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Article ; Online: Charge-changing point mutations in the E protein of tick-borne encephalitis virus.

Kozlovskaya, Liubov I / Osolodkin, Dmitry I / Tuchynskaya, Ksenia K / Shevtsova, Anastasia S / Okhezin, Egor V / Palyulin, Vladimir A / Nikitin, Nikolai A / Karganova, Galina G

Archives of virology

2023 Volume 168, Issue 3, Page(s) 100

Abstract: Introduction of point mutations is one of the forces enabling arboviruses to rapidly adapt in a changing environment. The influence of these mutations on the properties of the virus is not always obvious. In this study, we attempted to clarify this ... ...

Abstract	Introduction of point mutations is one of the forces enabling arboviruses to rapidly adapt in a changing environment. The influence of these mutations on the properties of the virus is not always obvious. In this study, we attempted to clarify this influence using an in silico approach. Using molecular dynamics (MD) simulations, we investigated how the position of charge-changing point mutations influences the structure and conformational stability of the E protein for a set of variants of a single TBEV strain. The computational findings were supported by experimental evaluation of relevant properties of virions, such as binding to heparan sulfate, thermostability, and susceptibility of the viral hemagglutinating activity to detergents. Our results also point to relationships between E protein dynamics and viral neuroinvasiveness.
MeSH term(s)	Point Mutation ; Encephalitis Viruses, Tick-Borne ; Mutation ; Molecular Dynamics Simulation ; Transcription Factors
Chemical Substances	Transcription Factors
Language	English
Publishing date	2023-03-05
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-023-05728-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 Binding and Neutralization Properties of Peptides Derived from N-Terminus of Human ACE2.

Astrakhantseva, Irina V / Ershova, Alina E / Chuvpilo, Sergei A / Kruglova, Natalia A / Ishmukhametov, Aydar A / Drutskaya, Marina S / Kozlovskaya, Liubov I / Nedospasov, Sergei A

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: The binding properties of synthetic and recombinant peptides derived from N-terminal part of ACE2, the main receptor for SARS-CoV-2, were evaluated. Additionally, the ability of these peptides to prevent virus entry in vitro was addressed using both ... ...

Abstract	The binding properties of synthetic and recombinant peptides derived from N-terminal part of ACE2, the main receptor for SARS-CoV-2, were evaluated. Additionally, the ability of these peptides to prevent virus entry in vitro was addressed using both pseudovirus particles decorated with the S protein, as well as through infection of Vero cells with live SARS-CoV-2 virus. Surprisingly, in spite of effective binding to S protein, all linear peptides of various lengths failed to neutralize the viral infection in vitro. However, the P1st peptide that was chemically "stapled" in order to stabilize its alpha-helical structure was able to interfere with virus entry into ACE2-expressing cells. Interestingly, this peptide also neutralized pseudovirus particles decorated with S protein derived from the Omicron BA.1 virus, in spite of variations in key amino acid residues contacting ACE2.
MeSH term(s)	Animals ; Chlorocebus aethiops ; Humans ; SARS-CoV-2/metabolism ; Vero Cells ; Angiotensin-Converting Enzyme 2/metabolism ; Protein Binding ; COVID-19 ; Peptides/pharmacology ; Peptides/metabolism
Chemical Substances	Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Peptides
Language	English
Publishing date	2023-05-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24098269
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Article ; Online: Non-Polio Enteroviruses Isolated by Acute Flaccid Paralysis Surveillance Laboratories in the Russian Federation in 1998-2021: Distinct Epidemiological Features of Types.

Ivanova, Olga E / Eremeeva, Tatiana P / Morozova, Nadezhda S / Mikhailova, Yulia M / Kozlovskaya, Liubov I / Baikova, Olga Y / Shakaryan, Armen K / Krasota, Alexandr Y / Korotkova, Ekaterina A / Yakovchuk, Elizaveta V / Shustova, Elena Y / Lukashev, Alexander N

Viruses

2024 Volume 16, Issue 1

Abstract: More than 100 types of non-polio enteroviruses (NPEVs) are ubiquitous in the human population and cause a variety of symptoms ranging from very mild to meningitis and acute flaccid paralysis (AFP). Much of the information regarding diverse pathogenic ... ...

Abstract	More than 100 types of non-polio enteroviruses (NPEVs) are ubiquitous in the human population and cause a variety of symptoms ranging from very mild to meningitis and acute flaccid paralysis (AFP). Much of the information regarding diverse pathogenic properties of NPEVs comes from the surveillance of poliovirus, which also yields NPEV. The analysis of 265 NPEV isolations from 10,433 AFP cases over 24 years of surveillance and more than 2500 NPEV findings in patients without severe neurological lesions suggests that types EV-A71, E13, and E25 were significantly associated with AFP. EV-A71 was also significantly more common among AFP patients who had fever at the onset and residual paralysis compared to all AFP cases. In addition, a significant disparity was noticed between types that were common in humans (CV-A2, CVA9, EV-A71, E9, and E30) or in sewage (CVA7, E3, E7, E11, E12, and E19). Therefore, there is significant evidence of non-polio viruses being implicated in severe neurological lesions, but further multicenter studies using uniform methodology are needed for a definitive conclusion.
MeSH term(s)	Humans ; Laboratories ; alpha-Fetoproteins ; Poliomyelitis/epidemiology ; Enterovirus Infections/epidemiology ; Enterovirus A, Human ; Poliovirus ; Russia ; Antigens, Viral ; Myelitis ; Neuromuscular Diseases ; Central Nervous System Viral Diseases
Chemical Substances	alpha-Fetoproteins ; Antigens, Viral
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v16010135
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Article: Dry immersion induced acute low back pain and its relationship with trunk myofascial viscoelastic changes.

Plehuna, Anastasija / Green, David Andrew / Amirova, Liubov E / Tomilovskaya, Elena S / Rukavishnikov, Ilya V / Kozlovskaya, Inessa B

Frontiers in physiology

2022 Volume 13, Page(s) 1039924

Abstract: Microgravity induces spinal elongation and Low Back Pain (LBP) but the pathophysiology is unknown. Changes in paraspinal muscle viscoelastic properties may play a role. Dry Immersion (DI) is a ground-based microgravity analogue that induces changes in m. ...

Abstract	Microgravity induces spinal elongation and Low Back Pain (LBP) but the pathophysiology is unknown. Changes in paraspinal muscle viscoelastic properties may play a role. Dry Immersion (DI) is a ground-based microgravity analogue that induces changes in m.
Language	English
Publishing date	2022-10-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.1039924
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Article ; Online: Charge-changing point mutations in the E protein of tick-borne encephalitis virus

Kozlovskaya, Liubov I. / Osolodkin, Dmitry I. / Tuchynskaya, Ksenia K. / Shevtsova, Anastasia S. / Okhezin, Egor V. / Palyulin, Vladimir A. / Nikitin, Nikolai A. / Karganova, Galina G.

Arch Virol. 2023 Mar., v. 168, no. 3 p.100-100

2023

Abstract	Introduction of point mutations is one of the forces enabling arboviruses to rapidly adapt in a changing environment. The influence of these mutations on the properties of the virus is not always obvious. In this study, we attempted to clarify this influence using an in silico approach. Using molecular dynamics (MD) simulations, we investigated how the position of charge-changing point mutations influences the structure and conformational stability of the E protein for a set of variants of a single TBEV strain. The computational findings were supported by experimental evaluation of relevant properties of virions, such as binding to heparan sulfate, thermostability, and susceptibility of the viral hemagglutinating activity to detergents. Our results also point to relationships between E protein dynamics and viral neuroinvasiveness.
Keywords	Tick-borne encephalitis virus ; arboviruses ; computer simulation ; hemagglutination ; heparan sulfate ; molecular dynamics ; thermal stability
Language	English
Dates of publication	2023-03
Size	p. 100.
Publishing place	Springer Vienna
Document type	Article ; Online
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-023-05728-3
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Elongation of N

Zenchenko, Anastasia A / Drenichev, Mikhail S / Khvatov, Evgeny V / Uvarova, Victoria I / Goryashchenko, Alexander S / Frolenko, Vasilisa S / Karpova, Evgenia V / Kozlovskaya, Liubov I / Osolodkin, Dmitry I / Ishmukhametov, Aydar A / Mikhailov, Sergey N / Oslovsky, Vladimir E

Bioorganic & medicinal chemistry

2023 Volume 98, Page(s) 117552

Abstract: Decoration of nucleoside analogues with lipophilic groups often leads to compounds with improved antiviral activity. For example, ... ...

Abstract	Decoration of nucleoside analogues with lipophilic groups often leads to compounds with improved antiviral activity. For example, N
MeSH term(s)	Humans ; Palladium ; West Nile virus ; Encephalitis Viruses, Tick-Borne ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Adenosine/analogs & derivatives
Chemical Substances	Palladium (5TWQ1V240M) ; N(6)-benzyladenosine (4294-16-0) ; Antiviral Agents ; Adenosine (K72T3FS567)
Language	English
Publishing date	2023-12-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2023.117552
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Zs.A 3815: Show issues

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Article ; Online: Will Peptides Help to Stop COVID-19?

Krut', Viktoriya G / Chuvpilo, Sergei A / Astrakhantseva, Irina V / Kozlovskaya, Liubov I / Efimov, Grigory A / Kruglov, Andrei A / Drutskaya, Marina S / Nedospasov, Sergei A

Biochemistry. Biokhimiia

2022 Volume 87, Issue 7, Page(s) 590–604

Abstract: Peptides are widely used for the diagnostics, prevention, and therapy of certain human diseases. How useful can they be for the disease caused by the SARS-CoV-2 coronavirus? In this review, we discuss the possibility of using synthetic and recombinant ... ...

Abstract	Peptides are widely used for the diagnostics, prevention, and therapy of certain human diseases. How useful can they be for the disease caused by the SARS-CoV-2 coronavirus? In this review, we discuss the possibility of using synthetic and recombinant peptides and polypeptides for prevention of COVID-19 via blocking the interaction between the virus and its main receptor ACE2, as well as components of antiviral vaccines, in particular, against new emerging virus variants.
MeSH term(s)	Angiotensin-Converting Enzyme 2 ; Antiviral Agents/therapeutic use ; COVID-19 ; Humans ; Peptides/therapeutic use ; SARS-CoV-2
Chemical Substances	Antiviral Agents ; Peptides ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2022-09-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1109-5
ISSN	1608-3040 ; 0006-2979 ; 0320-9717
ISSN (online)	1608-3040
ISSN	0006-2979 ; 0320-9717
DOI	10.1134/S0006297922070021
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Zs.A 220: Show issues

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Article ; Online: Cytotoxicity reduction by O-nicotinoylation of antiviral 6-benzylaminopurine ribonucleosides.

Zenchenko, Anastasia A / Oslovsky, Vladimir E / Varizhuk, Irina V / Karpova, Evgenia V / Osolodkin, Dmitry I / Kozlovskaya, Liubov I / Ishmukhametov, Aydar A / Drenichev, Mikhail S

Toxicology in vitro : an international journal published in association with BIBRA

2022 Volume 82, Page(s) 105355

Abstract: One of the promising approaches in the development of nucleoside prodrugs is to use the nucleoside analogs containing lipophilic biodegradable residues, which are cleaved to biologically active forms after metabolic transformations in the cell. The ... ...

Abstract	One of the promising approaches in the development of nucleoside prodrugs is to use the nucleoside analogs containing lipophilic biodegradable residues, which are cleaved to biologically active forms after metabolic transformations in the cell. The introduction of such fragments makes it possible to reduce the general toxicity of the drug candidate and increase its stability in the cell. In order to study the influence of biodegradable lipophilic groups on antiviral activity and cytotoxicity, in this work we synthesized N
MeSH term(s)	Adenosine/pharmacology ; Antiviral Agents/toxicity ; Benzyl Compounds ; Enterovirus A, Human/physiology ; Humans ; Nucleosides ; Prodrugs/pharmacology ; Purines ; Ribonucleosides/pharmacology
Chemical Substances	Antiviral Agents ; Benzyl Compounds ; Nucleosides ; Prodrugs ; Purines ; Ribonucleosides ; Adenosine (K72T3FS567) ; benzylaminopurine (KXG6A989PS)
Language	English
Publishing date	2022-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	639064-x
ISSN	1879-3177 ; 0887-2333
ISSN (online)	1879-3177
ISSN	0887-2333
DOI	10.1016/j.tiv.2022.105355
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Article ; Online: Effect of 5-day dry immersion on the human foot morphology evaluated by computer plantography and soft tissues stiffness measuring.

Saveko, Alina / Amirova, Liubov / Ermakov, Ivan / Smirnov, Yuri / Tomilovskaya, Elena / Kozlovskaya, Inesa

Scientific reports

2021 Volume 11, Issue 1, Page(s) 6232

Abstract: 16 participants have been subjected to Dry Immersion model (DI) for 5 days. DI reproduces the space flight factors such as lack of support, mechanical and axial unloading, physical inactivity, elimination of vertical vascular gradient. Long-term bed rest ...

Abstract	16 participants have been subjected to Dry Immersion model (DI) for 5 days. DI reproduces the space flight factors such as lack of support, mechanical and axial unloading, physical inactivity, elimination of vertical vascular gradient. Long-term bed rest is also associated with similar factors, so the results of the study may be useful for clinical medicine. Computer plantography and measuring the stiffness of the soft tissues of the foot and superficial muscles of the shin (mm. tibialis anterior and peroneus longus) were performed twice before DI exposure, on the 2nd and 4th days of DI exposure, as well as on the 2nd day of the recovery period. DI exposure effects the parameters under study in two ways: by raising the longitudinal arch and by flattening the transverse arch, which is accompanied by a decrease in the soft tissues stiffness of the foot and superficial muscles of the shin. The work reveals the phenomenon of compensating the longitudinal arch state by changing the characteristics that reflect the transverse arch state. The results of the study for the first time demonstrate the correlation of the foot morphological characteristics with a decrease in stiffness of mm. peroneus longus and tibialis anterior.
MeSH term(s)	Adult ; Biomechanical Phenomena ; Foot ; Hindlimb Suspension/instrumentation ; Hindlimb Suspension/methods ; Humans ; Male ; Muscle, Skeletal/physiology ; Sedentary Behavior ; Weightlessness Simulation
Language	English
Publishing date	2021-03-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-85771-9
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Article ; Online: Effect of 5-day dry immersion on the human foot morphology evaluated by computer plantography and soft tissues stiffness measuring

Alina Saveko / Liubov Amirova / Ivan Ermakov / Yuri Smirnov / Elena Tomilovskaya / Inesa Kozlovskaya

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 10

Abstract: Abstract 16 participants have been subjected to Dry Immersion model (DI) for 5 days. DI reproduces the space flight factors such as lack of support, mechanical and axial unloading, physical inactivity, elimination of vertical vascular gradient. Long-term ...

Abstract	Abstract 16 participants have been subjected to Dry Immersion model (DI) for 5 days. DI reproduces the space flight factors such as lack of support, mechanical and axial unloading, physical inactivity, elimination of vertical vascular gradient. Long-term bed rest is also associated with similar factors, so the results of the study may be useful for clinical medicine. Computer plantography and measuring the stiffness of the soft tissues of the foot and superficial muscles of the shin (mm. tibialis anterior and peroneus longus) were performed twice before DI exposure, on the 2nd and 4th days of DI exposure, as well as on the 2nd day of the recovery period. DI exposure effects the parameters under study in two ways: by raising the longitudinal arch and by flattening the transverse arch, which is accompanied by a decrease in the soft tissues stiffness of the foot and superficial muscles of the shin. The work reveals the phenomenon of compensating the longitudinal arch state by changing the characteristics that reflect the transverse arch state. The results of the study for the first time demonstrate the correlation of the foot morphological characteristics with a decrease in stiffness of mm. peroneus longus and tibialis anterior.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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