN 0022-2585
    DOI 10.1093/jme/tjaa269
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 303: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: ME/CFS and Long COVID share similar symptoms and biological abnormalities

    Anthony L. Komaroff / W. Ian Lipkin

    Frontiers in Medicine, Vol

    road map to the literature

    2023  Volume 10

    Abstract: Some patients remain unwell for months after “recovering” from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms ... ...

    Abstract Some patients remain unwell for months after “recovering” from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms that greatly interfere with their ability to function and that can leave some people housebound and disabled. The illness (Long COVID) is similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well as to persisting illnesses that can follow a wide variety of other infectious agents and following major traumatic injury. Together, these illnesses are projected to cost the U.S. trillions of dollars. In this review, we first compare the symptoms of ME/CFS and Long COVID, noting the considerable similarities and the few differences. We then compare in extensive detail the underlying pathophysiology of these two conditions, focusing on abnormalities of the central and autonomic nervous system, lungs, heart, vasculature, immune system, gut microbiome, energy metabolism and redox balance. This comparison highlights how strong the evidence is for each abnormality, in each illness, and helps to set priorities for future investigation. The review provides a current road map to the extensive literature on the underlying biology of both illnesses.
    Keywords chronic fatigue syndrome (CFS) ; myalgic encephalomyelitis (ME) ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; Long COVID ; post-acute sequelae of SARS-CoV-2 infection ; post-infectious fatigue syndrome ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book: Microbiology, immunology and toxicology of autism and other neurodevelopmental disorders

    Lipkin, W. Ian

    [Banbury Center of Cold Spring Harbor Meeting on Microbiology, Immunology and Toxicology of Autism and Other Neurodevelopmental Disorders, February 11 - 14, 2001]

    (Molecular psychiatry ; 7, Suppl. 2)

    2002  

    Institution Meeting on Microbiology, Immunology and Toxicology of Autism and Other Neurodevelopmental Disorders
    Banbury Center
    Author's details guest ed.: W. Ian Lipkin
    Series title Molecular psychiatry ; 7, Suppl. 2
    Collection
    Keywords Autismus ; Mikrobiologie ; Immunologie ; Toxikologie ; Gehirn ; Entwicklungsstörung
    Subject Giftkunde ; Klinische Toxikologie ; Entwicklungsanomalie ; Cerebrum ; Hirn ; Encephalon ; Enzephalon ; Hirngewebe ; Hirnmasse ; Gehirnmasse ; Klinische Immunologie ; Autismus-Spektrum-Störung ; Autism
    Language English
    Size S52 S. : Ill., graph. Darst.
    Publisher Nature Publ. Group
    Publishing place Basingstoke, Hampshire
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013451925
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 4812 -7,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  10. Article ; Online: Middle East Respiratory Syndrome Coronavirus Recombination and the Evolution of Science and Public Health in China.

    Lipkin, W Ian

    mBio

    2015  Volume 6, Issue 5, Page(s) e01381–15

    MeSH term(s) Coronavirus Infections/virology ; Evolution, Molecular ; Humans ; Middle East Respiratory Syndrome Coronavirus/classification ; Middle East Respiratory Syndrome Coronavirus/genetics ; Recombination, Genetic
    Keywords covid19
    Language English
    Publishing date 2015-09-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01381-15
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