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  1. Article: Isolation of Viable SARS-CoV-2 Virus from Feces of an Immunocompromised Patient Suggesting a Possible Fecal Mode of Transmission.

    Dergham, Julie / Delerce, Jeremy / Bedotto, Marielle / La Scola, Bernard / Moal, Valérie

    Journal of clinical medicine

    2021  Volume 10, Issue 12

    Abstract: 1) Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) excretion in stools is well documented by RT-PCR, but evidences that stools contain infectious particles are scarce. (2) Methods: After observing a Corona Virus 2019 Disease ( ... ...

    Abstract (1) Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) excretion in stools is well documented by RT-PCR, but evidences that stools contain infectious particles are scarce. (2) Methods: After observing a Corona Virus 2019 Disease (COVID-19) epidemic cluster associated with a ruptured sewage pipe, we search for such a viable SARS-CoV-2 particle in stool by inoculating 106 samples from 46 patients. (3) Results: We successfully obtained two isolates from a unique patient with kidney transplantation under immunosuppressive therapy who was admitted for severe diarrhea. (4) Conclusions: This report emphasizes that SARS-CoV-2 is an enteric virus, and infectious virus particles can be isolated from the stool of immune-compromised patients like, in our case, kidney transplant recipient. Immune-compromised patients are likely to have massive multiplication of the virus in the gastrointestinal tract and this report suggests possible fecal transmission of SARS-CoV-2.
    Language English
    Publishing date 2021-06-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10122696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Isolation of Viable SARS-CoV-2 Virus from Feces of an Immunocompromised Patient Suggesting a Possible Fecal Mode of Transmission

    Julie Dergham / Jeremy Delerce / Marielle Bedotto / Bernard La Scola / Valérie Moal

    Journal of Clinical Medicine, Vol 10, Iss 2696, p

    2021  Volume 2696

    Abstract: 1) Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) excretion in stools is well documented by RT-PCR, but evidences that stools contain infectious particles are scarce. (2) Methods: After observing a Corona Virus 2019 Disease ( ... ...

    Abstract (1) Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) excretion in stools is well documented by RT-PCR, but evidences that stools contain infectious particles are scarce. (2) Methods: After observing a Corona Virus 2019 Disease (COVID-19) epidemic cluster associated with a ruptured sewage pipe, we search for such a viable SARS-CoV-2 particle in stool by inoculating 106 samples from 46 patients. (3) Results: We successfully obtained two isolates from a unique patient with kidney transplantation under immunosuppressive therapy who was admitted for severe diarrhea. (4) Conclusions: This report emphasizes that SARS-CoV-2 is an enteric virus, and infectious virus particles can be isolated from the stool of immune-compromised patients like, in our case, kidney transplant recipient. Immune-compromised patients are likely to have massive multiplication of the virus in the gastrointestinal tract and this report suggests possible fecal transmission of SARS-CoV-2.
    Keywords SARS-CoV-2 ; stools ; cell culture ; Covid-19 ; organ transplantation ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Is it time to rethink how we page physicians? Understanding paging patterns in a tertiary care hospital.

    Witherspoon, Luke / Nham, Emily / Abdi, Hamidreza / Dergham, Ali / Skinner, Thomas / Oake, J Stuart / Watterson, James / Lavallée, Luke T

    BMC health services research

    2019  Volume 19, Issue 1, Page(s) 992

    Abstract: ... Resident paging data from April 1 to July 31, 2018 were collected for services with a single primary pager ...

    Abstract Background: Frequent pages can disrupt workflow, interrupt patient care, and may contribute to physician burnout. We hypothesized that paging volumes followed consistent temporal trends, regardless of the medical or surgical service, reflecting systems based issues present in our hospitals.
    Methods: A retrospective review of the hospital paging systems for 4 services at The Ottawa Hospital was performed. Resident paging data from April 1 to July 31, 2018 were collected for services with a single primary pager number including orthopaedic surgery, general surgery, neurology, and neurosurgery. Trends in paging volume during the 4-month period were examined. Variables examined included the location of origin of the page (emergency room vs. inpatient unit), and day/time of the page.
    Results: During the study period, 25,797 pages were received by the 4 services, averaging 211 (± Standard Deviation (SD) 12) pages per day. 19,371 (75%) pages were from in-patient hospital units, while 6426 (24%) were pages from the emergency room. The median interval between pages across all specialties was 22:30 min. Emergency room pages peaked between 16:30 and 20:00, while in-patient units peaked between 17:30 and 18:30.
    Conclusions: Each service experienced frequent paging with similar patterns of marked increases at specific times. This study identifies areas for future study about what the factors are that contribute to the paging patterns observed.
    MeSH term(s) Burnout, Professional ; Canada ; Hospital Communication Systems/statistics & numerical data ; Humans ; Patient Care ; Physicians/psychology ; Retrospective Studies ; Tertiary Care Centers ; Workflow
    Language English
    Publishing date 2019-12-23
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1472-6963
    ISSN (online) 1472-6963
    DOI 10.1186/s12913-019-4844-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Is it time to rethink how we page physicians? Understanding paging patterns in a tertiary care hospital

    Luke Witherspoon / Emily Nham / Hamidreza Abdi / Ali Dergham / Thomas Skinner / J. Stuart Oake / James Watterson / Luke T. Lavallée

    BMC Health Services Research, Vol 19, Iss 1, Pp 1-

    2019  Volume 6

    Abstract: ... Resident paging data from April 1 to July 31, 2018 were collected for services with a single primary pager ...

    Abstract Abstract Background Frequent pages can disrupt workflow, interrupt patient care, and may contribute to physician burnout. We hypothesized that paging volumes followed consistent temporal trends, regardless of the medical or surgical service, reflecting systems based issues present in our hospitals. Methods A retrospective review of the hospital paging systems for 4 services at The Ottawa Hospital was performed. Resident paging data from April 1 to July 31, 2018 were collected for services with a single primary pager number including orthopaedic surgery, general surgery, neurology, and neurosurgery. Trends in paging volume during the 4-month period were examined. Variables examined included the location of origin of the page (emergency room vs. inpatient unit), and day/time of the page. Results During the study period, 25,797 pages were received by the 4 services, averaging 211 (± Standard Deviation (SD) 12) pages per day. 19,371 (75%) pages were from in-patient hospital units, while 6426 (24%) were pages from the emergency room. The median interval between pages across all specialties was 22:30 min. Emergency room pages peaked between 16:30 and 20:00, while in-patient units peaked between 17:30 and 18:30. Conclusions Each service experienced frequent paging with similar patterns of marked increases at specific times. This study identifies areas for future study about what the factors are that contribute to the paging patterns observed.
    Keywords Medical education ; Medical residency ; Physician burnout ; Physician paging ; Public aspects of medicine ; RA1-1270
    Subject code 005
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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